CN221056466U - Platelet adhesion detector - Google Patents
Platelet adhesion detector Download PDFInfo
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- CN221056466U CN221056466U CN202322233873.4U CN202322233873U CN221056466U CN 221056466 U CN221056466 U CN 221056466U CN 202322233873 U CN202322233873 U CN 202322233873U CN 221056466 U CN221056466 U CN 221056466U
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- platelet adhesion
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- 238000001514 detection method Methods 0.000 claims abstract description 37
- 238000010438 heat treatment Methods 0.000 claims abstract description 19
- 239000012530 fluid Substances 0.000 claims abstract description 9
- 239000007788 liquid Substances 0.000 claims description 25
- 238000007789 sealing Methods 0.000 claims description 7
- 238000012360 testing method Methods 0.000 claims description 6
- 230000001276 controlling effect Effects 0.000 claims description 5
- 230000001105 regulatory effect Effects 0.000 claims description 4
- 239000012085 test solution Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 abstract description 7
- 239000008280 blood Substances 0.000 abstract description 7
- 238000000034 method Methods 0.000 abstract description 5
- 238000004458 analytical method Methods 0.000 abstract description 4
- 230000002776 aggregation Effects 0.000 abstract description 3
- 238000004220 aggregation Methods 0.000 abstract description 3
- 210000001772 blood platelet Anatomy 0.000 description 29
- 239000000725 suspension Substances 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 3
- 208000007536 Thrombosis Diseases 0.000 description 2
- 230000004308 accommodation Effects 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 238000004879 turbidimetry Methods 0.000 description 1
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- Investigating Or Analysing Biological Materials (AREA)
Abstract
The present utility model provides a platelet adhesion detector comprising: the device comprises a detection unit, a driving unit, a sample setting unit, a heating unit, a lifting unit and a control unit. The platelet adhesion detector provided by the utility model can simulate the physiological fluid shear force environment and can be used for platelet adhesion detection at different temperatures. The method has the advantages of small blood sample consumption, limited analysis and detection of blood, simple and easy operation, and can provide a new way for detecting the adhesion and aggregation behavior of the platelets in physiological fluid shear force environments and at different temperatures.
Description
Technical Field
The utility model relates to the technical field of detection equipment, in particular to a platelet adhesion detector.
Background
Platelets are intimately involved in numerous pathological thrombosis and physiological hemostasis, coagulation and other processes, which are important components of peripheral blood. Platelet adhesion is closely related to coronary artery disease, apoplexy and other diseases, so that detection of platelet adhesion is of great significance to research and clinical treatment of thrombotic diseases.
Currently, existing methods for detecting platelet adhesion include a platelet analyzer, a photoelectric turbidimetry, a thromboelastography, a whole blood resistance method, and the like. However, the above methods all detect platelet adhesion under static conditions, which is quite different from the environment where platelets undergo adhesion aggregation under in vivo physiological fluid shear force. Therefore, the current strategy for detecting platelet adhesion in static environment does not truly reflect in vivo platelet adhesion behavior. Therefore, we designed a novel platelet adhesion detector which can simulate the in vivo physiological fluid shear force environment, detect platelet adhesion at different temperatures, and has the advantages of small blood sample consumption and limited analysis and detection of blood.
Disclosure of Invention
The utility model aims to provide a platelet adhesion detector which can simulate a physiological fluid shear force environment through structural design and detect platelet adhesion aggregation under the physiological fluid shear force environment.
In order to achieve the object, the utility model provides a platelet adhesion detector, which is characterized in that a detection unit comprises two or more cones, and each cone is connected with an independent driving shaft;
The driving unit is connected with the cones through the driving shaft so as to independently control each cone to rotate;
The sample setting unit is arranged below the detection unit and comprises a containing unit corresponding to each cone; the device also comprises a bottom plate, each containing unit is matched with the bottom plate to form an independent detection liquid containing space, and the cone can extend into the corresponding detection liquid containing space to rotate;
and a heating unit for heating the detection liquid in the detection liquid accommodating space.
Further, the accommodating unit is integrally formed with the bottom plate, thereby forming the detection liquid accommodating space.
Further, the containing unit is assembled with the base plate, thereby forming the detection liquid containing space.
Further, the bottom plate or the side wall of the accommodating unit corresponding to the accommodating space of the detection liquid is provided with a sample setting area for setting samples.
Further, a sealing element is arranged between the sample setting area and the bottom plate, and the sealing element can strengthen the sealing performance and prevent the liquid to be measured from flowing out.
Further, the bottom plate and the accommodation unit corresponding to the detection liquid accommodation space are matched to clamp the sample.
Further, the lifting unit is connected with the driving unit, and the lifting of the cone is regulated and controlled through the driving unit.
Further, the driving unit is connected with the cone through a driving shaft, and the driving unit can control the rotation speed of the driving shaft, thereby controlling the rotation speed of the cone.
Further, the driving unit is a motor.
Furthermore, the cones are respectively combined with the corresponding driving shafts through the fixing devices, and the driving units can adjust the positions of the cones through the driving shafts, so that the cones are at the same height or different heights.
Further, the fixing device is a screw.
Further, the cone taper angle is 0-20 degrees, and the taper angle is the included angle between the cone generatrix and the horizontal plane.
Further, the cone angle is 3-10 degrees, and the cone angle is the included angle between the cone generatrix and the horizontal plane.
Further, the heating unit is embedded in the sample setting unit, and can heat and keep the detection liquid at a certain temperature.
The utility model also comprises a control unit connected with the platelet adhesion detector and used for controlling the driving unit and the heating unit to work.
Compared with the prior art, the platelet adhesion detector has at least one or more of the following beneficial effects:
(1) The platelet adhesion detector can regulate and control the rotation speed of the cone and the shearing force of fluid, thereby simulating the blood flow speed in the blood vessel of a human body;
(2) According to the platelet adhesion detector, the accommodating unit is heated through the heating action of the heating unit, so that the platelet adhesion can be detected at different temperatures;
(3) The platelet adhesion detector disclosed by the application has the advantages of small required blood consumption and limited detection on blood deficiency;
(4) The platelet adhesion detector provided by the application has the advantages that the detection units can be manually regulated to perform independent work or simultaneous work, and different requirements of testers are met.
Drawings
FIG. 1 is a schematic diagram of the overall structure of a platelet adhesion detector according to an embodiment of the present utility model;
FIG. 2 is a schematic top view of a sample setting unit according to an embodiment of the present utility model;
FIG. 3 is a schematic front view of a sample setting unit according to an embodiment of the present utility model;
FIG. 4 is a schematic view of cone angle of a cone according to an embodiment of the present utility model;
Fig. 5 is a flowchart of a platelet adhesion detection method according to an embodiment of the present utility model.
Reference numerals in the drawings:
1-a detection unit; a 2-drive unit; 3-a sample setting unit; 4-a heating unit; 5-a lifting unit;
6-driving shaft; 7-a bottom plate; 8-sleeve; 9-a containing unit; 10-a control unit; 11-cone;
12-Cone angle
Detailed Description
In order to further describe the technical means and effects adopted by the present utility model to achieve the purpose, the following description is given of the specific embodiments of the present utility model with reference to the accompanying drawings.
The present embodiment provides a platelet adhesion detector, which includes a detection unit 1, a driving unit 2, a sample setting unit 3, a heating unit 4, a lifting unit 5, and a control unit 10, as shown in fig. 1. The control unit is preferably a computer for controlling the operation of the drive unit 2 and the heating unit 4, and further preferably for displaying the operating parameters. The detection unit 1 comprises two or more cones 11, the cone angle 12 of the cones 11 is shown in fig. 4, the degree of the cone angle 12 is 0-20 degrees, preferably 3-10 degrees, each cone 11 is connected with the driving unit 2 through an independent driving shaft 6, the driving unit controls the rotation speed of the cone through the driving shaft, the fluid shear force is regulated and controlled, and the driving unit 2 is preferably a motor. The detection units can work independently or simultaneously, and the rotation rates of the cones can be the same or different, so that various detection requirements are met.
The sample setting unit 3 is disposed below the detecting unit 1, and as shown in fig. 2 and 3, the sample setting unit 3 is a metal plate which is made of metal and is embedded with sleeves the same as the cones in number, so as to form a plurality of accommodating units 9. The sample setting unit further comprises a bottom plate 7, and the accommodating unit 9 and the bottom plate 7 may be assembled together or may be integrally formed. Each containing unit 9 and the bottom plate 7 are matched to form independent detection liquid containing spaces, and the cone 11 can extend into the corresponding detection liquid containing spaces to rotate. The sample setting unit 3 may be attached to and detached from the base plate 7 and the housing unit 9 by screws, or may be provided on the housing unit side wall in the form of a sleeve or the like. A seal is provided between the base plate 7 and the sample to enhance the sealing and prevent liquid from flowing out of the containment unit 9 during testing. The heating unit 4 includes a heating device, and can heat and maintain the detection liquid at a certain temperature.
In one embodiment, the sample to be tested is fixed between the detachable bottom plate 7 and the containing unit 9 by screw disassembly, the heating unit 4 is started and opened, the temperature is set to be the temperature of a human body, the red blood cells/blood platelets suspension is injected into the containing unit 9, the driving unit 2 controls the driving shaft 6 to drive the cone 11 to descend until the tip of the cone contacts the material to be tested, and the rotary button is started. At a set temperature, the cone 11 rotates at a set speed, after a set time, the driving unit 2 controls the cone 11 to ascend through the driving shaft 6, the suspension is sucked out of the accommodating unit 9, and then the sample to be tested is taken out for subsequent analysis.
In another embodiment, the containing unit 9 is integrally formed with the base plate 7, and the sample is provided at a side wall of the containing unit 9. In specific implementation, a sample to be measured is placed on the side wall of the accommodating unit 9, the heating unit 4 is started and turned on, the temperature is set to be the human body temperature, the red blood cell/platelet suspension is injected into the accommodating unit 9, and the driving unit 2 controls the driving shaft 6 to drive the cone 11 to descend until the tip of the cone contacts the detection liquid. At a set temperature, the cone 11 rotates at a set speed, after a set time, the driving unit 2 controls the cone 11 to ascend through the driving shaft 6, the suspension is sucked out of the accommodating unit 9, and then the sample to be tested is taken out for subsequent analysis.
The above embodiments are merely illustrative of the principles of the present utility model and its effectiveness, and are not intended to limit the utility model. Modifications and variations may be made to the above-described embodiments by those skilled in the art without departing from the spirit and scope of the utility model. Accordingly, the scope of protection of the present utility model is to be determined by the appended claims.
As shown in fig. 5, the platelet adhesion detection method provided by the embodiment of the utility model includes:
S1, placing a sample in a sample setting unit;
s2, starting equipment and starting a heating button;
s3, injecting detection liquid into the accommodating unit, and starting a rotary button of the cone;
and S4, after the test is finished, taking out the liquid and taking out the sample.
Claims (15)
1. A platelet adhesion detector, comprising:
The detection unit comprises two or more cones, and each cone is connected with an independent driving shaft;
The driving unit is connected with the cones through the driving shaft so as to independently control each cone to rotate;
The sample setting unit is arranged below the detection unit and comprises a containing unit corresponding to each cone; the device also comprises a bottom plate, each containing unit is matched with the bottom plate to form an independent detection liquid containing space, and the cone can extend into the corresponding detection liquid containing space to rotate;
and a heating unit for heating the detection liquid in the detection liquid accommodating space.
2. The platelet adhesion tester according to claim 1, wherein the containing unit is integrally formed with the bottom plate, thereby forming the test liquid containing space.
3. The platelet adhesion tester according to claim 1, wherein the containing unit and the bottom plate are assembled together to form the test liquid containing space.
4. A platelet adhesion tester according to any one of claims 1 to 3 wherein the bottom plate or the side wall of the holding unit corresponding to the test solution holding space has a sample setting area for setting a sample.
5. The platelet adhesion tester according to claim 4, wherein a sealing member is provided between the sample-mounting region and the bottom plate, and the sealing member can enhance sealing property and prevent the fluid to be tested from flowing out.
6. A platelet adhesion tester according to claim 3 wherein the bottom plate and the holding unit of the test liquid holding space cooperate to hold the sample.
7. The platelet adhesion detector according to claim 1, further comprising a lifting unit connected to the driving unit, wherein lifting of the cone is regulated by the driving unit.
8. The platelet adhesion tester according to claim 1, wherein the drive unit is connected to the cone via a drive shaft, the drive unit being capable of controlling the rotational speed of the drive shaft and thereby the rotational rate of the cone.
9. The platelet adhesion tester according to claim 7 or 8, wherein the drive unit is a motor.
10. The platelet adhesion tester according to claim 1, wherein the cones are coupled to the corresponding drive shafts by fixing means, and the drive unit can adjust the positions of the cones by the drive shafts so that the different cones are at the same height or at different heights.
11. The platelet adhesion tester according to claim 10, wherein the fixing means is a screw.
12. The platelet adhesion tester according to claim 1, wherein the cone angle is 0 to 20 °, the cone angle being an angle of a cone generatrix with respect to a horizontal plane.
13. The platelet adhesion tester according to claim 1, wherein the cone angle is 3 to 10 °, the cone angle being the angle of the cone generatrix with the horizontal plane.
14. The platelet adhesion tester according to claim 1, wherein the heating unit is embedded in the sample setting unit, and can heat and maintain the test liquid at a certain temperature.
15. The platelet adhesion detector according to claim 1, further comprising a control unit connected to the platelet adhesion detector for controlling the operation of the drive unit and the heating unit.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322233873.4U CN221056466U (en) | 2023-08-19 | 2023-08-19 | Platelet adhesion detector |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322233873.4U CN221056466U (en) | 2023-08-19 | 2023-08-19 | Platelet adhesion detector |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN221056466U true CN221056466U (en) | 2024-05-31 |
Family
ID=91201476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322233873.4U Active CN221056466U (en) | 2023-08-19 | 2023-08-19 | Platelet adhesion detector |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN221056466U (en) |
-
2023
- 2023-08-19 CN CN202322233873.4U patent/CN221056466U/en active Active
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