CN220703663U - SND anaerobic fermentation device for crude heparin sodium - Google Patents
SND anaerobic fermentation device for crude heparin sodium Download PDFInfo
- Publication number
- CN220703663U CN220703663U CN202322309762.7U CN202322309762U CN220703663U CN 220703663 U CN220703663 U CN 220703663U CN 202322309762 U CN202322309762 U CN 202322309762U CN 220703663 U CN220703663 U CN 220703663U
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- snd
- anaerobic fermentation
- fermentation device
- heparin sodium
- extrusion
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- 238000000855 fermentation Methods 0.000 title claims abstract description 57
- 229920000669 heparin Polymers 0.000 title claims abstract description 36
- ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 title claims abstract description 30
- 229960001008 heparin sodium Drugs 0.000 title claims abstract description 30
- 230000004151 fermentation Effects 0.000 claims abstract description 28
- 238000003756 stirring Methods 0.000 claims abstract description 27
- 238000010438 heat treatment Methods 0.000 claims abstract description 10
- 230000002093 peripheral effect Effects 0.000 claims abstract description 8
- 230000000149 penetrating effect Effects 0.000 claims abstract description 5
- 238000001125 extrusion Methods 0.000 claims description 37
- 230000005540 biological transmission Effects 0.000 claims description 16
- 238000002156 mixing Methods 0.000 claims description 6
- 238000007790 scraping Methods 0.000 claims description 2
- 239000000463 material Substances 0.000 description 16
- 239000000126 substance Substances 0.000 description 15
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 6
- 230000015556 catabolic process Effects 0.000 description 6
- 238000006731 degradation reaction Methods 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 229960002897 heparin Drugs 0.000 description 6
- 239000002994 raw material Substances 0.000 description 6
- 239000012535 impurity Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 238000004065 wastewater treatment Methods 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 241000237983 Trochidae Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- 239000003055 low molecular weight heparin Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000002351 wastewater Substances 0.000 description 1
Abstract
The utility model provides a crude heparin sodium SND anaerobic fermentation device, which comprises a fermentation box, wherein one side of the top of the fermentation box is provided with a spiral extruder in a penetrating manner, a discharge hole of the spiral extruder is positioned in the fermentation box, a spiral feed pipe communicated with the spiral extruder is arranged on the spiral extruder, a rotary cutter positioned at the discharge hole of the spiral extruder is arranged in the fermentation box, a stirring shaft is arranged in the fermentation box, the peripheral wall of the stirring shaft is fixedly connected with a stirring plate, and a heating rod is arranged in the stirring plate. The utility model can greatly improve the purity of crude heparin sodium by arranging the spiral feeding pipe and the spiral extruder.
Description
Technical Field
The utility model relates to the technical field of crude heparin sodium purification, in particular to an SND anaerobic fermentation device for crude heparin sodium.
Background
Heparin is the compound with the most complex molecular structure known so far in the world, cannot be artificially and chemically synthesized in a short time, and only heparin from porcine intestinal mucosa can be used for clinical treatment at present. The raw material of the heparin raw material medicine is crude heparin sodium, and the extraction of the heparin raw material medicine can only be derived from small intestine mucous membranes of healthy live pigs, and because the heparin raw material medicine contains a large amount of impurity proteins, impurity nucleic acids, microorganisms and other impurities, the heparin sodium with complete natural structural groups is directionally obtained through physical and chemical extraction and separation processes, so that the heparin sodium raw material medicine is prepared. Heparin sodium bulk drugs are the only active ingredients of standard heparin preparations and the production starting point of low molecular heparin raw materials, so that the heparin sodium bulk drugs need great purity.
Publication number CN217709177U provides an anaerobic fermentation device for kitchen garbage waste water treatment, relates to kitchen garbage waste water treatment technical field. The top shell is installed to the upper end of anaerobic fermentation device shell, the both sides of anaerobic fermentation device shell upper end all are provided with the charge door, still include a driving motor, a driving motor installs in the inside upper end of anaerobic fermentation device shell through first dead lever, fixed outer loop, extension spring and fixed sleeve are installed to a driving motor's output, fixed outer loop and a driving motor's output fixed connection, the puddler is all installed to the outside both sides of fixed sleeve. The first face gear and the second face gear at the lower end of the fixed sleeve are mutually rotated and collided, and the acting force generated by the telescopic spring on the fixed sleeve enables the fixed sleeve to do lifting and reciprocating motion, so that the stirring rod is enabled to stir up and down to shake, further the garbage and the wastewater are enabled to be more fully mixed, and sedimentation is prevented;
the anaerobic fermentation device has the following defects when carrying out anaerobic treatment on nondegradable substances in crude heparin sodium: 1. the roller and the stirring blade are arranged, so that the comprehensive contact and fusion of the crude heparin sodium and the substances for assisting in degradation are difficult to realize, the final fermentation is incomplete, and the purity of the crude heparin sodium is influenced; 2. during anaerobic fermentation, the heating speed is slow, that is to say, the heater is installed on the puddler, and its area of contact with the material is lower, and then can influence the speed and the degree of consistency that the material heated.
Therefore, the utility model provides an SND anaerobic fermentation device for crude heparin sodium.
Disclosure of Invention
Aiming at the defects existing in the prior art, the utility model aims to provide an SND anaerobic fermentation device for crude heparin sodium, so as to solve the problems in the prior art.
In order to achieve the above object, the present utility model is realized by the following technical scheme: the SND anaerobic fermentation device for the crude heparin sodium comprises a fermentation tank, wherein a spiral extruder is arranged on one side of the top of the fermentation tank in a penetrating manner, a discharge hole of the spiral extruder is positioned in the fermentation tank, a spiral feed pipe communicated with the spiral extruder is arranged on the spiral extruder, a rotary cutter positioned at the discharge hole of the spiral extruder is arranged in the fermentation tank, a stirring shaft is arranged in the fermentation tank, a stirring plate is fixedly connected to the peripheral wall of the stirring shaft, and a heating rod is arranged in the stirring plate.
Further, the spiral extruder comprises an outer barrel and an extrusion spiral positioned in the outer barrel, wherein one end of the outer barrel positioned in the fermentation box is fixedly connected with an extrusion disc, and extrusion holes which are uniformly distributed are formed in the disc surface of the extrusion disc.
Further, the extrusion screw comprises a rotating shaft and an extrusion screw arranged on the rotating shaft, and one end of the rotating shaft is fixedly connected with a scraping plate which is contacted with the inner side of the extrusion disc.
Further, the extrusion disc is connected with the outer cylinder in a screwing way, and a handle rod is fixedly connected to the peripheral wall of the extrusion disc.
Further, the spiral feeding pipe comprises a conveying pipe and a conveying spiral arranged in the conveying pipe, and the peripheral wall of the conveying pipe is fixedly connected with an adding pipe.
Further, the transfer tube is conical with the small end facing the screw extruder.
Further, one side of the fermentation box is provided with a transmission shaft in a penetrating mode, and one end of the transmission shaft is fixedly connected with the rotary cutter.
The beneficial effects of the utility model are as follows:
1. according to the utility model, the spiral extruder is connected to the fermentation tank, so that the mixed substances consisting of the crude heparin sodium and the substances for assisting in degradation enter the fermentation tank and are extruded and mixed by the spiral extruder, the uniformity of the distribution of the substances for assisting in degradation in the mixed substances is greatly improved, the anaerobic fermentation degradation efficiency of the nondegradable substances in the crude heparin sodium is greatly improved, and the purity of the crude heparin sodium is improved.
2. According to the utility model, the extruding disc which is detachably connected is arranged at one end of the extruder, so that the easily blocked objects on the inner side of the extruding disc can be conveniently cleaned, and the convenience of blocking cleaning is greatly improved.
3. According to the utility model, the heating rod is arranged in the stirring plate and moves along with the stirring plate to stir the materials, so that the materials are heated uniformly, and the uniformity of material fermentation is greatly improved.
Drawings
FIG. 1 is a schematic diagram of a crude heparin sodium SND anaerobic fermentation device;
FIG. 2 is a plan view of the connection of the crushing cutter and the transmission shaft of the present utility model;
FIG. 3 is an enlarged schematic view of the portion "a" of FIG. 1;
in the figure: 1. a fermentation tank; 2. a screw extruder; 21. an outer cylinder; 211. extruding a tray; 2111. extruding the hole; 2112. a handle bar; 22. extruding a screw; 221. a rotation shaft; 2211. a scraper; 222. extruding and spiraling; 3. rotating the cutter; 4. a spiral feed tube; 41. a transmission tube; 411. an addition tube; 42. a transmission screw; 5. a stirring shaft; 6. a stirring plate; 7. a heating rod; 8. and a transmission shaft.
Detailed Description
The utility model is further described in connection with the following detailed description, in order to make the technical means, the creation characteristics, the achievement of the purpose and the effect of the utility model easy to understand.
Referring to fig. 1 to 3, the present utility model provides a technical solution: the SND is a non-directly degradable substance, the device comprises a fermentation box 1, the fermentation box 1 provides an anaerobic fermentation environment, one side of the top of the fermentation box 1 is penetrated and provided with a screw extruder 2, a discharge hole of the screw extruder 2 is positioned in the fermentation box 1, the screw extruder 2 comprises an outer barrel 21 and an extrusion screw 22 positioned in the outer barrel 21, one end of the outer barrel 21 positioned in the fermentation box 1 is fixedly connected with an extrusion disc 211, extrusion holes 2111 which are uniformly distributed are formed in the disc surface of the extrusion disc 211, the screw extruder 2 is used for comprehensively mixing heparin sodium particles containing the SND with substances (such as glucose and ethanol) which are degraded in an auxiliary manner, then the mixture is conveyed into the fermentation box through the extrusion holes 2111, and the substances discharged from the extrusion holes 2111 are columnar.
The screw extruder 2 is provided with a screw feeding pipe 4 communicated with the screw extruder 2, the screw feeding pipe 4 is used for conveying materials and substances for assisting degradation into the screw extruder 2, the screw feeding pipe 4 comprises a conveying pipe 41 and a conveying screw 42 positioned in the conveying pipe 41, the peripheral wall of the conveying pipe 41 is fixedly connected with an adding pipe 411, and preferably the conveying pipe 41 is conical, and the small end of the conveying pipe faces the screw extruder 2.
The fermenting case 1 is internally provided with a rotary cutter 3 positioned at the discharge port of the screw extruder 2, the rotary cutter 3 plays a role in scattering extruded rod-shaped substances, and particularly, one side of the fermenting case 1 is provided with a transmission shaft 8 in a penetrating way, one end of the transmission shaft 8 is fixedly connected with the rotary cutter 3, and the rotary cutter 3 rotates at a high speed to scatter extruded bars.
Be provided with (mixing) shaft 5 in the fermentation tank 1, the periphery wall fixedly connected with stirring board 6 of this (mixing) shaft 5, stirring board 6 content have heating rod 7, and stirring board 6 and heating rod 7 make the material in the fermentation tank 1 be heated evenly, improve the degree of consistency of mixed material anaerobic fermentation.
In this embodiment, the extrusion screw 22 includes a rotary shaft 221 and an extrusion screw 222 provided on the rotary shaft 221, and a flight 2211 in contact with the inside of the extrusion disk 211 is fixedly attached to one end of the rotary shaft 221, and the flight 2211 functions to prevent the extrusion hole 2111 from being blocked.
In this embodiment, the extrusion disc 211 is screwed with the outer cylinder 21, and the handle bar 2112 is fixedly connected to the outer peripheral wall of the extrusion disc 211, so that the material which is accumulated inside the extrusion disc 211 and is difficult to discharge can be cleaned conveniently.
When the device is used, firstly crude heparin sodium containing nondegradable substances and substances for auxiliary degradation are added through the adding pipe 411, then an external transmission motor is used for driving the transmission screw 42 to rotate, the transmission screw 42 utilizes screw blades on the transmission screw to transmit mixed materials into the outer cylinder 21, then an external extrusion motor is used for driving the rotating shaft 221 to rotate, the mixed materials are extruded and mixed through the extrusion screw 222 in the rotating process, then the extruded materials are outwards discharged through extrusion holes 2111 on the extrusion disc 211 under the pushing of the extrusion force, the mixing position discharged through the extrusion holes 2111 is columnar, at the moment, the transmission shaft 8 is driven by the external high-speed motor to rotate at a high speed, the transmission shaft 8 drives the rotary cutter 3 to rotate at a high speed and scatter the columnar mixed materials and fall into the fermentation tank, the stirring shaft 5 is driven by the external stirring motor to rotate, then the heating rod 7 is electrified, the stirring shaft 5 stirs the mixed materials through the stirring plate 6, and the heating rod 7 heats the mixed materials through the stirring plate 6, so that the mixed materials are heated uniformly.
Furthermore, it should be understood that although the present disclosure describes embodiments, not every embodiment is provided with a separate embodiment, and that this description is provided for clarity only, and that the disclosure is not limited to the embodiments described in detail below, and that the embodiments described in the examples may be combined as appropriate to form other embodiments that will be apparent to those skilled in the art.
Claims (7)
1. The utility model provides a crude heparin sodium SND anaerobic fermentation device, includes fermenting case (1), its characterized in that, one side at the top of fermenting case (1) runs through and is provided with screw extruder (2), and the discharge gate of this screw extruder (2) is located fermenting case (1), be provided with screw feed pipe (4) of intercommunication screw extruder (2) on screw extruder (2), be provided with rotary cutter (3) that are located screw extruder (2) discharge gate department in fermenting case (1), be provided with (mixing) shaft (5) in fermenting case (1), the periphery wall fixedly connected with stirring board (6) of this (mixing) shaft (5), stirring board (6) are interior to have heating rod (7).
2. The SND anaerobic fermentation device for crude heparin sodium according to claim 1, wherein the SND anaerobic fermentation device is characterized in that: the spiral extruder (2) comprises an outer barrel (21) and an extrusion spiral (22) positioned in the outer barrel (21), wherein one end of the outer barrel (21) positioned in the fermentation box (1) is fixedly connected with an extrusion disc (211), and extrusion holes (2111) which are uniformly distributed are formed in the disc surface of the extrusion disc (211).
3. The SND anaerobic fermentation device for crude heparin sodium according to claim 2, wherein the SND anaerobic fermentation device is characterized in that: the extrusion screw (22) comprises a rotating shaft (221) and an extrusion screw (222) positioned on the rotating shaft (221), and one end of the rotating shaft (221) is fixedly connected with a scraping plate (2211) which is contacted with the inner side of the extrusion disc (211).
4. A crude heparin sodium SND anaerobic fermentation device according to claim 3, wherein: the extrusion disc (211) is connected with the outer cylinder (21) in a screwing way, and a handle bar (2112) is fixedly connected to the outer peripheral wall of the extrusion disc (211).
5. The SND anaerobic fermentation device for crude heparin sodium according to claim 1, wherein the SND anaerobic fermentation device is characterized in that: the spiral feeding pipe (4) comprises a conveying pipe (41) and a conveying spiral (42) arranged in the conveying pipe (41), and the peripheral wall of the conveying pipe (41) is fixedly connected with an adding pipe (411).
6. The SND anaerobic fermentation device for crude heparin sodium according to claim 5, wherein the SND anaerobic fermentation device comprises the following components: the transfer tube (41) is conical and has a small end facing the screw extruder (2).
7. The SND anaerobic fermentation device for crude heparin sodium according to claim 1, wherein the SND anaerobic fermentation device is characterized in that: one side of the fermentation box (1) is provided with a transmission shaft (8) in a penetrating way, and one end of the transmission shaft (8) is fixedly connected with the rotary cutter (3).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322309762.7U CN220703663U (en) | 2023-08-28 | 2023-08-28 | SND anaerobic fermentation device for crude heparin sodium |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322309762.7U CN220703663U (en) | 2023-08-28 | 2023-08-28 | SND anaerobic fermentation device for crude heparin sodium |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220703663U true CN220703663U (en) | 2024-04-02 |
Family
ID=90435863
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322309762.7U Active CN220703663U (en) | 2023-08-28 | 2023-08-28 | SND anaerobic fermentation device for crude heparin sodium |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220703663U (en) |
-
2023
- 2023-08-28 CN CN202322309762.7U patent/CN220703663U/en active Active
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