CN220603494U - Reagent supply device, reagent supply module, reagent bottle, and sample analyzer - Google Patents

Abstract

The utility model discloses a reagent supply device, a reagent supply module, a reagent bottle and a sample analyzer, and relates to the technical field of reagent supply. The device comprises a containing part for containing a reagent bottle, a liquid outlet needle and an air inlet needle, wherein the inside of the reagent bottle is loaded with liquid, the reagent bottle is provided with a bottle cap, the bottle cap is provided with a sealing plug, and the sealing plug enables the liquid in the reagent bottle to be sealed relative to the outside. The device comprises a liquid outlet needle which penetrates through the sealing plug, and the liquid outlet needle is communicated with the liquid pump so as to extract liquid in the reagent bottle through the liquid outlet needle. The device comprises an air inlet needle which penetrates through the sealing plug, and the air inlet needle is communicated with ambient air so as to suck air through the air inlet needle to balance the air pressure in the reagent bottle. The liquid is extracted by only one-time insertion without uncovering. And no liquid residue is caused, so that corrosion injury and pollution are avoided.

Description

Reagent supply device, reagent supply module, reagent bottle, and sample analyzer

Technical Field

The present utility model relates to the field of reagent supply technologies, and in particular, to a reagent supply device, a reagent supply module, a reagent bottle, and a sample analyzer.

Background

A sample analyzer is an instrument for determining the concentration of a target substance in a blood sample to be measured. For detecting a target substance, a detection reagent is generally mixed with a blood sample to label the target substance, so that a sample analyzer can detect the mixed solution to obtain the concentration of the target substance.

In high throughput sample analyzers, test reagent bottles in bottled form are typically used. Such test reagent bottles can supply tens or even hundreds of test requirements so that a user does not have to change a new test reagent for each test.

In some sample analyzers, a pipetting needle is used to transfer a test reagent from a reagent bottle to a cuvette containing a blood sample to be tested. However, this pipetting needle solution also suffers from certain pipetting accuracy errors and requires long pipetting and pipetting times.

Thus, in other sample analyzers, the supply of detection reagent is accomplished using a perfusion line. In a common solution, the perfusion tube is provided with a liquid inlet needle at the end. The liquid inlet needle enters the reagent bottle through a specific mechanism. The filling pipeline can suck the liquid in the reagent bottle by means of the liquid inlet needle and directly drip the liquid into the reaction cup.

Conventional reagent bottles typically have only one cap. When placing a reagent bottle into a reagent tank of a reagent cartridge of a sample analyzer, it is necessary to replace the bottle cap of the reagent bottle with a bottle cap adapter of the instrument, so that liquid is sucked out, for example, by means of a rubber tube or the like. This form may inevitably leave liquid on the cap adaptor, especially when the liquid is corrosive or bio-contaminating, which may cause corrosion damage or risk of bio-contamination.

There is also another solution, in which a liquid inlet needle is provided at the bottom of the reagent tank of the instrument. When a user puts in the reagent, the reagent bottle is inserted into the liquid inlet needle, and the bottle cap of the reagent bottle is unscrewed. At this time, the rubber tube connected with the liquid inlet needle can suck liquid from the reagent bottle. The disadvantage of this solution is that the bottle cap must be unscrewed to maintain the air pressure balance of the reagent bottle during the liquid extraction. Thus, the user fails to suck liquid when forgetting to unscrew the bottle cap and causes the operation of the instrument to be stopped.

Disclosure of Invention

The present utility model has been made in view of the above problems, and provides a reagent supplying apparatus, a reagent bottle, and a sample analyzer that overcome or at least partially solve the above problems.

Based on a first aspect of the present utility model, there is provided a reagent supply device, the device comprising:

the container is used for containing a reagent bottle, the interior of the reagent bottle is loaded with liquid, the reagent bottle is provided with a bottle cap, and the bottle cap is also provided with a sealing plug, and the sealing plug seals the liquid in the reagent bottle relative to the exterior;

the liquid outlet needle penetrates through the sealing plug and is communicated with the liquid pump so as to extract liquid in the reagent bottle through the liquid outlet needle;

and the air inlet needle penetrates through the sealing plug, and is communicated with ambient air so as to balance the air pressure in the reagent bottle by sucking air through the air inlet needle.

Optionally, the liquid outlet needle and the air inlet needle are arranged side by side at the reagent bottle accommodating part of the reagent supply device and are opposite to the bottle cap of the reagent bottle. Here, the reagent bottle storage part may be a reagent tank, for example. The shape of the reagent tank is matched with the shape of the reagent bottle. The liquid outlet needle and the air inlet needle can be arranged above or at the bottom of the reagent tank.

Optionally, the device further comprises an air filter, and the air filter is communicated with the air inlet needle so as to filter the air entering the reagent bottle.

Based on a second aspect of the present utility model, a reagent supply module is provided with a reagent supply device and a reagent bottle as described in any of the above summary of the utility model. The inside liquid that bears of reagent bottle, the reagent bottle has the bottle lid, the bottle lid is furnished with the sealing plug with be provided with the liquid barrier layer between the liquid, the liquid barrier layer is used for keeping apart the contact of liquid and sealing plug, and, sealing plug and liquid barrier layer can be by reagent supply device's play liquid needle and air inlet needle run through.

Optionally, the liquid-proof layer is located on an end face of the sealing plug close to the liquid and forms a cover for the sealing plug.

Optionally, the liquid-proof layer and the sealing plug are arranged at intervals.

Optionally, the liquid-proof layer is an aluminum foil layer or a tin foil layer.

Optionally, an accommodating through hole is formed in the end face of the bottle cap, and the sealing plug is arranged in the accommodating through hole.

According to a third aspect of the present utility model there is provided a reagent bottle carrying a liquid therein, the reagent bottle having a cap provided with a sealing plug, a liquid barrier layer being provided between the sealing plug and the liquid, the liquid barrier layer being arranged to isolate contact of the liquid with the sealing plug, and the sealing plug and liquid barrier layer being penetrable by a liquid outlet needle and an air inlet needle of a reagent supply device.

According to a fourth aspect of the present utility model there is provided a sample analyser comprising a reagent supply module as described in any of the above aspects of the utility model and a reagent transfer line, wherein the reagent transfer line is connected to a liquid pump of a reagent supply device for transferring liquid from the reagent bottle.

The reagent transmission pipeline is used for transmitting the reagent from the reagent bottle to a reaction cup of an incubation mechanism of the sample analyzer so as to form a mixed solution of the reagent and a blood sample to be tested.

Compared with the prior art, the reagent supply device realizes the suction of liquid in the reagent bottle in a very simple mode by arranging the liquid outlet needle and the air inlet needle, and particularly balances the air pressure in the reagent bottle through the arranged air inlet needle by sucking air, thereby realizing the smooth suction of the liquid. Therefore, when the reagent bottle is put into the reagent supply module of the sample analyzer, the liquid can be extracted only by inserting the reagent bottle into the accommodating part of the reagent supply device, and the bottle cap is not required to be opened, replaced or otherwise operated. In addition, no liquid residue is caused, and corrosion injury and pollution are avoided.

The foregoing description is only an overview of the present utility model, and is intended to be implemented in accordance with the teachings of the present utility model in order that the same may be more clearly understood and to make the same and other objects, features and advantages of the present utility model more readily apparent.

Drawings

Various other advantages and benefits will become apparent to those of ordinary skill in the art upon reading the following detailed description of the preferred embodiments. The drawings are only for purposes of illustrating the preferred embodiments and are not to be construed as limiting the utility model. Also, like reference numerals are used to designate like parts throughout the figures.

In the drawings:

fig. 1 is a schematic structural view of a reagent supplying apparatus according to an embodiment of the present utility model;

FIG. 2 is a schematic diagram of another reagent supplying apparatus according to an embodiment of the present utility model;

fig. 3 is a schematic diagram of a bottle cap structure of a reagent bottle according to an embodiment of the present utility model;

fig. 4 is a schematic diagram of a bottle cap of another reagent bottle according to an embodiment of the present utility model;

reference numerals: 1. a reagent bottle; 101. an inner bottom; 102. an inner top; 2. a bottle cap; 201. accommodating the through hole; 3. a sealing plug; 4. a liquid outlet needle; 5. an air inlet needle; 6. a liquid barrier layer; 7. a liquid pump; 8. an air filter; 9. and a housing part.

Detailed Description

Exemplary embodiments of the present utility model will be described in more detail below with reference to the accompanying drawings. While exemplary embodiments of the present utility model are shown in the drawings, it should be understood that the present utility model may be embodied in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the utility model to those skilled in the art.

Referring to fig. 1-4, an embodiment of the present utility model provides a reagent supplying apparatus. The reagent supply means comprises a receiving portion 9 in the form of a reagent tank for receiving the reagent bottle 1 and matching the shape of the reagent bottle.

The reagent supply may further comprise a liquid outlet needle 4 and an air inlet needle 5. The reagent bottle 1 is internally provided with liquid, the reagent bottle 1 is provided with a bottle cap 2, the bottle cap 2 is arranged on the bottle mouth of the reagent bottle 1, the end face of the bottle cap 2 is provided with a containing through hole 201, the bottle cap 2 is also provided with a sealing plug 3, and the sealing plug 3 is fixed in the containing through hole 201. The liquid outlet needle 4 penetrates through the sealing plug 3, and the liquid outlet needle 4 is communicated with the liquid pump 7 so as to extract liquid in the reagent bottle 1 through the liquid outlet needle 4. An air inlet needle 5 is provided penetrating the sealing plug 3, and the air inlet needle 5 communicates with the ambient air to suck the ambient air through the air inlet needle 5 to balance the air pressure in the reagent bottle 1. On the one hand, the sealing plug 3 is convenient for the puncture and the fixation of the liquid outlet needle 4 and the air inlet needle 5, and on the other hand, the sealing plug 3 is also used for sealing the reagent bottle 1.

In the use, can connect liquid pump 7 on liquid outlet needle 4, when liquid pump 7 outside inhale liquid, lead to producing the negative pressure in the reagent bottle 1, intake needle 5 inhale the air, then can guarantee the smooth extraction of the liquid in the reagent bottle 1 through the air pressure in the intake needle 5 balance reagent bottle 1. Thus, the liquid can be extracted without opening the lid. In addition, no liquid residue is caused, and corrosion injury and pollution are avoided. The liquid pump may be located outside the housing 9 and integrated in the reagent supply module.

In one example, the outlet needle and the inlet needle are arranged side by side in the housing 9 of the reagent supply device of the sample analyzer. In the scheme of the application, the design of the air inlet needle can realize air pressure balance without unscrewing the bottle cap as in the prior art. By means of this side-by-side design, the user can thus achieve a solution taking of the reagent supply device and an air pressure equalization in the reagent bottle using one insertion action.

In one example, referring to fig. 3 and 4, the end of the tapping needle 4 outside the reagent bottle 1 is provided smoothly. The smooth arrangement means that the end of the needle outside the reagent bottle 1 is not designed with sharp corners, burrs, etc. In another example, the end of the air inlet needle 5 located outside the reagent bottle 1 is provided smoothly. Similarly, the end part of the liquid outlet needle 4 outside the reagent bottle 1 and the end part of the air inlet needle 5 outside the reagent bottle 1 are both arranged smoothly. Thus, the operation safety of the operator can be ensured while ensuring that the liquid in the reagent bottle 1 is conveniently extracted.

Preferably, the liquid outlet needle 4 and the air inlet needle 5 may be made of a metal material, such as a steel material.

In an example, the end part of the liquid outlet needle 4 positioned in the reagent bottle 1 is a tip part, the design of the tip part can facilitate the liquid outlet needle 4 to pierce the sealing plug 3 from outside and enter the reagent bottle 1, and the assembly convenience of the structure at the bottle cap 2 is improved. In another example, the end of the air inlet needle 5 located inside the reagent bottle 1 is a tip. Similarly, the end of the liquid outlet needle 4 positioned in the reagent bottle 1 and the end of the air inlet needle 5 positioned in the reagent bottle 1 are tip parts.

In an alternative embodiment of the utility model, referring to fig. 1, the reagent supplying apparatus may further comprise a liquid pump 7, the liquid pump 7 being integrated in the reagent supplying module outside the accommodating portion 9, and the liquid pump 7 and the liquid outlet needle 4 being provided in communication to draw out the liquid in the reagent bottle 1.

An alternative embodiment of the utility model, shown with reference to fig. 1, the reagent supply device may further comprise an air filter 8, the air filter 8 being arranged in communication with the air inlet needle 5 for filtering ambient air entering the reagent bottle 1. The air filter 8 can prevent the impurity in the air from entering the reagent bottle 1 to pollute the liquid, and when the liquid is extracted, the air filter 8 is connected to the air inlet needle 5, so that the stability of the liquid can be improved.

Referring to fig. 1-4, an embodiment of the present utility model provides a reagent supply module. Which comprises the aforementioned reagent supply device and a reagent bottle.

Referring to fig. 1 and 4, the reagent bottle may further include a liquid barrier layer 6, and the liquid barrier layer 6 is disposed between the sealing plug 3 and the liquid to isolate the liquid from the sealing plug 3. In one example, the liquid barrier layer 6 is an aluminum foil layer or a tin foil layer, wherein the thickness of the aluminum foil layer or the tin foil layer is preferably easy to be pierced by the air inlet needle 5 and the liquid outlet needle 4, and is not limited in any way. This solution is simple in construction and low in cost.

The sealing plug can be made of a common material that can be pierced by a metal needle, for example, in the form of a rubber plug.

The separation of the reagent from the sealing plug, in particular the plug, can be achieved by means of a liquid barrier. Thus, the reagent component can be prevented from reacting with the rubber stopper due to long-term contact. Further prevent the rubber plug from aging or corrosion and other phenomena caused by the reaction.

In this embodiment, the cap is designed as a separate component from the body of the reagent bottle. However, it is also conceivable that the cap is designed as an integral part of the body of the reagent bottle. In this case, the sealing plug is only required to be directly arranged at the bottle cap part.

In one embodiment, the liquid barrier layer 6 is located on the end face of the sealing plug 3 close to the liquid and forms a cover for the sealing plug 3. Wherein the covering is understood to mean that the liquid barrier layer 6 encloses the sealing plug 3. The aluminum foil layer or the tin foil layer can be attached directly to the sealing plug, for example.

In another embodiment, the liquid barrier layer 6 may be located on the end surface of the sealing plug 3 close to the liquid and spaced apart from the sealing plug 3. In this case, for example, a flange may be formed on the bottle body, and the liquid barrier layer configured as an aluminum foil layer or a tin foil layer may be supported by the flange. For example, it may be attached to the flange.

An alternative inventive embodiment is shown with reference to fig. 2, in which the reagent bottles 1 are placed upright, i.e. in the receiving portion 9 of the reagent supply device of the reagent supply module.

At this time, the bottle cap 2 is placed upward, and the liquid outlet needle and the air inlet needle are provided above the accommodating portion 9, for example, in a top cover portion of the reagent supplying apparatus. After the liquid outlet needle 4 is inserted into the reagent bottle, the liquid outlet needle extends to the inner bottom 101 of the reagent bottle 1, so that the whole liquid in the reagent bottle 1 can be extracted when the liquid is extracted.

In another example, referring to fig. 1, the reagent bottle 1 is placed upside down, that is, the reagent bottle is placed upside down in the accommodating portion 9.

At this time, the bottle cap 2 is placed downward, and the liquid outlet needle and the air inlet needle are provided at the bottom of the accommodating portion 9 of the reagent supplying apparatus. The accommodating part 9 is provided with a stepped surface, so that limit is formed on the bottle cap 2 and the reagent bottle 1. The liquid outlet needle 4 extends to the inner top 102 of the reagent bottle 1, so that the length of the liquid outlet needle 4 can be reduced and the whole liquid in the reagent bottle 1 can be extracted at the same time when the liquid is extracted.

The embodiment of the utility model also provides a reagent bottle, the reagent bottle 1 internally bears liquid, the reagent bottle 1 is provided with a bottle cap 2, the bottle cap 2 is provided with a sealing plug 3, a liquid separation layer 6 is arranged between the sealing plug 3 and the liquid, the liquid separation layer 6 is used for isolating the contact between the liquid and the sealing plug 3, and the sealing plug 3 and the liquid separation layer 6 can be penetrated by a liquid outlet needle 4 and an air inlet needle 5 of the reagent supply device according to any one of the embodiment of the utility model.

The embodiment of the utility model also provides a sample analyzer, which is used for detecting sample blood, wherein the sample analyzer can comprise a biochemical analyzer, a chemiluminescent immunoassay analyzer, a blood routine analyzer and the like.

The sample analyzer may include the reagent supply module and the reagent transfer line described in any of the above embodiments of the utility model, and the reagent supply device of the above embodiments of the utility model may be integrated in the reagent supply module and connected to the reagent transfer line by a liquid pump to transfer the liquid from the reagent bottle.

In this specification, each embodiment is described in a progressive manner, and each embodiment is mainly described by differences from other embodiments, and identical and similar parts between the embodiments are all enough to be referred to each other.

As will be readily appreciated by those skilled in the art: any combination of the above embodiments is possible, and thus is an embodiment of the present utility model, but the present specification is not limited by the text.

In the description provided herein, numerous specific details are set forth. However, it is understood that embodiments of the utility model may be practiced without these specific details. In some instances, well-known methods, structures and techniques have not been shown in detail in order not to obscure an understanding of this description.

Similarly, it should be appreciated that in the above description of exemplary embodiments of the utility model, various features of the utility model are sometimes grouped together in a single embodiment, figure, or description thereof for the purpose of streamlining the disclosure and aiding in the understanding of one or more of the various inventive aspects.

Furthermore, those skilled in the art will appreciate that while some embodiments described herein include some features but not others included in other embodiments, combinations of features of different embodiments are meant to be within the scope of the utility model and form different embodiments. For example, in the claims, any of the claimed embodiments may be used in any combination.

Claims (10)

1. A reagent supply device, the device comprising:

a containing part (9) for containing a reagent bottle (1), wherein the reagent bottle (1) is internally provided with a liquid, the reagent bottle is provided with a bottle cap (2), the bottle cap (2) is provided with a sealing plug (3), and the sealing plug (3) seals the liquid in the reagent bottle from the outside;

the liquid outlet needle (4) is used for penetrating through the sealing plug (3), and the liquid outlet needle (4) is communicated with the liquid pump (7) so as to extract liquid in the reagent bottle (1) through the liquid outlet needle (4);

and the air inlet needle (5) is used for penetrating the sealing plug (3), and the air inlet needle (5) is communicated with ambient air so as to suck air through the air inlet needle (5) to balance the air pressure in the reagent bottle (1).

2. Reagent supply according to claim 1, characterized in that the outlet needle and the inlet needle are arranged side by side at the receiving portion (9) of the reagent supply and opposite the bottle cap of the reagent bottle.

3. Reagent supply according to claim 1, characterized in that the device further comprises an air filter (8), the air filter (8) and the air inlet needle (5) being arranged in communication for filtering air entering the reagent bottle (1).

4. A reagent supply module, characterized by having a reagent supply device and a reagent bottle according to any of claims 1-3, wherein the reagent bottle (1) is internally loaded with a liquid, the reagent bottle (1) has a cap (2), the cap (2) is provided with a sealing plug (3), a liquid barrier layer (6) is provided between the sealing plug (3) and the liquid, the liquid barrier layer (6) is used to isolate the liquid from contact with the sealing plug (3), and the sealing plug (3) and the liquid barrier layer (6) can be penetrated by a liquid outlet needle (4) and an air inlet needle (5) of the reagent supply device.

5. A reagent supply module according to claim 4, characterized in that the liquid barrier layer (6) is located on the end face of the sealing plug (3) close to the liquid and forms a cover for the sealing plug (3).

6. Reagent supply module according to claim 4, characterized in that the liquid barrier layer (6) and the sealing plug (3) are arranged at intervals.

7. Reagent supply module according to claim 5 or 6, characterized in that the liquid barrier layer (6) is an aluminium foil layer or a tin foil layer.

8. Reagent supply module according to claim 4, characterized in that the end face of the bottle cap (2) is provided with a receiving through hole (201), in which the sealing plug (3) is arranged.

9. The utility model provides a reagent bottle, its characterized in that, reagent bottle (1) inside bears liquid, reagent bottle (1) have bottle lid (2), bottle lid (2) are furnished with sealing plug (3) with be provided with liquid barrier layer (6) between the liquid, liquid barrier layer (6) are used for keeping apart contact of liquid and sealing plug (3), and, sealing plug (3) and liquid barrier layer (6) can be run through by reagent supply device's play liquid needle (4) and air inlet needle (5).

10. A sample analyzer comprising a reagent supply module according to any one of claims 4-8 and a reagent transfer line, wherein the reagent transfer line is connected to a liquid pump of a reagent supply device to transfer liquid from the reagent bottle.