CN104107733B - A kind of reagent bottle and reagents loaded device and method thereof - Google Patents
A kind of reagent bottle and reagents loaded device and method thereof Download PDFInfo
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- CN104107733B CN104107733B CN201310131464.1A CN201310131464A CN104107733B CN 104107733 B CN104107733 B CN 104107733B CN 201310131464 A CN201310131464 A CN 201310131464A CN 104107733 B CN104107733 B CN 104107733B
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Abstract
The invention discloses a kind of reagent bottle and reagents loaded device and method thereof, described reagent bottle comprises bottle, bottle cap and bottle stopper, and described bottle cap is placed on bottle top, and bottle body bottom has a through hole, and described bottle stopper plug is in described through hole.Described reagents loaded device comprises support and puncture needle; Described support is used for supporting and the described reagent bottle that leads; Described puncture needle comprises the needle point, needle stand and the backshank screw thread that are fixedly connected sequentially.During reagents loaded, only need unscrew bottle cap, directly reagent bottle be pressed down, make puncture needle pass the bottle stopper of bottom, the loading of reagent bottle can be completed.The bottom of the present invention mode that punctures is adopted to load reagent, quick and convenient, do not need both hands to work in coordination with simultaneously, during reagent unloading, reagent bottle is pulled away puncture needle, the drippage of reagent can not be caused; When reagent uses, by twist-off closure, directly pour reagent into from bottle mouth position, reagent can be supplemented in real time, solve the shortcoming that prior art cannot be supplemented in real time or be supplemented inconvenience.
Description
Technical field
The present invention relates to medical equipment field, be specifically related to a kind of reagent bottle and reagents loaded device and method thereof.
Background technology
At the inspection automation such as biochemical analysis and immunoassay analysis field, some reagent can be used, described reagent need adopt independently liquid-way system to realize dispensing, namely the arrival end of fluid path is connected in reagent bottle, reagent is drawn in reagent bottle, the port of export of fluid path is connected in the device such as reaction vessel or measuring chamber, realizes the dispensing of reagent.It is general that these reagent are generally multiple test event institute, as the cleaning fluid in biochemical analysis, for the cleaning to instrument flow pipeline and sampling needle and reaction cup; Cleaning buffer solution in immunoassay, for out-phase chemiluminescence immune assay B/F(Bound-Free, cleaning is separated) in cleaning to non-bond; Preexciting liquid in immunoassay, exciting liquid or luminous substrate liquid, for the luminescence-producing reaction after out-phase chemiluminescence immune assay B/F; The reagent such as the dilution in blood cell analysis and hemolytic agent, for the detection of haemocyte.This kind of reagent is generally filling after the old reagent bottle on instrument is finished, to be needed first to unload in common reagent bottle (or reagent barrel, be below referred to as reagent bottle), then loads upper new reagent bottle.
In the prior art, reagent bottle adopts common structure, as square or cylindrical, when being loaded on the loading position on instrument, need first the bottle cap on novel agent bottle to be turned on to throw away, older reagent bottle on loading position is unloaded, then novel agent bottle is changed.In the process of the old reagent bottle of unloading, need manually to turn on the bottle cap (bottle cap had also is connected to the liquid level sensors such as liquid level float) being connected to pipette, bottle cap is upwards carried by a hand, until pipette departs from bottleneck, another is hand-held opens old reagent bottle, then pipette is put into novel agent bottle and bottle cap of screwing on.The bottle cap being connected to pipette is different from the new Bottle cap structure on novel agent bottle, have employed special design, in order to keep the pressure in bottle, generally also leaving vent portion or being connected with vent line on bottle cap or bottom bottle.In addition, existing bottle bottom ventilation mode, enters after in bottle at air and will pass reagent emersion on reagent liquid level, when particularly having the compositions such as surfactant in reagent, a lot of bubble or foam will be formed on reagent liquid level, bad impact can be caused on the performance of reagent.
The complex structure of this common reagent bottle, need liquid level sensor and the relevant air-breather such as reagent bottle cap and special liquid level float that specialized designs instrument uses, use cost is high; The co-operating of reagents loaded action need user both hands, in loading process, be adsorbed on the easy dropping liquid of reagent on pipette and float, the reagent of drippage has potential source biomolecule risk, easily works the mischief to people.
Summary of the invention
The object of the invention is to for above-mentioned defect of the prior art, design a kind ofly to load fast, convenient and safe reagent bottle and reagents loaded device and method thereof, solve operation inconvenience, reagent dropping liquid, health risk that available reagent bottle and reagents loaded device exist in reagents loaded process, the problems such as reagent cannot be supplemented in real time.
For achieving the above object, the present invention is by the following technical solutions:
A kind of reagent bottle, comprise bottle, bottle cap and bottle stopper, described bottle cap is placed on bottle top, and described bottle body bottom has a through hole be communicated with bottle inside, and described bottle stopper plug is in described through hole;
Wherein, the bottom of described bottle has the recessed shrinkage pool to bottle inside, and described shrinkage pool bottom face has flange, and forms through hole by flange;
Described bottle stopper comprises cock body, is positioned at neck and the back-off at middle part, and neck is clipped in the middle by described back-off and cock body, and the diameter of described back-off is greater than through hole, and the size of described neck matches with through hole, and the diameter of described cock body is greater than through hole;
The neck axial width of described bottle stopper and the thickness of flange match, and flange is clamped between back-off and cock body.
A kind of reagents loaded device, for loading mentioned reagent bottle, comprises support and puncture needle; Described support is used for supporting and the described reagent bottle that leads; Described puncture needle comprises the needle point, needle stand and the backshank screw thread that connect successively, and puncture needle center has through hole, and described through hole forms thin-and-long opening at the prism of needle point, and described needle stand is connected with support, and described backshank screw thread is connected with external infusion pipeline;
Described support comprises a gathering sill, and described puncture needle is installed on bottom gathering sill, and described gathering sill is used for leading to reagent bottle, makes the bottle stopper on reagent bottle relative with puncture needle;
Described needle stand is removably connected on support, and wherein, gathering sill bottom surface has two arc stators, the needle stand of puncture needle have two corresponding holding sections arranged, holding section, by screwing in back-out mode, screws in or screws out stator, to be fixed and to unclamp by puncture needle.
A kind of immunity analysis instrument, described immunity analysis instrument is provided with described reagents loaded device.
Use described reagents loaded device to load a method for described reagent bottle, comprising:
The bottle stopper of reagent bottle is relative with the puncture needle of reagents loaded device;
Push reagent bottle to needle point direction, make needle point pass bottle stopper, enter in reagent bottle.
The invention provides a kind of reagent bottle and reagents loaded device and method thereof, the through hole bottom described reagent bottle fills in bottle stopper, and the reagents loaded position of reagents loaded device is provided with puncture needle; During reagents loaded, only need unscrew bottle cap, directly reagent bottle be pressed down, make puncture needle pass the bottle stopper of bottom, the loading of reagent bottle can be completed.The bottom of the present invention mode that punctures is adopted to load reagent, quick and convenient, do not need both hands to work in coordination with simultaneously, during reagent unloading, reagent bottle is pulled away puncture needle, the drippage of reagent can not be caused; When reagent uses, by twist-off closure, directly pour reagent into from bottle mouth position, reagent can be supplemented in real time, solve the shortcoming that prior art cannot be supplemented in real time or be supplemented inconvenience.On the other hand, the bottle cap that can unscrew not only can prevent the pollutants such as dust to enter in bottle, but also allow when reagent uses, and allow the air outside bottle enter in bottle, the air pressure balance in maintenance bottle, eliminates custom-designed inlet duct, saved cost.In addition, adopt this bottom fluid, the mode of top air inlet, can effectively solve the harmful effect that in prior art, bottom inflow causes reagent performance.
Accompanying drawing explanation
In order to be illustrated more clearly in the embodiment of the present invention or technical scheme of the prior art, be briefly described to the accompanying drawing used required in embodiment or description of the prior art below, apparently, accompanying drawing in the following describes is only some embodiments of the present invention, for those of ordinary skill in the art, under the prerequisite not paying creative work, other accompanying drawing can also be obtained according to these accompanying drawings.
Fig. 1 is the package assembly schematic diagram of the reagent bottle of the embodiment of the present invention one.
Fig. 2 is the Split type structure schematic diagram of the reagent bottle of the embodiment of the present invention one.
Fig. 3 is the structural representation of the bottle stopper in the embodiment of the present invention one.
Fig. 4 is the modified node method schematic diagram of the bottle stopper in the embodiment of the present invention one.
Fig. 5 is the overall structure schematic diagram of the reagent bottle of the embodiment of the present invention two.
Fig. 6 is the cross section structure schematic diagram of the reagent bottle of the embodiment of the present invention two.
Fig. 7 is the part isometric schematic cross-section that the reagents loaded device of the embodiment of the present invention three carries out reagent bottle loading.
Fig. 8 is the structural representation of the puncture needle in the embodiment of the present invention three.
Fig. 9 is the needle stand mounting structure schematic diagram in the embodiment of the present invention three.
Detailed description of the invention
Below in conjunction with the accompanying drawing in the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only a part of embodiment of the present invention, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment one
As depicted in figs. 1 and 2, a kind of reagent bottle that the embodiment of the present invention provides is made up of bottle cap 3, bottle 1 and bottle stopper 2.
The outer surface of the top bottleneck of described bottle 1 has external screw thread 11, and the lower inner surface of described bottle cap 3 has internal thread, and bottle cap 3 is cooperatively interacted by internal thread and external screw thread 11, is placed on the top of bottle 1.The bottom of bottle 1 has the recessed shrinkage pool 12 to bottle 1 inside, and the bottom face of described shrinkage pool 12 has flange 13, and forms through hole 14 by flange 13.
As shown in Figure 3, described bottle stopper 2 comprises back-off 21, neck 22 and cock body 23, back-off 21 is positioned at the top of neck 22, cock body 23 is positioned at the bottom of neck 22, neck 22 is clipped in the middle by back-off 21 and cock body 23, the size of described neck 22 matches with through hole 14, and the diameter of described back-off 21 and cock body 23 is greater than through hole 14.
Particularly, the material of described bottle stopper 2 can be universal or special rubber, as butyl rubber, EP rubbers or silica gel etc.Neck 22 axial width (distance namely between back-off 21 and cock body 23) of bottle stopper 2 and the thickness of flange 13 match, and flange 13 is clamped between back-off 21 and cock body 23.Particularly, the back-off 21 of bottle stopper 2 is by crimp through after the through hole 14 bottom bottle 1, and back-off 21 recovers deformation, and periphery fits in the surface of bottle bottom flange 13 towards the inner side of bottle 1, and links closely thereon, can prevent bottle stopper 2 from outwards departing from bottle 1; The upper surface of cock body 23 and bottle bottom flange 13 are fitted towards the surface of the outside side of bottle 1, can prevent bottle stopper 2 from inwardly departing from bottle 1.
After bottle stopper 2 fills in bottle 1 from through hole 14, the neck 22 of bottle stopper 2 coordinates with through hole 14, and cock body 23 coordinates with bottle bottom recess 12.In order to realize sealing and prevent bottle stopper 2 from coming off further, during above-mentioned two places coordinate, at least one place must be interference fit; In order to easy to assembly, a place is preferably had to be non-interference fit.In embodiments of the present invention, preferred neck 22 is non-interference fit with coordinating of through hole 14, and cock body 23 is interference fit with coordinating of shrinkage pool 12.
As improvement, in back taper bottom bottle 1 in the embodiment of the present invention, the dead volume that the inverted cone-shaped structure at the bottom of bottle can effectively reduce in bottle 1 (in proper testing process, enters bubble to prevent pipeline, general meeting remaining reagent in bottle, reagent volume remaining in bottle is dead volume).Further, the top of the back-off 21 of described bottle stopper 2 is provided with gap 210, also can reduce the dead volume in bottle 1 further.
As shown in Figure 4, the side of the cock body 23 of diagram bottle stopper 2 is provided with scrobicular ring 230 to the another kind of modified node method of the bottle stopper 2 in the embodiment of the present invention, and other part-structures are same as shown in Figure 3.This concave ring structure makes cock body 23 more easily be out of shape, and when cock body 23 and shrinkage pool 12 interference fit, more easily fills in bottle 1.
Embodiment two
As shown in Figure 5 and Figure 6, the another kind of reagent bottle that the embodiment of the present invention provides is made up of bottle cap 3, bottle 1, bottle stopper fixture 4 and bottle stopper 2.Wherein, bottle cap 3 is placed on the top of bottle 1; The bottom of bottle 1 has one to the bottleneck of the outside projection of bottle, and the through hole in bottleneck filled in by described bottle stopper 2; Described bottle stopper fixture 4 is also a bottle cap, is placed on the bottle mouth position bottom bottle 1, bottle stopper 2 is pressed in the through hole of bottleneck simultaneously.
Because bottle cap commonly uses the most and parts that are the easiest and bottle combination, therefore the embodiment of the present invention adopts bottle cap as bottle stopper fixture 4, in addition, also can adopt other conventional fixed structures such as aluminium envelope, as long as bottle stopper 2 can be pressed in through hole, the function preventing bottle stopper 2 from coming off can be realized.
Embodiment three
A kind of reagents loaded device that the embodiment of the present invention provides as shown in Figure 7, is made up of support 20 and puncture needle 30.Described support 20 is for supporting and guiding reagent bottle 10.
Particularly, described support 20 is provided with gathering sill 21, and puncture needle 30 is installed on bottom gathering sill 21; Described gathering sill 21, for after reagent bottle 10 puts into loading position, leads to it, the puncture needle 30 bottom the bottle stopper 2 center automatic alignment gathering sill 21 making reagent bottle 10.
As shown in Figure 8, described puncture needle 30 comprises the needle point 31, needle stand 33 and the backshank screw thread 35 that are fixedly connected sequentially, and puncture needle 30 center has through hole 34, and described through hole 34 forms thin-and-long opening 32 at the prism of needle point 31.The offering of described thin-and-long opening 32 highly needs to ensure that needle point 31 is through after bottle stopper 2, thin-and-long opening 32 to be exposed to bottle stopper 2 at least partially outside.Needle stand 33 is for being fixed on support 20 by puncture needle 30.Backshank screw thread 35 is for being connected with external infusion pipeline by seal nipple, and the liquid-way system of composition dispensing reagent, exterior line is connected with the fluid path such as syringe pump and valve control device, for annotating to the reagent in reagent bottle 10.
In order to the convenience safeguarded and change, the puncture needle 30 in the embodiment of the present invention is removably fixed on bottom gathering sill 21 by needle stand 33.Particularly, puncture needle 30 can be fixed by the simple back-out mode that screws in and be unclamped; As shown in Figure 9, gathering sill 21 bottom surface has two arc stators 22, the needle stand 33 of puncture needle 30 has two corresponding holding sections arranged.Time fixing, only holding section need be screwed in stator 22 by puncture needle 30 90-degree rotation.
As improvement, on support 20, the indicator lamp corresponding with reagent bottle 10 or button can also be installed.Indicator lamp is used for the service condition of reagent in real-time visualizingre agent bottle 10, as the state such as " expiring ", " in use ", " surplus is not enough " and " exhausting ".Button is used for carrying out man-machine interaction, and namely operating personnel are when changing reagent bottle 10 or supplementary reagent, press corresponding button, and notice instrument upgrades the state display situation of reagent bottle 10.
Corresponding, present invention also offers a kind of method using mentioned reagent charger to load described reagent bottle, specifically comprise the following steps:
S1, unscrew bottle cap 3;
S2, by gathering sill 21, the bottle stopper 2 of reagent bottle 10 is relative with the puncture needle 30 of reagents loaded device;
S3, push reagent bottle 10 to needle point 31 direction, make needle point 31 through bottle stopper 2, enter in reagent bottle 10, complete loading.
Adopt reagent bottle of the present invention and reagents loaded device to carry out the loading of reagent very convenient, loading procedure does not have reagent yet and oozes, and avoids reagent to the potential danger of operating personnel and injury.In reagent use procedure, operating personnel can also open bottle cap at any time, observe the reagent service condition in bottle, when finding that amount of reagent is not enough, directly can pour reagent into, realize supplementing in real time of consumptive material, convenient and reliable operation.
The invention provides a kind of reagent bottle and reagents loaded device and method thereof, the through hole bottom described reagent bottle fills in bottle stopper, and the reagents loaded position of reagents loaded device is provided with puncture needle; During reagents loaded, only need unscrew bottle cap, directly reagent bottle be pressed down, make puncture needle pass the bottle stopper of bottom, the loading of reagent bottle can be completed.The bottom of the present invention mode that punctures is adopted to load reagent, quick and convenient, do not need both hands to work in coordination with simultaneously, during reagent unloading, reagent bottle is pulled away puncture needle, the drippage of reagent can not be caused; When reagent uses, by twist-off closure, directly pour reagent into from bottle mouth position, reagent can be supplemented in real time, solve the shortcoming that prior art cannot be supplemented in real time or be supplemented inconvenience.On the other hand, the bottle cap that can unscrew not only can prevent the pollutants such as dust to enter in bottle, but also allow when reagent uses, and allow the air outside bottle enter in bottle, the air pressure balance in maintenance bottle, eliminates custom-designed inlet duct, saved cost.In addition, adopt this bottom fluid, the mode of top air inlet, can effectively solve the harmful effect that in prior art, bottom inflow causes reagent performance.
Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in previous embodiment, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of various embodiments of the present invention technical scheme.
Claims (12)
1. a reagent bottle, is characterized in that, comprises bottle, bottle cap and bottle stopper, and described bottle cap is placed on bottle top, and described bottle body bottom has a through hole be communicated with bottle inside, and described bottle stopper plug is in described through hole;
Wherein, the bottom of described bottle has the recessed shrinkage pool to bottle inside, and described shrinkage pool bottom face has flange, and forms through hole by flange;
Described bottle stopper comprises cock body, is positioned at neck and the back-off at middle part, and neck is clipped in the middle by described back-off and cock body, and the diameter of described back-off is greater than through hole, and the size of described neck matches with through hole, and the diameter of described cock body is greater than through hole;
The neck axial width of described bottle stopper and the thickness of flange match, and flange is clamped between back-off and cock body.
2. reagent bottle according to claim 1, is characterized in that, also comprises bottle stopper fixture, and described bottle stopper fixture is connected with bottle, and bottle stopper is pressed in through hole.
3. reagent bottle according to claim 1, is characterized in that, described bottle stopper is filled in by through hole, and the neck of bottle stopper coordinates with through hole, and cock body coordinates with shrinkage pool, and during described two places coordinate, at least one place is interference fit.
4. reagent bottle according to claim 3, is characterized in that, described cock body and shrinkage pool interference fit.
5. reagent bottle according to claim 4, is characterized in that, the side of described cock body is provided with scrobicular ring.
6. reagent bottle according to claim 5, is characterized in that, the top of described back-off is provided with gap.
7. a reagents loaded device, for loading reagent bottle according to claim 1, is characterized in that, comprises support and puncture needle; Described support is used for supporting and the described reagent bottle that leads; Described puncture needle comprises the needle point, needle stand and the backshank screw thread that connect successively, and puncture needle center has through hole, and described through hole forms thin-and-long opening at the prism of needle point, and described needle stand is connected with support, and described backshank screw thread is connected with external infusion pipeline;
Described support comprises a gathering sill, and described puncture needle is installed on bottom gathering sill, and described gathering sill is used for leading to reagent bottle, makes the bottle stopper on reagent bottle relative with puncture needle;
Described needle stand is removably connected on support, and wherein, gathering sill bottom surface has two arc stators, the needle stand of puncture needle have two corresponding holding sections arranged, holding section, by screwing in back-out mode, screws in or screws out stator, to be fixed and to unclamp by puncture needle.
8. reagents loaded device according to claim 7, is characterized in that, described needle point through after bottle stopper, thin-and-long opening be exposed to bottle stopper outside at least partially.
9. reagents loaded device according to claim 7, is characterized in that, also comprises and is installed on indicator lamp on support or button, for showing or upgrade the service condition of reagent in reagent bottle.
10. an immunity analysis instrument, is characterized in that, described immunity analysis instrument is provided with the arbitrary described reagents loaded device of claim 7 to 9.
11. 1 kinds of methods using the reagents loaded device described in claim 7 to load reagent bottle according to claim 1, is characterized in that, comprising:
The bottle stopper of reagent bottle is relative with the puncture needle of reagents loaded device;
Push reagent bottle to needle point direction, make needle point pass bottle stopper, enter in reagent bottle.
12. methods according to claim 11, is characterized in that, also comprise: unscrew bottle cap.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310131464.1A CN104107733B (en) | 2013-04-16 | 2013-04-16 | A kind of reagent bottle and reagents loaded device and method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310131464.1A CN104107733B (en) | 2013-04-16 | 2013-04-16 | A kind of reagent bottle and reagents loaded device and method thereof |
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| CN104107733A CN104107733A (en) | 2014-10-22 |
| CN104107733B true CN104107733B (en) | 2016-01-20 |
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| CN201310131464.1A Active CN104107733B (en) | 2013-04-16 | 2013-04-16 | A kind of reagent bottle and reagents loaded device and method thereof |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104721048A (en) * | 2015-03-31 | 2015-06-24 | 周红英 | Eyedrop bottle |
| CN106645624A (en) * | 2017-02-13 | 2017-05-10 | 山东省地矿工程勘察院 | Device and method for maintaining stable state of field detection water body and application |
| TWI797939B (en) * | 2021-12-30 | 2023-04-01 | 王群凱 | Household plumbing lotion bottle and method of use |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2853079Y (en) * | 2005-03-24 | 2007-01-03 | 通用电气医疗集团股份有限公司 | Needle for puncture container plug and reagent box |
| CN2912786Y (en) * | 2005-12-09 | 2007-06-20 | 赵瑾明 | Separate sealed test tube |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7753095B2 (en) * | 2006-12-15 | 2010-07-13 | Helicos Biosciences Corporation | Storing and handling liquid reagents |
| WO2013048553A1 (en) * | 2011-09-29 | 2013-04-04 | Rarecyte, Inc. | Tube and float systems |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2853079Y (en) * | 2005-03-24 | 2007-01-03 | 通用电气医疗集团股份有限公司 | Needle for puncture container plug and reagent box |
| CN2912786Y (en) * | 2005-12-09 | 2007-06-20 | 赵瑾明 | Separate sealed test tube |
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Application publication date: 20141022 Assignee: Shenzhen Mindray Animal Medical Technology Co.,Ltd. Assignor: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS Co.,Ltd. Contract record no.: X2022440020009 Denomination of invention: A reagent bottle and reagent loading device and method thereof Granted publication date: 20160120 License type: Common License Record date: 20220804 |