CN218401837U

CN218401837U - Liquid storage device of chemiluminescence immunoassay analyzer

Info

Publication number: CN218401837U
Application number: CN202222333342.8U
Authority: CN
Inventors: 韦剑洪; 吴督; 张道兵
Original assignee: Zhuhai Gaoruite Medical Equipment Co ltd; Boai Hospital of Zhongshan
Current assignee: Zhuhai Gaoruite Medical Equipment Co ltd; Boai Hospital of Zhongshan
Priority date: 2022-09-02
Filing date: 2022-09-02
Publication date: 2023-01-31
Anticipated expiration: 2032-09-02

Abstract

The utility model discloses a chemiluminescence immunity analyzer liquid storage device, which comprises a buffer bottle component and a base component, wherein the buffer bottle component comprises a buffer bottle, a bottle cap and a column sleeve structure; the column sleeve structure runs through the bottle cap and is arranged in the buffer bottle, the bottle cap is provided with the filling port and the exhaust hole, the weight sensor is adopted to measure the weight of the exciting liquid buffer bottle assembly in real time, the amount of exciting liquid in the buffer bottle can be monitored, and the remaining testable times can be estimated through calculation. In addition, the bottle cap is provided with the filling port and the exhaust hole, the structure is simple, dust can be prevented from falling into the bottle cap, reagent is polluted, the balance of internal and external air pressure is kept, the reagent can be extracted by the water pump, and the orifice is small so that the volatilization of the reagent can be slowed down. When the excitation liquid needs to be filled, the machine does not need to be stopped, and the excitation liquid is directly filled into the buffer bottle by the injector, so that the problem that the capillary absorbs bubbles because the water suction pipe needs to be pulled up and then the reagent is replenished and poured in the traditional containing device is solved.

Description

Liquid storage device of chemiluminescence immunoassay analyzer

Technical Field

The utility model belongs to the technical field of mechanical structure and specifically relates to a chemiluminescence immunoassay appearance liquid storage device.

Background

Chemiluminescence immunoassay is a relatively new immunoassay technology developed after radioimmunoassay, enzyme immunoassay, fluorescence immunoassay and time-resolved fluorescence immunoassay, combines chemiluminescence immunoassay technology with high sensitivity with high specificity immunoreaction, and is used for detecting and analyzing various antigens, haptens, antibodies, hormones, enzymes, fatty acids, vitamins, medicines and the like. For example, using micro magnetic beads as a carrier, fixing specific antibodies or antigens on the micro magnetic beads, combining high-specificity immunoreaction of the antigen and the antibody, combining a target object in a sample with the magnetic beads to form a reactant, washing away impurities which are not combined with the magnetic beads, then adding a luminescent marker to perform incubation reaction, washing away the unreacted impurities, finally adding a luminescent promoter (excitation liquid), increasing the self-luminescence speed and intensity of the reactant, and then measuring the luminescent intensity of the reactant. The concentration of the target in the sample is in a certain proportional relation with the luminous intensity. The full-automatic chemiluminescence immunoassay analyzer is an instrument and equipment for analyzing the content of a substance to be detected in human body fluid based on the principle, and the detection efficiency is improved.

The exciting liquid is different from other reagents, does not need to be selected according to specific measurement items, is a relatively fixed reagent, is added at the final stage of the reaction, and is usually pumped by a micro water pump and added into a reaction cup. The full-automatic chemiluminescence immunoassay analyzer needs continuous and stable operation of equipment due to large sample amount, and excitation liquid needs to be stored separately by using a reagent bottle with large capacity. How to store the excitation liquid with low cost, reduce concentration change caused by reagent volatilization, how to estimate the measurable times of the residual excitation liquid and realize filling and supplementing the excitation liquid without stopping machine is a problem to be solved urgently by technical personnel in the field.

SUMMERY OF THE UTILITY MODEL

Problem to prior art existence, the utility model aims to provide a chemiluminescence immunoassay appearance liquid storage device realizes can detect reagent surplus, need not shut down just can supply the storage device of liquid, reduces doctor's the operation degree of difficulty and work load, and then promotes detection efficiency.

In order to achieve the above purpose, the technical scheme of the utility model is as follows:

a liquid storage device of a chemiluminescence immunoassay analyzer comprises a buffer bottle component and a base component, wherein the buffer bottle component comprises a buffer bottle, a bottle cap and a column sleeve structure, the buffer bottle component is arranged on the base component, and a weighing sensor is arranged on the base component; the column sleeve structure penetrates through the bottle cap and is arranged in the buffer bottle, and the bottle cap is provided with a filling port and an exhaust hole.

Further, post cover structure includes capillary, protecting pipe, compresses tightly knob, clamp and stand pipe, the stand pipe suit is in the capillary the buffer bottle is inside, the protecting pipe suit is in the capillary the buffer bottle is outside. Further, the clamp is the toper structure, and the lateral wall is opened there is the notch.

Further, the bottle lid center is provided with the through-hole that supplies the capillary to pass through, the capillary passes through compress tightly the knob with the clamp cooperation is fixed in the bottle lid center through-hole.

Further, the inner diameter of the periphery of the bottle cap is larger than the diameter of the bottle opening of the buffer bottle.

Further, the filling opening and the exhaust hole are transversely arranged on the bottle cap.

Further, set up the via hole in the middle of compressing tightly the knob, the bottom set up with the bell shape matching's bell jar, the external diameter that compresses tightly the knob head is greater than the diameter of bottle lid central through-hole, compress tightly the knob head and arrange in on the bottle lid.

Furthermore, the side wall of the lower part of the pressing knob is provided with an external thread, and the central through hole of the bottle cap is provided with an internal thread which is matched with the internal thread to fix the pressing knob.

Further, the base subassembly is provided with the accommodation hole, the accommodation hole bottom is provided with the weighing sensor holding tank.

Further, the supporting plate is installed at the top of the weighing sensor, so that the buffer bottle can be placed on the weighing sensor more stably.

The utility model discloses a chemiluminescent immunoassay appearance liquid storage device adopts weighing sensor to carry out the weight measurement to arousing liquid buffer bottle subassembly in real time, can monitor the volume of arousing liquid in the buffer bottle, can estimate remaining testable number of times through calculating simultaneously. In addition, the bottle cap is provided with the filling port and the exhaust hole, the structure is simple, dust can be prevented from falling into the bottle cap, reagent is polluted, the balance of internal and external air pressure is kept, a water pump can extract the reagent, and the orifice is small, so that the volatilization of the reagent can be slowed down. When the exciting liquid needs to be filled, the machine does not need to be stopped, the buffer liquid is directly filled into the buffer bottle by the injector, and the problem that the capillary absorbs bubbles because the water absorption tube needs to be pulled up and then the reagent is replenished and poured in the traditional containing device is solved.

Further, the utility model discloses in use the stereoplasm stand pipe to tie the capillary, make the capillary be in straight state, avoided because of the terminal altitude variation brought of the crooked water sucking mouth that causes of capillary harmful effects, make the estimation more accurate.

Drawings

FIG. 1 is a schematic view of a buffer bottle in a base according to an embodiment of the present invention;

FIG. 2 is a top view of a base assembly in one embodiment of the present invention;

FIG. 3 is an exploded view of the base assembly of the present invention in one embodiment;

FIG. 4 is an exploded view of the buffer bottle assembly according to one embodiment of the present invention;

FIG. 5 is a schematic view of a clamp according to an embodiment of the present invention;

fig. 6 is a schematic view of a pressing knob according to an embodiment of the present invention;

fig. 7 is a schematic view of a bottle cap according to an embodiment of the present invention;

fig. 8 is a cross-sectional view of a storage device in an embodiment of the invention.

In the figure:

1. a bottle seat; 2. a buffer bottle; 3. a bottle cap; 4. a compression knob; 5. sheathing a pipe; 6. a capillary tube; 7. a support plate; 8. a screw; 9. a weighing sensor; 10. clamping a hoop; 11. a guide tube.

Detailed Description

To clearly illustrate the design concept of the present invention, the following description is made with reference to the examples.

In order to make the technical solutions of the present invention better understood by those skilled in the art, the technical solutions in the embodiments of the present invention are clearly and completely described below with reference to the drawings in the examples of the present invention, and it is obvious that the described examples are only a part of examples of the present invention, and not all examples. Based on the examples in the present disclosure, all other embodiments obtained by those skilled in the art without any creative work shall fall within the protection scope of the present disclosure.

In the description of the present embodiment, the terms "upper", "lower", "left", "right", and the like indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention.

The example provides a liquid storage device of a chemiluminescence immunoassay analyzer, which comprises a buffer bottle component and a base component, wherein the buffer bottle component comprises a buffer bottle, a bottle cap and a column sleeve structure, the buffer bottle component is arranged on the base component, and a weighing sensor is arranged on the base component; the column sleeve structure runs through the bottle cap and is arranged in the buffer bottle, and the bottle cap is provided with a filling port and an exhaust hole. The method comprises the steps of measuring the weight of an excitation liquid buffer bottle component in real time by adopting a micro weighing sensor, subtracting the weight of a designated reagent for triggering low liquid level alarm and the weight of the buffer bottle component in an empty bottle, and dividing the weight by the weight of the excitation liquid required by each test to estimate the remaining testable times. The bottle cap is provided with an exhaust hole and an injection port, the structure is simple, and the dust can be prevented from falling into the bottle cap to pollute the reagent. The exhaust hole keeps the balance of the internal air pressure and the external air pressure, so that the reagent can be pumped by the water pump, and the orifice is small, so that the volatilization of the reagent can be slowed down. When the excitation liquid needs to be filled, the machine does not need to be stopped, and the excitation liquid is directly filled into the buffer bottle by the injector. The problem that the capillary absorbs bubbles because the water suction pipe needs to be pulled up and then the reagent is added into the traditional accommodating device is solved. The integrated structure is used, the capillary tube is a whole capillary tube, and the middle part of the capillary tube is not provided with a joint, so that inaccurate sample suction caused by air leakage is avoided. The quick-release structure makes the operation of replacing the capillary tube more simple and convenient.

In order to clarify the technical solution of the present invention, the present invention will be described in detail with reference to the accompanying drawings and embodiments. The embodiments and features of the embodiments in the present application may be combined with each other without conflict.

Examples

As shown in fig. 1, 4, 7, and 8, an embodiment of the liquid storage device of the chemiluminescent immunoassay analyzer of the present invention is provided, the liquid storage device of the chemiluminescent immunoassay analyzer comprises a buffer bottle assembly and a base assembly, the buffer bottle assembly comprises two buffer bottles 2, a plug-in type bottle cap 3 and a column sleeve structure, the buffer bottle assembly is installed on the base assembly, and the base assembly is provided with a weighing sensor 9; the column sleeve structure runs through the through hole of the bottle cap 3 and is arranged in the buffer bottle 2, the bottle cap 3 is transversely provided with a filling port and an exhaust hole, the radial size of the filling port is larger than that of the exhaust hole, and an air flow channel is formed by crossing the side surface and the lower surface of the bottle cap in a drilling mode.

Referring to fig. 2 and 3, the base member is formed with a receiving hole having a diameter slightly larger than that of the buffer bottle 2 so that the buffer bottle 2 can be inserted into the receiving hole without being jammed. The weighing sensor holding tank has been seted up to the accommodation hole bottom for install weighing sensor 9, 9 bottom fixed mounting of weighing sensor use screw 8 installation in this embodiment in the weighing sensor holding tank. Supporting plate 7 is installed at the top of weighing sensor 9, and supporting plate 7 can make buffer bottle 2 more steady place on weighing sensor 9, prevents to weigh the production error. In addition, the buffer bottle 2 in the embodiment is a standard reagent bottle, and the supporting plate 7 is made of aluminum material, so that the whole weight is reduced.

Referring to fig. 4, in this embodiment, the column jacket structure includes a capillary tube 6, a sheath tube 5, a pressing knob 4, a clip 10, and a guide tube 11, the capillary tube 6 is disposed in the sheath tube 5, the pressing knob 4, the clip 10, and the guide tube 11 in a penetrating manner, the guide tube 11 is sleeved on a portion of the capillary tube 6 located in the buffer bottle 2, and the sheath tube 5 is sleeved on a portion of the capillary tube 6 located above the bottle cap 3.

In addition, in the embodiment, the center of the bottle cap 3 is provided with a through hole for the capillary 6 to pass through, and a part of the capillary 6 is fixed above the bottle cap 3 through the pressing knob 4 and the clamp 10 in a matching way. Referring to fig. 5, 6 and 8, the guide tube 11 is inserted tightly in the buffer bottle 2, and the inner diameter of the guide tube 11 is slightly larger than the outer diameter of the capillary tube 6. There is the via hole in the middle of compressing tightly knob 4, and there is the bell jar bottom, and the bell jar is used for compressing tightly clamp 10, and it has the notch to open on the clamp 10, and when being compressed tightly, the notch width diminishes can hold tightly and insert inside capillary 6, plays the positioning action.

Referring to fig. 8, in this embodiment, the buffer bottle 2 may be a plastic bottle with a threaded opening, or a special plastic bottle with a non-threaded opening. The inner diameter of the periphery of the bottle cap 3 is slightly larger than the diameter of the buffer bottle mouth, so that the bottle cap 3 can be directly sleeved on the buffer bottle mouth. The center of the bottle cap 3 is provided with a through hole for the column sleeve structure to pass through, and the column sleeve structure and the through hole are pressed in an interference fit manner or are glued. The through hole arranged in the center of the bottle cap 3 is provided with threads close to the upper part for screwing the compression knob 4. Compress tightly 4 head diameters of knob and be greater than the through-hole diameter at 3 centers of bottle lids, the lateral wall that compresses tightly 4 lower parts of knob is provided with the external screw thread, and the head lateral wall is provided with the non-slip texture. During capillary installation, penetrate earlier in the clamp 10, the position is adjusted, will compress tightly the through-hole at knob 4 screw in bottle lid 3 center, and after the clamp 10 of screwing is fixed the position, the top is installed protecting pipe 5, and the below is inserted in the stand pipe 11, and the stand pipe 11 then sets up in the bottle of through-hole to buffer bottle 2, when compressing tightly knob 4 and screwing on bottle lid 3, capillary 6 is in straight state.

In the above-mentioned example, the utility model discloses a weighing sensor carries out weight measurement to exciting liquid buffer bottle subassembly in real time, subtracts the reagent weight that appointed triggering low liquid measure was reported to the police (for example the exciting liquid weight that the liquid level height that is shown in fig. 8 corresponds, liquid level height is equipped with certain surplus apart from the imbibition mouth, for the user filling supplementary exciting liquid certain operating time that flows), subtracts the weight of buffer bottle subassembly and layer board when empty bottle again, divides again and can estimate remaining testable number of times with the exciting liquid weight that at every turn the test is required.

The capillary tube is bound by the hard guide tube, so that the capillary tube is in a straight state, adverse effects caused by the height change of the tail end of the water suction port due to the bending of the capillary tube are avoided, and the estimation is more accurate. The mould opening cost can be reduced by using the standard reagent bottle, the bottle cap of the plug-in type without threads is designed, the rest reagent bottles can be conveniently and quickly sleeved, and the pipeline distortion caused by screwing the bottle cap is avoided. The bottle cap is provided with the transverse exhaust hole and the filling port, the structure is simple, and dust can be prevented from falling into the bottle cap to pollute the reagent. The exhaust hole keeps the balance of the internal air pressure and the external air pressure, so that the reagent can be pumped by the water pump, and the orifice is small, so that the volatilization of the reagent can be slowed down. When the excitation liquid needs to be filled, the machine does not need to be stopped, and the excitation liquid is directly filled into the buffer bottle by the injector. The problem that the capillary tube sucks air bubbles because the water suction tube needs to be pulled up and then the reagent is added in the traditional accommodating device is solved. The integrated structure is used, the capillary tube is a whole capillary tube, and the middle part of the capillary tube is not provided with a joint, so that inaccurate sample suction caused by air leakage is avoided. The quick-release structure makes the operation of replacing the capillary tube more simple and convenient.

In addition, capillary 6 adopts corrosion-resistant teflon pipe preparation, and the stand pipe 11 adopts the higher and corrosion-resistant PEEK material of hardness to make, compresses tightly knob 4 and clamp 10 and adopts the PP material preparation, and protective sheath 5 adopts flexible silicone tube or PU pipe preparation, adopts flexible silicone tube preparation in this embodiment.

It is noted that some of the structures may be selected differently than the specific examples given above. For example, the arrangement positions and the number of the load cells 9 can be freely arranged as required; the material of the pallet 7 is not limited to the material mentioned in the present embodiment; the number of buffer bottles in the buffer bottle assembly can be adjusted according to actual conditions, the structure of the corresponding base assembly is changed accordingly, and the buffer bottles can be made based on basic skills of the base assembly on the basis of understanding of the technical idea of the utility model, so that the buffer bottle assembly is not listed one by one.

Finally, it is to be understood that the above embodiments are merely exemplary embodiments that have been employed to illustrate the principles of the present invention, and that the present invention is not limited thereto. It will be apparent to those skilled in the art that various changes and modifications may be made without departing from the spirit and scope of the invention, and these changes and modifications are to be considered within the scope of the invention.

Claims

1. A liquid storage device of a chemiluminescence immunoassay analyzer is characterized by comprising a buffer bottle component and a base component, wherein the buffer bottle component comprises a buffer bottle, a bottle cap and a column sleeve structure; the column sleeve structure penetrates through the bottle cap and is arranged in the buffer bottle, and the bottle cap is provided with a filling port and an exhaust hole.

2. The chemiluminescent immunoassay analyzer liquid storage device of claim 1 wherein the cartridge structure comprises a capillary tube, a sheath tube, a compression knob, a collar and a guide tube, the guide tube fits over the buffer bottle inner portion of the capillary tube, the sheath tube fits over the buffer bottle outer portion of the capillary tube.

3. The chemiluminescent immunoassay analyzer liquid storage device of claim 2 wherein the band is of a tapered configuration with a notch in a side wall.

4. The chemiluminescent immunoassay analyzer liquid storage device of claim 2 wherein the center of the bottle cap is provided with a through hole for the column sleeve structure to pass through, and the capillary tube is fixed in the through hole of the bottle cap through the pressing knob and the clamp in a matching way.

5. The chemiluminescent immunoassay analyzer liquid storage device of claim 4 wherein the bottle cap peripheral inner diameter is larger than the bottle mouth diameter of the buffer bottle.

6. The chemiluminescent immunoassay analyzer liquid storage device of claim 5 wherein the fill port and the vent are disposed laterally on the vial cap.

7. The chemiluminescent immunoassay analyzer liquid storage device of claim 6 wherein the compression knob has a through hole in the middle and a tapered groove at the bottom for mating with the clamp, the compression knob having a head with an outer diameter larger than the diameter of the central through hole of the cap so that the head is disposed above the cap.

8. The chemiluminescent immunoassay analyzer liquid storage device of claim 7 wherein the compression knob has an external thread on the lower side wall, and the bottle cap has an internal thread in the central through hole to cooperate with the internal thread to fix the compression knob.

9. The chemiluminescent immunoassay analyzer liquid storage device of claim 1 wherein the base assembly is provided with an accommodation hole, the bottom of which is provided with a load cell accommodation groove.

10. The chemiluminescent immunoassay analyzer liquid storage device of claim 9 wherein a support plate is mounted on top of the load cell to allow a buffer bottle to be placed more smoothly over the load cell.