CN220597426U - Magnetic frame in field of multifunctional molecular biology application - Google Patents
Magnetic frame in field of multifunctional molecular biology application Download PDFInfo
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- CN220597426U CN220597426U CN202322013838.1U CN202322013838U CN220597426U CN 220597426 U CN220597426 U CN 220597426U CN 202322013838 U CN202322013838 U CN 202322013838U CN 220597426 U CN220597426 U CN 220597426U
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- molecular biology
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- frame body
- frame
- multifunctional molecular
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- 238000001179 sorption measurement Methods 0.000 claims abstract description 35
- 230000007246 mechanism Effects 0.000 claims abstract description 16
- 230000004224 protection Effects 0.000 claims description 18
- 238000007789 sealing Methods 0.000 claims description 17
- 238000000034 method Methods 0.000 abstract description 7
- 238000002474 experimental method Methods 0.000 abstract description 5
- 230000008569 process Effects 0.000 abstract description 5
- 239000003153 chemical reaction reagent Substances 0.000 abstract description 4
- 108020004707 nucleic acids Proteins 0.000 description 7
- 150000007523 nucleic acids Chemical class 0.000 description 7
- 102000039446 nucleic acids Human genes 0.000 description 7
- 230000009471 action Effects 0.000 description 5
- 239000011324 bead Substances 0.000 description 5
- 230000007547 defect Effects 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
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- 238000000576 coating method Methods 0.000 description 1
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- 238000011840 criminal investigation Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 238000012214 genetic breeding Methods 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000009979 protective mechanism Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Abstract
The utility model relates to the field of multifunctional molecular biology, in particular to a magnetic force frame in the field of multifunctional molecular biology application, which comprises a supporting mechanism for fixing a centrifuge tube, wherein the supporting mechanism comprises a frame body, two baffle plates are respectively fixed on two sides of the frame body, and a piston cavity and a movable groove are respectively arranged in the middle of the frame body. According to the utility model, the baffle plates are utilized to open hole sites with different specifications, the conditions of multiple purposes of the same magnetic rack are met, the laboratory space is saved, the carrying is more convenient, the baffle plates are additionally provided to provide comfortable gripping points, the rubber rings in the hole sites strengthen the stability of the centrifuge tube, the centrifuge tube is not easy to be carelessly thrown away in the shaking process, the reagent is saved, the experiment time is saved, the pressing plate is utilized to drive the piston rack to move downwards, the piston rack is utilized to pump air in the piston cavity and the adsorption groove, and then a low-pressure area is formed between the adsorption groove and the centrifuge tube and is used for adsorbing and fixing the low-pressure area, so that the centrifuge tube is prevented from falling in the shaking process.
Description
Technical Field
The utility model relates to the field of multifunctional molecular biology, in particular to a magnetic frame in the field of multifunctional molecular biology application.
Background
The micro-nano magnetic beads can separate nucleic acid from whole blood, plasma, serum, animal and plant tissues, feces, soil, oral swab washing liquid and vaginal swab washing liquid under the action of a magnetic field by generating specific adsorption capacity to genes through special coating treatment. The method is widely applied to the fields of colleges and universities such as scientific research, medical detection, entrance and exit quarantine inspection, animal epidemic disease inspection, public security criminal investigation, genetic breeding and the like. Short extraction time, high efficiency, small volume and convenient carrying;
the extraction reagent of the magnetic bead method can be divided into four steps: (1) cleavage- (2) binding- (3) washing- (4) elution. Firstly, enabling nucleic acid of a sample to be free under the action of a lysate, adding magnetic beads to adsorb the free nucleic acid, enabling the magnetic beads to gather around a magnet with the nucleic acid under the action of a magnetic field, cleaning by a cleaning solution, and finally separating the magnetic beads from the nucleic acid under the action of an eluent to obtain high-quality nucleic acid for downstream experiments;
defect 1: the transverse direction (two sides) has no gripping points, so that the gripping is inconvenient;
defect 2: the prior art can only test a centrifuge tube with 1.5ml and 2ml, and the hole site is too small to meet the current experiment requirement and can not meet the nucleic acid extraction of a large sample;
defect 3: the centrifuge tube in the prior art is easy to fall off in the process of experiment, so that the experiment is interrupted, and the reagent and the time are wasted.
Disclosure of Invention
The utility model aims to solve the problems and provide a magnetic frame in the application field of multifunctional molecular biology.
The utility model realizes the above purpose through the following technical scheme:
the utility model provides a magnetic force frame in biological application field of multifunctional molecule, includes the supporting mechanism who is used for the centrifuging tube to fix, supporting mechanism includes the support body, the support body both sides are fixed with two baffles respectively, piston chamber and movable groove have been seted up respectively to support body intermediate position, the piston chamber is located the movable groove top, piston frame sliding connection is in piston intracavity portion, the piston frame lower extreme is fixed with can be in the gliding clamp plate in the movable groove, the clamp plate below is provided with and fixes be used for carrying out fixed absorption subassembly to the clamp plate in movable groove bottom, corresponding hole site has been seted up respectively on support body top and the two sets of baffles, the inside rubber circle that is fixed with respectively of hole site.
Preferably: an adsorption groove is formed in the inner wall of the hole site, and notches used for fixing the rubber ring are formed in two sides of the adsorption groove.
Preferably: the hole site on the support body with the piston chamber passes through the second gas pocket intercommunication, the hole site on the baffle with the piston chamber passes through first gas pocket intercommunication.
Preferably: the protection mechanism for preventing gas from entering the adsorption groove without installing the centrifuge tube is respectively installed at the holes on the frame body and the baffle plate.
Preferably: the protection mechanism comprises a protection seat arranged on the hole site, a spring is fixed on the protection seat, and a sealing ring mutually attached to the rubber ring is fixed at the central position of the protection seat.
Preferably: and a sealing driving sealing ring for sealing the piston cavity is fixed outside the piston frame.
Compared with the prior art, the utility model has the following beneficial effects:
1. the baffle plates are utilized to open holes with different specifications, so that the conditions of multiple purposes of the same magnetic frame are met, the space of a laboratory is saved, the portable magnetic force frame is more convenient to carry, and a comfortable gripping point is provided by adding a plurality of baffle plates;
2. the rubber ring in the hole site strengthens the stability of the centrifuge tube, so that the centrifuge tube is not easy to be carelessly thrown away in the shaking process, the reagent is saved, and the experimental time is saved;
3. the piston frame is driven to move downwards by the pressing plate, the piston cavity and the adsorption groove are pumped by the piston frame, a low-pressure area is formed between the adsorption groove and the centrifuge tube immediately, the adsorption groove and the centrifuge tube are adsorbed and fixed, and the centrifuge tube is prevented from falling off when shaking;
4. utilize the rubber circle of hole site on paired to support fixedly to the centrifuging tube, offered the adsorption tank simultaneously between two rubber circles to adsorb fixed region through rubber circle and adsorption tank and can prevent that the centrifuging tube from breaking away from the condition emergence of hole site.
Drawings
In order to more clearly illustrate the embodiments of the utility model or the technical solutions of the prior art, the drawings that are necessary for the description of the embodiments or the prior art will be briefly described, it being obvious that the drawings in the following description are only some embodiments of the utility model and that other drawings can be obtained according to these drawings without inventive faculty for a person skilled in the art.
FIG. 1 is a schematic structural diagram of a magnetic rack in the field of application of multifunctional molecular biology according to the utility model;
FIG. 2 is a partial cross-sectional view of a first air hole of a magnetic rack for a multi-functional molecular biology application field according to the present utility model;
FIG. 3 is a partial cross-sectional view of an adsorption tank of a magnetic rack in the field of application of multifunctional molecular biology according to the utility model;
FIG. 4 is a partial cross-sectional view of a second air hole of a magnetic rack for a multi-functional molecular biology application field according to the present utility model;
FIG. 5 is a partial part diagram of a protection mechanism of a magnetic frame in the field of application of the multifunctional molecular biology according to the utility model;
FIG. 6 is a partial part view of a frame body of a magnetic frame in the field of application of the multifunctional molecular biology according to the utility model;
FIG. 7 is a view of a part of a baffle of a magnetic rack in the field of application of the multifunctional molecular biology according to the present utility model;
FIG. 8 is a partial detail view of a piston frame of a magnetic frame of the field of application of the multifunctional molecular biology of the utility model.
The reference numerals are explained as follows:
1. a support mechanism; 2. a protective mechanism; 3. a rubber ring; 4. hole sites; 5. adsorbing the magnetic blocks; 11. a frame body; 12. a baffle; 13. a piston holder; 14. a pressing plate; 15. an adsorption tank; 16. a first air hole; 17. a second air hole; 18. a piston chamber; 19. a movable groove; 21. a protective seat; 22. a spring; 23. and (3) sealing rings.
Detailed Description
In the description of the present utility model, it should be understood that the terms "center", "longitudinal", "lateral", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, are merely for convenience in describing the present utility model and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present utility model. Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first", "a second", etc. may explicitly or implicitly include one or more such feature. In the description of the present utility model, unless otherwise indicated, the meaning of "a plurality" is two or more.
In the description of the present utility model, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present utility model can be understood by those of ordinary skill in the art in a specific case.
The utility model is further described below with reference to the accompanying drawings:
as shown in fig. 1-8, a magnetic force frame in the application field of multifunctional molecular biology comprises a supporting mechanism 1 for fixing a centrifuge tube, wherein the supporting mechanism 1 comprises a frame body 11, two baffle plates 12 are respectively fixed on two sides of the frame body 11, a piston cavity 18 and a movable groove 19 are respectively arranged in the middle of the frame body 11, the piston cavity 18 is positioned above the movable groove 19, the piston frame 13 is slidably connected in the piston cavity 18, a pressing plate 14 capable of sliding in the movable groove 19 is fixed at the lower end of the piston frame 13, an adsorption magnetic block 5 fixed at the bottom of the movable groove 19 is arranged below the pressing plate 14, corresponding hole sites 4 are respectively arranged on the top of the frame body 11 and the two groups of baffle plates 12, rubber rings 3 are respectively fixed in the hole sites 4, adsorption grooves 15 are respectively arranged on the inner walls of the hole sites 4, notches for fixing the rubber rings 3 are respectively arranged on two sides of the adsorption grooves 15, the hole sites 4 on the frame body 11 are communicated with the piston cavity 18 through second air holes 17, the hole site 4 on the baffle plate 12 is communicated with the piston cavity 18 through the first air hole 16, the protection mechanism 2 for preventing gas from entering the adsorption groove 15 without installing a centrifugal tube is respectively installed on the frame body 11 and the hole site 4 on the baffle plate 12, the sealing driving sealing ring is fixed outside the piston frame 13 and is sealed with the piston cavity 18, more centrifugal tubes can be conveniently inserted by utilizing the frame body 11 and the hole site 4 on the baffle plate 12, meanwhile, the piston frame 13 is driven to move downwards by utilizing the pressing plate 14, then the adsorption groove 15 communicated with the piston cavity 18 can be respectively pumped through the first air hole 16 and the second air hole 17, then the centrifugal tube inserted into the hole site 4 is adsorbed and fixed through the low pressure in the adsorption groove 15, meanwhile, the adsorption groove 15 is sealed by utilizing the paired rubber rings 3 to prevent external gas from entering the adsorption groove 15, and can also support and fix the centrifuge tube.
In this embodiment: the protection mechanism 2 comprises a protection seat 21 arranged on the hole site 4, a spring 22 is fixed on the protection seat 21, a sealing ring 23 mutually attached to the rubber ring 3 is fixed at the center of the protection seat 21, the end parts of the sealing ring 23 are pulled by the elasticity of the spring 22 on the protection seat 21 to respectively extend into the hole site 4 corresponding to the sealing ring, and the sealing ring 23 is mutually contacted with the rubber ring 3 in the hole site 4 in pairs, so that the adsorption groove 15 which is not inserted into the centrifuge tube is guaranteed to be in a sealing state.
Working principle: when the centrifugal tube is used, a centrifugal tube to be fixed is inserted into a hole site 4 corresponding to the frame 11 or the baffle 12 according to the diameter or the capacity of the centrifugal tube, in the process of inserting the centrifugal tube, the sealing ring 23 inserted into the hole site 4 is ejected outwards through the centrifugal tube, then the spring 22 on the protection seat 21 is stretched, then the rubber rings 3 are firstly adhered with the multi-lining sealing ring 23 and mutually adhered with the outer wall of the centrifugal tube, then the inserted centrifugal tube is supported by the paired rubber rings 3 in the hole site 4, and meanwhile, the adsorption groove 15 area in the hole site 4 can be sealed by the paired rubber rings 3;
then pressing down the pressing plate 14, driving the piston frame 13 to slide downwards in the piston cavity 18 through the pressing plate 14, then pumping air from the adsorption grooves 15 in the plurality of holes 4 through the first air holes 16 and the second air holes 17, and then adsorbing the outer wall of the centrifugal tube by the adsorption grooves 15 in the plurality of holes 4 in a low-pressure area, so that the fixation of the centrifugal tube is firmer, and simultaneously when the pressing plate 14 moves downwards to be attached to the adsorption magnetic block 5, the adsorption magnetic block 5 is used for adsorbing and fixing the centrifugal tube, and then the positions of the piston cavity 18 and the adsorption grooves 15 are both in the low-pressure area, so that the fixation of the whole magnetic frame to the centrifugal tube is ensured;
when the centrifuge tube is required to be taken out, the pressing plate 14 is lifted upwards to separate the centrifuge tube from the adsorption magnetic block 5, then the pressing plate 14 and the piston frame 13 can move upwards to the initial position under the action of negative pressure, and then the adsorption groove 15 is separated from the adsorption effect on the centrifuge tube, so that the centrifuge tube can be pulled out.
The foregoing has shown and described the basic principles, principal features and advantages of the utility model. It will be understood by those skilled in the art that the present utility model is not limited to the embodiments described above, and that the above embodiments and descriptions are merely illustrative of the principles of the present utility model, and various changes and modifications may be made without departing from the spirit and scope of the utility model, which is defined in the appended claims.
Claims (6)
1. A magnetic frame in the field of multifunctional molecular biology application is characterized in that: the centrifugal tube fixing device is characterized by further comprising a supporting mechanism (1) used for fixing the centrifugal tube, the supporting mechanism (1) comprises a frame body (11), two baffle plates (12) are respectively fixed on two sides of the frame body (11), a piston cavity (18) and a movable groove (19) are respectively formed in the middle of the frame body (11), the piston cavity (18) is located above the movable groove (19), a piston frame (13) is slidably connected inside the piston cavity (18), a pressing plate (14) capable of sliding in the movable groove (19) is fixed at the lower end of the piston frame (13), an adsorption assembly (5) used for fixing the pressing plate (14) is arranged below the pressing plate (14), corresponding hole sites (4) are respectively formed in the top of the frame body (11) and on the two groups of baffle plates (12), and rubber rings (3) are respectively fixed inside the hole sites (4).
2. The magnetic rack for the application field of multifunctional molecular biology according to claim 1, wherein: an adsorption groove (15) is formed in the inner wall of the hole site (4), and notches used for fixing the rubber ring (3) are formed in two sides of the adsorption groove (15).
3. The magnetic rack for the application field of multifunctional molecular biology according to claim 1, wherein: the hole site (4) on the frame body (11) is communicated with the piston cavity (18) through a second air hole (17), and the hole site (4) on the baffle plate (12) is communicated with the piston cavity (18) through a first air hole (16).
4. The magnetic rack for the application field of multifunctional molecular biology according to claim 1, wherein: the protection mechanism (2) used for preventing gas from entering the adsorption groove (15) without installing the centrifugal tube is respectively installed at the holes (4) on the frame body (11) and the baffle plate (12).
5. The magnetic rack for the application field of multifunctional molecular biology according to claim 4, wherein: the protection mechanism (2) comprises a protection seat (21) arranged on the hole site (4), a spring (22) is fixed on the protection seat (21), and a sealing ring (23) mutually attached to the rubber ring (3) is fixed at the central position of the protection seat (21).
6. The magnetic rack for the application field of multifunctional molecular biology according to claim 1, wherein: and a sealing driving sealing ring which is sealed with the piston cavity (18) is fixed outside the piston frame (13).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322013838.1U CN220597426U (en) | 2023-07-28 | 2023-07-28 | Magnetic frame in field of multifunctional molecular biology application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322013838.1U CN220597426U (en) | 2023-07-28 | 2023-07-28 | Magnetic frame in field of multifunctional molecular biology application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220597426U true CN220597426U (en) | 2024-03-15 |
Family
ID=90169469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322013838.1U Active CN220597426U (en) | 2023-07-28 | 2023-07-28 | Magnetic frame in field of multifunctional molecular biology application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220597426U (en) |
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2023
- 2023-07-28 CN CN202322013838.1U patent/CN220597426U/en active Active
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