CN220572849U - Polypeptide preparation facilities convenient to edulcoration - Google Patents
Polypeptide preparation facilities convenient to edulcoration Download PDFInfo
- Publication number
- CN220572849U CN220572849U CN202322078353.0U CN202322078353U CN220572849U CN 220572849 U CN220572849 U CN 220572849U CN 202322078353 U CN202322078353 U CN 202322078353U CN 220572849 U CN220572849 U CN 220572849U
- Authority
- CN
- China
- Prior art keywords
- impurity removal
- filter
- edulcoration
- cylinder
- polypeptide preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229920001184 polypeptide Polymers 0.000 title claims abstract description 24
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 24
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 239000012535 impurity Substances 0.000 claims abstract description 44
- 230000007246 mechanism Effects 0.000 claims abstract description 40
- 230000005540 biological transmission Effects 0.000 claims description 31
- 235000017166 Bambusa arundinacea Nutrition 0.000 claims description 11
- 235000017491 Bambusa tulda Nutrition 0.000 claims description 11
- 241001330002 Bambuseae Species 0.000 claims description 11
- 235000015334 Phyllostachys viridis Nutrition 0.000 claims description 11
- 239000011425 bamboo Substances 0.000 claims description 11
- 238000007599 discharging Methods 0.000 claims description 3
- 239000007788 liquid Substances 0.000 abstract description 4
- 230000002035 prolonged effect Effects 0.000 abstract description 2
- 239000003814 drug Substances 0.000 description 7
- 238000001914 filtration Methods 0.000 description 7
- 239000011550 stock solution Substances 0.000 description 7
- 229940079593 drug Drugs 0.000 description 4
- 238000003780 insertion Methods 0.000 description 4
- 230000037431 insertion Effects 0.000 description 4
- 108010010803 Gelatin Proteins 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 230000007797 corrosion Effects 0.000 description 3
- 238000005260 corrosion Methods 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 1
- 230000005526 G1 to G0 transition Effects 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000003670 easy-to-clean Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Landscapes
- Centrifugal Separators (AREA)
Abstract
The utility model discloses a polypeptide preparation device convenient for impurity removal, which comprises a driving box, wherein a motor is fixedly arranged in the driving box, and an impurity removal box is arranged at the top of the driving box, a cover body is arranged at the top of the impurity removal box, a feed pipe is fixedly inserted on the cover body, an impurity removal cylinder is arranged at the center in the impurity removal box, a discharge pipe is arranged at the bottom of the impurity removal cylinder, a filter cylinder is rotatably arranged in the impurity removal cylinder, the end part of the feed pipe is positioned in the filter cylinder, at least two rotating mechanisms are uniformly arranged outside the impurity removal cylinder, the rotating mechanisms are used for driving the filter cylinder to rotate in different spaces, and filter liquid cannot invade the rotating mechanisms to corrode and damage the rotating mechanisms, so that the service life of equipment is prolonged.
Description
Technical Field
The utility model relates to the technical field of polypeptide production, in particular to a polypeptide preparation device convenient for impurity removal.
Background
The polypeptide medicine refers to polypeptide with specific therapeutic effect extracted by chemical synthesis, gene recombination or animals and plants, and is a specific application of the polypeptide in the field of medicine. Although the development history of the polypeptide as a medicament is short, the development is very rapid, and the polypeptide becomes a hot spot for market development at present. Polypeptide drugs are mainly used for treating cancers and major diseases related to metabolic disorders, and drugs related to the diseases have a very important market worldwide. Currently, 200 to 300 polypeptide drugs are in clinical trials, 500 to 600 are in preclinical trials, and more polypeptide drugs are in laboratory research stages.
The chinese patent of publication No. CN215310764U discloses a centrifugal filter device for donkey-hide gelatin polypeptide preparation, through setting up filtration jar mechanism and centrifugal mechanism, conveniently carries out centrifugal filtration with the impurity in the donkey-hide gelatin liquid, avoids the donkey-hide gelatin liquid of straining out to hang on the filtration jar simultaneously, and the convenience of use is very high, adopts supporting seat mechanism to support the device simultaneously, utilizes first spring, second spring and hydraulic damper to carry out the shock attenuation, has improved the stability when the device operates greatly, has reduced the noise when the device uses.
The device filter cartridge is fixed at the carousel top, and centrifugal mechanism's main part first gear, second gear, first pivot and second pivot all set up in the filter cartridge below, and this kind of structure setting has following not enoughly: the sealing part of the second rotating shaft is easy to loosen under the conditions of high-speed rotation and corrosion of the stock solution, the stock solution enters into the corrosion first gear and the second gear due to the loosening of the sealing, and the centrifugal mechanism is damaged; in addition, the bottom of the filter cylinder is directly contacted with the rotary table, the bottom of the filter cylinder is not easy to clean, and a filter screen at the bottom of the filter cylinder accumulates impurities in stock solution for a long time, so that the filtering effect is affected.
Disclosure of Invention
The utility model aims to provide a polypeptide preparation device convenient for impurity removal, which solves the problems that a centrifugal mechanism is easy to be corroded and damaged by stock solution and a filtering mechanism is difficult to clean in the background art.
The aim of the utility model can be achieved by the following technical scheme:
the utility model provides a polypeptide preparation facilities convenient to edulcoration, is provided with the feed pipe including inside fixed driving box that is provided with the motor and set up in the edulcoration case at driving box top, edulcoration case top is provided with the lid, fixed grafting on the lid, and the center is provided with the edulcoration section of thick bamboo in the edulcoration case, edulcoration section of thick bamboo bottom is provided with the discharging pipe, still includes:
the filter cartridge is rotatably arranged in the impurity removal cartridge, and the end part of the feed pipe is positioned in the filter cartridge;
and the rotating mechanisms are uniformly arranged outside the impurity removing cylinders and are used for driving the filter cylinders to rotate in the impurity removing cylinders.
As a further scheme of the utility model: the utility model discloses a filter cartridge, including edulcoration section of thick bamboo inner wall top, the fixed embedding of edulcoration section of thick bamboo inner wall top is equipped with the bearing, the bearing inner ring side is provided with the supporting ring, evenly set up a plurality of spliced eyes on the supporting ring, cartridge filter top edge set up a plurality of with spliced eye assorted spacing post.
As a further scheme of the utility model: the rotating mechanism comprises:
the transmission shaft is rotatably arranged outside the impurity removing cylinder, and the bottom end of the transmission shaft extends into the driving box;
the transmission belt is connected to the motor output shaft from the bottom end of the transmission shaft;
the transmission gear is fixedly sleeved on the top end of the transmission shaft.
As a further scheme of the utility model: the periphery of the top end of the filter cartridge is fixedly sleeved with a gear ring, and the gear ring is meshed with the transmission gear.
As a further scheme of the utility model: the cover bottom still evenly is provided with a plurality of anti-shake mechanisms, anti-shake mechanism is used for preventing the edulcoration section of thick bamboo shakes from top to bottom when rotating.
As a further scheme of the utility model: the anti-shake mechanism comprises a hollow column fixedly arranged at the bottom of the cover body, a spring is arranged in the hollow column, a connecting rod capable of moving in the hollow column is arranged at the end part of the spring, and a rotatable spherical roller is arranged at the bottom end of the connecting rod.
As a further scheme of the utility model: the filter cartridge is provided with a first filter screen cylinder, a second filter screen cylinder and a third filter screen cylinder from inside to outside in sequence.
The utility model has the beneficial effects that:
(1) Through setting up the motor in the drive box, drive box top sets up the edulcoration case, and edulcoration incasement center sets up the edulcoration section of thick bamboo, and cartridge filter rotatable mounting is in the edulcoration section of thick bamboo, is equipped with at least two slewing mechanism outside the edulcoration section of thick bamboo, and the motor passes through the device that slewing mechanism drive cartridge filter was in the edulcoration section of thick bamboo internal rotation, and the cartridge filter is in different spaces with slewing mechanism, and the filtrate can not invade the slewing mechanism in the corrosion damage slewing mechanism, has improved the life of equipment.
(2) Through evenly being provided with a plurality of anti-shake mechanisms in the lid bottom, when the lid closes the edulcoration case top, under anti-shake mechanism's effect, prevent cartridge filter shake from top to bottom when fast rotation, improve the stability of device.
Drawings
The utility model is further described below with reference to the accompanying drawings.
FIG. 1 is a schematic elevational cross-sectional view of the overall structure of the present utility model;
FIG. 2 is a schematic diagram of a front cross-sectional view of the structure of the drive box and the impurity removal box of the present utility model;
FIG. 3 is a schematic cross-sectional view of a filter cartridge of the present utility model;
FIG. 4 is a schematic top view of the bearing and support ring structure of the present utility model;
FIG. 5 is a schematic front view of the cover structure of the present utility model;
fig. 6 is an enlarged schematic view of the structure at a in fig. 5.
In the figure: 1. a motor; 2. a drive box; 3. a impurity removing box; 4. a cover body; 5. a feed pipe; 6. a impurity removing cylinder; 7. a filter cartridge; 8. a rotating mechanism; 81. a transmission shaft; 82. a drive belt; 83. a transmission gear; 9. a bearing; 10. a support ring; 11. a plug hole; 12. a limit column; 13. a gear ring; 14. an anti-shake mechanism; 141. a hollow column; 142. a spring; 143. a connecting rod; 144. spherical roller; 15. a first filter screen cylinder; 16. a second filter screen drum; 17. a third filter screen drum; 18. and a discharging pipe.
Detailed Description
The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
Referring to fig. 1-6, the utility model provides a polypeptide preparation device convenient for impurity removal, which comprises a driving box 2 with a motor 1 fixedly arranged therein and an impurity removal box 3 arranged at the top of the driving box 2, wherein a cover body 4 is arranged at the top of the impurity removal box 3, a feed pipe 5 is fixedly inserted on the cover body 4, an impurity removal cylinder 6 is arranged at the center in the impurity removal box 3, a discharge pipe 18 is arranged at the bottom of the impurity removal cylinder 6, the polypeptide preparation device further comprises a filter cylinder 7 and a rotating mechanism 8, the filter cylinder 7 is rotatably arranged in the impurity removal cylinder 6, the end part of the feed pipe 5 is positioned in the filter cylinder 7, raw materials to be filtered are added into the filter cylinder 7 from the feed pipe 5, at least two rotating mechanisms 8 are uniformly arranged outside the impurity removal cylinder 6, the rotating mechanism 8 is used for driving the filter cylinder 7 to rotate in the impurity removal cylinder 6, filtered raw liquid flows out from the discharge pipe 18 to enter subsequent analysis and extraction synthesis to obtain polypeptide, conventionally, a C18 column is a common reversed-phase chromatographic column, a separation principle is based on the hydrophilic interaction between compounds on the C18 column, and a C4 stationary phase is a hydrophobic compound, and a hydrophobic compound can be adsorbed in the C18 column, and the same as the C18 carbon chain can be separated, and the C4 can be well separated, and the C18 carbon chain 4 can be well loaded in the same volume as the C4, and the C4 can be well, and the best volume can be separated.
As shown in fig. 2 and 4, in an embodiment of the present utility model, a bearing 9 is fixedly embedded above an inner wall of the impurity removing cylinder 6, a supporting ring 10 is provided on an inner ring side surface of the bearing 9, a plurality of insertion holes 11 are uniformly provided on the supporting ring 10, a plurality of limit posts 12 matched with the insertion holes 11 are provided on a top edge of the filter cartridge 7, and the filter cartridge 7 is inserted into the corresponding insertion holes 11 through the limit posts 12, so as to realize limit fixation of the filter cartridge 7 on the supporting ring 10.
As shown in fig. 2, in an embodiment of the present utility model, the rotation mechanism 8 includes a transmission shaft 81, a transmission belt 82, and a transmission gear 83.
The transmission shaft 81 is rotatably arranged outside the impurity removing cylinder 6, and the bottom end of the transmission shaft 81 extends into the driving box 2; the transmission belt 82 is connected to the output shaft of the motor 1 from the bottom end of the transmission shaft 81;
the transmission gear 83 is fixedly sleeved on the top end of the transmission shaft 81;
and the periphery of the top end of the filter cartridge 7 is fixedly sleeved with a gear ring 13, and the gear ring 13 is meshed with the transmission gear 83.
During the implementation, the motor 1 rotates, the output shaft of the motor 1 drives the transmission shaft 81 to synchronously rotate through the transmission belt 82, the transmission shaft 81 drives the transmission gears 83 to rotate, the gear ring 13 rotates under the driving of the transmission gears 83, and the gear ring 13 drives the filter cartridge 7 to rotate in the impurity removal cartridge 6 to filter the stock solution in the filter cartridge 7.
The rotating mechanism 8 is arranged in the structure, the filter cartridge 7 and the rotating mechanism 8 are in different spaces, filtrate cannot invade the rotating mechanism 8 to corrode and damage the rotating mechanism 8, and the service life of the device is prolonged.
Further, as shown in fig. 5, in an embodiment of the present utility model, the bottom of the cover 4 is further uniformly provided with a plurality of anti-shake mechanisms 14, and the anti-shake mechanisms 14 are used for preventing the impurity removing cartridge 6 from shaking up and down during rotation.
As shown in fig. 6, the anti-shake mechanism 14 includes a hollow column 141 fixedly disposed at the bottom of the cover 4, a spring 142 is disposed in the hollow column 141, a connecting rod 143 movable in the hollow column 141 is disposed at an end of the spring 142, and a rotatable spherical roller 144 is disposed at a bottom end of the connecting rod 143.
As shown in fig. 1, when the cover 4 is covered on the top end of the impurity removing box 3, the spherical roller 144 is pressed against the top end surface of the filter cartridge 7, so that the filter cartridge 7 is prevented from shaking up and down during rapid rotation, and the stability of the device is improved.
As shown in fig. 3, in order to improve the fine filtering effect of the device, the filter cartridge 7 is sequentially provided with a first filter screen drum 15, a second filter screen drum 16 and a third filter screen drum 17 from inside to outside, the filter cartridge 7 is detachably arranged in the impurity removal drum 6, the filter cartridge 7 is conveniently taken out after the filtration is completed, the filter cartridge 7 is conveniently cleaned, and impurities are prevented from being left on the filter cartridge 7 for a long time.
When the utility model is used, the filter cartridge 7 is inserted into the corresponding insertion hole 11 through the limit post 12 and fixed on the support ring 10, then the cover body 4 is covered, then the motor 1 is started, the motor 1 drives the filter cartridge 7 to rotate through the rotating mechanism 8, then the stock solution is added into the filter cartridge 7 from the feed pipe 5, and the stock solution filtered by the filter cartridge 7 flows out from the discharge pipe 18 to enter the subsequent analysis and extraction synthesis process.
In the description of the present utility model, it should be understood that the terms "upper," "lower," "left," "right," "front," "rear," and the like indicate an orientation or a positional relationship based on that shown in the drawings, and are merely for convenience in describing the present utility model and simplifying the description, and do not indicate or imply that the apparatus or element in question must have a specific orientation, as well as a specific orientation configuration and operation, and thus should not be construed as limiting the present utility model.
In addition, unless explicitly stated or limited otherwise, the terms "mounted," "connected," "coupled," and the like should be construed broadly, and may be, for example, fixedly attached, detachably attached, or integrally attached; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present utility model will be understood in specific cases by those of ordinary skill in the art.
The foregoing detailed description of the preferred embodiments of the utility model should not be taken as limiting the scope of the utility model. All equivalent changes and modifications within the scope of the present utility model are intended to be covered by the present utility model.
Claims (5)
1. Polypeptide preparation facilities convenient to edulcoration, including inside fixed driving box (2) that are provided with motor (1) and set up in edulcoration case (3) at driving box (2) top, edulcoration case (3) top is provided with lid (4), and fixed grafting has inlet pipe (5) on lid (4), and the center is provided with edulcoration section of thick bamboo (6) in edulcoration case (3), edulcoration section of thick bamboo (6) bottom is provided with discharging pipe (18), its characterized in that still includes:
the filter cartridge (7) is rotatably arranged in the impurity removal cartridge (6), and the end part of the feed pipe (5) is positioned in the filter cartridge (7);
the rotating mechanisms (8) are uniformly arranged outside the impurity removing cylinders (6), and the rotating mechanisms (8) are used for driving the filter cylinders (7) to rotate in the impurity removing cylinders (6).
2. The polypeptide preparation device convenient for impurity removal according to claim 1, wherein a bearing (9) is fixedly embedded above the inner wall of the impurity removal barrel (6), a supporting ring (10) is arranged on the side face of the inner ring of the bearing (9), a plurality of inserting holes (11) are uniformly formed in the supporting ring (10), and a plurality of limiting columns (12) matched with the inserting holes (11) are arranged at the top edge of the filter barrel (7).
3. A polypeptide preparation device facilitating the removal of impurities according to claim 2, wherein the rotating mechanism (8) comprises:
the transmission shaft (81) is rotatably arranged outside the impurity removing cylinder (6), and the bottom end of the transmission shaft (81) extends into the driving box (2);
the transmission belt (82) is connected to the output shaft of the motor (1) from the bottom end of the transmission shaft (81);
and the transmission gear (83) is fixedly sleeved at the top end of the transmission shaft (81).
4. A polypeptide preparation device convenient for impurity removal according to claim 3, wherein a gear ring (13) is fixedly sleeved on the periphery of the top end of the filter cartridge (7), and the gear ring (13) is meshed with the transmission gear (83).
5. The polypeptide preparation device convenient for impurity removal according to any one of claims 1 to 4, wherein the filter cartridge (7) is provided with a first filter screen cylinder (15), a second filter screen cylinder (16) and a third filter screen cylinder (17) in sequence from inside to outside.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322078353.0U CN220572849U (en) | 2023-08-03 | 2023-08-03 | Polypeptide preparation facilities convenient to edulcoration |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322078353.0U CN220572849U (en) | 2023-08-03 | 2023-08-03 | Polypeptide preparation facilities convenient to edulcoration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220572849U true CN220572849U (en) | 2024-03-12 |
Family
ID=90119549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322078353.0U Active CN220572849U (en) | 2023-08-03 | 2023-08-03 | Polypeptide preparation facilities convenient to edulcoration |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220572849U (en) |
-
2023
- 2023-08-03 CN CN202322078353.0U patent/CN220572849U/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN115364514B (en) | Edible salt preparation method and preparation system | |
| CN220572849U (en) | Polypeptide preparation facilities convenient to edulcoration | |
| CN113547562B (en) | Herbal pieces-production is with wasing screening device | |
| CN208865275U (en) | A kind of centrifugal solid-liquid drug separator | |
| CN219376328U (en) | Dewaxing continuous crystallization device | |
| CN209923300U (en) | White spirit filter equipment | |
| CN110935684A (en) | Cleaning and screening device for pearl processing and using method thereof | |
| CN214763739U (en) | Filter press | |
| CN215026486U (en) | Chemical liquid medicine filter equipment | |
| CN213466833U (en) | Bio-pharmaceuticals extract filter equipment who easily fully stirs and grind | |
| CN113318502A (en) | Quick pressure boost filtration equipment of on-spot honey is bred to honeybee | |
| CN113476936A (en) | Separation rotation type filter equipment is handled with useless medicine | |
| CN218982359U (en) | Fodder raw materials screening equipment | |
| CN215609824U (en) | Chinese-medicinal material extract purifies edulcoration device | |
| CN111892267A (en) | Sludge treatment device convenient to change filter chamber | |
| CN111014014A (en) | A sieving mechanism for herbal pieces-production | |
| CN114225546B (en) | Method for taking slurry | |
| CN217191261U (en) | Belt cleaning device is used in herbal pieces-raw and other materials processing | |
| CN217188075U (en) | Glass fiber filtering device for high-protein food sample | |
| CN112924215B (en) | Plant root system soil sampling equipment | |
| CN220111330U (en) | Spirulina separation sieving mechanism | |
| CN215538999U (en) | Filtration equipment of making wine raw materials | |
| CN219308102U (en) | Biopharmaceutical extracting solution filtering device | |
| CN220779391U (en) | Foam extractor for extracting donkey-hide gelatin liquid impurities | |
| CN218530059U (en) | Automatic discharging circulating filter device and frying machine comprising same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant |