CN220381370U

CN220381370U - Sperm morphology image automatic acquisition device

Info

Publication number: CN220381370U
Application number: CN202321932779.1U
Authority: CN
Inventors: 于海利; 于洋; 关玉婷; 崔凯; 马振予
Original assignee: Suzhou Institute of Biomedical Engineering and Technology of CAS
Current assignee: Suzhou Institute of Biomedical Engineering and Technology of CAS
Priority date: 2023-07-21
Filing date: 2023-07-21
Publication date: 2024-01-23
Anticipated expiration: 2033-07-21

Abstract

The utility model discloses an automatic collection device of sperm morphology images, which comprises: a carrying platform; a power device; an imaging module; a lighting module; in the process of controlling the power device to drive the object carrying platform to move and adjust the position relation between the morphological sperm sample to be detected and the objective lens so as to perform automatic focusing and visual field switching, the illumination module is used for synchronously adjusting to a matched illumination mode, and the camera acquires and outputs sperm morphology images, so that the rapid automatic acquisition of all sperm morphology images is realized. The utility model can effectively improve the collection quality and collection efficiency of the sperm morphology image, reduce the technical threshold of inspection staff, save the labor cost of scanning the image during the detection of the sperm morphology index, and simultaneously avoid the inaccuracy of the sperm morphology detection index caused by the image difference caused by manual collection.

Description

Sperm morphology image automatic acquisition device

Technical Field

The utility model relates to the technical field of assisted reproduction, in particular to an automatic sperm morphology image acquisition device.

Background

In the assisted reproduction field, a inspector usually uses microscopic equipment such as a microscope to collect morphological images of sperms, and usually repeatedly manually focuses and switches fields of view to obtain clear images of enough sperms so as to perform morphological quality analysis of sperms.

However, the frequent manual focusing and visual field switching work not only puts higher requirements on technical operation of inspectors, but also has the defects of low acquisition speed, low consistency of acquired samples and the like.

Therefore, there is a need to provide a new way to solve the above technical problems.

Disclosure of Invention

Aiming at the defects of the prior art, the utility model aims to provide an automatic sperm morphology image acquisition device which can realize the rapid and automatic acquisition of all sperm morphology images, effectively improve the acquisition quality and the acquisition efficiency of sperm morphology images, reduce the technical threshold of inspection staff, save the labor cost of scanning images during the detection of sperm morphology indexes, and simultaneously avoid the inaccuracy of sperm morphology detection indexes caused by the image difference brought by manual acquisition.

The technical scheme of the utility model is summarized as follows:

an automatic collection device for sperm morphology images, comprising:

the carrying platform is used for carrying a morphological sperm sample to be detected;

the power device is positioned beside the carrying platform and assembled with the carrying platform to adjust the position of the carrying platform;

the imaging module is arranged on one side of the carrying platform; and the imaging module comprises a camera and an objective lens, wherein the objective lens is used for acquiring sperm morphology images, and the camera is arranged above the objective lens and used for acquiring the sperm morphology images;

the illumination module is arranged below the carrying platform and used for illuminating the sperm sample on the carrying platform;

the camera is used for collecting and outputting sperm morphology images, so that the rapid automatic collection of all sperm morphology images is realized.

Preferably, the carrying platform comprises a first platform and a second platform; wherein,

the first platform is positioned between the imaging module and the illumination module;

the second platform is arranged in parallel with the first platform and is used for being assembled with the power device.

Preferably, the first platform surface is provided with a clamping jaw for clamping the morphological sperm sample to be tested.

Preferably, the power device is a micro-motion platform.

Preferably, the power device comprises a base, a first mobile platform and a second mobile platform; wherein,

the base is used for forming an installation foundation of the first mobile platform and the second mobile platform;

the first moving platform is positioned above the second moving platform and is used for being connected with the carrying platform and controlling the carrying platform to move in the X-axis direction;

the second moving platform is positioned above the base and used for controlling the first moving platform and the carrying platform to move in the Y-axis direction.

Preferably, the base is provided with a Z-axis moving assembly for controlling the first moving platform, the second moving platform and the carrying platform to do lifting motion.

Preferably, the imaging module further comprises a lifting component, wherein the lifting component is assembled with the objective lens and used for controlling the distance between the objective lens and the morphological sperm sample to be detected.

Preferably, the illumination module comprises a kohler illumination source.

Preferably, the camera is a large target surface camera.

Preferably, the objective lens is a 100-fold objective lens.

Compared with the prior art, the utility model has the beneficial effects that:

the utility model provides an automatic collection device for sperm morphology images, which drives a carrying platform to move through a power device so as to adjust the position relationship between a sperm sample to be detected and an objective lens on the carrying platform, and when an illumination module is synchronously adjusted to a matched illumination mode in the automatic focusing and visual field switching process, the camera is controlled to collect and output sperm morphology images, so that the rapid automatic collection of all sperm morphology images is realized, the collection quality and collection efficiency of sperm morphology images are effectively improved, the technical threshold of a inspector is reduced, the labor cost of scanning images during the detection of sperm morphology indexes is saved, and meanwhile, the inaccuracy of sperm morphology detection indexes caused by image difference brought by manual collection is avoided.

The foregoing description is only an overview of the present utility model, and is intended to provide a better understanding of the present utility model, as it is embodied in the following description, with reference to the preferred embodiments of the present utility model and the accompanying drawings. Specific embodiments of the present utility model are given in detail by the following examples and the accompanying drawings.

Drawings

The accompanying drawings, which are included to provide a further understanding of the utility model and are incorporated in and constitute a part of this application, illustrate embodiments of the utility model and together with the description serve to explain the utility model and do not constitute a limitation on the utility model. In the drawings:

FIG. 1 is a diagram showing the whole structure of an automatic sperm morphology image acquisition device;

FIG. 2 is a diagram showing the whole structure of an automatic sperm morphology image acquisition device;

FIG. 3 is a cross-sectional view of the automated sperm morphology image acquisition device of the present utility model;

FIG. 4 is a schematic view of a loading platform according to the present utility model;

FIG. 5 is a schematic diagram of a power plant according to the present utility model;

fig. 6 is a schematic structural diagram of a power device according to the present utility model.

In the figure: 1. an automatic acquisition device;

10. a carrying platform; 11. a first platform; 111. a through groove; 12. a second platform; 121. a mounting hole; 13. a connecting plate; 14. a clamping jaw; 141. a first clamping part; 142. a second clamping portion; 1421. a hand-held part;

20. a power device; 21. a base; 22. a first mobile platform; 23. a second mobile platform; 231. a first side plate; 24. a substrate assembly; 241. a second side plate; 25. a first drive assembly; 26. a second drive assembly; 27. a first guide rail; 28. a second guide rail;

30. an imaging module; 31. a camera; 32. an objective lens; 33. a lifting assembly; 331. a telescopic rod; 332. fixing the side plates; 333. a slide rail; 34. a bracket;

40. a lighting module; 41. an LED light source; 42. a collimating lens group; 43. a reflecting mirror; 44. a converging lens group;

2. sperm slide.

Detailed Description

The following description of the embodiments of the present utility model will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are only some, but not all embodiments of the utility model. All other examples, which a person of ordinary skill in the art would obtain without undue burden based on the embodiments of the utility model, are within the scope of the utility model.

In the drawings, the shape and size may be exaggerated for clarity, and the same reference numerals will be used throughout the drawings to designate the same or similar components.

In the following description, terms such as center, thickness, height, length, front, back, rear, left, right, top, bottom, upper, lower, etc. are defined with respect to the configuration shown in the drawings, and in particular, "height" corresponds to the top-to-bottom dimension, "width" corresponds to the left-to-right dimension, and "depth" corresponds to the front-to-back dimension, are relative concepts, and thus may vary accordingly depending on the location and use of the terms, and therefore these or other orientations should not be interpreted as limiting terms.

Terms (e.g., "connected" and "attached") referring to an attachment, coupling, etc., refer to a relationship wherein these structures are directly or indirectly secured or attached to one another through intervening structures, as well as both movable or rigid attachments or relationships, unless expressly described otherwise.

Examples

The embodiment of the utility model provides an automatic sperm morphology image acquisition device, which is shown in combination with figures 1-6 and comprises:

a loading platform 10 for loading a morphological sperm sample to be tested;

the power device 20 is positioned beside the carrying platform 10 and assembled with the carrying platform 10 to adjust the position of the carrying platform 10;

an imaging module 30 mounted on one side of the loading platform 10; and the imaging module 30 comprises a camera 31 and an objective lens 32, wherein the objective lens 32 is used for acquiring sperm morphology images, and the camera 31 is arranged above the objective lens 32 and used for acquiring sperm morphology images;

an illumination module 40 mounted below the carrier platform 10 for illuminating the sperm sample on the carrier platform 10;

wherein, the power device 20 is controlled to drive the carrying platform 10 to move and adjust the position relationship between the morphological sperm sample to be measured and the objective lens 32 so as to perform auto-focusing and field switching, the illumination module 40 is used to adjust to a matched illumination mode synchronously, and the camera 31 collects and outputs sperm morphological images, thereby realizing rapid and automatic collection of all sperm morphological images.

The utility model effectively improves the collection quality and collection efficiency of the sperm morphology image, reduces the technical threshold of inspection staff, saves the labor cost of scanning the image during the detection of the sperm morphology index, and simultaneously avoids the inaccuracy of the sperm morphology detection index caused by the image difference caused by manual collection.

In one embodiment, as shown in fig. 1, 2 and 4, the carrying platform 10 includes a first platform 11 and a second platform 12; wherein,

the first platform 11 is located between the imaging module 30 and the illumination module 40;

the second platform 12 is disposed parallel to the first platform 11 for assembling with the power unit 20.

Specifically, the first platform 11 is connected with the second platform 12 through a connecting plate 13; the connecting plate 13 is perpendicular to the first platform 11 and the second platform 12, and the sectional area of the connecting plate 13 is gradually increased from the second platform 12 to the first platform 11 so as to strengthen the bearing capacity of the first platform 11; when the second platform 12 moves under the driving of the power device 20, the second platform 12 parallel to the first platform 11 can move synchronously and keep consistent motion, and the device has the advantages of simple structure, convenience in regulation and control, and the like, and has good stability and reliability.

Wherein, a through groove 111 has been seted up to first platform 11 central point put, and during operation, sperm slide 2 covers through groove 111 places, lighting module 40 tip position with through groove 111 position is corresponding, so that lighting module 40's light can be accurate shine on sperm slide 2 for the three-dimensional transparent of sperm image that camera 31 gathered improves the collection image quality.

Further, a clamping jaw 14 is disposed on the surface of the first platform 11, so as to clamp the morphological sperm sample to be tested. Specifically, the clamping jaw 14 is configured to clamp the sperm slide 2, the clamping jaw 14 includes a fixed first clamping portion 141 and a rotatable second clamping portion 142, wherein the first clamping portion 141 may be fixedly connected with the first platform 11 through a fastener, and a mounting structure adapted to the shape of the sperm slide 2 is formed on the inner side of the first clamping portion 141, so as to limit the position of the sperm slide 2; the second clamping part 142 can rotate around the end of the first clamping part 141; when the sperm slide 2 is positioned in the mounting structure, the second clamping part 142 is rotated towards the direction of the sperm slide 2 to be abutted against the first clamping part 141, so that the clamping effect is realized; further, the second clamping portion 142 is further formed with a bent and upturned hand-held portion 1421, so that an operator can adjust the position of the second clamping portion 142.

Therefore, on one hand, the phenomenon that the position of the sperm slide 2 is deviated in the moving process of the carrying platform 10 can be avoided, the stability of the sperm slide 2 is ensured, and on the other hand, the light rays of the lighting module 40 can be accurately projected to a preset position, so that the precision of sperm morphology image acquisition is further improved.

In an embodiment, as shown in fig. 1-2 and fig. 5-6, the power device 20 is a micro-motion platform, which has the advantages of high precision, quick response and the like, meets the positioning requirement of high precision, controls the object carrying platform 10 to perform micro-positioning and micro-feeding through the micro-motion platform to switch the view field so as to gradually collect the sperm images, effectively ensures the consistency rate of the collected samples, does not need manual operation, and optimizes the collection quality.

In one embodiment, the power unit 20 includes a base 21, a first mobile platform 22, and a second mobile platform 23; wherein,

the base 21 is used for forming a mounting foundation of the first mobile platform 22 and the second mobile platform 23;

the first moving platform 22 is located above the second moving platform 23, and is connected to the carrying platform 10 and controls the movement of the carrying platform in the X-axis direction;

the second moving platform 23 is located above the base 21, and is used for controlling the first moving platform 22 and the carrying platform 10 to move in the Y-axis direction.

Further, a first drive assembly 25 and a second drive assembly 26 are included; wherein,

the first driving component 25 is used for driving the first moving platform 22 to move in the X-axis direction;

the second driving assembly 26 is configured to drive the second moving platform 23 to move in the Y-axis direction.

Specifically, the lower part of the second moving platform 23 is further provided with a substrate assembly 24 for assembling with the base 21; the second moving platform 23 is formed with a first side plate 231 by protruding and extending near the side part of the first driving component 25, and the base plate 24 is formed with a second side plate 241 by protruding and extending near the side part of the second driving component 26; wherein, the first driving assembly 25 is mounted on the first side plate 231, and the power output end thereof is connected with the first moving platform 22; the second driving assembly 26 is mounted on the second side plate 241, and its power output end is connected to the second moving platform 23.

Further, a first guide rail 27 is disposed between the first moving platform 22 and the second moving platform 23, for guiding the movement path of the first moving platform 22; a second guide rail 28 is provided between the second moving platform 23 and the base plate assembly 24 for guiding a movement path of the second moving platform 23.

When the first driving assembly 25 drives the first moving platform 22 to move, the first moving platform 22 moves along the X-axis direction through the first guide rail 27, so as to drive the carrying platform 10 to move synchronously along the X-axis; when the second driving assembly 26 drives the second moving platform 23 to move, the second moving platform 23 moves along the Y-axis direction through the second guide rail 28, so as to drive the first moving platform 22 and the carrying platform 10 to move synchronously along the Y-axis.

Further, the second platform 12 of the carrying platform 10 is adapted to the shape of the first moving platform 22; specifically, the first platform 11, the first mobile platform 22 and the second mobile platform 23 keep the same shape, and are square or rectangular; the arrangement is beneficial to strengthening the rigidity and the bearing capacity of the first moving platform 22 and the second moving platform 23 and the carrying capacity of the carrying platform 10, and is beneficial to the accurate control of the power device 20 on the carrying platform 10; and the structure is simplified, and the assembly is convenient.

Further, a plurality of mounting holes 121 are formed in the second platform 12; specifically, at least four mounting holes 121 are uniformly distributed on the surface of the second platform 12, so as to be assembled with the first moving platform 22 through fasteners, and the stable assembly is beneficial to the precise positioning of the carrying platform 10.

Further, a Z-axis moving assembly is mounted on the base 21, so as to control the first moving platform 22, the second moving platform 23 and the carrying platform 10 to perform lifting movement, thereby realizing the adjustment of the height of the carrying platform 10. Specifically, the base 21 is assembled with the second moving platform 23 through the substrate assembly 24, so as to buffer the vibration generated by the stress of the power device 20, and improve the stability of the carrying platform 10.

In one embodiment, as shown in fig. 1 and 3, the imaging module 30 further includes a lifting assembly 33, where the lifting assembly 33 is assembled with the objective lens 32 to control the distance between the objective lens 32 and the morphological sperm sample to be measured.

Further, the lifting assembly 33 includes a telescopic rod 331 and a fixed side plate 332; wherein,

one end of the fixed side plate 332 is assembled with the telescopic rod 331, and the other end is assembled with the objective lens 32;

the fixed side plate 332 is driven to move by the telescopic rod 331, so as to drive the objective lens 32 to lift and adjust the position.

Specifically, the imaging module 30 further includes a bracket 34, where the camera 31, the objective lens 32, and the lifting assembly 33 are installed on a side of the bracket 34 near the carrying platform 10; a sliding rail 333 is disposed between the fixed side plate 332 and the bracket 34, for guiding the movement track of the objective lens 32, so as to improve positioning accuracy.

In one embodiment, as shown in fig. 3, the lighting module 40 comprises a kohler lighting unit; the kohler lighting unit comprises an LED light source 41, a collimating lens group 42, a reflecting mirror 43 and a converging lens group 44, wherein light rays emitted by the LED light source 41 are collimated by the collimating lens group and then emitted to the sperm slide 2 through the reflecting mirror 43 and the converging lens group, so that incident light can be homogenized, and the three-dimensional brightness of sperm images is further improved.

Further, the illumination module 40 may adjust the illumination brightness and the spot size according to the control signal.

In one embodiment, the camera 31 is a large target surface camera 31. The large target surface camera 31 can meet the high-quality imaging requirement of sperm morphology images, and the large target surface camera 31 is organically combined with an automatic focusing structure and the lighting module 40 to realize rapid, high-precision and high-resolution imaging.

Further, the objective lens 32 is 100 times of the objective lens, and the objective lens 32 is selected to be 100 times of the objective lens, so as to properly amplify the image, thereby better matching the size of the target surface of the camera 31.

The working process of the sperm morphology image automatic acquisition device 1 in the utility model comprises the following steps:

placing a morphological sperm sample to be detected (namely a sperm slide 2) on an objective table, and setting the number of sperm scanning and the number of sperm pictures in a control module; when the control module controls the automatic acquisition device 1 to work, the objective lens 32 of the objective lens 32 is controlled to descend to a coarse focus position, and then the control module controls the power device 20 to work so as to drive the carrying platform 10 to move and adjust the position relationship between the sperm slide 2 and the objective lens 32, and meanwhile, the position of the objective lens 32 is further adjusted through the lifting component 33, so that automatic focusing is realized; collecting sperm images after focusing, identifying the number of sperm in the images by using a camera 31 and driving the carrying platform 10 to move by using the power device 20 so as to switch the field of view; after the camera 31 acquires the sperm morphology images step by step, all sperm morphology images are transmitted to a terminal device such as a computer for further analysis.

Although embodiments of the present utility model have been disclosed above, it is not limited to the details and embodiments shown and described, it is well suited to various fields of use for which the utility model would be readily apparent to those skilled in the art, and accordingly, the utility model is not limited to the specific details and illustrations shown and described herein, without departing from the general concepts defined in the claims and their equivalents.

Claims

1. An automatic collection device for sperm morphology images, comprising:

2. The automated sperm-morphology image acquisition device of claim 1, wherein: the carrying platform comprises a first platform and a second platform; wherein,

3. The automated sperm-morphology image acquisition device of claim 2, wherein: the surface of the first platform is provided with a clamping jaw for clamping a morphological sperm sample to be tested.

4. The automated sperm-morphology image acquisition device of claim 1, wherein: the power device is a micro-motion platform.

5. The automated sperm-morphology image acquisition device of claim 1 or 4, wherein: the power device comprises a base, a first mobile platform and a second mobile platform; wherein,

6. The automated sperm-morphology image acquisition device of claim 5, wherein: the base is provided with a Z-axis moving assembly for controlling the first moving platform, the second moving platform and the carrying platform to do lifting motion.

7. The automated sperm-morphology image acquisition device of claim 1, wherein: the imaging module further comprises a lifting component, wherein the lifting component is assembled with the objective lens and used for controlling the distance between the objective lens and the morphological sperm sample to be detected.

8. The automated sperm-morphology image acquisition device of claim 1, wherein: the illumination module includes a kohler illumination source.

9. The automated sperm-morphology image acquisition device of claim 1, wherein: the camera is a large target surface camera.

10. The automated sperm-morphology image acquisition device of claim 9, wherein: the objective lens is 100 times of the objective lens.