CN219715463U - Swift magnetic bead mixing device - Google Patents

Swift magnetic bead mixing device Download PDF

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Publication number
CN219715463U
CN219715463U CN202223432528.5U CN202223432528U CN219715463U CN 219715463 U CN219715463 U CN 219715463U CN 202223432528 U CN202223432528 U CN 202223432528U CN 219715463 U CN219715463 U CN 219715463U
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China
Prior art keywords
magnetic bead
mixing
reagent
mixing device
kit
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CN202223432528.5U
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Chinese (zh)
Inventor
王世豪
施晓如
郭于新
蔡田
谷晓辉
秦琼
王涛
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Zhengzhou Jinyu Clinical Laboratory Center Co ltd
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Zhengzhou Jinyu Clinical Laboratory Center Co ltd
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Abstract

The utility model relates to a rapid magnetic bead mixing device, which comprises: a base; the reagent tube is arranged in the reagent kit; the kit is connected with the limiting component; the limiting component is arranged at the top of the base and used for limiting the kit; and the mixing component is connected with the reagent tube and is used for mixing magnetic beads through the reagent tube. The utility model can realize the uniform mixing operation without separating the reagent tubes from the reagent kit, can realize the uniform mixing of a plurality of groups of reagent tubes in batches, combines the magnetic attraction effect and the centrifugal force in the uniform mixing, and overcomes the defect that the rapid uniform mixing cannot be realized by adopting higher centrifugal force due to the limitation of parts in the full-automatic analyzer; the defect that the air bubbles are easy to interfere experiments when the instrument is blown and evenly mixed outside and the mixing is reversed is overcome; meanwhile, the advantages of the two are combined, so that the mixing mode is optimized, the mixing time is shortened, the working efficiency is greatly improved, and the labor cost is reduced.

Description

Swift magnetic bead mixing device
Technical Field
The utility model relates to the technical field of full-automatic chemiluminescence immunoassay, in particular to a rapid magnetic bead mixing device.
Background
At present, when a full-automatic chemiluminescence immunoassay system is used for medical detection, a magnetic bead coating method is generally adopted to carry a required enzyme-labeled antigen or antibody, but the magnetic beads are necessarily accumulated and precipitated at the bottom of a reagent in a long-term standing process before the kit is used. Therefore, the magnetic bead bottle is always required to be premixed and homogenized before being used. Whether the magnetic beads are mixed fully or not directly determines the quality of the medical detection result, and the mixing time length also influences the working efficiency of the instrument.
However, in the fully automatic detection analyzer, although a mode of combining magnetic attraction and mechanical mixing is adopted, because the magnetic attraction and mechanical mixing are limited by other components, it is difficult to provide high centrifugal force, and the high-concentration aggregated magnetic beads and the interaction between the magnetic beads and the kit make it difficult to quickly mix the magnetic beads and the kit by a self-contained mixing device, which often requires a long waiting time and cannot ensure whether the magnetic beads and the kit are sufficiently mixed. The operation is carried out by manually blowing and evenly mixing outside the instrument, which not only affects the efficiency and consumes energy, but also can cause unnecessary reagent pollution. Sometimes, a mode of reversing and evenly mixing after magnetic attraction is also used, so that the speed is increased, but bubbles are more likely to be generated to influence the liquid level sensing of the instrument, and further influence the result.
In view of this, the present utility model has been made.
Disclosure of Invention
In order to overcome the technical defects in the prior art, the utility model provides a rapid magnetic bead mixing device which can effectively solve the problems in the background art.
In order to solve the technical problems, the technical scheme provided by the utility model is as follows:
the embodiment of the utility model discloses a rapid magnetic bead mixing device which comprises a base, a reagent tube, a reagent box, a limiting assembly and a mixing assembly, wherein the reagent tube is arranged in the reagent box, the reagent box is connected with the limiting assembly, the limiting assembly is arranged at the top of the base and used for limiting the reagent box, and the mixing assembly is connected with the reagent tube and used for mixing magnetic beads of the reagent tube.
In any of the above schemes, it is preferable that an anti-falling groove, a placing groove and an anti-blocking ring are arranged inside the kit, the anti-falling groove and the placing groove are integrally formed inside the kit, the anti-falling groove is located above the placing groove, and the anti-blocking ring is mounted on the inner wall of the anti-falling groove.
In any of the above schemes, it is preferable that the reagent tube is more stable in the storage of the reagent kit by arranging the anti-falling groove, and the friction force of the reagent tube in the placing groove is reduced by arranging the anti-blocking ring in the anti-falling groove, so that the reagent tube is prevented from wearing when rotating for a long time, and the overall stability and safety are enhanced.
In any of the above schemes, preferably, the limiting component comprises a frame body, a containing space and a limiting mechanism, the bottom of the frame body is fixedly connected with the top surface of the base, the containing space is arranged on the frame body, multiple groups of containing spaces are arranged, the limiting mechanism is arranged on the top of the containing space, and the limiting mechanism is connected with the frame body.
In any of the above schemes, it is preferable that a plurality of groups of the accommodating spaces are provided, so that the reagent tubes in the plurality of groups of the reagent boxes can be processed in batches, and the reagent boxes in the accommodating spaces can be limited by the limiting mechanism, so that the reagent boxes are prevented from being displaced in operation.
In any of the above schemes, preferably, the limiting mechanism includes a threaded rod and a nut, the nut is mounted on the top of the frame, the nut is rotationally connected with the frame, and one end of the threaded rod is connected with the nut and extends into the accommodating space.
In any of the above solutions, it is preferable that the threaded rod is displaced by manually rotating the nut, so as to change the length of the threaded rod in the accommodating space, thereby realizing the fixation of the kit by using the threaded rod.
In any of the above schemes, preferably, the top of the kit is provided with a limiting hole, and the limiting hole is in abutting connection with one end of the threaded rod extending to the inside of the accommodating space.
In any of the above schemes, preferably, the limit hole is provided, so that the limit hole can be matched with the threaded rod, and the limit effect of the threaded rod on the kit is enhanced.
In any of the above schemes, preferably, the mixing assembly includes a magnetic bead adsorption mechanism, a rotation mechanism and a mixing control circuit, the magnetic bead adsorption mechanism is disposed in the frame, and the magnetic bead adsorption mechanism is electrically connected with the mixing control circuit, the rotation mechanism is disposed on the base, and the rotation mechanism is electrically connected with the mixing control circuit.
In any of the above schemes, preferably, the magnetic bead adsorption mechanism includes an electromagnet, and the electromagnet is disposed in two side walls of the accommodating space.
In any of the above aspects, preferably, the electromagnet is provided in both side walls of the accommodating space, so that the electromagnet can generate magnetism when energized, and the magnetic beads in the reagent tube can be adsorbed on both sides of the reagent tube.
In any of the above schemes, preferably, the rotating mechanism comprises a rotating motor, a transmission rod and a clamping block, the rotating motor is arranged in the base, one end of the transmission rod is fixedly connected with the output end of the rotating motor, and the other end of the transmission rod is fixedly connected with the clamping block.
In any of the above-described aspects, preferably, the driving lever may be rotated by operation of the rotation motor, and the clamping block may be rotated, so that the reagent tube in the reagent kit may be rotated by the clamping block.
In any of the above schemes, preferably, the bottom of the reagent tube is provided with a clamping groove, and the clamping block is in abutting connection with the inner wall of the clamping groove.
In any of the above schemes, preferably, the clamping groove is formed, and the clamping block is in abutting connection with the inner wall of the clamping groove, so that the reagent tube can be prevented from being deviated from the clamping block when rotated, and the centrifugal effect of the reagent tube can be increased.
In any of the above schemes, preferably, the mixing control circuit includes a power source, an electromagnet power end, a rotating motor power end, a varistor, and a switch, the electromagnet power end is connected in parallel with the rotating motor power end, and the electromagnet power end is connected with the power source through the switch, the rotating motor power end is connected in series with the varistor, and the rotating motor power end is connected with the power source through the switch.
In any of the above schemes, preferably, the power supply is mainly used for connecting an external power supply, when the reagent tubes are uniformly mixed, the switch is adjusted to enable the power ends of the electromagnets to be electrified so as to enable the electromagnets to generate magnetism, the magnetic beads in the reagent tubes are adsorbed to the tube walls at two sides, and then the switch is adjusted to enable the power ends of the electromagnets to be powered off, and the power ends of the rotating motor are electrified so as to uniformly mix the reagent tubes in the reagent box through the clamping blocks; the rotating speed of the clamping block can be adjusted through adjusting the rheostat during mixing, so that proper rotating speed is selected for mixing the reagent tube; after the mixing is completed, the switch is adjusted to enable the whole mixing control circuit to be powered off, the nut is rotated, the kit is taken out, and the mixing operation is completed.
Compared with the prior art, the utility model has the beneficial effects that:
the utility model provides a rapid magnetic bead mixing device, which can realize mixing operation without separating a reagent tube from the reagent box through a base, the reagent tube, the reagent box, a limiting component and the mixing component, can mix a plurality of groups of reagent tubes in batches, and overcomes the defect that the rapid mixing with higher centrifugal force cannot be adopted in a full-automatic analyzer due to the limitation of components by combining magnetic attraction and centrifugal force in the mixing; the defect that the air bubbles are easy to interfere experiments when the instrument is blown and evenly mixed outside and the mixing is reversed is overcome; meanwhile, the advantages of the two are combined, so that the mixing mode is optimized, the mixing time is shortened, the working efficiency is greatly improved, and the labor cost is reduced.
Drawings
The accompanying drawings are included to provide a further understanding of the utility model, and are incorporated in and constitute a part of this specification.
FIG. 1 is a three-dimensional view of a frame of a rapid magnetic bead mixing device of the present utility model;
FIG. 2 is a cross-sectional view of a kit and a reagent tube of the rapid magnetic bead mixing device of the present utility model;
FIG. 3 is a cross-sectional view of a kit of the instant magnetic bead mixing device of the present utility model;
FIG. 4 is a schematic top view of a kit of the instant magnetic bead mixing device of the present utility model;
FIG. 5 is a cross-sectional view of a frame of the instant magnetic bead mixing device of the present utility model;
FIG. 6 is a cross-sectional view of the base of the instant magnetic bead blending device of the present utility model;
fig. 7 is a circuit diagram of a mixing control circuit of the rapid magnetic bead mixing device of the present utility model.
The reference numerals in the figures illustrate:
1. a base; 2. a reagent tube; 21. a clamping groove; 3. a kit; 31. an anti-falling groove; 32. a placement groove; 33. an anti-blocking ring; 34. a limiting hole; 4. a frame; 41. an accommodating space; 42. a threaded rod; 43. a nut; 5. an electromagnet; 51. a rotating motor; 52. a transmission rod; 53. a clamping block; 54. a power supply; 55. an electromagnet power end; 56. rotating the motor power end; 57. a varistor; 58. and (3) a switch.
Detailed Description
The present utility model will be described in further detail with reference to the drawings and examples, in order to make the objects, technical solutions and advantages of the present utility model more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the utility model.
It will be understood that when an element is referred to as being "mounted" or "disposed" on another element, it can be directly on the other element or be indirectly on the other element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or be indirectly connected to the other element.
In the description of the present utility model, it should be understood that the terms "length," "width," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like indicate orientations or positional relationships based on the orientation or positional relationships shown in the drawings, merely to facilitate describing the present utility model and simplify the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and therefore should not be construed as limiting the present utility model.
Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include one or more such feature. In the description of the present utility model, the meaning of "a plurality" is two or more, unless explicitly defined otherwise.
In order to better understand the above technical scheme, the following detailed description of the technical scheme of the present utility model will be given with reference to the accompanying drawings of the specification and the specific embodiments.
As shown in fig. 1 to 7, the utility model provides a rapid magnetic bead mixing device, which comprises a base 1, a reagent tube 2, a reagent box 3, a limiting component and a mixing component, wherein the reagent tube 2 is arranged in the reagent box 3, the reagent box 3 is connected with the limiting component, the limiting component is arranged at the top of the base 1 and is used for limiting the reagent box 3, and the mixing component is connected with the reagent tube 2 and is used for uniformly mixing magnetic beads by the reagent tube 2.
As shown in fig. 1 to 7, the inside of the kit 3 is provided with an anti-falling groove 31, a placement groove 32 and an anti-blocking ring 33, the anti-falling groove 31 and the placement groove 32 are integrally formed in the inside of the kit 3, the anti-falling groove 31 is located above the placement groove 32, and the anti-blocking ring 33 is mounted on the inner wall of the anti-falling groove 31.
In the rapid magnetic bead mixing device according to the embodiment of the utility model, the reagent tube 2 can be more stably stored in the reagent kit 3 by arranging the anti-falling groove 31, and the friction force of the reagent tube 2 in the placing groove 32 can be reduced by arranging the anti-blocking ring 33 in the anti-falling groove 31, so that the reagent tube 2 is prevented from being worn when rotating for a long time, and the overall stability and safety are enhanced.
As shown in fig. 1 to 7, the limiting component includes a frame body 4, a containing space 41, and a limiting mechanism, the bottom of the frame body 4 is fixedly connected with the top surface of the base 1, the containing space 41 is arranged on the frame body 4, multiple groups of containing spaces 41 are arranged, the limiting mechanism is arranged at the top of the containing space 41, and the limiting mechanism is connected with the frame body 4.
In the rapid magnetic bead mixing device provided by the embodiment of the utility model, a plurality of groups of containing spaces 41 are arranged to realize batch processing of the reagent tubes 2 in a plurality of groups of reagent boxes 3, and the reagent boxes 3 in the containing spaces 41 can be limited by the limiting mechanism to prevent the reagent boxes 3 from displacement in operation.
As shown in fig. 1 to 7, the limiting mechanism includes a threaded rod 42 and a nut 43, the nut 43 is mounted on the top of the frame 4, the nut 43 is rotatably connected with the frame 4, and one end of the threaded rod 42 is connected with the nut 43 and extends into the accommodating space 41.
In the rapid magnetic bead mixing device according to the embodiment of the present utility model, the threaded rod 42 may be displaced by manually rotating the nut 43, so as to change the length of the threaded rod 42 in the accommodating space 41, thereby fixing the kit 3 by using the threaded rod 42.
As shown in fig. 1 to 7, the top of the kit 3 is provided with a limiting hole 34, and the limiting hole 34 is in abutting connection with one end of the threaded rod 42 extending into the accommodating space 41.
In the rapid magnetic bead mixing device according to the embodiment of the utility model, the limit hole 34 is provided to cooperate with the threaded rod 42, so that the limit effect of the threaded rod 42 on the kit 3 is enhanced.
As shown in fig. 1 to 7, the mixing assembly comprises a magnetic bead adsorption mechanism, a rotating mechanism and a mixing control circuit, wherein the magnetic bead adsorption mechanism is arranged in the frame body 4 and is electrically connected with the mixing control circuit, the rotating mechanism is arranged on the base 1, and the rotating mechanism is electrically connected with the mixing control circuit.
As shown in fig. 1 to 7, the magnetic bead adsorption mechanism includes an electromagnet 5, and the electromagnet 5 is disposed in two side walls of the accommodating space 41.
In the rapid magnetic bead mixing device according to the embodiment of the present utility model, the electromagnets 5 are disposed in the two side walls of the accommodating space 41, so that the electromagnets 5 generate magnetism when energized, and the magnetic beads in the reagent tube 2 are adsorbed on the two sides of the reagent tube.
As shown in fig. 1 to 7, the rotating mechanism comprises a rotating motor 51, a transmission rod 52 and a clamping block 53, the rotating motor 51 is arranged in the base 1, one end of the transmission rod 52 is fixedly connected with the output end of the rotating motor 51, and the other end of the transmission rod 52 is fixedly connected with the clamping block 53.
In the rapid magnetic bead mixing device according to the embodiment of the present utility model, the driving rod 52 may be rotated by the operation of the rotation motor 51, and the clamping block 53 may be further rotated, so that the reagent tube 2 in the reagent kit 3 may be rotated by using the clamping block 53.
As shown in fig. 1 to 7, the bottom of the reagent tube 2 is provided with a clamping groove 21, and the clamping block 53 is in abutting connection with the inner wall of the clamping groove 21.
In the rapid magnetic bead mixing device according to the embodiment of the present utility model, by providing the clamping groove 21 and enabling the clamping block 53 to be in abutting connection with the inner wall of the clamping groove 21, the reagent tube 2 and the clamping block 53 can be prevented from being offset when the reagent tube 2 is rotated, and thus the centrifugal effect on the reagent tube 2 can be increased.
As shown in fig. 1 to 7, the mixing control circuit includes a power supply 54, an electromagnet power end 55, a rotating motor power end 56, a varistor 57, and a switch 58, wherein the electromagnet power end 55 is connected in parallel with the rotating motor power end 56, the electromagnet power end 55 is connected with the power supply 54 through the switch 58, the rotating motor power end 56 is connected in series with the varistor 57, and the rotating motor power end 56 is connected with the power supply 54 through the switch 58.
In the rapid magnetic bead mixing device according to the embodiment of the utility model, the power supply 54 is mainly used for connecting an external power supply, when the reagent tube 2 is uniformly mixed, the switch 58 is adjusted to enable the electromagnet power end 55 to be electrified so as to enable the electromagnet 5 to generate magnetism, the magnetic beads in the reagent tube 2 are adsorbed to the tube walls at two sides, the switch 58 is further adjusted to enable the electromagnet power end 55 to be powered off, and the rotating motor power end 56 is enabled to be electrified so as to uniformly mix the reagent tubes 2 in the reagent box 3 through the clamping block 53; the rotating speed of the clamping block 53 can be adjusted by adjusting a rheostat during mixing, so that a proper rotating speed is selected to mix the reagent tube 2; after the mixing is completed, the switch 58 is adjusted to power off the whole mixing control circuit, the nut 43 is rotated, the kit 3 is taken out, and the mixing operation is completed.
Compared with the prior art, the utility model has the beneficial effects that:
the utility model provides a rapid magnetic bead mixing device, which can realize mixing operation without separating a reagent tube from the reagent box through a base, the reagent tube, the reagent box, a limiting component and the mixing component, can mix a plurality of groups of reagent tubes in batches, and overcomes the defect that the rapid mixing with higher centrifugal force cannot be adopted in a full-automatic analyzer due to the limitation of components by combining magnetic attraction and centrifugal force in the mixing; the defect that the air bubbles are easy to interfere experiments when the instrument is blown and evenly mixed outside and the mixing is reversed is overcome; meanwhile, the advantages of the two are combined, so that the mixing mode is optimized, the mixing time is shortened, the working efficiency is greatly improved, and the labor cost is reduced.
The above is only a preferred embodiment of the present utility model, and the present utility model is not limited thereto, but it is to be understood that the present utility model is described in detail with reference to the foregoing embodiments, and modifications and equivalents of some of the technical features described in the foregoing embodiments may be made by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present utility model should be included in the protection scope of the present utility model.

Claims (10)

1. A swift magnetic bead mixing device which characterized in that: comprising the following steps:
a base (1);
a reagent tube (2), wherein the reagent tube (2) is arranged in the reagent box (3);
the kit (3) is connected with the limiting component;
the limiting component is arranged at the top of the base (1) and used for limiting the kit (3);
the mixing component is connected with the reagent tube (2) and is used for carrying out magnetic bead mixing on the reagent tube (2).
2. The rapid magnetic bead mixing device according to claim 1, wherein: the anti-falling device is characterized in that an anti-falling groove (31), a placing groove (32) and an anti-blocking ring (33) are arranged inside the kit (3), the anti-falling groove (31) and the placing groove (32) are integrally formed in the kit (3), the anti-falling groove (31) is located above the placing groove (32), and the anti-blocking ring (33) is mounted on the inner wall of the anti-falling groove (31).
3. The rapid magnetic bead mixing device according to claim 2, wherein: the limiting assembly comprises a frame body (4), a containing space (41) and a limiting mechanism, wherein the bottom of the frame body (4) is fixedly connected with the top surface of the base (1), the containing space (41) is formed in the frame body (4), multiple groups of containing spaces (41) are arranged, the limiting mechanism is arranged at the top of the containing space (41), and the limiting mechanism is connected with the frame body (4).
4. A rapid magnetic bead mixing device according to claim 3, characterized in that: the limiting mechanism comprises a threaded rod (42) and a nut (43), the nut (43) is mounted at the top of the frame body (4), the nut (43) is rotationally connected with the frame body (4), and one end of the threaded rod (42) is connected with the nut (43) and extends into the accommodating space (41).
5. The rapid magnetic bead mixing device according to claim 4, wherein: the top of the kit (3) is provided with a limiting hole (34), and the limiting hole (34) is in abutting connection with one end of the threaded rod (42) extending to the inside of the accommodating space (41).
6. The rapid magnetic bead mixing device according to claim 5, wherein: the mixing assembly comprises a magnetic bead adsorption mechanism, a rotating mechanism and a mixing control circuit, wherein the magnetic bead adsorption mechanism is arranged in the frame body (4), the magnetic bead adsorption mechanism is electrically connected with the mixing control circuit, the rotating mechanism is arranged on the base (1), and the rotating mechanism is electrically connected with the mixing control circuit.
7. The rapid magnetic bead mixing device according to claim 6, wherein: the magnetic bead adsorption mechanism comprises an electromagnet (5), and the electromagnet (5) is arranged in two side walls of the accommodating space (41).
8. The rapid magnetic bead mixing device according to claim 7, wherein: the rotating mechanism comprises a rotating motor (51), a transmission rod (52) and a clamping block (53), wherein the rotating motor (51) is arranged in the base (1), one end of the transmission rod (52) is fixedly connected with the output end of the rotating motor (51), and the other end of the transmission rod (52) is fixedly connected with the clamping block (53).
9. The rapid magnetic bead mixing device according to claim 8, wherein: the bottom of the reagent tube (2) is provided with a clamping groove (21), and the clamping block (53) is in abutting connection with the inner wall of the clamping groove (21).
10. The rapid magnetic bead mixing device according to claim 9, wherein: the mixing control circuit comprises a power supply (54), an electromagnet power end (55), a rotating motor power end (56), a rheostat (57) and a switch (58), wherein the electromagnet power end (55) is connected with the rotating motor power end (56) in parallel, the electromagnet power end (55) is connected with the power supply (54) through the switch (58), the rotating motor power end (56) is connected with the rheostat (57) in series, and the rotating motor power end (56) is connected with the power supply (54) through the switch (58).
CN202223432528.5U 2022-12-21 2022-12-21 Swift magnetic bead mixing device Active CN219715463U (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202223432528.5U CN219715463U (en) 2022-12-21 2022-12-21 Swift magnetic bead mixing device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202223432528.5U CN219715463U (en) 2022-12-21 2022-12-21 Swift magnetic bead mixing device

Publications (1)

Publication Number Publication Date
CN219715463U true CN219715463U (en) 2023-09-19

Family

ID=87997753

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202223432528.5U Active CN219715463U (en) 2022-12-21 2022-12-21 Swift magnetic bead mixing device

Country Status (1)

Country Link
CN (1) CN219715463U (en)

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