CN219507888U

CN219507888U - Cell experiment device for photodynamic therapy research

Info

Publication number: CN219507888U
Application number: CN202121451379.XU
Authority: CN
Inventors: 朱崇涛; 屈晓雯; 李霆; 王琳; 卢伟伟
Original assignee: First Peoples Hospital of Yunnan Province
Current assignee: First Peoples Hospital of Yunnan Province
Priority date: 2021-06-29
Filing date: 2021-06-29
Publication date: 2023-08-11
Anticipated expiration: 2031-06-29

Abstract

The utility model discloses a cell experiment device for photodynamic therapy research, which comprises a base, wherein the upper end of the base is rotationally connected with an experiment table, the periphery of the experiment table is sleeved with a shading sleeve, the lower end of the shading sleeve is connected with the base, the middle part of the experiment table is provided with a supporting rod, the upper end of the supporting rod is provided with a mounting table, at least two shading sheets are arranged between the mounting table and the experiment table, the left side and the right side of each shading sheet are respectively contacted with the periphery of the supporting rod and the inner wall of the shading sleeve, a microprocessor and a light source emitter are arranged in the mounting table, the lower end of the mounting table is provided with a telescopic motor between two adjacent shading sheets, the other end of the telescopic motor is provided with a laser emission head, and the periphery of the mounting table is provided with a plurality of control panels. According to the utility model, a plurality of experimental spaces are formed by matching the shading sleeve and the shading sheet, the experiments do not affect each other, and then the experimental conditions of different experimental spaces are respectively adjusted, so that a plurality of groups of experiments can be performed simultaneously, and the effect of improving the research efficiency is achieved.

Description

Cell experiment device for photodynamic therapy research

Technical Field

The utility model relates to the technical field of medical equipment, in particular to a cell experiment device for photodynamic therapy research.

Background

Photodynamic therapy is a photosensitizing chemical reaction involving oxygen molecules with concomitant biological effects. The process is that the photosensitizer in the tissue is excited by the laser irradiation with specific wavelength, and the excited photosensitizer transmits energy to the surrounding oxygen to generate active oxygen, especially the singlet oxygen with strong activity, and the singlet oxygen and the adjacent biomacromolecule generate oxidation reaction to generate cytotoxicity, thereby causing damage and death of cells. Realizes physiotherapy and ablation of tumors and has good inhibition effect on affected parts of the tumors.

With the rapid development of nanotechnology, attempts have been made to combine nanomedicine with photodynamic therapy, i.e. a new method for treating tumor diseases by photosensitizing drugs and laser activation. The irradiation of the tumor site with a specific wavelength activates the photosensitizing drug selectively accumulated in the tumor tissue, which causes a photochemical reaction to destroy the tumor, and the photodynamic therapy has the advantage of being able to precisely and effectively treat the tumor, and the side effects of the therapy are small, compared with the conventional tumor therapy.

Therefore, we generally need to study the photodynamic therapy principle through a large number of cell experiments to seek better therapeutic effects; however, in the conventional experimental apparatus, a large number of control experiments cannot be performed at the same time, resulting in low research efficiency.

Disclosure of Invention

The utility model aims to provide a cell experiment device for photodynamic therapy research, which is characterized in that a plurality of experiment spaces are formed by matching a shading sleeve and a shading sheet, the experiments are not mutually influenced, and then the experiment conditions of the different experiment spaces are respectively adjusted, so that multiple groups of experiments can be ensured to be carried out simultaneously, and the effect of improving the research efficiency is achieved.

The technical aim of the utility model is realized by the following technical scheme:

the utility model provides a cell experimental device for photodynamic therapy research, includes the base, the upper end of base rotates and is connected with the laboratory bench that is the cylinder, laboratory bench level sets up, the week side cover of laboratory bench is equipped with the shading cover, the lower extreme of shading cover can dismantle connect in the base, the vertical bracing piece that is provided with in middle part of laboratory bench, the upper end of bracing piece be equipped with the mount table of laboratory bench symmetry, the mount table is located the upper end of shading cover, use between mount table and the laboratory bench the bracing piece is evenly provided with the multi-disc shading piece as the centre of a circle, the left and right sides of two piece at least shading pieces contact respectively in the week side of bracing piece and the inner wall of shading cover, be equipped with microprocessor and a plurality of light source transmitter in the mount table, each light source transmitter all electric link to microprocessor, the lower extreme of mount table is all vertically provided with flexible motor between two adjacent shading pieces, flexible motor keep away from the one end of mount table installs the laser emission head, each flexible motor all electric link to microprocessor, each electric link to each one and are equipped with in each electric control panel in each electric panel links to each one side.

The utility model is further provided with: the base is internally provided with a rotating motor, and an output shaft of the rotating motor is connected with the experiment table.

The utility model is further provided with: an operation opening is formed in the periphery of the shading sleeve, and an openable door is arranged on the operation opening.

The utility model is further provided with: the door is provided with a handle.

The utility model is further provided with: the anti-dazzling screen is characterized in that a plurality of sliding grooves opposite to the anti-dazzling screen in position are vertically formed in the mounting table, the anti-dazzling screens are in one-to-one sliding fit with the sliding grooves, a connecting plate is arranged at the upper end of the mounting table, the upper end of the anti-dazzling screen is connected with the connecting plate, and a handle is arranged at the upper end of the connecting plate.

The utility model is further provided with: and an illuminating lamp is arranged at the lower end of the mounting table between two adjacent light shielding sheets.

The utility model is further provided with: cameras are arranged between two adjacent light shielding sheets on the periphery of the supporting rod, and each camera is electrically connected with the microprocessor.

The utility model is further provided with: the lower end of the laser emission head is provided with a height sensor, and the height sensor is electrically connected with the microprocessor.

In summary, the utility model has the following beneficial effects:

firstly, the utility model forms a plurality of experimental spaces through the cooperation of the shading sleeve and the shading sheet, the experiments do not affect each other, and then the experimental conditions of the different experimental spaces are respectively adjusted, so that the simultaneous performance of a plurality of groups of experiments can be ensured, and the utility model has the effect of improving the research efficiency.

Secondly, the light source emitter is used for generating different light sources, and the telescopic motor can change the interval between the laser emitting head and the irradiated cells, so that the variable is convenient to control.

Thirdly, when the experiment is carried out, different experiments can be operated at the operation port only by rotating the test bed, and the experiment device is simple and convenient.

Drawings

FIG. 1 is a schematic view of the overall structure of the present utility model;

FIG. 2 is an exploded view of the structure of the present utility model;

fig. 3 is a partial cross-sectional view of the present utility model.

In the figure: 1. a base; 11. a rotating motor; 2. an experiment table; 3. a shading sleeve; 31. an operation port; 32. a door; 33. a handle; 4. a support rod; 41. a camera; 5. a mounting table; 51. a chute; 52. a lighting lamp; 6. a light shielding sheet; 7. a telescopic motor; 8. a laser emitting head; 81. a height sensor; 9. a control panel; 10. a connecting plate; 101. a handle.

Detailed Description

The present utility model will be described in further detail with reference to the accompanying drawings.

In the description of the present utility model, it should be understood that the directions or positional relationships indicated by the terms "upper", "lower", "left", "right", "front", "rear", "inner", "outer", etc., are based on the directions or positional relationships shown in the drawings, are merely for convenience of description and to simplify the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as limiting the present utility model.

Furthermore, the terms "horizontal," "vertical," and the like do not denote a requirement that the component be absolutely horizontal or overhang, but rather may be slightly inclined. As "horizontal" merely means that its direction is more horizontal than "vertical", and does not mean that the structure must be perfectly horizontal, but may be slightly inclined.

In the description of the present utility model, it should also be noted that, unless explicitly specified and limited otherwise, the terms "disposed," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; the two components can be mechanically connected, can be directly connected or can be indirectly connected through an intermediate medium, and can be communicated with each other. The specific meaning of the above terms in the present utility model can be understood by those of ordinary skill in the art according to the specific circumstances.

An embodiment, as shown in fig. 1 to 3, a cell experiment device for photodynamic therapy research, including a base 1, wherein the upper end of the base 1 is rotatably connected with a cylindrical experiment table 2, the experiment table 2 is horizontally arranged, a light shielding sleeve 3 is sleeved on the periphery of the experiment table 2, the lower end of the light shielding sleeve 3 is detachably connected with the base 1, a supporting rod 4 is vertically arranged in the middle of the experiment table 2, an installation table 5 symmetrical to the experiment table 2 is arranged at the upper end of the supporting rod 4, the installation table 5 is arranged at the upper end of the light shielding sleeve 3, and at least two light shielding sheets 6 are uniformly arranged between the installation table 5 and the experiment table 2 by taking the supporting rod 4 as a center of a circle, specifically, the number of the light shielding sheets 6 in the embodiment is four, and of course, three or five light shielding sheets do not affect the protection scope of the utility model; the left and right sides of every anti-dazzling screen 6 contact respectively in the week side of bracing piece 4 and the inner wall of light-proof cover 3, be equipped with microprocessor and a plurality of light source transmitter in the mount table 5, every light source transmitter all links in microprocessor, the lower extreme of mount table 5 all is vertical to be provided with flexible motor 7 between two adjacent anti-dazzling screens 6, the one end that flexible motor 7 kept away from mount table 5 is installed laser emission head 8, every flexible motor 7 all links in microprocessor, every laser emission head 8 one-to-one electricity links in every light source transmitter, the week side of mount table 5 is equipped with a plurality of control panel 9, every control panel 9 electricity links in microprocessor.

In detail, the experiment table 2 rotates on the base 1, and the space between the experiment table 2 and the mounting table 5 is divided into a plurality of mutually non-interfering experiment spaces by the light shielding sleeve 3 and the light shielding sheet 6, so that a plurality of groups of experiments can be ensured to be carried out simultaneously, and the study efficiency is improved; and can also be convenient for operating different experiments. The light source emitter is used for generating different light sources, and the telescopic motor 7 can change the interval between the laser emitting head 8 and the irradiated cells, so that the control variable is convenient to control, and a control experiment can be carried out. Each control panel 9 is respectively controlled with a light source emitter and a telescopic motor 7, so that the relevant experimental parameters can be conveniently adjusted.

Preferably, a rotating motor 11 is arranged in the base 1, and an output shaft of the rotating motor 11 is connected with the experiment table 2. Specifically, the test bed is convenient to rotate, and the test bed is enabled to rotate more stably, so that the experiment is prevented from being influenced.

Preferably, the periphery of the shade sleeve 3 is provided with an operation opening 31, and the operation opening 31 is provided with an openable door 32. In particular, it is convenient to operate on different experiments.

Preferably, the door 32 is provided with a handle 33. In particular, opening the door 32 is facilitated.

Preferably, a plurality of sliding grooves 51 opposite to the light shielding sheets 6 are vertically formed in the mounting table 5, the light shielding sheets 6 are in one-to-one sliding fit with the sliding grooves 51, a connecting plate 10 is arranged at the upper end of the mounting table 5, the upper end of the light shielding sheets 6 is connected to the connecting plate 10, and a handle 101 is arranged at the upper end of the connecting plate 10. Specifically, the light shielding sheet 6 is taken out, so that adjustment and unification of experimental conditions, such as temperature, humidity, etc., are facilitated for each experiment.

Preferably, the lower end of the mounting table 5 is provided with an illumination lamp 52 between two adjacent light shielding sheets 6. Specifically, the illumination lamp 52 can be used as an experimental condition, and the illumination lamp 52 can provide sufficient light for an experimenter to facilitate operation.

Preferably, cameras 41 are arranged between two adjacent light shielding sheets 6 on the peripheral side of the supporting rod 4, and each camera 41 is electrically connected to the microprocessor. In particular, it is convenient to observe the experimental process.

Preferably, the lower end of the laser emitting head 8 is provided with a height sensor 81, and the height sensor 81 is electrically connected to the microprocessor. Facilitating adjustment of the spacing between the laser emitting head 8 and the irradiated cell.

The present embodiment is only for explanation of the present utility model and is not to be construed as limiting the present utility model, and modifications to the present embodiment, which may not creatively contribute to the present utility model as required by those skilled in the art after reading the present specification, are all protected by patent laws within the scope of claims of the present utility model.

Claims

1. Cell experiment device for photodynamic therapy research, comprising a base (1), characterized in that: the upper end of the base (1) is rotationally connected with a cylindrical experiment table (2), the experiment table (2) is horizontally arranged, a shading sleeve (3) is sleeved on the periphery of the experiment table (2), the lower end of the shading sleeve (3) is detachably connected with the base (1), a supporting rod (4) is vertically arranged in the middle of the experiment table (2), the upper end of the supporting rod (4) is provided with an installation table (5) symmetrical to the experiment table (2), the installation table (5) is arranged at the upper end of the shading sleeve (3), at least two shading sheets (6) are uniformly arranged between the installation table (5) and the experiment table (2) by taking the supporting rod (4) as a circle center, the left side and the right side of each shading sheet (6) are respectively contacted with the periphery of the supporting rod (4) and the inner wall of the shading sleeve (3), a microprocessor and a plurality of light source transmitters are arranged in the installation table (5), each light source transmitter is electrically connected with the installation table (5), the installation table (5) is provided with a telescopic motor (7) which is arranged at the lower end of the installation table (5), the telescopic motor (7) is arranged between the two telescopic motor (7) and the telescopic motor (7) which is far away from the telescopic motor (7), each laser emission head (8) is electrically connected to each light source emitter in a one-to-one correspondence manner, a plurality of control panels (9) are arranged on the periphery of the mounting table (5), and each control panel (9) is electrically connected to the microprocessor.

2. A cell assay device for photodynamic therapy research according to claim 1, wherein: a rotating motor (11) is arranged in the base (1), and an output shaft of the rotating motor (11) is connected with the experiment table (2).

3. A cell assay device for photodynamic therapy research according to claim 1, wherein: an operation opening (31) is formed in the periphery of the shading sleeve (3), and an openable door (32) is arranged on the operation opening (31).

4. A cell assay device for photodynamic therapy research according to claim 3, wherein: the door (32) is provided with a handle (33).

5. A cell assay device for photodynamic therapy research according to claim 1, wherein: the anti-dazzling screen is characterized in that a plurality of sliding grooves (51) opposite to the anti-dazzling screens (6) in position are vertically formed in the mounting table (5), the anti-dazzling screens (6) are in one-to-one sliding fit with the sliding grooves (51), a connecting plate (10) is arranged at the upper end of the mounting table (5), the upper end of the anti-dazzling screens (6) is connected to the connecting plate (10), and a lifting handle (101) is arranged at the upper end of the connecting plate (10).

6. A cell assay device for photodynamic therapy research according to claim 1, wherein: and an illuminating lamp (52) is arranged between two adjacent light shielding sheets (6) at the lower end of the mounting table (5).

7. A cell assay device for photodynamic therapy research according to claim 1, wherein: cameras (41) are arranged between two adjacent light shielding sheets (6) on the periphery of the supporting rod (4), and each camera (41) is electrically connected with the microprocessor.

8. A cell assay device for photodynamic therapy research according to claim 1, wherein: the lower end of the laser emission head (8) is provided with a height sensor (81), and the height sensor (81) is electrically connected with the microprocessor.