CN219369570U

CN219369570U - Preview camera module and pathological section scanner

Info

Publication number: CN219369570U
Application number: CN202320265465.4U
Authority: CN
Inventors: 梅园
Original assignee: Shanghai Shenzhi Medical Technology Co ltd
Current assignee: Shanghai Shenzhi Medical Technology Co ltd
Priority date: 2023-02-21
Filing date: 2023-02-21
Publication date: 2023-07-18
Anticipated expiration: 2033-02-21

Abstract

The utility model discloses a preview camera module and a pathological section scanner, wherein the preview camera module comprises a mounting box, a camera arranged on the mounting box, a first light source and a second light source, wherein the camera is used for shooting an image of a slide, the first light source is used for illuminating the slide, the second light source is used for irradiating excitation light to the slide, fluorescent substances in pathological sections on the slide are excited by the excitation light to emit fluorescence, and therefore the position of the pathological sections is determined according to the fluorescent image. The beneficial effects are that: according to the technical scheme, the camera is provided with the second light source for exciting the pathological section to emit fluorescence, and in a fluorescence imaging mode, when the pathological section is transparent, the position of the pathological section is determined by shooting a fluorescence image through the camera, so that the pathological section micro scanner is ensured to smoothly realize focusing, and the acquisition efficiency of sample information on a slide is not influenced.

Description

Preview camera module and pathological section scanner

Technical Field

The utility model relates to the field of pathological section scanners, in particular to a preview camera module and a pathological section scanner.

Background

A pathological section microscan is generally configured with a light source and a preview camera, wherein the preview camera is used for shooting a slide image to obtain sample information carried in a label on the slide, and if the pathological section microscan is operated in a bright field imaging mode, the scanned sample can be dyed by using a dye, for example, the sample is prepared by using an HE dyeing method (hematoxylin-eosin dyeing method), so that the sample (pathological section) is previewed to select a focusing position.

At present, the pathological section microscan work in a bright field imaging mode and also can work in a fluorescent imaging mode, but in the fluorescent imaging mode, when the pathological section is transparent, the position of the pathological section cannot be positioned by the preview camera, focusing is affected, and the acquisition efficiency of sample information on a slide is reduced.

Disclosure of Invention

The utility model mainly aims to provide a preview camera module and a pathological section scanner, and aims to solve the problem that the conventional pathological section microscopic scanner cannot determine the position of a transparent pathological section in a fluorescence imaging mode.

In order to solve the above problems, the present utility model provides a preview camera module, which includes a mounting box, a camera disposed on the mounting box, a first light source and a second light source, wherein the camera is used for capturing an image of a slide, the first light source is used for illuminating the slide, the second light source is used for illuminating excitation light to the slide, and fluorescent substances in pathological sections on the slide are excited by the excitation light to emit fluorescence so as to determine positions of the pathological sections according to the fluorescent images.

In one embodiment, the excitation light is blue-violet light.

In one embodiment, the mounting box comprises a box body, a box cover and a bracket, wherein the box cover is detachably connected with the box body, and the bracket is fixedly mounted on the outer wall of the box body;

the camera and the first light source are fixedly arranged in the box body, and two positioning holes are formed in the box cover and are respectively used for enabling lenses of the camera and the first light source to extend out of the box body;

the second light source is arranged on the bracket.

In one embodiment, the second light source is hinged to the bracket.

In one embodiment, the bracket is provided with an arc hole and a first mounting hole, a second connecting piece sliding along an arc where the arc hole is arranged in the arc hole in a penetrating manner, and the second connecting piece is fixedly connected with a second light source;

a first connecting piece is rotatably installed in the first mounting hole and fixedly connected with a second light source;

the circle center of the arc-shaped hole coincides with the circle center of the first mounting hole.

In an embodiment, the excitation light is inclined with respect to the vertical.

In an embodiment, 0 ° < the excitation light forms an angle with the vertical < 60 °.

In an embodiment, the first light source comprises a first sleeve, and a first frosted glass and a first lamp panel which are stacked in the first sleeve, wherein a light through hole is formed in the bottom of the first sleeve, one side of the first frosted glass faces the light through hole and is clung to the bottom of the first sleeve, and the other side of the first frosted glass is clung to the first lamp panel.

In an embodiment, the second light source comprises a second sleeve, and a second frosted glass and a second lamp panel which are stacked in the second sleeve, wherein a light through hole is formed in the bottom of the second sleeve, one side of the second frosted glass faces the light through hole and is clung to the bottom of the second sleeve, and the other side of the second frosted glass is clung to the second lamp panel;

the second light source also comprises a cover plate which is detachably and fixedly connected with the top of the second sleeve, a cushion block is arranged between the cover plate and the second lamp panel, and the cushion block is tightly clung to the cover plate and the second lamp panel;

and the cover plate is fixedly provided with a convex block which is clung to the second lamp panel, and the convex blocks and the cushion blocks are alternately arranged.

In addition, the utility model also provides a pathological section scanner, which comprises the preview camera module of any one of the above.

The beneficial effects are that: according to the technical scheme, the camera is provided with the second light source for exciting the pathological section to emit fluorescence, and in a fluorescence imaging mode, when the pathological section is transparent, the position of the pathological section is determined by shooting a fluorescence image through the camera, so that the pathological section micro scanner is ensured to smoothly realize focusing, and the acquisition efficiency of sample information on a slide is not influenced.

Drawings

In order to more clearly illustrate the embodiments of the utility model or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, it being obvious that the drawings in the following description are only some embodiments of the utility model, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.

FIG. 1 is a schematic diagram of a preview camera module according to the present utility model;

FIG. 2 is a schematic diagram of a preview camera module according to a second embodiment of the present utility model;

FIG. 3 is an exploded view of the preview camera module of the present utility model;

FIG. 4 is a schematic view of a second embodiment of the light source of the present utility model;

FIG. 5 is a cross-sectional view A-A of FIG. 4;

fig. 6 is an exploded view of a second light source of the present utility model.

The reference numerals are explained as follows:

1. a case;

2. a case cover; 21. positioning holes;

3. a first light source; 31. a sleeve I; 32. frosted glass I; 33. a first lamp panel;

4. a camera;

5. a bracket; 51. a first mounting hole;

6. a first connecting piece; 7. an arc-shaped hole; 8. a second connecting piece;

9. a second light source; 91. a cover plate; 92. a bump; 93. a cushion block; 94. a second sleeve; 95. a light-transmitting hole; 96. frosted glass II; 97. a second lamp panel; 98. a second mounting hole; 99. and a mounting hole III.

Detailed Description

The following description of the embodiments of the present utility model will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are only some, but not all embodiments of the utility model. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.

It should be noted that, if directional indications (such as up, down, left, right, front, and rear … …) are included in the embodiments of the present utility model, the directional indications are merely used to explain the relative positional relationship, movement conditions, etc. between the components in a specific posture (as shown in the drawings), and if the specific posture is changed, the directional indications are correspondingly changed.

In the present utility model, unless specifically stated and limited otherwise, the terms "connected," "affixed," and the like are to be construed broadly, and for example, "affixed" may be a fixed connection, a removable connection, or an integral body; can be mechanically or electrically connected; either directly or indirectly, through intermediaries, or both, may be in communication with each other or in interaction with each other, unless expressly defined otherwise. The specific meaning of the above terms in the present utility model can be understood by those of ordinary skill in the art according to the specific circumstances.

In addition, if there is a description of "first", "second", etc. in the embodiments of the present utility model, the description of "first", "second", etc. is for descriptive purposes only and is not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include at least one such feature. In addition, the meaning of "and/or" as it appears throughout includes three parallel schemes, for example "A and/or B", including the A scheme, or the B scheme, or the scheme where A and B are satisfied simultaneously. In addition, the technical solutions of the embodiments may be combined with each other, but it is necessary to base that the technical solutions can be realized by those skilled in the art, and when the technical solutions are contradictory or cannot be realized, the combination of the technical solutions should be considered to be absent and not within the scope of protection claimed in the present utility model.

The utility model provides a preview camera module.

In an embodiment of the utility model, as shown in fig. 1-2, the preview camera module includes a mounting box, and a camera 4, a first light source 3 and a second light source 9 disposed on the mounting box, where the camera 4 is used for capturing an image of a slide, preferably, the camera 4 is a digital camera 4 with 800 ten thousand pixels and a wide angle of 120 degrees, and the camera 4 has an auto-focusing function and a distortion correcting function.

In this embodiment, the first light source 3 is used to illuminate the slide so that the camera 4 can clearly capture an image of the slide, and further, the first light source 3 emits white light to illuminate the slide, and after illuminating the slide, the camera 4 captures an image of the entire slide.

Preferably, the color temperature of the white light emitted by the first light source 3 is 6000K.

Specifically, in this embodiment, as shown in fig. 3, the first light source 3 includes a first sleeve 31, a first frosted glass 32 and a first lamp plate 33 stacked in the first sleeve 31, a light passing hole 95 is formed at the bottom of the first sleeve 31, the bottom surface of the first frosted glass 32 faces the light passing hole 95 and is closely attached to the bottom of the first sleeve 31, the upper surface of the first frosted glass 32 is closely attached to the first lamp plate 33, the first lamp plate 33 is fixed in the first sleeve 31, the first sleeve 31 is fixedly connected with the mounting box, after the first lamp plate 33 is electrified and emits light, the light is emitted from the bottom of the first sleeve 31 through the first frosted glass 32 and the light passing hole 95 to irradiate onto a slide below the preview camera module, and after the slide is illuminated, the camera 4 captures an image of the whole slide.

In this embodiment, the ground glass one 32 is used to make the light emitted from the light source one 3 uniform.

In this embodiment, preferably, the bottom surface of the ground glass one 32 is adhered and fixed to the bottom of the sleeve one 31.

In this embodiment, as shown in fig. 1 to 3, the mounting box includes a box body 1, a box cover 2, and a bracket 5, where the box cover 2 is located on the lower surface of the box body 1, the box cover 2 is detachably connected to the box body 1, and the bracket 5 is fixedly mounted on the outer wall of the box body 1; the camera 4 and the first light source 3 are fixedly arranged in the box body 1, as shown in fig. 3, the top parts of the camera 4 and the first sleeve 31 are fixedly connected with the top surface of the inner side of the box body 1, and the fixedly connected mode can be realized by adopting screws.

In this embodiment, as shown in fig. 1-3, the case cover 2 is provided with two positioning holes 21, the lenses for the camera 4 and the light source one 3 respectively extend out of the case 1, and the positioning holes 21 are through holes, so that the camera 4 and the light source one 3 are fixedly installed in the case 1 without affecting the image of the whole slide shot by the camera 4 and the light source one 3 illuminates the slide.

In this embodiment, as shown in fig. 1-3, the second light source 9 is mounted on the bracket 5, the second light source 9 is used for irradiating excitation light to the slide, and the excitation light excites fluorescent substances in pathological sections on the slide to emit fluorescence, so that the slide is photographed by the camera 4, a fluorescent image in the slide image is obtained, and the position of the pathological section is determined according to the fluorescent image.

In this embodiment, the excitation light is blue-violet light, the fluorescent substance is a cell, and the cell is likely to have a fluorescent reaction to the blue-violet light, preferably, the wavelength of the excitation light is in the range of 390 to 395nm.

In this embodiment, as shown in fig. 1-3, the second light source 9 is hinged to the bracket 5, so that the second light source 9 can be stirred to rotate around the horizontal axis to adjust the irradiation direction of the excitation light, so that the excitation light is inclined relative to the vertical direction, and the proportion of the reflected excitation light entering the camera 4 after the excitation light is reflected by the glass slide can be reduced, so that the proportion of the fluorescence entering the camera 4 is improved, and the signal-to-noise ratio is improved.

Preferably, 0 DEG < the included angle of the excitation light with the vertical direction < 60 deg.

Preferably, as shown in fig. 1 and 2, the camera 4 is located between the first light source 3 and the second light source 9.

In this embodiment, when the pathological section scanner works in the fluorescence imaging mode, if the pathological section is transparent, the second light source 9 irradiates excitation light to the slide, the fluorescent substance in the pathological section on the slide is excited by the excitation light to emit fluorescence, and then the slide is photographed by the camera 4 to obtain a fluorescent image in the slide image, so as to determine the position of the pathological section, ensure that the pathological section microscopic scanner realizes focusing smoothly, and do not affect the acquisition efficiency of sample information on the slide.

Typically, the slide includes a specimen information region including a label of the specimen and a section region including a pathological section, wherein the label may be a bar code or a two-dimensional code, and the label of the slide specimen carries a specimen identification.

In this embodiment, the slide image shot by the camera 4 includes a label image and a pathological section image, the processor of the pathological section scanner can process the label image to obtain a sample identifier carried by a label of the sample information area, the sample identifier can be a sample number, and the pathological section image is displayed, so that a user can select a focusing position according to the pathological section image.

In this embodiment, as shown in fig. 4-6, the second light source 9 includes a second sleeve 94, and a second frosted glass 96 and a second lamp plate 97 stacked in the second sleeve 94, a light passing hole 95 is formed at the bottom of the second sleeve 94, the bottom surface of the second frosted glass 96 faces the light passing hole 95 and is tightly attached to the bottom of the second sleeve 94, preferably, the bottom surface of the second frosted glass 96 is fixedly attached to the bottom of the second sleeve 94, the upper surface of the second frosted glass 96 is tightly attached to the second lamp plate 97, the second lamp plate 97 is fixedly arranged in the second sleeve 94, the second sleeve 94 is hinged to the bracket 5, after the second lamp plate 97 is energized to emit light from the bottom of the second sleeve 94 through the second frosted glass 96 and the light passing hole 95 to irradiate onto a slide below the preview camera module, fluorescent substances in pathological sections on the slide are excited to emit fluorescent light, then the slide images are photographed through the camera 4, so as to obtain fluorescent images in the slide images, and to determine the positions of the pathological sections, so that the pathological sections can be successfully realized, and the efficiency of obtaining information of the upper samples is not affected.

In this embodiment, the second frosted glass 96 is used to make the light emitted from the second light source 9 uniform.

Further, as shown in fig. 4-6, the second light source 9 further includes a cover plate 91 detachably and fixedly connected to the top of the second sleeve 94, a cushion block 93 is disposed between the cover plate 91 and the second lamp panel 97, and the cushion block 93 is tightly attached to the cover plate 91 and the second lamp panel 97; the lower surface of the cover plate 91 is fixedly provided with the convex blocks 92 which are tightly attached to the second lamp panel 97, the convex blocks 92 and the cushion blocks 93 are alternately arranged, and after the cover plate 91 is fixedly connected with the second sleeve 94, the convex blocks 92 and the cushion blocks 93 tightly press and fix the second lamp panel 97 in the second sleeve 94.

In this embodiment, as shown in fig. 1-3, the bracket 5 is provided with an arc hole 7 and a first mounting hole 51, as shown in fig. 4, the second sleeve 94 is provided with a second mounting hole 98 and a third mounting hole 99, a second connecting piece 8 sliding along the arc line where the arc hole 7 is located is arranged in the arc hole 7 in a penetrating manner, and one end of the second connecting piece 8 extends into the third mounting hole 99 and is fixedly connected with the second sleeve 94; a first connecting piece 6 is rotatably arranged in the first mounting hole 51, one end of the first connecting piece 6 extends into the second mounting hole 98 and is fixedly connected with the second sleeve 94, and the circle center of the arc-shaped hole 7 coincides with the circle center of the first mounting hole 51; by the design, the second connecting piece 8 slides along the arc line where the arc-shaped hole 7 is positioned, and the second light source 9 can be driven to rotate around the first connecting piece 6 to adjust the irradiation angle of the excitation light.

Preferably, the first connecting piece 6 and the second connecting piece 8 are screws or threaded rods.

In addition, the utility model also provides a pathological section scanner, which comprises any one of the preview camera modules, and because the pathological section scanner adopts any one of the preview camera modules, the pathological section scanner has all the beneficial effects of any one of the preview camera modules, and redundant description is omitted.

The foregoing description is only of the preferred embodiments of the present utility model and is not intended to limit the scope of the utility model, and all equivalent structural changes made by the description of the present utility model and the accompanying drawings or direct/indirect application in other related technical fields are included in the scope of the utility model.

Claims

1. The preview camera module is characterized by comprising a mounting box, a camera, a first light source and a second light source, wherein the camera, the first light source and the second light source are arranged on the mounting box, the camera is used for shooting an image of a slide, the first light source is used for illuminating the slide, the second light source is used for irradiating excitation light to the slide, fluorescent substances in pathological sections on the slide are excited by the excitation light to emit fluorescence, and therefore the position of the pathological sections is determined according to the fluorescent image.

2. The preview camera module of claim 1, wherein the excitation light is bluish violet light.

3. The preview camera module of claim 1, wherein the mounting case comprises a case body, a case cover and a bracket, the case cover is detachably connected with the case body, and the bracket is fixedly mounted on an outer wall of the case body;

the second light source is arranged on the bracket.

4. A preview camera module as recited in claim 3, wherein the second light source is hingedly connected to the bracket.

5. The preview camera module as recited in claim 4, wherein the bracket is provided with an arc hole and a first mounting hole, a second connecting piece sliding along an arc where the arc hole is located is arranged in the arc hole in a penetrating manner, and the second connecting piece is fixedly connected with the second light source;

6. The preview camera module of claim 1, wherein the excitation light is tilted with respect to vertical.

7. A preview camera module as recited in claim 6, wherein 0 ° < said excitation light is at an angle of < 60 ° to vertical.

8. The preview camera module of claim 1, wherein the first light source comprises a first sleeve and a first frosted glass and a first lamp plate stacked in the first sleeve, a light passing hole is formed in the bottom of the first sleeve, one side of the first frosted glass faces the light passing hole and is clung to the bottom of the first sleeve, and the other side of the first frosted glass is clung to the first lamp plate.

9. The preview camera module of claim 1, wherein the second light source comprises a second sleeve, and a second frosted glass and a second lamp panel which are stacked in the second sleeve, wherein a light passing hole is formed in the bottom of the second sleeve, one side of the second frosted glass faces the light passing hole and is clung to the bottom of the second sleeve, and the other side of the second frosted glass is clung to the second lamp panel;

10. A pathological slice scanner comprising the preview camera module of any one of claims 1-9.