CN219331846U

CN219331846U - Transfer tube for transferring biopsy sample and biopsy sample transfer device

Info

Publication number: CN219331846U
Application number: CN202223039254.3U
Authority: CN
Inventors: 薛侠
Original assignee: Individual
Current assignee: Individual
Priority date: 2022-11-14
Filing date: 2022-11-14
Publication date: 2023-07-14
Anticipated expiration: 2032-11-14

Abstract

The present application provides a transfer tube and biopsy sample transfer apparatus for transferring a biopsy sample, the transfer tube comprising: a capillary portion configured to enable entry of a droplet having a biopsy sample by capillary action; and the connecting pipe part is communicated with the capillary part and is used for being connected with a pushing device, and the pushing device is used for pushing out the biopsy sample entering the capillary part. According to the technical scheme, capillary action is adopted to enable liquid drops containing biopsy samples to enter the transfer tube, after the transfer tube is connected with the pushing device, the biopsy samples are pushed into the preset device through the pushing device, the transfer operation is simple and stable, a novice is easy to get on the hand, and the samples are not lost in the transfer process. In addition, the transfer pipe has simple structure and low manufacturing cost.

Description

Transfer tube for transferring biopsy sample and biopsy sample transfer device

Technical Field

The application relates to the technical field of medical treatment, in particular to a transfer tube for transferring a biopsy sample and a biopsy sample transfer device.

Background

The genetic detection technology before planting in the auxiliary reproductive center usually comprises the steps of culturing embryos to the blastocyst stage of the fifth day, and performing genetic detection on 5-10 trophectoderm cells of the biopsy blastocyst to judge whether the corresponding blastocyst is available or unavailable according to whether the result is normal.

Currently, the transfer of blastula biopsied cells (called biopsy samples) is performed mainly by laboratory personnel pinching the suction cap connected to a drawn glass tube to aspirate the sample under a microscope, transferring it into a small EP tube (microcentrifuge tube) containing liquid, and then centrifuging it for detection.

However, since the suction cap of the glass tube is manually pinched, the operation stability of sucking the sample is completely dependent on manual control, the operation precision is not high, the sample is not easy to check when being transferred into the EP tube containing liquid, the sample is easy to lose, the final detection has no result, and the problem of transferring the sample or the problem of detecting which link is difficult to trace afterwards is solved.

Disclosure of Invention

In view of the above, the present application provides a transfer tube and a biopsy sample transfer device for transferring a biopsy sample, so as to solve the problems of poor operation stability and easy sample loss of the current transfer biopsy sample.

The present application provides a transfer tube for transferring a biopsy sample, the transfer tube comprising:

a capillary portion configured to enable entry of a droplet having a biopsy sample by capillary action;

and the connecting pipe part is communicated with the capillary part and is used for being connected with a pushing device, and the pushing device is used for pushing out the biopsy sample entering the capillary part.

Optionally, the transfer tube further includes a holding portion, the holding portion is a tubular structure that communicates with the capillary portion, and the connecting tube portion is disposed at a distal end of the holding portion that is away from the capillary portion.

Optionally, the opposite sides of the holding part are formed with concave parts for holding.

Optionally, the transfer tube further comprises a transition tube portion;

the transition pipe portion is communicated with the capillary portion and the handheld portion, and the cross-sectional area of the transition pipe portion is larger than the cross-sectional area of the capillary portion and smaller than the cross-sectional area of the handheld pipe portion.

Optionally, the capillary portion has an inner diameter Φ1 of 0.4 to 0.8mm.

Optionally, the connecting pipe part is arranged to be sleeved on the connecting end of the pushing device and is tightly matched with the connecting end.

Optionally, the inner diameter Φ1 of the capillary tube part is 0.4-0.8 mm, the inner diameter Φ2 of the transition tube part is 1-2.5 mm, and the inner diameter Φ3 of the connecting tube part is 3-6 mm.

Optionally, the length L1 of the capillary portion is: 20-30 mm;

and/or, the length L2 of the transition pipe portion is: 30-40 mm;

and/or, the overall length L3 of the hand-held part and the connecting part is: 30-40 mm.

According to another aspect of the present application there is also provided a biopsy sample transfer device comprising a transfer tube according to the above and a pushing device for connection with the connecting tube portion of the transfer tube.

Optionally, the pushing device is a syringe.

According to the technical scheme, the liquid drop containing the biopsy sample is enabled to enter the transfer tube by utilizing capillary action, and after the transfer device is connected, the biopsy sample is pushed into the preset device through the push device, so that the transfer operation is simple and stable, a novice is easy to get on the hand, and the sample is not lost in the transfer process. In addition, the transfer pipe has simple structure and low manufacturing cost.

Additional features and advantages of the present application will be set forth in the detailed description which follows.

Drawings

The accompanying drawings, which are included to provide a further understanding of the application, illustrate and explain the application and are not to be construed as limiting the application. In the drawings:

FIG. 1 is a schematic view of a transfer tube according to one embodiment of the present application;

FIG. 2 is a schematic illustration of a transfer tube coupled to a pushing device according to one embodiment of the present application;

FIG. 3 is a schematic illustration of taking a biopsy sample using a transfer tube according to one embodiment of the present application.

Reference numerals illustrate:

10-transfer tube; 11-a capillary portion; 12-a transition pipe section; 13-a hand-held part; 131-a depression; 14-connecting part; 20-pushing device; 21-a barrel; 211-connection end; 22-a piston rod; 30-culture dish; 31-first droplets; 32-a second droplet; 33-third droplets; 34-biopsy samples.

Detailed Description

The following description of the technical solutions in the embodiments of the present application will be made clearly and completely with reference to the drawings in the embodiments of the present application, and it is apparent that the described embodiments are only some embodiments of the present application, not all embodiments. All other embodiments, which can be made by one of ordinary skill in the art without undue burden from the present disclosure, are within the scope of the present disclosure. In the case of no conflict, the present application, embodiments and features of the embodiments may be controlled in combination with each other.

In the description of the present application, it should be understood that the terms "center," "longitudinal," "transverse," "upper," "lower," "left," "right," "vertical," "horizontal," "top," "bottom," "axial," "radial," "circumferential," and the like indicate orientations or positional relationships based on the orientation or positional relationships shown in the drawings, merely to facilitate description of the present application and simplify the description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be configured and operated in a particular orientation, and therefore should not be construed as limiting the present application. In addition, "inner and outer" refer to inner and outer with respect to the outline of each component itself.

Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include at least one such feature.

The present application provides a transfer tube 10 for transferring a biopsy sample, as shown in fig. 1 and 2, the transfer tube 10 includes a capillary portion 11 and a connection tube portion 14;

the capillary portion 11 is provided so as to enable entry of a droplet having a biopsy sample by capillary action;

the connecting tube portion 14 communicates with the capillary portion 11, the connecting tube portion 14 being for connecting with a pushing device 20, the pushing device 20 being for pushing out a biopsy sample entering the capillary portion 11.

According to the technical scheme provided by the application, the liquid drop containing the biopsy sample enters the transfer tube 10 by utilizing capillary phenomenon, then the connecting tube part 14 of the transfer tube 10 is connected with the pushing device 20, and the liquid containing the biopsy sample in the transfer tube 10 is pushed into a preset device (such as an EP tube) by utilizing the pushing device 20.

Compared with the prior art, the mode that the sample enters into the glass tube by extruding the rubber ball on the glass tube is simple and stable in operation, and the sample can not be lost by a novice user. In addition, the transfer tube that this application provided simple structure, with low costs.

Alternatively, the inner diameter Φ1 of the capillary portion 11 is 0.4 to 0.8mm, and more preferably, the inner diameter Φ1 of the capillary portion 11 is 0.6mm. The inner diameter of the capillary portion 11 is set so that the size of the droplet to be entered is also defined by the inner diameter size, provided that it is ensured that the droplet containing the biopsy sample can enter the capillary portion 11 by capillary action.

Alternatively, the connecting pipe portion 14 is configured to be sleeved on the connecting end 211 of the pushing device 20 and is tightly matched with the connecting end 211, so that the connection and the disconnection of the transfer pipe 10 and the pushing device 20 can be realized through the plugging action, and the operation is simple and convenient.

Alternatively, the inner diameter Φ3 of the connection pipe portion 14 is 3 to 6mm. The inner diameter is an inner diameter matched with the connecting end 211 of the pushing device 20, wherein the pushing device 20 can be a syringe, and when Φ3 is 4mm, the inner diameter Φ3 of the connecting pipe portion 14 is 4mm, and the inner diameter of the connecting pipe portion 14 is matched with the front end of the syringe.

The transfer tube 10 can be made of medical grade plastic, and is conveniently connected with the connecting end of the pushing device 20 in a tight fit manner on the basis that the plastic material can enable the transfer tube to have certain hardness.

In one embodiment, as shown in fig. 1 and 2, the transfer tube 10 further includes a holding portion 13, the holding portion 13 is a tubular structure communicating with the capillary portion 11, and the connection tube portion 14 is disposed at an end of the holding portion 13 remote from the capillary portion 11.

Alternatively, opposite sides of the holding part 13 are formed with concave parts 131 for holding. In taking a biopsy sample, the hand-held portion 13 may be held to perform an operation, and specifically, fingers may be pinched at the groove portions 131 on both sides.

In one embodiment, the transfer tube 10 further includes a transition tube portion 12, the transition tube portion 12 communicates the capillary portion 11 and the hand-held portion 13, and the cross-sectional area of the transition tube portion 12 is larger than the cross-sectional area of the capillary portion 11 and smaller than the cross-sectional area of the hand-held portion 13.

Because the cross section of the holding part 13 is larger than that of the capillary part 11, the transition pipe part 12 for the cross section transition is arranged between the holding part 13 and the capillary part 11, the manufacturing process is simple, and the visual effect on the appearance can be improved.

Alternatively, the inner diameter Φ1 of the capillary portion 11 is 0.4 to 0.8mm, the inner diameter Φ2 of the transition tube portion 12 is 1 to 2.5mm, the inner diameter Φ3 of the connection tube portion 14 is 3 to 6mm, the holding portion 13 and the connection tube portion 14 may be formed as an integral tube having the same inner diameter, and the recess portion 131 for facilitating holding is formed on the tube body.

Optionally, the length L1 of the capillary portion is: 20-30 mm; the length L2 of the transition pipe portion is: 30-40; the overall length L3 of the hand-held portion 13 and the connecting portion 14 is: 30-40.

In one embodiment, the capillary portion 11 has an inner diameter Φ1 of 0.6mm, a length L1 of 16mm, an inner diameter Φ2 of the transition tube portion 12 of 2mm, a length L2 of 20mm, an inner diameter Φ3 of the grip portion 13 and the connection portion 14 of 4mm, and an overall length L3 of the grip portion 13 and the connection portion 14 of 30mm.

It will be appreciated that the size of the transfer tube 10 is not limited to that shown above, and that the size of the transfer tube in this embodiment is set to be suitable for transfer of a biopsy sample of blasts, and the size of the transfer tube 10 may be varied as desired, such as the type of biopsy sample to be transferred, or the droplet size required for the biopsy sample, etc.

According to another aspect of the present application there is also provided a biopsy sample transfer device comprising a transfer tube 10 as above and a pushing device 20 for connection with the connecting tube portion 14 of the transfer tube 10.

The pushing device 20 may include a cylinder 21 and a piston rod 22 located in the cylinder 21, the connecting pipe 14 of the transfer pipe 10 may be connected to the connecting end 211 of the cylinder 21, and pushing the piston rod 22, the piston rod 22 may push the gas in the cylinder 21, so as to push out the liquid droplets in the transfer pipe 10.

Alternatively, the pushing device 20 may be a syringe, or other devices or means capable of performing a similar function.

The following describes a specific procedure for transferring a biopsy sample of blasts using the biopsy sample transfer apparatus provided herein.

As shown in fig. 3, a biopsy sample of blasts is removed from blasts and placed in a culture dish 30, where the dish 30 has a plurality of droplets, such as a first droplet 31, a second droplet 32, and a third droplet 33, although other numbers of droplets may be provided, and the biopsy sample is transferred to the second droplet 32 (using a device such as a glass transfer tube) after the first droplet 31 is washed, and then to the third droplet 33 after the second droplet 32 is washed.

The transfer tube 10 may then be held by hand, and the capillary portion 11 of the transfer tube 10 is brought gradually closer to the third droplet 33 under the magnification of the microscope, and the capillary portion 11 aspirates the third droplet 33 containing the living sample 34 under the capillary action.

The pushing device 20 is connected with the transfer tube 10, the liquid drop containing the biopsy sample 34 in the transfer tube 10 is pushed into the EP tube by the pushing device 20, the liquid drop containing the biopsy sample 34 can be seen to adhere to the tube wall by a microscope, the cover of the EP tube is covered, the seal is closed, and then the test is performed.

The biopsy sample transferring device is stable and simple in sample transferring operation, easy to operate and high in transferring rate up to 100%.

The foregoing description of the preferred embodiments of the present utility model is not intended to limit the utility model to the precise form disclosed, and any modifications, equivalents, and alternatives falling within the spirit and principles of the present utility model are intended to be included within the scope of the present utility model.

Claims

1. A transfer tube for transferring a biopsy sample, the transfer tube comprising:

2. The transfer tube of claim 1, further comprising a handle portion having a tubular structure in communication with the capillary portion, the connecting tube portion being disposed at an end of the handle portion distal from the capillary portion.

3. A transfer tube according to claim 2, wherein opposite sides of the grip are formed with recesses for holding.

4. The transfer tube of claim 2, wherein the transfer tube further comprises a transition tube portion;

the transition pipe portion is communicated with the capillary portion and the handheld portion, and the cross-sectional area of the transition pipe portion is larger than the cross-sectional area of the capillary portion and smaller than the cross-sectional area of the handheld portion.

5. A transfer tube according to claim 1, wherein the capillary portion has an inner diameter Φ1 of 0.4-0.8 mm.

6. A transfer tube according to claim 1, wherein the connecting tube portion is arranged to fit over and to be a tight fit with the connecting end of the pushing device.

7. The transfer tube according to claim 4, wherein the capillary portion has an inner diameter Φ1 of 0.4 to 0.8mm, the transition tube portion has an inner diameter Φ2 of 1 to 2.5mm, and the connecting tube portion has an inner diameter Φ3 of 3 to 6mm.

8. The transfer tube of claim 4, wherein the capillary portion has a length L1 of: 20-30 mm;

and/or, the length L2 of the transition pipe portion is: 30-40 mm;

and/or, the overall length L3 of the holding portion and the connecting tube portion is: 30-40 mm.

9. A biopsy sample transfer device, comprising a transfer tube according to any one of claims 1-8 and a pushing device for connection with the connecting tube portion of the transfer tube.

10. The biopsy sample transfer apparatus of claim 9, wherein the pushing means is a syringe.