CN219201079U

CN219201079U - Blood sample diluting and mixing device for blood cell analyzer and blood cell analyzer

Info

Publication number: CN219201079U
Application number: CN202320084629.3U
Authority: CN
Inventors: 刘佳; 朱剑焕; 张晓楠; 王明栋
Original assignee: Shanghai Aopu Biomedical Co ltd
Current assignee: Shanghai Aopu Biomedical Co ltd
Priority date: 2023-01-29
Filing date: 2023-01-29
Publication date: 2023-06-16
Anticipated expiration: 2033-01-29

Abstract

The utility model provides a blood sample dilution mixing device and blood cell analyzer for blood cell analyzer, blood sample dilution mixing device includes dilution pond and mixing mechanism, the dilution pond includes mixing chamber, spills over the liquid room, mixing mechanism includes motor, transmission structure, stirring rod, mixing chamber with spill the liquid room form in the inside of dilution pond, mixing chamber with the upper portion of spills the liquid room is formed with the opening that is linked together, transmission structure is connected to respectively the motor with the stirring rod, so that the motor drives stirring rod rotary motion, stirring rod part stretches into mixing chamber is in order to mix diluent and plasma.

Description

Blood sample diluting and mixing device for blood cell analyzer and blood cell analyzer

Technical Field

The present disclosure relates to the field of blood cell analysis, and more particularly, to a blood sample dilution and mixing device for a blood cell analyzer and a blood cell analyzer.

Background

The blood cell analyzer is also called a blood cell analyzer, a hemocytometer, a blood cell counter and the like, and is one of the very wide instruments for clinical examination in hospitals. One of the important development directions of the blood cell analyzer is to gradually increase the automation degree of the blood cell analyzer so as to improve the accuracy and convenience of analysis and detection of the blood cell analyzer. Common blood cell analyzers generally comprise a sample injection mechanism, a sampling mechanism, a detection mechanism, a sample withdrawal mechanism, a data transmission device and the like.

Diluting and mixing the blood sample to be detected is a necessary pretreatment link for blood cell analysis. Most semiautomatic blood cell analyzers are not provided with an in-machine blood sample dilution and mixing device, which may result in poor repeatability of blood sample detection and lower accuracy of detection values. And the service life of part of detection components can be reduced.

Some blood cell analyzers are only provided with two mechanical arms to respectively realize the functions of adding diluent and uniformly mixing blood samples. The structure cost of the blood sample diluting and mixing mechanism is higher, the operation efficiency is low while a larger instrument internal movement space is needed, and the blood sample detection speed is greatly influenced.

Meanwhile, in the actual use process, the diluting mechanism and the mixing mechanism in the existing blood cell analyzer sometimes cause the diluent to overflow the diluting container due to equipment failure or operator error. The overflowed diluent has certain corrosiveness, can pollute and corrode the internal structure of the blood cell analyzer, and reduces the accuracy and durability of the device.

Patent application CN110398600a discloses an automatic blood sample mixing device and blood cell analysis equipment, the mixing device comprises a body and a vibration module. Be equipped with test tube storehouse on the body, vibration module includes first drive unit, eccentric block and test tube support module. The test tube support module, the first driving unit and the eccentric block are sequentially connected. The test tube support module is used for propping against the bottom of the blood sample collection test tube so as to contain the blood sample collection test tube in the test tube bin. The first driving unit drives the eccentric block to rotate so as to drive the test tube supporting module and the bottom of the blood sample collecting test tube to do swinging motion, so that the blood sample in the blood sample collecting test tube is uniformly mixed. The blood cell analysis equipment comprises a mixing device and an automatic feeding device.

The automatic blood sample mixing device and the blood cell analysis equipment provided by the patent application are mixing equipment designed for 'peripheral blood samples' with smaller sample size, so as to replace the traditional operation of manually shaking and mixing peripheral blood samples. The device has the advantages of complex structure and relatively high manufacturing cost, and is not suitable for being applied to the uniform mixing operation of the common venous blood sample. And the device does not provide the function of diluting the blood sample nor is it designed to prevent spillage of the diluent.

Disclosure of Invention

The present application has been made in view of the state of the art described above. The utility model aims at providing a simple structure, small in size's blood sample dilution mixing device for blood cell analyzer, this blood sample dilution mixing device can realize carrying out automatic dilution and mixing to the blood sample that awaits measuring and prevent that diluent from spilling over to the outside of blood sample dilution mixing device. The application also provides a blood cell analyzer using the blood sample dilution and mixing device.

Embodiments of the present application provide a blood sample dilution and mixing device for a blood cell analyzer, the blood sample dilution and mixing device comprising a dilution tank and a mixing mechanism,

the dilution tank comprises a mixing chamber and an overflow liquid chamber, the mixing mechanism comprises a motor, a transmission structure and a stirring rod,

the mixing chamber and the overflow chamber are formed in the dilution tank, the upper parts of the mixing chamber and the overflow chamber are provided with communicated openings,

the transmission structure is respectively connected to the motor and the stirring rod so that the motor drives the stirring rod to rotate,

the stirring rod part extends into the mixing chamber to mix the diluent with the plasma.

In at least one possible embodiment, the dilution tank further comprises a dilution liquid loading port, a waste liquid outlet, an overflow liquid outlet,

the diluent sample adding port is arranged at the upper part of the mixing chamber and is used for adding diluent into the mixing chamber;

the waste liquid outlet is arranged at the lower part of the mixing chamber and is used for discharging waste liquid from the mixing chamber;

the overflow outlet is arranged at the lower part of the overflow chamber and is used for discharging overflow liquid from the overflow chamber.

In at least one possible embodiment, the dilution tank further comprises a flow channel for connecting the mixing chamber and the overflow chamber,

the runner is connected to one end of the mixing chamber higher than one end of the runner connected to the overflow liquid chamber.

In at least one possible embodiment, the stirring rod comprises a stirring head formed at an upper end thereof,

the stirring head is provided with two first stirring surfaces and two second stirring surfaces,

the two first stirring surfaces and the axis of the stirring rod form an included angle, the orthographic projection of the two first stirring surfaces along the axial direction of the stirring rod is symmetrical,

the two second stirring surfaces are formed on the side surfaces of the stirring rod and are parallel to the axis of the stirring rod.

In at least one possible embodiment, the two first stirring surfaces form an angle of 45 degrees with the axis of the stirring rod, an angle of 90 degrees is formed between the two first stirring surfaces,

the two second stirring surfaces are parallel to each other.

In at least one possible embodiment, the dilution tank further comprises a waste outlet,

the waste liquid outlet is arranged at the lower part of the mixing chamber and is the same as the second stirring surface of the stirring head in height.

In at least one possible embodiment, the mixing mechanism further comprises a base, one or more bearings,

the dilution tank and the motor are arranged on the base,

the stirring rod is provided with a protruding part which is axially limited by the base,

the one or more bearings are disposed within the base,

the stirring rod passes through the inner ring of the one or more bearings.

In at least one possible embodiment, the mixing mechanism further comprises a sealing ring and a sealing gasket,

the sealing ring is arranged between the base above the protruding part and the stirring rod,

the sealing gasket is arranged between the sealing ring and the stirring rod.

In at least one possible embodiment, the transmission structure is a synchronous pulley structure,

the transmission structure comprises two synchronous wheels and a synchronous belt,

the two synchronous wheels are in transmission connection through the synchronous belt,

the two synchronous wheels are respectively connected to the motor and the stirring rod, so that the motor drives the stirring rod to rotate.

Embodiments of the present application also provide a blood cell analyzer,

the device comprises a sampling needle mechanism and a detection unit; and

the blood sample diluting and mixing device for the blood cell analyzer,

the sampling needle mechanism is capable of adding a blood sample to the blood sample dilution and mixing device and transferring the diluted blood sample to the detection unit.

Drawings

Fig. 1 is a schematic structural view of a blood sample dilution and homogenization device according to an embodiment of the present application.

Fig. 2 is a schematic cross-sectional structure of a blood sample dilution and mixing apparatus according to an embodiment of the present application.

Fig. 3 is a schematic structural view of a stirring rod according to an embodiment of the present application.

Fig. 4 is an enlarged view of a portion of the blood sample dilution and mixing apparatus of fig. 2.

Description of the reference numerals

10. Dilution tank

11. Dilution liquid sample adding port

12. Waste liquid outlet

13. Overflow outlet

14. Mixing chamber

15. Spill liquid chamber

16. Flow passage

20. Mixing mechanism

21. Motor with a motor housing

211. Motor shaft

22. Base seat

23. Transmission structure

231. Synchronous wheel

232. Synchronous belt

24. Stirring rod

241. Stirring head

2411. First stirring surface

2412. Second stirring surface

242. Projection part

243. Rod body

25. Bearing

26. Retainer ring

27. Sealing ring

28. Sealing gasket

Detailed Description

Exemplary embodiments of the present application are described below with reference to the accompanying drawings. It should be understood that these specific descriptions are merely illustrative of how one skilled in the art may practice the present application and are not intended to be exhaustive of all of the possible ways of practicing the present application nor to limit the scope of the present application.

In this application, "drive coupling" refers to a torque-transmittable connection between two components, including direct or indirect connection of the two components.

Embodiments of the present application provide a blood sample dilution and mixing apparatus (hereinafter sometimes simply referred to as "blood sample dilution and mixing apparatus") for a blood cell analyzer, as shown in fig. 1, which may include a dilution tank 10 and a mixing mechanism 20.

The dilution tank 10 may include a dilution liquid loading port 11, a waste liquid outlet 12, an overflow liquid outlet 13, a mixing chamber 14, an overflow liquid chamber 15, and a flow channel 16.

Specifically, as shown in fig. 1 and 2, a mixing chamber 14 is formed in the dilution tank 10, and an opening is formed in an upper portion of the mixing chamber 14. The dilution tank 10 is provided with a dilution liquid sample inlet 11 and a waste liquid outlet 12 at the outside thereof, and a mixing chamber 14 is respectively connected to the dilution liquid sample inlet 11 and the waste liquid outlet 12. The diluent inlet 11 may be located relatively at the upper portion of the mixing chamber 14, and the waste outlet 12 may be located relatively at the lower or bottom portion of the mixing chamber 14.

The diluent inlet 11 may be connected to a plunger pump, and the diluent is added to the mixing chamber 14 through the diluent inlet 11 by the plunger pump. The waste outlet 12 may be connected to a peristaltic pump, which brings waste from the mixing chamber 14 through the waste outlet 12. It will be appreciated that the plunger pump and peristaltic pump may be replaced by other types of pumps.

The diluent and the blood sample in the mixing chamber 14 may overflow from the mixing chamber 14 due to equipment failure, human error, or the like. The dilution tank 10 may be formed with an overflow chamber 15 and a flow passage 16 inside. The overflow chamber 15 has an opening in the upper part thereof, and the upper opening of the overflow chamber 15 can be connected to the upper opening of the mixing chamber 14 by a flow passage 16. The flow channel 16 is connected to the mixing chamber 14 at an end higher than the end thereof connected to the overflow chamber 15 so that liquid overflowed from the mixing chamber 14 can spontaneously flow to the overflow chamber 15. The overflow outlet 13 may be provided at a lower portion (including a bottom surface) of the dilution tank 10 and communicate with the overflow chamber 15, and the liquid stored in the overflow chamber 15 may be discharged through the overflow outlet 13.

Preferably, the diluent addition port 11 is located below the junction of the flow channel 16 and the mixing chamber 14.

Preferably, the cross section of the bottom surface of the flow channel 16 may be an arc surface so that the overflow smoothly flows to the overflow chamber 15.

As shown in fig. 1 and 2, the mixing mechanism 20 may include a motor 21, a base 22, a transmission structure 23, a stirring rod 24, a bearing 25, a retainer ring 26, and a seal ring 27.

Specifically, as shown in fig. 1 and 2, the motor 21 may be disposed at one side of the dilution tank 10 and may be closely adjacent to the dilution tank 10 to save installation space. The motor 21 may extend downward beyond the motor shaft 211. The base 22 may be connected to the dilution tank 10 (illustratively, the base 22 is connected below the mixing chamber 14), and the motor 21 may be disposed on the base 22. Illustratively, the motor 21 may be bolted to the base 22.

A transmission structure 23 may be disposed under the base 22, and the transmission structure 23 may be a synchronous pulley structure, for example. The transmission structure 23 may comprise two synchronizing wheels 231 and a timing belt 232. Two synchronizing wheels 231 may be respectively connected to the motor shaft 211 and the stirring rod 24, so that the stirring rod 24 can rotate along with the motor shaft 211 to stir the diluent and the blood in the mixing chamber 14. It will be appreciated that the center of the synchronizing wheel 231 may have a hole that allows the motor shaft 211 or the stirring bar 24 to pass through or partially pass through. The two synchronizing wheels 231 are drivingly connected by a timing belt 232, i.e., the timing belt 232 is respectively connected to the outer peripheral surfaces of the two synchronizing wheels 231.

It will be appreciated that the transmission structure 23 is not limited to a synchronous pulley structure, and that, for example, gear transmission, chain transmission, worm gear transmission, etc. may be used.

The stirring rod 24 may be limited by the base 22 and the stirring rod 24 may be disposed at the bottom of the mixing chamber 14. The rotational movement of the motor shaft 211 can be transmitted to the stirring bar 24 by means of the transmission 23. Specifically, as shown in fig. 2, 3 and 4, the stirring rod 24 may include a stirring head 241, a protrusion 242 and a rod body 243. A stirring head 241 is formed at the upper end of stirring bar 24 and may extend into or partially into mixing chamber 14. A protruding part 242 is formed below the stirring head 241, and the protruding part 242 can be buckled with a groove in the base 22 to form axial limit of the base 22 to the stirring rod 24. As shown in fig. 4, a seal ring 27 is provided between the base 22 and the stirring head 241 above the projection 242, and a seal gasket 28 is provided between the seal ring 27 and the stirring head 241 to seal between the stirring head 241 and the base 22. The sealing gasket 28 may also extend upward from the junction of the sealing ring 27 and the stirring rod 24 to seal the mixing chamber 14 from the base 22 to avoid sample contamination in the mixing chamber 14. Referring to fig. 4, the gasket 28 may be a hollow umbrella-shaped gasket, the cylindrical portion of which may be pressed against the stirring head 241, and the canopy portion of which may be pressed against the (peripheral) bottom surface of the mixing chamber 14. A rod body 243 is formed below the protrusion 242 of the stirring rod 24, and the rod body 243 may pass through an inner ring of one or more bearings 25, and the one or more bearings 25 are disposed in the base 22. Illustratively, two bearings 25 are provided. The two axial end surfaces of the bearing 25 may be provided with retainers 26, respectively. It will be appreciated that in the case of overlapping two bearings 25, the collar 26 may not be provided between the adjacent axial end faces of the two bearings.

Preferably, the retainer ring disposed above the bearing 25 may be a hole retainer ring, and the retainer ring disposed below the bearing 25 may be a shaft retainer ring.

Preferably, the bearings 25 are roller bearings.

Preferably, as shown in fig. 3, the stirring head 241 may be formed with two first stirring surfaces 2411 and two second stirring surfaces 2412. Specifically, the first stirring surface 2411 may be a partial inclined cross section (slope surface) of the stirring rod 24, and the areas and shapes of the two first stirring surfaces 2411 may be the same, which have an included angle with the axis of the stirring rod 24. The projections of the two first stirring surfaces 2411 on the horizontal plane may be symmetrical (when the axis of the stirring rod 24 is perpendicular to the horizontal plane), i.e. the projections of the two first stirring surfaces 2411 along the axial direction of the stirring rod 24 may be symmetrical.

Preferably, the angle between the first stirring surface 2411 and the axis of the stirring rod 24 may be 45 degrees, i.e., the angle between the two first stirring surfaces 2411 may be 90 degrees.

The second stirring surface 2412 may be formed at a side of the stirring head 241 and may be connected to the first stirring surface 2411. The second stirring surface 2412 may be a cross section parallel to the axial direction of the stirring rod 24 and perpendicular to the first stirring surface 2411. The two second stirring surfaces 2412 may have the same area and shape and may be parallel to each other. Illustratively, as shown in FIG. 3, the second stirring surface 2412 is approximately triangular in cross-section.

It will be appreciated that parameters such as the angle and position of first stirring surface 2411 and second stirring surface 2412 of stirring head 241 may vary, and that the foregoing provides only one preferred stirring head example.

During rotation of the stirring rod 24, the first stirring surface 2411 mainly plays a role in stirring the diluent and the blood sample, and the second stirring surface 2412 is mainly used for assisting the peristaltic pump in sufficiently discharging the liquid in the mixing chamber 14 during discharging the waste liquid. It will be appreciated that in order to better assist in the drainage of waste liquid from the stirring bar 24 (and in particular the second stirring surface 2412), the waste liquid outlet 12 may be located near the position of the stirring head 241 of the stirring bar 24 (and in particular may be at the same height as the position of the second stirring surface 2412).

As shown in fig. 3 and 4, the stirring head 241 may be formed with a cylindrical surface adjacent to the protrusion 242, and the diameter of the cylindrical surface may be close to the diameter of the mixing chamber 14. Further, the segment of cylindrical surface may extend axially to a side of the stirring head 241 adjacent to the first stirring surface 2411 and the second stirring surface 2412 to form a partial cylindrical surface. This structure can make the stirring head 241 fully discharge the liquid at the bottom of the mixing chamber 14 during the rotary motion, and avoid the liquid remaining in the gap between the stirring rod 24 and the mixing chamber 14 to cause sample contamination.

The flow of the blood sample dilution and homogenization device for a blood cell analyzer provided by the present application is briefly described below.

The diluent is added into the mixing chamber 14 through the diluent sample adding port 11 by a plunger pump, and the motor 21 of the mixing mechanism 20 drives the stirring rod 24 to stir the diluent in a rotating way through the transmission structure 23. A sampling needle mechanism in the blood cell analyzer takes out a blood sample (whole blood sample) from a sample tube, and adds the blood sample to the mixing chamber 14 to mix with the diluent uniformly. The blood sample mixed with the diluent is drawn by the sampling needle mechanism and transferred to the detection unit. The residual liquid in the mixing chamber 14 is discharged from the waste liquid outlet 12 by a peristaltic pump in cooperation with the stirring rod 24. When the liquid overflows from the mixing chamber 14 due to instrument failure or human operation error, the overflowed liquid is discharged into the overflowed liquid chamber 15 along with the flow channel 16 for storage, and can be discharged from the overflowed liquid outlet 13.

The embodiment of the application also provides a blood cell analyzer, which comprises the blood sample diluting and mixing device, a sampling needle mechanism and a detection unit.

Some of the advantageous effects of the above-described embodiments of the present application are briefly described below.

(1) The embodiment of the application provides a blood sample dilution mixing device and blood cell analyzer for blood cell analyzer, it can realize that automatic dilution and mixing operation are carried out to blood sample in the blood cell analysis process, can replace traditional manual dilution to shake the work of even blood sample, promotes blood analysis detection efficiency.

(2) The embodiment of the application provides a structure volume that is used for blood cell analyzer's blood sample dilution mixing device is less, only needs to occupy less installation space, easy to install and maintain.

(3) The embodiment of the application provides a blood sample dilution mixing device for blood cell analyzer and blood cell analyzer is furnished with overflow liquid chamber and overflow liquid mouth, when the circumstances such as system failure take place, can make the diluent that overflows get into the overflow liquid chamber and follow overflow liquid mouth and discharge, and can not remain inside the blood cell analyzer.

It is to be understood that in the present application, when the number of parts or members is not particularly limited, the number may be one or more, and the number herein refers to two or more. For the case where the number of parts or members is shown in the drawings and/or described in the specification as a specific number such as two, three, four, etc., the specific number is generally illustrative and not restrictive, it may be understood that a plurality, i.e., two or more, but this does not mean that the present application excludes one.

It should be understood that the above embodiments are merely exemplary and are not intended to limit the present application. Those skilled in the art can make various modifications and changes to the above-described embodiments without departing from the scope of the present application.

Claims

1. A blood sample diluting and mixing device for a blood cell analyzer is characterized by comprising a diluting tank and a mixing mechanism,

2. The dilution and homogenization device for a blood sample of a blood cell analyzer of claim 1, wherein the dilution tank further includes a diluent loading port, a waste liquid outlet, and an overflow outlet,

3. The dilution and mixing apparatus for a blood sample of a blood cell analyzer according to claim 1, wherein said dilution tank further comprises a flow passage for connecting said mixing chamber and said spill liquid chamber,

4. The dilution and homogenization device for a blood cell analyzer of claim 1, wherein the stirring rod includes a stirring head formed at an upper end thereof,

5. The dilution and mixing apparatus for a blood sample of a blood cell analyzer according to claim 4, wherein the two first stirring surfaces are disposed at an angle of 45 degrees to the axis of the stirring rod, and the two first stirring surfaces are disposed at an angle of 90 degrees,

the two second stirring surfaces are parallel to each other.

6. The dilution and homogenization device for a blood cell analyzer of claim 4, wherein the dilution tank further includes a waste liquid outlet,

7. The dilution and mixing apparatus for a blood sample of a blood cell analyzer of claim 1, wherein the mixing mechanism further comprises a base, one or more bearings,

the dilution tank and the motor are arranged on the base,

the one or more bearings are disposed within the base,

the stirring rod passes through the inner ring of the one or more bearings.

8. The dilution and mixing apparatus for a blood sample of a blood cell analyzer according to claim 7, wherein the mixing mechanism further comprises a seal ring and a seal gasket,

the sealing gasket is arranged between the sealing ring and the stirring rod.

9. The device for diluting and mixing blood samples for a blood cell analyzer according to claim 1, wherein the transmission structure is a synchronous pulley structure,

10. A blood cell analyzer is characterized in that,

comprises a sampling needle mechanism and a detection unit; and

the dilution and homogenization device for a blood sample of a blood cell analyzer of any one of claim 1 to 9,