A kind of novel a small amount of blood sample automatic mixing system and device that is applicable to
One, technical field
A kind of novel a small amount of blood sample automatic mixing system and device that is applicable to, can make sample in the sample hose (such as blood sample) just can fully be continued mixing need not the capping state, and guarantee that sample (blood sample) is not excessive, can satisfy again simultaneously the automated analysis instrument takes out easily sample also or adds reagent when stopping this evenly mixing device is of short duration at any time from sample hose, and operating steadily of this device is suitable as the evenly mixing device of rigorous analysis detecting instrument.This device can be used as the parts of automatic precision analytical instrument, bear sample (blood sample) is continued abundant mixing and guarantees to make things convenient for instrument automatically to sample automatic sampling in the sample hose, and assist the automated analysis instrument to finish whole automatic samples to process and analyte detection process to adding reagent in the sample.This device belongs to the medical test ambit.
Two, background technology
Detect in the analysis of experiments process at some fluid samples (such as whole blood) with easy precipitation composition, often need to continue mixing to fluid sample keeps this sample to be in all the time fully good mixing state, thereby guarantee that by this composition that sample that obtains contains is all even consistent when sampling detects at any time in the sample hose of mixing.Existing evenly mixing device generally is sample mouth of pipe sealing to be put upside down mixing or vibration mixing to sample hose or in the inner magnetic stir bar of placing of sample hose, drives the mode that causes the magnetic stir bar motion by external magnet and realizes continuous mixing to fluid sample.These blending manner should not be added a cover sealing for sample hose, and are difficult to again arrange the internal motivation driving sample that (containing the magnetic force Indirect driven), rabbling mechanism stirred, and original way is all inapplicable.For this reason we designed a kind of sample mouth of pipe open, need not that magnetic force drives the inner stirrer of sample hose and the device of realizing sample in the sample hose is carried out abundant and lasting mixing again, this device can solve the automated analysis instrument and repeatedly take a sample for fluid sample (such as the blood) continuous detecting of uneven distribution and keep sample to continue the needs of mixing, and this device can also satisfy in the instrument automatic analysis process at any time the needs that add reagent in the sample hose.Simultaneously, this device motion is steady, quiet, without transient vibration and noise, therefore is more suitable for the rigorous analysis detecting instrument and uses.
Three, summary of the invention
The technical problems to be solved in the utility model is a kind of novel a small amount of blood sample automatic mixing system and device that is applicable to.The utility model design a kind of novel is applicable to a small amount of blood sample automatic mixing system and device, this system and device by: drive motor 1, load sample platform 4, sample hose 5, motor and load sample platform coupling arrangement 2 and load sample platform location code-disc 3 with locate the critical pieces such as positioning system that light lotus root 8 forms and form.Wherein sample hose 5 is that a cylindrical inner is the hollow tubular thing, and it is suitable for reading to be open ports, the little large inverted trapezoidal in bottom semisphere or the end or taper, and be closed.This sample hose length is not more than 100mm, interior diameter is not more than 15mm.In addition, can also in sample hose, add proportion greater than by the agitation beads 11 of mixing sample for strengthening Blending Efficiency of Blending.Be the Quality control temperature, on the application of sample platform, can also install heating rotary device 7, temp probe 6 and temperature-control circuit etc. additional so that the temperature of application of sample platform is well controlled.This device is fit to the automated analysis instrument to detections of repeatedly taking a sample of a small amount of sample, and keeps simultaneously that sample continues to be in the mixing state in the sample hose, can satisfy in addition in the sample blending process at any time in the sample hose several functions needs such as adding reagent.
In load sample platform loading grade, put into during this device work be equipped with a small amount of blood sample (less than the sample hose total measurement (volume) 10%) sample hose, the load sample platform of this mixing system and device single or the sample hose that makes as the center of circle take the sample hose vertical position as starting point take load sample platform axle center repeatedly under the driving of drive motor become respectively to be not more than to the left and right the crankmotion of 90 ° (both sides accumulative total is not more than 180 °).I.e. this device motion or when static under the sample hose mouth lowest part 12 on edge be higher than all the time sample hose bottom sample liquid level 10, the sample (blood sample) during this device work in the sample hose occurs mobile so that sample obtains abundant mixing with the deflection of sample hose.For strengthening the stirring to sample, also can in sample hose, add proportion greater than the spherical stirring pearl of sample, the rolling reinforcement also occurs to the mixing of sample (blood sample) with sample hose angular deflection in agitation beads when sample hose deflection.The distance that outer, liquid inclined-plane should be controlled with the sample mouth of pipe in load sample platform when motion sample hose is not less than 1 centimetre.Needs to sample hose in the as required at any time stop motion of evenly mixing device when maybe needing to add reagent of sample when sampling, be convenient to instrument by taking out sample in the sample hose.The state of sample stage motion and the position that stops to be determined by the fixing location code-disc in sample stage bottom and supporting location optocoupler, generally this device should stop at sample hose vertically, sample hose opening upwards position is convenient to self-reacting device and takes out sample in the sample hose.The load sample platform can be that the load sample platform directly is connected with motor shaft by shaft coupling with the connected mode of motor, and the load sample platform also can pass through the modes such as belt, connecting rod and be connected with motor.Heating arrangement 7 can also be set the load sample platform and temp probe 6 keeps suitable temperature with control load sample platform.
Four, description of drawings
Accompanying drawing 1. is a kind of novel cut-open view that is applicable to a small amount of blood sample automatic mixing system and device.
Accompanying drawing 2. is a kind of novel vertical view that is applicable to a small amount of blood sample automatic mixing system and device.
Accompanying drawing 3. is a kind of novel sample hose cut-open view that is applicable to be equipped with in a small amount of blood sample automatic mixing system and device sample and agitation beads.
Accompanying drawing 4. designs the sample stereographic map for a kind of novel a small amount of blood sample automatic mixing system and device that is applicable to.
Among the figure, 1, drive motor, 2, shaft coupling, 3, code-disc, 4, the load sample platform, 5, sample hose, 6, temp probe, 7, heating rod, 8, the location optocoupler, 9, control system, 10, sample, 11, agitation beads, 12, edge under the sample mouth of pipe.
Design is further described to this utility model below in conjunction with accompanying drawing:
As shown in Figure 1, sample hose 5 is placed in the load sample platform sample position of mixing system and device of the utility model design, agitation beads and a certain amount of blood sample are put into sample hose; The sample hose length of this evenly mixing device is not more than 100mm, interior diameter is not more than 15mm, the little large inverted trapezoidal in the one-tenth end, pipe bottom or semisphere or taper; Start drive motor and drive sample stage by shaft coupling and come and go to do less than 180 ° at surface level and rotatablely move, namely the one-sided anglec of rotation in the sample body left and right sides all is not more than 90 °, and sample body and surface level are at a certain angle all the time.Location code-disc 3 cooperates the location status of determining load sample platform (sample hose) with location optocoupler 8, sample hose is remained when the sample mouth of pipe moves to the most closely the plane, all the time be higher than in the sample hose plane on the sample liquids along 12 under its sample mouth of pipe, guarantee that namely blood sample can not overflow the sample mouth of pipe in the sample hose; Determine that simultaneously the position that sample hose stops to be generally vertical state.In addition, at the load sample platform heating rod 7 and temp probe 6 are set, guarantee to be in all the time in the sample hose temperature constant state.Total system motion, stop and temperature control etc. all has control circuit, software to cooperate with corresponding hardware to work in coordination with and finishes.