CN219051657U - Porous magnetic separation frame - Google Patents

Abstract

The utility model discloses a porous magnetic separation frame, which belongs to the technical field of biology, and comprises a base, wherein the upper end of the base is fixedly connected with two side support external-open plates, the inner ends of the two side support external-open plates are both in sliding connection with a pressing connecting rod.

Description

Porous magnetic separation frame

Technical Field

The utility model relates to the technical field of biology, in particular to a porous magnetic separation frame.

Background

The magnetic separation frame is also called a magnetic separation frame, a magnetic bead separation frame or a magnetic frame, is mainly used for the solid-liquid rapid separation of magnetic particles, and is a necessary device for carrying out experiments such as nucleic acid extraction or purification, antibody or protein purification, immunoprecipitation and the like based on a magnetic bead method.

The position of the magnet in the existing magnetic separation frame is fixed, the height of the magnet cannot be adjusted, when the liquid amount in the reagent tube is particularly small, an experimenter is required to manually lift the reagent tube to enable the magnetic beads in the small-volume liquid to be in contact with the magnetic field, and the use mode is inconvenient, so that the porous magnetic separation frame convenient for adjusting the position of the magnet is required to be designed to solve the problem.

Disclosure of Invention

1. Technical problem to be solved

Aiming at the problems existing in the prior art, the utility model aims to provide a porous magnetic separation frame, when the porous magnetic separation frame is used, a reagent tube body can be placed into a corresponding inner hole to be inserted and combined, the lower end tube wall of the reagent tube body is close to the center of a magnet body, so that the magnetic separation efficiency is maximized, meanwhile, separated magnetic beads are gathered on the lower end side wall of the reagent tube body instead of the tube bottom, a pipette or other suction heads of a liquid suction device can conveniently contact the tube bottom to thoroughly suck up supernatant, and when the liquid amount in the reagent tube body is extremely small, a pressing connecting rod can be pressed down to enable the position of the magnet body to move downwards, so that the magnetic beads in small-volume liquid contact a magnetic field, and an experimenter is not required to manually lift the reagent tube body, so that the use mode is more humanized.

2. Technical proposal

In order to solve the problems, the utility model adopts the following technical scheme.

The utility model provides a porous magnetic separation frame, includes the base, the upper end fixedly connected with two side of base struts the external-open board, two the equal sliding connection of inner of side struts the external-open board presses the connecting rod, press the connecting rod to be located the part fixedly connected with a plurality of magnet bodies of side struts the external-open inboard, two the upper end fixedly connected with top cardboard of side struts the external-open board, a plurality of holes have been seted up to the upper end of top cardboard, and a plurality of holes cooperate with corresponding magnet body respectively, two lower edge grooves that lie in side struts the external-open board lower extreme have been seted up to the inner of side struts the external-open board, can at first place the reagent pipe body into the lower extreme of correspondence in the groove of inserting the connection, the lower extreme pipe wall of reagent pipe body pastes magnet body central authorities to make magnetic separation efficiency maximize, simultaneously, the magnetic bead after the separation gathers in reagent pipe body lower extreme lateral wall and non-tube bottom, and the contact tip bottom of the pipette or other device thoroughly absorbs supernatant fluid, and runs into the volume when the reagent pipe body, and the volume of liquid in the special volume of pressing down can be reduced, the position of magnet body is pressed down in the manual mode, the magnetic field is needed to the manual experiment personnel is more to the volume is reduced.

Further, the lower edge groove and the side support outer opening plate are mutually communicated up and down, and the pressing connecting rod and the magnet body on the surface of the pressing connecting rod can move into the lower edge groove.

Further, two side inner grooves close to the lower edge grooves are formed in the inner end of the base, and one ends, close to each other, of the two side inner grooves are communicated with the corresponding lower edge grooves.

Further, two the inner sliding connection of side inside groove has the sliding plate, two the equal fixedly connected with sponge friction strip of one end that the sliding plate is close to each other, and sponge friction strip and magnet body contact each other, and magnet body and sponge friction strip rub each other, can effectively erase the partial liquid agent that is infected with on the magnet body, avoid producing the corruption to the magnet body, be favorable to guaranteeing the life of magnet body.

Further, the inner end of the inner hole is inserted with a reagent tube body, and the side wall of the reagent tube body is matched with the magnet body.

Further, the specific number of the plurality of magnet bodies is eight, and the specific number of the plurality of inner holes is eight.

3. Advantageous effects

Compared with the prior art, the utility model has the advantages that:

(1) When this scheme was used porous magnetic separation frame, can be at first place the reagent pipe body and get into the interior hole that corresponds in inserting, the lower extreme pipe wall of reagent pipe body is close to magnet body central authorities, thereby make magnetic separation efficiency maximize, simultaneously, the magnetic bead after the separation gathers in reagent pipe body lower extreme lateral wall and not the tube bottom, the suction head contact tube bottom of the pipette or other liquid absorbing device of being convenient for thoroughly absorbs the supernatant, and when meetting reagent pipe body liquid volume very little, can push down the position that presses the connecting rod and make magnet body down move, make the magnetic bead contact magnetic field in the small volume liquid, no longer need the manual reagent pipe body of pulling of laboratory personnel, the mode of use is more humanized.

(2) Simultaneously still set up the lower edge groove of mutual intercommunication in the lower extreme of side stay external-open board, after single separation operation is accomplished, can push down two pressing connection bars and push down a plurality of magnet bodies to down in the groove, make its and two sponge friction strips on the sliding plate rub each other, can effectively erase the partial liquid agent that is infected with on the magnet body, avoid producing the corruption to the magnet body, be favorable to guaranteeing the life of magnet body.

Drawings

FIG. 1 is a schematic view of the axial structure of a magnetic separator body according to the present utility model;

FIG. 2 is a schematic view of the structure of the present utility model shown in FIG. 1 at a partially enlarged scale;

fig. 3 is a schematic view showing a pulled-out state structure of the sponge friction strip of the present utility model.

The reference numerals in the figures illustrate:

1. a base; 2. a side inner tank; 3. a sliding plate; 4. pressing the connecting rod; 5. a magnet body; 6. side-supporting outer opening plates; 7. a top card; 8. an inner bore; 9. a sponge friction strip; 10. a lower edge groove; 11. a reagent tube body.

Detailed Description

The technical solutions in the embodiments of the present utility model will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present utility model; it is apparent that the described embodiments are only some embodiments of the present utility model, not all embodiments, and that all other embodiments obtained by persons of ordinary skill in the art without making creative efforts based on the embodiments in the present utility model are within the protection scope of the present utility model.

In the description of the present utility model, it should be noted that the positional or positional relationship indicated by the terms such as "upper", "lower", "inner", "outer", "top/bottom", etc. are based on the positional or positional relationship shown in the drawings, are merely for convenience of describing the present utility model and simplifying the description, and do not indicate or imply that the apparatus or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as limiting the present utility model. Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.

In the description of the present utility model, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "configured to," "engaged with," "connected to," and the like are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present utility model will be understood in specific cases by those of ordinary skill in the art.

Example 1:

referring to fig. 1-3, a porous magnetic separation frame includes a base 1, wherein the upper end of the base 1 is fixedly connected with two side-support external-open plates 6, the inner ends of the two side-support external-open plates 6 are both slidably connected with a pressing connecting rod 4, a plurality of magnet bodies 5 are fixedly connected with a part of the pressing connecting rod 4 located in the side-support external-open plates 6, the upper ends of the two side-support external-open plates 6 are fixedly connected with a top clamping plate 7, a plurality of inner holes 8 are formed in the upper ends of the top clamping plate 7, the plurality of inner holes 8 are respectively matched with the corresponding magnet bodies 5, and two lower edge grooves 10 located at the lower ends of the side-support external-open plates 6 are formed in the inner ends of the side-support external-open plates 6.

Referring to fig. 1-3, the lower edge groove 10 and the side supporting outer opening plate 6 are mutually communicated up and down, the pressing connecting rod 4 and the magnet body 5 on the surface thereof can move into the lower edge groove 10, two side inner grooves 2 close to the lower edge groove 10 are arranged at the inner end of the base 1, one ends of the two side inner grooves 2 close to each other are mutually communicated with the corresponding lower edge groove 10, the inner ends of the two side inner grooves 2 are slidably connected with the sliding plates 3, the sponge friction strips 9 are fixedly connected with one ends of the two sliding plates 3 close to each other, the sponge friction strips 9 are in contact with the magnet body 5, the inner ends of the inner holes 8 are inserted with the reagent tube bodies 11, the side walls of the reagent tube bodies 11 are mutually matched with the magnet body 5, the specific number of the plurality of magnet bodies 5 is eight, and the specific number of the plurality of inner holes 8 is eight.

Referring to fig. 1-3, when using the porous magnetic separation rack, the reagent tube body 11 can be placed into the corresponding inner hole 8 to be inserted, the lower end tube wall of the reagent tube body 11 is close to the center of the magnet body 5, so that the magnetic separation efficiency is maximized, meanwhile, the separated magnetic beads are gathered on the side wall of the lower end of the reagent tube body 11 instead of the tube bottom, so that the pipette or the suction head of other liquid suction devices can contact the tube bottom to thoroughly suck the supernatant, and when the liquid amount in the reagent tube body 11 is extremely small, the pressing connecting rod 4 can be pressed down to enable the position of the magnet body 5 to move downwards, so that the magnetic beads in the small-volume liquid can contact the magnetic field, no experiment personnel are required to manually lift the reagent tube body 11 any more, the use mode is more humanized, meanwhile, the lower end of the side support external opening plate 6 is also provided with the mutually communicated lower edge groove 10, after the single separation operation is completed, the two pressing connecting rods 4 can be pressed down to press the plurality of magnet bodies 5 into the lower edge groove 10, so that the two friction strips 9 on the sliding plate 3 can rub against each other, the magnet body 5 can be effectively prevented from corroding the magnet body 5, and the magnet body 5 can be prevented from being corroded by the liquid.

The above description is only of the preferred embodiments of the present utility model; the scope of the utility model is not limited in this respect. Any person skilled in the art, within the technical scope of the present disclosure, may apply to the present utility model, and the technical solution and the improvement thereof are all covered by the protection scope of the present utility model.

Claims (6)

1. A porous magnetic separation frame, comprising a base (1), characterized in that: the utility model discloses a magnetic iron plate structure, including base (1), magnet body, upper end fixedly connected with top cardboard (7), a plurality of holes (8) have been seted up to the upper end of top cardboard (7), and a plurality of holes (8) cooperate with corresponding magnet body (5) respectively, the lower border groove (10) that are located side propping out of the board (6) lower extreme are seted up to the inner of side propping out of the board (6).

2. A porous magnetic separator frame according to claim 1, wherein: the lower edge groove (10) and the side support outer opening plate (6) are mutually communicated up and down, and the pressing connecting rod (4) and the magnet body (5) on the surface of the pressing connecting rod can move into the lower edge groove (10).

3. A porous magnetic separator frame according to claim 1, wherein: two side inner grooves (2) close to the lower edge groove (10) are formed in the inner end of the base (1), and one ends, close to each other, of the two side inner grooves (2) are communicated with the corresponding lower edge groove (10).

4. A porous magnetic separator frame according to claim 3, characterized in that: the inner ends of the two side inner grooves (2) are slidably connected with sliding plates (3), one ends, close to each other, of the two sliding plates (3) are fixedly connected with sponge friction strips (9), and the sponge friction strips (9) are in contact with the magnet body (5).

5. A porous magnetic separator frame according to claim 1, wherein: the inner end of the inner hole (8) is inserted with a reagent tube body (11), and the side wall of the reagent tube body (11) is matched with the magnet body (5).

6. A porous magnetic separator frame according to claim 1, wherein: the specific number of the plurality of magnet bodies (5) is eight, and the specific number of the plurality of inner holes (8) is eight.

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