CN219010329U - Biological tissue treatment device - Google Patents
Biological tissue treatment device Download PDFInfo
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- CN219010329U CN219010329U CN202320823066.5U CN202320823066U CN219010329U CN 219010329 U CN219010329 U CN 219010329U CN 202320823066 U CN202320823066 U CN 202320823066U CN 219010329 U CN219010329 U CN 219010329U
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- biological tissue
- heating
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- tissue treatment
- heater
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Abstract
The present utility model relates to a biological tissue treatment device comprising a power plug and a heater, wherein: the heater is whole to be flat box-shaped, includes: the top has open casing, sets up at the inside heating pipe of casing and sets up the heat conduction apron of dull and stereotyped shape on the opening, and heat conduction apron top includes one or more and heats the target shape matched and bear the weight of the heating region, and every bears the weight of the heating region and is equipped with a set of screens wire casing with the support frame shape matched of heating target. The heater is provided with the heat conduction cover plate with a flat plate shape and the clamping line groove matched with the shape of the supporting outer frame of the heating object, so that the heater is suitable for placing the heating object such as the biological tissue flat-bottom culture plate with a flat bottom shape. The flat bottom of the heating object is parallel to the heat conduction cover plate, so that the heating object can be heated uniformly; and the supporting outer frame of the heating object can be embedded into the clamping line groove, so that the heating object is stably fixed and is not easy to slide.
Description
Technical Field
The utility model relates to the technical field of biological instruments, in particular to a biological tissue treatment device.
Background
Most cell culture modes are suspension culture. Suspension culture refers to a tissue culture system for culturing single cells and small cell clusters in a liquid medium that is constantly agitated or shaken, a culture mode that is non-anchorage dependent. A conventional cell culture temperature regulating device is shown in FIG. 1 and FIG. 2, wherein 01 is an orifice plate; 02 is an incubator; 03 is a separator; 04 is a slot; 05 is a temperature sensor; 06 is a heating pipe; reference numeral 07 denotes a control panel; 08 is a through slot; 09 is a screen. Referring to the shape of the 01-well plate, the cell culture temperature regulating device is suitable for a culture container (such as a centrifuge tube) with a V-shaped bottom.
However, recent studies have found that stem cells and organoids are more suitable for use in non-suspension culture, i.e., in adherent culture. Stem cells are a class of cells with multipotent differentiation potential, which are widely present in humans. The organoid is differentiated from stem cells, can characterize the development and physiology of organs in vivo in vitro, can carry out drug screening, and provides an advantageous tool for researching the mechanism and pathology of organs of human tissues. The stem cell and organoid culture process typically requires the provision of reasonable temperature conditions and the timed replacement of the medium to maintain the metabolic demands of growth. The stem cells and organoids are more suitable for adherent culture by using biological tissue flat-bottom culture plates. FIG. 3 is a schematic perspective view of a biological tissue flat bottom culture plate 100 for culturing stem cells and organoids. The biological tissue flat bottom plate 100 includes six cylindrical wells 101, the wells 101 for receiving biological tissue culture medium, the bottom being planar. Biological tissue flat bottom culture plate 100 also includes a representation support housing 102. As shown in fig. 4, there is a height difference Δh between the lowest point of the supporting frame 102 and the lowest point of the hole site 101, so that the bottom of the hole site 101 is usually suspended.
The cell culture temperature regulating device shown in fig. 1 and 2 is obviously not applicable to the biological tissue flat bottom culture plate 100 shown in fig. 3 and 4, and thus it is highly desirable to propose a cell treatment device more applicable to the biological tissue flat bottom culture plate.
Disclosure of Invention
In view of the above, the present utility model provides a biological tissue treatment device, which overcomes the technical drawbacks of the prior art and is suitable for heating a biological tissue flat bottom culture plate.
The utility model provides a biological tissue treatment device, which comprises a power plug and a heater, wherein: the heater is whole to be flat box-shaped, includes: the top has open casing, sets up the inside heating pipe of casing and the setting is in the heat conduction apron of flat board shape on the opening, heat conduction apron top includes one or more and heats the object shape matched bear the weight of the heating region, every bear the weight of the heating region be equipped with a set of with the support frame shape matched card position wire casing of heating object.
Optionally, the heating object is a biological tissue flat bottom culture plate.
Optionally, the depth of the clamping line groove is larger than the height difference between the hole site bottom of the biological tissue flat bottom culture plate and the bottom of the supporting outer frame.
Optionally, the number of the carrying heating areas is a plurality, and the heater further comprises a plurality of numbered identifiers corresponding to the carrying heating areas one by one.
Optionally, the heating pipes are arranged in an S-shape in the same horizontal plane inside the housing.
Optionally, the device further comprises a temperature sensor and a controller, wherein: the temperature sensor is arranged inside the shell; the controller is electrically connected with the heating pipe and the temperature sensor respectively, and the controller comprises: a switch component, a temperature setting component, and a screen electrically connected with the switch component and the temperature setting component.
Optionally, the number of the temperature sensors is plural, and the plurality of temperature sensors are uniformly distributed inside the housing.
Optionally, the controller further comprises: and the magnet is arranged at the back of the screen and used for magnetically fixing the controller at a magnetically attractable position.
Optionally, the method further comprises: and the anti-slip pad is arranged at the bottom of the shell.
Optionally, the method further comprises: the anti-skid structure is arranged on the side edge of the heat conduction cover plate and is used for increasing friction force when a user grasps the heat conduction cover plate.
According to the technical scheme of the utility model, the heater is provided with the flat-plate-shaped heat conduction cover plate and the clamping line groove matched with the shape of the supporting outer frame of the heating object, so that the heater is suitable for placing the heating objects such as flat-bottom-shaped biological tissue culture plates and the like. On the one hand, the flat bottom position of the heating object such as the biological tissue flat bottom culture plate is parallel to the heat conduction cover plate, so that the heating object can be heated uniformly; on the other hand, the supporting frame of the heating object such as the biological tissue flat-bottom culture plate can be embedded into the clamping line groove, so that the heating object can be stably fixed and is not easy to slide.
Drawings
For purposes of illustration and not limitation, the utility model will now be described in accordance with its preferred embodiments, particularly with reference to the accompanying drawings, in which:
FIG. 1 is a schematic perspective view of a prior art cell culture temperature regulating device;
FIG. 2 is a schematic cross-sectional view of a prior art cell culture temperature regulating device;
FIG. 3 is a schematic perspective view of a biological tissue flat bottom culture plate;
FIG. 4 is a schematic side view of a biological tissue flat bottom culture plate;
FIG. 5 is a schematic perspective view of a biological tissue treatment device according to an embodiment of the present utility model;
FIG. 6 is a schematic perspective view of the heater of FIG. 5;
FIG. 7 is an external top view schematic of the heater of FIG. 5;
FIG. 8 is a schematic view of a heating tube and temperature sensor inside the heater of FIG. 5;
FIG. 9 is a schematic cross-sectional view of a biological tissue treatment device according to an embodiment of the present utility model;
FIG. 10 is a schematic diagram of a controller of a biological tissue processing device according to an embodiment of the present utility model;
FIG. 11 is a schematic view showing a state of use of the biological tissue treatment apparatus according to the embodiment of the present utility model;
fig. 12 is a sectional view showing a use state of the biological tissue treatment apparatus according to the embodiment of the present utility model.
In the figure:
01 is an orifice plate; 02 is an incubator; 03 is a separator; 04 is a heat radiation hole; 05 is a temperature sensor; 06 is a heating pipe; reference numeral 07 denotes a control panel; 08 is a through slot; 09 is a screen; 100 is a biological tissue flat bottom culture plate; 101 is a hole site; 102 is a supporting outer frame;
1 is a heater; 2 is a controller; 3 is a connecting wire; 4 is a power plug; 11 is a shell; 12 is a heat conducting cover plate; 13 is a clamping slot; 14 is a numbered identification; 15 is a heating pipe; 16 is an anti-slip pad; 21 is a switching element; 22 is a temperature setting component; 23 is a screen; 24 is a magnet; and 5 is a temperature sensor.
Detailed Description
Fig. 5 to 12 are schematic views of a biological tissue treatment device according to an embodiment of the present utility model. Exemplary embodiments of the present utility model will now be described with reference to the accompanying drawings, in which various details of the embodiments of the present utility model are included to facilitate understanding, and are to be considered merely exemplary. Accordingly, those of ordinary skill in the art will recognize that various changes and modifications of the embodiments described herein can be made without departing from the scope and spirit of the utility model. Also, descriptions of well-known functions and constructions are omitted in the following description for clarity and conciseness.
As shown in fig. 5, the biological tissue treatment device according to the embodiment of the present utility model includes a power plug 4, a controller 2, a connection wire 3, and a heater 1, which are sequentially connected. Wherein the controller 2 and the connecting wires 3 are optional and not necessary, only the power plug 4 and the heater 1 may be provided to achieve the basic heating function.
FIG. 6 is a schematic perspective view of a heater; fig. 7 is an external top view schematic of a heater. The heater 1 is flat box-shaped as a whole, and comprises: the top has an open housing 11, a heating tube 15 disposed inside the housing 11, and a flat plate-shaped heat conductive cover plate 12 disposed over the opening. The top of the thermally conductive cover plate 12 includes one or more load bearing heating regions that match the shape of the heating target. Each bearing heating area is provided with a group of clamping line grooves 13 matched with the shape of the supporting outer frame of the heating object. The heating object can be a biological tissue flat-bottom culture plate, or can be a culture dish, a flat-bottom conical flask or other flat-bottom container.
In order to improve the thermal conductivity and durability of the device, the housing 11 and the thermally conductive cover plate 12 are preferably made of a metal material, such as medical grade stainless steel.
In the biological tissue treatment device, each clamping wire slot in each bearing heating area is in a rectangular outline shape with the length of 127.2mm and the width of 85.47mm, the depth of the clamping wire slot is 3mm or more, and the sizes of the clamping wire slots are matched with each other so as to be the most common biological tissue flat-bottom culture plate.
In order to heat a plurality of heating objects at the same time, the number of carrying heating areas in the heater 1 is generally plural (for example, four as shown in the drawing), and the heater 1 further includes a plurality of number marks 14 (for example, "ABCD" four letter marks as shown in fig. 6 and 7) in one-to-one correspondence with the plurality of carrying heating areas, which is advantageous for a user to record the experimental process more clearly and orderly.
Since the heater 1 has a generally flat box shape, it is preferable that the heating pipes 15 are arranged in an S-shape in the same horizontal plane inside the housing 11, and reference is made to fig. 8 and 9 in particular. This improves heating uniformity and saves space.
In order to achieve a basic heating function and also a temperature control function, the biological tissue treatment device further comprises a temperature sensor 5. As shown in fig. 9, the temperature sensor 5 may be provided inside the housing 11; the controller 2 is electrically connected with the heating pipe 15 and the temperature sensor 5, respectively. As shown in fig. 10, the controller 2 may include: a switch part 21, a temperature setting part 22, and a screen 23 electrically connected to the switch part 21 and the temperature setting part 22.
The number of the temperature sensors 5 is preferably plural, and the plurality of temperature sensors 5 are uniformly distributed inside the housing 11. As shown in fig. 9, the biological tissue treatment device includes two temperature sensors 5 provided on the left and right sides of the housing 11, respectively.
As shown in fig. 10, the controller 2 may further include a magnet 24 disposed at a back of the screen 23, for magnetically fixing the controller 2 at a magnetically attractable position, for example, on a side wall steel plate of the experiment operation table, so that a three-dimensional space can be effectively utilized, a use area of the operation table is saved, and liquid splashing of the controller 2 can be effectively avoided.
In order to increase the friction between the biological tissue treatment device and the laboratory bench, a non-slip mat 16 may be provided at the bottom of the housing 11.
Sometimes, a user needs to directly push or pull or lift the heat conducting cover plate 12, and in order to increase the friction force when the user grasps the heat conducting cover plate 12, an anti-slip structure (not shown in the figure) may be further arranged on the side edge of the heat conducting cover plate 12. The anti-slip structure can be a plurality of parallel rubber short strips attached to the side edge of the heat conducting cover plate.
Fig. 11 is a schematic view showing a use state of the biological tissue treatment apparatus according to the embodiment of the present utility model. The biological tissue treatment device has four load bearing heating zones, one of which has placed thereon a biological tissue flat bottom culture plate 100. When in use, the power plug 4 is powered on, then the target temperature is set on the controller 2, and the switch is started, so that the power plug can be normally used.
Preferably, the depth of the clamping slot 13 is larger than the height difference between the hole site bottom of the biological tissue flat bottom culture plate and the bottom of the supporting outer frame. In this embodiment, a schematic sectional view of the biological tissue treatment apparatus in use is shown in FIG. 12. As can be seen from fig. 12, when the depth of the clamping slot 13 is deep enough, the lower part of the supporting frame 102 of the flat-bottom biological tissue culture plate can be embedded into the clamping slot 13, and the flat-shaped heat conducting cover plate 12 directly supports and heats the bottom of the hole site 101 of the flat-bottom biological tissue culture plate, so that the flat-bottom biological tissue culture plate has the advantages of uniform heating and stable fixation.
According to the biological tissue treatment device of the present utility model, the heater has the heat conductive cover plate having a flat plate shape and the positioning slot matching the shape of the supporting frame of the heating object, so that the device is suitable for placing the heating object such as the biological tissue flat-bottom culture plate having a flat bottom shape. On the one hand, the flat bottom position of the heating object such as the biological tissue flat bottom culture plate is parallel to the heat conduction cover plate, so that the heating object can be heated uniformly; on the other hand, the supporting frame of the heating object such as the biological tissue flat-bottom culture plate can be embedded into the clamping line groove, so that the heating object can be stably fixed and is not easy to slide.
The above embodiments do not limit the scope of the present utility model. It will be apparent to those skilled in the art that various modifications, combinations, sub-combinations and alternatives can occur depending upon design requirements and other factors. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present utility model should be included in the scope of the present utility model.
Claims (10)
1. A biological tissue treatment device comprising a power plug and a heater, wherein:
the heater is whole to be flat box-shaped, includes: the top has open casing, sets up the inside heating pipe of casing and the setting is in the heat conduction apron of flat board shape on the opening, heat conduction apron top includes one or more and heats the object shape matched bear the weight of the heating region, every bear the weight of the heating region be equipped with a set of with the support frame shape matched card position wire casing of heating object.
2. The biological tissue treatment device of claim 1, wherein the heated subject is a biological tissue flat bottom culture plate.
3. The biological tissue treatment device of claim 2, wherein the depth of the detent slot is greater than the difference in height between the bottom of the aperture of the biological tissue flat bottom culture plate and the bottom of the support housing.
4. The biological tissue treatment device of claim 1, wherein the number of load bearing heating zones is a plurality, and the heater further comprises a plurality of numbered identifiers in one-to-one correspondence with the plurality of load bearing heating zones.
5. The biological tissue treatment device of claim 1, wherein the heating tubes are arranged in an S-shape within the housing in a same horizontal plane.
6. The biological tissue treatment device of claim 1, further comprising a temperature sensor and a controller, wherein:
the temperature sensor is arranged inside the shell;
the controller is electrically connected with the heating pipe and the temperature sensor respectively, and the controller comprises: a switch component, a temperature setting component, and a screen electrically connected with the switch component and the temperature setting component.
7. The biological tissue treatment device of claim 6, wherein the number of temperature sensors is a plurality and the plurality of temperature sensors are evenly distributed within the housing.
8. The biological tissue treatment device of claim 6, wherein the controller further comprises: and the magnet is arranged at the back of the screen and used for magnetically fixing the controller at a magnetically attractable position.
9. The biological tissue treatment device of claim 1, further comprising: and the anti-slip pad is arranged at the bottom of the shell.
10. The biological tissue treatment device of claim 1, further comprising: the anti-skid structure is arranged on the side edge of the heat conduction cover plate and is used for increasing friction force when a user grasps the heat conduction cover plate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320823066.5U CN219010329U (en) | 2023-04-14 | 2023-04-14 | Biological tissue treatment device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320823066.5U CN219010329U (en) | 2023-04-14 | 2023-04-14 | Biological tissue treatment device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219010329U true CN219010329U (en) | 2023-05-12 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202320823066.5U Active CN219010329U (en) | 2023-04-14 | 2023-04-14 | Biological tissue treatment device |
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| Country | Link |
|---|---|
| CN (1) | CN219010329U (en) |
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- 2023-04-14 CN CN202320823066.5U patent/CN219010329U/en active Active
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