CN218921254U

CN218921254U - Metabolism cage for multiple mice

Info

Publication number: CN218921254U
Application number: CN202320685821.8U
Authority: CN
Inventors: 邓振领; 高月明; 张海东; 王悦
Original assignee: Peking University Third Hospital Peking University Third Clinical Medical College
Current assignee: Peking University Third Hospital Peking University Third Clinical Medical College
Priority date: 2023-03-31
Filing date: 2023-03-31
Publication date: 2023-04-28
Anticipated expiration: 2033-03-31

Abstract

The utility model discloses a metabolism cage for multiple mice, which comprises a feeding cabin, a collecting cabin and a liquid collecting cabin, wherein one end of the collecting cabin is connected with the feeding cabin, and the other end of the collecting cabin is connected with the liquid collecting cabin; the side wall of the collecting cabin is provided with a sampling component which is in sliding connection with the collecting cabin; the bottom of the sampling component is provided with a feces collecting baffle; the bottom of the liquid collecting cabin is provided with a connecting structure; one end of the connecting structure, which is far away from the liquid collecting tank, is provided with a urine collecting pipe; the inside of the connecting structure is provided with a urine filtering device. The beneficial effects are that: the excrement collecting baffle is inserted into the metabolism cage through the plug-in type, so that the stability is good; the sampling component which is in sliding connection with the metabolism cage is arranged, and the mouse excrement can be taken out by pulling out the sampling component from the side face, so that the device is convenient and quick; the urine filter is arranged above the urine collecting tube, so that the excrement or food is further prevented from falling into the urine collecting tube.

Description

Metabolism cage for multiple mice

Technical Field

The utility model belongs to the technical field of medical appliances, and particularly relates to a metabolism cage for multiple mice.

Background

The metabolism cage is used for collecting urine and excrement naturally discharged by experimental animals, is a specially designed closed feeding cage for collecting various excretions of the experimental animals, is a feeding cage for collecting the excretions of the experimental mice specially and is used for in-vivo metabolism experiments of the experimental mice, can provide comfortable living environment for the experimental mice, can quantify drinking water and food of the experimental mice, and can lead the experimental mice to naturally metabolize, and the separation device of the metabolism cage can separate the excrement and urine of the experimental mice so as to carry out in-vivo metabolism researches on various medicines, nutrient substances and the like.

The existing metabolism cages have the following defects:

1. the excrement collecting baffle plate in the existing metabolism cage is not firmly fixed, so that part of the mouse excrement falls into the urine collecting tube to pollute the urine of the mouse;

2. the existing metabolism cage is of an integrated structure, so that when the mouse excrement is taken out, the mouse is required to be transferred, and the operation is complicated;

3. food waste falls into the urine collection tube, resulting in inaccurate urine protein measurement.

The utility model aims at the problems and provides a metabolism cage for multiple mice.

Disclosure of Invention

In order to overcome the problems in the background art, the utility model provides a metabolism cage for multiple mice. The problem that the excrement collecting baffle is not fixed firmly in the existing metabolism cage is solved by adopting the plug-in type fixed excrement collecting baffle. The drawer type sampling component is adopted, the sampling component is pulled out from the side face, so that the mouse excrement can be taken out, the mouse is not required to be transferred, and the convenience and the rapidness are realized. The urine filter is arranged at the top of the urine collecting tube to prevent food residues from falling into the urine collecting tube.

The metabolism cage for the multiple mice comprises a feeding cabin, a collecting cabin and a liquid collecting cabin, wherein one end of the collecting cabin is connected with the feeding cabin, and the other end of the collecting cabin is connected with the liquid collecting cabin; the side wall of the collecting cabin is provided with a sampling component which is in sliding connection with the collecting cabin; the bottom of the sampling component is provided with a feces collecting baffle; the bottom of the liquid collecting cabin is provided with a connecting structure; one end of the connecting structure, which is far away from the liquid collecting tank, is provided with a urine collecting pipe; the inside of the connecting structure is provided with a urine filtering device.

Further, a foot pad is arranged between the feeding cabin and the collecting cabin; the foot pad is spliced with the collecting cabin.

Further, a partition board is arranged in the feeding cabin; the partition board is detachably connected with the feeding cabin.

Further, the urine collecting tube is in threaded connection with the connecting structure.

Further, a feeder is arranged on the side wall of the feeding cabin, and the feeder is detachably connected with the feeding cabin.

Further, a cabin door is arranged at the top of the feeding cabin, and the cabin door is hinged with the feeding cabin.

Further, a handle is arranged on one side of the cabin door and is fixedly connected with the cabin door.

Further, an air-permeable net is arranged in the cabin door and is fixedly connected with the cabin door.

Further, a low-temperature structure is arranged outside the urine collecting tube, and the low-temperature structure is detachably connected with the urine collecting tube.

Further, the urine filtration device includes a first filter layer and a second filter layer; the first filter layer and the second filter layer are connected with the connecting structure.

The utility model has the beneficial effects that: the excrement collecting baffle is inserted into the metabolism cage through the plug-in type, so that the stability is good; the sampling component which is in sliding connection with the metabolism cage is arranged, and the mouse excrement can be taken out by pulling out the sampling component from the side face, so that the device is convenient and quick; the urine filter is arranged above the urine collecting tube, so that the excrement or food is further prevented from falling into the urine collecting tube.

Drawings

FIG. 1 is a schematic structural view of a metabolic cage embodying the present utility model;

FIG. 2 is a front view of a metabolic cage embodying the present utility model;

FIG. 3 is a cross-sectional view of a metabolic cage embodying the present utility model;

FIG. 4 is a schematic diagram of a sampling assembly embodying the present utility model;

FIG. 5 is a schematic structural view of a footpad embodying the present utility model;

FIG. 6 is a schematic view of a construction of a urine filtration device embodying the present utility model;

in the figure, 1, a metabolism cage; 2. a feeding cabin; 3. a cabin door; 4. foot pads; 5. a feeder; 6. a sampling part; 7. a urine collecting tube; 8. a urine filtration device; 11. a collection chamber; 12. a support frame; 13. a liquid collecting tank; 14. a connection structure; 31. a handle; 32. a breathable net; 41. a mounting frame; 42. an isolation net; 61. a push-pull structure; 62. a manure collecting baffle; 81. a first filter layer; 82. and a second filter layer.

Detailed Description

The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. The utility model may be embodied or practiced in other different specific embodiments and features from the following examples and examples may be combined with one another without departing from the spirit or scope of the utility model. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.

In the description of the present utility model, it should be understood that the terms "long", "wide", "thick", "upper", "lower", and the like indicate an orientation or a positional relationship based on that shown in the drawings, and are merely for convenience of describing the present utility model and simplifying the description, and do not indicate or imply that the apparatus or element in question must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as limiting the present utility model.

Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include one or more such feature. In the description of the present utility model, the meaning of "a plurality" is two or more, unless explicitly defined otherwise.

The multi-rat metabolism cage 1 shown in the figures 1-6 comprises a feeding cabin 2, a collecting cabin 11 and a liquid collecting cabin 13, wherein one end of the collecting cabin 11 is connected with the feeding cabin 2, and the other end is connected with the liquid collecting cabin 13; the side wall of the collecting cabin 11 is provided with a sampling part 6, and the sampling part 6 is in sliding connection with the collecting cabin 11; the bottom of the sampling part 6 is provided with a feces collection baffle 62; the bottom of the liquid collecting tank 13 is provided with a connecting structure 14; the end of the connecting structure 14, which is far away from the liquid collecting tank 13, is provided with a urine collecting pipe 7; the urine filter device 8 is arranged inside the connecting structure 14.

When in use, mice or rats are placed in the feeding cabin 2, the feces of the mice fall into the sampling part 6 under the action of gravity, and urine is converged by the liquid collecting cabin 13 and filtered by the urine filtering device 8 and then enters the urine collecting tube 7. The sampling part 6 is in sliding connection with the collecting cabin 11, the sampling part 6 can collect the murine manure after being pulled out of the collecting cabin 11, the murine manure does not need to be taken out of the feeding cabin 2, the convenience and the rapidness are realized, and the risk that an experimenter is scratched or bitten by the murine manure can be reduced. Urine enters the urine collecting tube 7 after being filtered by the urine filtering device 8, so that excrement or feed is prevented from falling into the urine collecting tube 7, and the excrement is not required to be fished out of the urine collecting tube 7 in the experiment. If the food falls into urine, the protein component in the food directly affects the measurement of urine protein.

Specifically, the feces collection baffle 62 is of a stainless steel grid structure, and collects mouse feces while not affecting urine flow.

As shown in fig. 3, a foot pad 4 is provided between the feeding compartment 2 and the collecting compartment 11; the foot pad 4 is spliced with the collecting chamber 11. The foot pad 4 separates the feeding cabin 2 from the collecting cabin 11, prevents the mice placed in the feeding cabin 2 from entering the collecting cabin 11, separates the mice from the feces thereof, prevents the mice from crushing the feces, and allows the feces fragments to pass through the feces collecting baffle 62 and enter the liquid collecting cabin 13, thereby blocking the urine filtering device 8.

As shown in fig. 4, the sampling component 6 includes a push-pull structure 61 and a feces collection baffle 62, the push-pull structure 61 is a rectangular barrel structure with an open top, the feces collection baffle 62 is arranged on the bottom surface of the push-pull structure 61, and the two structures are fixedly connected. A slide adapted to the push-pull structure 61 is provided on the side wall of the collecting chamber 11, so that the sampling member 6 can be moved into and out of the collecting chamber 11 at will. In use, the excreta of the mice falls into the push-pull structure 61 after passing through the foot pad 4, the excrement collecting baffle 62 blocks the excreta of the mice and collects the excreta in the push-pull structure 61, and the sampling part 6 is pulled out from the collecting cabin 11 to collect or clean the excreta of the mice.

As shown in fig. 5, the footpad 4 includes a mounting bracket 41 and an isolation net 42; the filter screen is arranged inside the mounting frame 41 and is fixedly connected with the mounting frame 41. A mounting position (not shown) is provided between the feeding chamber 2 and the collecting chamber 11, which mounting position is adapted to the mounting frame 41. During use, the mounting frame 41 is clamped into the mounting position, so that the foot pad 4 is embedded into the metabolism cage 1, and the stability is good.

As shown in fig. 1-3, the feeding chamber 2 and the collecting chamber 11 are both hollow rectangular block structures. Specifically, the length of the feeding cabin 2 is 30cm, and the width thereof is 20cm; a partition (not shown) is provided every 7.5cm on the 30cm long side, and three partitions are provided in total to separate 4 mouse raising spaces. A sufficient number of samples can be collected in a minimum period of time to meet the common experiment of a plurality of mice in the same group. If a single mouse is used for the experiment, it takes 4-5 days or even longer to collect all the metabolites of the mice, so that the detection results of the metabolites of different mice are poor in comparability.

In some embodiments of the present application, a slot (not shown in the figure) is designed every 7.5cm on the 30cm long side, and 3 slots are altogether, and the partition board is detachably connected with the slots, so that 4 mouse feeding spaces can be separated at most, and different numbers of partition boards are inserted according to the number of experimental mice.

Specifically, the thickness of the separator was about 0.5cm.

As shown in fig. 1-2, a feeder 5 is provided on the side wall of the feeder cabin 2, and the feeder 5 is detachably connected to the feeder cabin 2. The interior of the feeder 5 is filled with functional gel for experimental animals, so that residues of granular feed are prevented from falling into the urine collecting tube 7.

As shown in fig. 1-2, a hatch door 3 is arranged at the top of the feeding chamber 2, and the hatch door 3 is hinged with the feeding chamber 2. The laboratory mice can be put into the rearing cabin 2 or taken out from the rearing cabin 2 by opening the cabin door 3.

Specifically, in order to facilitate opening the cabin door 3, a handle 31 is disposed at the top of the cabin door 3, and the handle 31 is fixedly connected with the cabin door 3. Pulling the handle 31 opens the door 3.

In some embodiments of the present application, to prevent the laboratory mice from escaping from the interior of the feeding chamber 2, a locking structure (not shown) is provided on the door 3, so that the door 3 and the feeding chamber 2 can be locked by using the locking structure, and the door 3 is prevented from being opened accidentally.

Specifically, the locking structure is a hasp.

Or the locking structure is a pull buckle.

Alternatively, the locking structure is a bayonet lock.

In some embodiments of the present application, as shown in fig. 3, in order to enhance the fluidity of the air inside the feeding cabin 2, an air-permeable net 32 is disposed inside the cabin door 3, and the air-permeable net 32 is fixedly connected to the cabin door 3.

As shown in fig. 6, the urine filter device 8 includes a first filter layer 81 and a second filter layer 82; the first filter layer 81 and the second filter layer 82 are both connected to the connection structure 14. After twice filtration, the urine of the mice is thoroughly removed with impurities such as food, feces and the like, and a clarified urine sample is obtained.

Specifically, the first filter layer 81 is a primary filter layer, and the second filter layer 82 is a fine filter layer.

In some embodiments of the present application, the urine collection tube 7 is designed as an externally connected sterile centrifuge tube that is threadably connected to the connection structure 14. The urine collection cup is not required to be repeatedly cleaned or pressurized when urine of different mice is collected.

Preferably, the centrifuge tube is 15ml in size.

In some embodiments of the present application, a cryogenic structure is provided outside the urine collecting tube 7, the cryogenic structure being detachably connected to the urine collecting tube 7. The cryogenic structure comprises a cryogenic centrifuge tube rack. The centrifuge tube is inserted into a low-temperature centrifuge tube rack when urine is collected, and the low temperature of the urine of the mice is kept.

As shown in fig. 1-3, a supporting frame 12 is arranged at the bottom of the collecting cabin 11, and the supporting frame 12 lifts the collecting cabin 11, the feeding cabin 2 and other components to leave the ground, so that an experimenter can conveniently install or remove the urine collecting tube 7 at the bottom of the connecting structure 14.

The foregoing has shown and described the basic principles, principal features and advantages of the utility model. It will be understood by those skilled in the art that the present utility model is not limited to the above-described embodiments, and that the above-described embodiments and descriptions are only preferred embodiments of the present utility model, and are not intended to limit the utility model, and that various changes and modifications may be made therein without departing from the spirit and scope of the utility model as claimed. The scope of the utility model is defined by the appended claims and equivalents thereof.

Claims

1. The metabolism cage for the multiple mice comprises a feeding cabin, a collecting cabin and a liquid collecting cabin, and is characterized in that one end of the collecting cabin is connected with the feeding cabin, and the other end of the collecting cabin is connected with the liquid collecting cabin; the side wall of the collecting cabin is provided with a sampling component which is in sliding connection with the collecting cabin; the bottom of the sampling component is provided with a feces collecting baffle; the bottom of the liquid collecting cabin is provided with a connecting structure; one end of the connecting structure, which is far away from the liquid collecting tank, is provided with a urine collecting pipe; the inside of the connecting structure is provided with a urine filtering device.

2. A multi-rat metabolic cage according to claim 1, characterized in that a foot pad is provided between the feeding compartment and the collection compartment; the foot pad is spliced with the collecting cabin.

3. The multi-rat metabolic cage according to claim 1, wherein a partition is provided inside the feeding compartment; the partition board is detachably connected with the feeding cabin.

4. A multi-rat metabolic cage according to claim 3, wherein the urine collection tube is threadably connected to the connecting structure.

5. A multi-rat metabolic cage according to claim 3, wherein the feeder is provided on a side wall of the feeder compartment, the feeder being detachably connected to the feeder compartment.

6. A multi-rat metabolic cage according to any of claims 1-5, wherein a hatch is provided in the top of the feeding chamber, the hatch being hinged to the feeding chamber.

7. The metabolism cage for multiple mice according to claim 6, wherein a handle is arranged on one side of the cabin door, and the handle is fixedly connected with the cabin door.

8. The metabolism cage for multiple mice according to claim 6, wherein a ventilation net is arranged inside the cabin door and is fixedly connected with the cabin door.

9. A multi-rat metabolic cage according to any of claims 1-5, wherein a low temperature structure is provided on the outside of the urine collection tube, the low temperature structure being removably attachable to the urine collection tube.

10. A multi-murine metabolic cage according to any of claims 1-5 wherein the urine filtration device comprises a first filtration layer and a second filtration layer; the first filter layer and the second filter layer are connected with the connecting structure.