CN218865779U

CN218865779U - Automatic slide scanning system

Info

Publication number: CN218865779U
Application number: CN202223102644.0U
Authority: CN
Inventors: 康子琛; 董必勤; 蒋海娃; 杨杰
Original assignee: Lishi Intelligent Technology Shanghai Co ltd
Current assignee: Lishi Intelligent Technology Shanghai Co ltd
Priority date: 2022-11-22
Filing date: 2022-11-22
Publication date: 2023-04-14
Anticipated expiration: 2032-11-22

Abstract

The utility model relates to an automatic slide scanning system belongs to chromosome scanning field, including storage mechanism, transport mechanism, scanning mechanism, oil drip mechanism, control mechanism and power, storage mechanism sets up in one side of transport mechanism to through transport mechanism and scanning mechanism intercommunication, oil drip mechanism sets up on scanning mechanism upper portion, and storage mechanism, transport mechanism, scanning mechanism and oil drip mechanism are connected with the control mechanism electricity respectively, and the power is connected with the control mechanism electricity. The utility model discloses can advance the scanning of piece automatically, shoot automatically, operating time that can significantly reduce improves doctor work efficiency, has the characteristics that the scanning is quick, use manpower sparingly, the rate of accuracy is high.

Description

Automatic slide scanning system

Technical Field

The utility model relates to an automatic slide scanning system belongs to the chromosome scanning field.

Background

Lymphocytes in peripheral blood are almost in the G0 or G1 phase and are generally not dividing. When Phytohemagglutinin (PHA) is added to the culture medium, such small lymphocytes are stimulated to be transformed into lymphoblasts and start mitosis. After short-term culture, a large number of metaphase cells can be obtained by treatment with colchicine, and after slide production, the chromosome can be clearly observed and analyzed.

In the diagnosis technology of the chromosome genetic disease, the only standard diagnosis method is the chromosome karyotype analysis technology, namely, the metaphase of the chromosome of the patient is directly shot, observed and analyzed through a microscope, and the chromosome information of the patient is judged by comparing with the ISCN international standard. Unfortunately, with this method, the chromosome analysis process only requires a large amount of work time for a doctor (30-50 minutes for human-computer interaction analysis/patient), a clinician is full-time invested, only 10 patients can be analyzed each day, resulting in a large number of patients stacked, and a pregnant woman needs to wait for one month to obtain a diagnosis report to determine whether the fetus in the abdomen needs abortion or even induction of labor. Therefore, departments such as prenatal diagnosis centers and reproductive centers of clinical hospitals at home and abroad urgently need rapid, intelligent and accurate human chromosome automatic auxiliary analysis and diagnosis equipment so as to accelerate diagnosis and treatment efficiency and improve clinical service level.

When clinical diagnosis is performed in hospitals and third-party medical inspection places, a digital microscope is often used for observing a glass slide coated with cell suspension, observing and photographing metaphase division items and the like of a chromosome, and then manual analysis or software automatic analysis is performed on the obtained picture, so that the efficiency is low.

Disclosure of Invention

In view of this, the utility model provides an automatic slide scanning system can advance the piece scanning automatically, shoot automatically, but the operating time that significantly reduces improves doctor work efficiency.

The utility model provides an above-mentioned technical problem's technical scheme as follows:

an automatic slide scanning system comprises a storage mechanism, a transmission mechanism, a scanning mechanism, an oil dripping mechanism, a control mechanism and a power supply,

the storage mechanism is arranged on one side of the conveying mechanism and communicated with the scanning mechanism through the conveying mechanism, the oil dripping mechanism is arranged on the upper portion of the scanning mechanism, the storage mechanism, the conveying mechanism, the scanning mechanism and the oil dripping mechanism are respectively electrically connected with the control mechanism, and the power supply is electrically connected with the control mechanism.

On the basis of the technical scheme, the utility model discloses can also do following improvement.

Further, scanning mechanism includes electron microscope, microscope stand and scanning platform, electron microscope sets up on the microscope stand, through microscope stand realizes vertical translation, scanning platform sets up the electron microscope below, scanning platform passes through the loose axle that has on the scanning platform realizes horizontal translation, the loose axle is connected with the activity motor transmission, electron microscope the microscope stand with the activity motor respectively with the control mechanism electricity is connected.

Further, the storage mechanism comprises a glass slide warehouse, a glass slide warehouse and a stepping motor are arranged in the glass slide warehouse, the stepping motor is in transmission connection with the glass slide warehouse, a handle is arranged at the top of the glass slide warehouse, a plurality of glass slide clamps are uniformly distributed in the glass slide warehouse in a clamping manner, a plurality of glass slides are arranged on the glass slide clamps, and the stepping motor is electrically connected with the control mechanism.

And the system further comprises a plurality of sensors, wherein the sensors are arranged on the slide library and used for detecting the positions of the slide clamps and the states of the bin gates of the slide library.

Further, the oil dripping mechanism comprises an oil pump, an oil pipe, an oil dripping needle head and an oil storage device, the oil pump is arranged on the oil storage device, the oil storage device is communicated with the oil dripping needle head through the oil pipe, the oil dripping needle head is arranged on the scanning mechanism, and the oil pump is electrically connected with the control mechanism.

Further, the control mechanism comprises a display screen, a control chip and a control panel, wherein a control program is preset in the control chip.

The beneficial effects of the utility model are that:

1. the scanning is quick: the special mechanical structure design can enable the device to load and unload the slide quickly, and the high-efficiency slide scanning logic can ensure that the microscope can scan the chromosome image quickly and take a picture.

2. Manpower is saved: the implementation of this project can carry out automatic scanning to the slide sample, need not to rely on the manual work to get like traditional mode and put the slide sample, has greatly saved the manpower, has alleviated doctor's burden.

3. And (3) accurate: the metaphase mitosis of the chromosome can be automatically scanned and photographed, redundant operations of finding the chromosome and focusing are avoided, and the diagnosis efficiency is improved.

Drawings

FIG. 1 is a schematic view of the overall structure of the automatic slide scanning system of the present invention;

FIG. 2 is a schematic view of the scanning mechanism of the automatic slide scanning system of the present invention;

FIG. 3 is a schematic structural view of a storage mechanism of the automatic slide scanning system of the present invention;

fig. 4 is a schematic view of the slide clamp of the automatic slide scanning system of the present invention.

In the drawings, the components represented by the respective reference numerals are listed below:

1. the device comprises a storage mechanism, 11, a slide library, 12, a slide cabin, 121, a handle, 122, a slide clamp, 123, a slide, 13, a stepping motor, 2, a conveying mechanism, 3, a scanning mechanism, 31, an electron microscope, 32, a microscope support, 33, a scanning platform, 4, an oil dripping mechanism, 41, an oil storage device, 5, a control mechanism, 51, a display screen, 6 and a power supply.

Detailed Description

The principles and features of the present invention are described below in conjunction with the following drawings, the examples given are only intended to illustrate the present invention and are not intended to limit the scope of the present invention.

As shown in fig. 1 to 4, the automatic slide 123 scanning system, which includes a storage mechanism 1, a transport mechanism 2, a scanning mechanism 3, an oil dropping mechanism 4, a control mechanism 5, and a power supply 6,

the storage mechanism 1 is arranged on one side of the conveying mechanism 2 and is communicated with the scanning mechanism 3 through the conveying mechanism 2, the oil dripping mechanism 4 is arranged on the upper portion of the scanning mechanism 3, the storage mechanism 1, the conveying mechanism 2, the scanning mechanism 3 and the oil dripping mechanism 4 are respectively and electrically connected with the control mechanism 5, and the power supply 6 is electrically connected with the control mechanism 5.

The utility model discloses an in another kind of embodiment, scanning mechanism 3 includes electron microscope 31, microscope stand 32 and scanning platform 33, electron microscope 31 sets up on microscope stand 32, realize vertical translation through microscope stand 32, scanning platform 33 sets up in electron microscope 31 below, horizontal translation is realized through the loose axle that has on scanning platform 33 to scanning platform 33, the loose axle is connected with the activity motor drive, electron microscope 31, microscope stand 32 and activity motor are connected with 5 electricity of control mechanism respectively.

In another embodiment of the present invention, the storage mechanism 1 comprises a slide library 11, a slide chamber 12 and a stepping motor 13 in transmission connection with the slide chamber 12 are provided in the slide library 11, a handle 121 is provided on the top of the slide chamber 12, a plurality of slide clips 122 are uniformly distributed in the slide chamber 12, a plurality of slides 123 are provided on the slide clips 122, and the stepping motor 13 is electrically connected with the control mechanism 5;

preferably, the number of slide magazines 12 in each slide magazine 11 is 2, the number of slide holders 122 in each slide magazine 12 is 25, and the number of slides 123 in each slide holder 122 is 4.

In another embodiment of the present invention, the slide library further comprises a plurality of sensors, which are disposed on the slide library 11 for detecting the position of the slide clamp 122 and the door status of the slide library 11.

The utility model discloses an in another embodiment, oil drip mechanism 4 includes oil pump, oil pipe, oil drip syringe needle and oil storage device 41, and the oil pump setting is on oil storage device 41, and oil storage device 41 passes through oil pipe and oil drip syringe needle intercommunication, and the oil drip syringe needle sets up on scanning mechanism 3, and the oil pump is connected with 5 electricity of control mechanism.

In another embodiment of the present invention, the control mechanism 5 includes a display screen 51, a control chip, and a control panel, and the control chip has a control program preset therein.

The utility model discloses an automatic slide scanning system work flow as follows:

1. a program is preset in the control chip, and the automatic scanning effect is realized through the program;

2. starting the equipment, wherein the control mechanism 5 sends a return-to-zero calibration signal to the outside, and the storage mechanism 1, the transmission mechanism 2 and the scanning mechanism 3 start to perform calibration operation after receiving the signal so as to ensure that the initial state of the equipment is normal;

3. the control mechanism 5 sends a scanning instruction outwards, the equipment feeds back the current state, if the state is that the zero resetting calibration operation is finished and the information of the slide clamp 122 in the slide chamber 12 at the moment is fed back to the control chip, the scanning process is started, firstly, the stepping motor 13 moves the slide chamber 12 to enable the slide clamp 122 to be scanned to move to the door of the slide chamber 11, the conveying mechanism 2 is clamped with the slide clamp 122 to move the slide clamp 122 to the scanning mechanism 3, the horizontal and vertical movement is realized through the microscope support 32 and the scanning platform 33, the slide 123 to be scanned moves to the objective position and finishes focusing and scanning, the slide 123 to be scanned is replaced and focused through the microscope support 32 and the scanning platform 33, and the oil dripping device is used for dripping oil on the slide 123 in the process;

4. after all the slides 123 with the slide clips 122 are scanned, the control mechanism 5 controls the microscope support 32 and the scanning platform 33 to return to zero, the scanned slide clips 122 are sent back to the slide chamber 12 through the conveying mechanism 2, the stepping motor 13 works, the next slide clip 122 is moved to a chamber door, the slide clips 122 are clamped and connected through the conveying mechanism 2 again to move to the scanning mechanism 3 for scanning, after all the slide clips 122 in the slide chamber 12 are scanned, the stepping motor 13 works to adjust the position relation of a plurality of slide chambers 12, the slide chamber 12 which is not scanned is moved to the chamber door for scanning, and the system is calibrated to return to zero again until all the slides are scanned;

5. any motion surpasss corresponding spacing and all can trigger the warning feedback of corresponding sensor among the scanning process, can send the newspaper error message to control chip very first time, and the system stops its work at once, prevents to take place unexpected motion trouble and causes unpredictable continuation harm to machine or user.

The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention should be included within the protection scope of the present invention.

Claims

1. An automatic slide scanning system is characterized by comprising a storage mechanism, a conveying mechanism, a scanning mechanism, an oil dripping mechanism, a control mechanism and a power supply,

2. The automated slide scanning system of claim 1, wherein the scanning mechanism comprises an electron microscope, a microscope support, and a scanning platform, the electron microscope is disposed on the microscope support and longitudinally translated by the microscope support, the scanning platform is disposed under the electron microscope, the scanning platform laterally translates by a movable shaft disposed on the scanning platform, the movable shaft is in driving connection with a movable motor, and the electron microscope, the microscope support, and the movable motor are electrically connected to the control mechanism, respectively.

3. The automated slide scanning system of claim 1, wherein the storage mechanism includes a slide magazine having a slide magazine and a stepper motor drivingly connected to the slide magazine, wherein the slide magazine has a handle at a top thereof, and wherein a plurality of slide holders are evenly distributed in the slide magazine and are engaged with the slide holders, and wherein the slide holders have a plurality of slides thereon, and wherein the stepper motor is electrically connected to the control mechanism.

4. The automated slide scanning system of claim 3, further comprising a plurality of sensors disposed on the slide library for detecting the position of the slide holder and the status of the door of the slide library.

5. The automatic slide scanning system of claim 1, wherein the oil dropping mechanism comprises an oil pump, an oil pipe, an oil dropping needle and an oil storage device, the oil pump is disposed on the oil storage device, the oil storage device is communicated with the oil dropping needle through the oil pipe, the oil dropping needle is disposed on the scanning mechanism, and the oil pump is electrically connected with the control mechanism.

6. The automated slide scanning system of claim 1, wherein the control mechanism includes a display screen, a control chip, and a control panel, the control chip having a control program pre-programmed therein.