CN218852895U

CN218852895U - Stomach irrigator

Info

Publication number: CN218852895U
Application number: CN202222507068.1U
Authority: CN
Inventors: 苏丹; 杨棣远; 孙效容; 陈玥; 陈根
Original assignee: Sichuan Hengshu Bio Technology Stock Co ltd; Sichuan Hetuo Chuangzhan Biotechnology Co ltd; Chengdu Bio Ht Biotechnology Co ltd
Current assignee: Sichuan Hengshu Bio Technology Stock Co ltd; Sichuan Hetuo Chuangzhan Biotechnology Co ltd; Chengdu Bio Ht Biotechnology Co ltd
Priority date: 2022-09-21
Filing date: 2022-09-21
Publication date: 2023-04-14
Anticipated expiration: 2032-09-21

Abstract

The application provides a stomach irrigator, and relates to the technical field of animal models. The stomach irrigator comprises a hose, a balloon and an opening piece. The two ends of the hose are respectively provided with a liquid inlet hole and a liquid outlet hole. The sacculus is located the hose and is close to the one end in liquid outlet hole. The opening piece is sleeved outside the hose and is in sliding fit with the hose, and when the opening piece slides to one end close to the liquid outlet hole, the opening piece is abutted to the balloon. Hose and opening piece structure as an organic whole in the gavage ware of this application, when adopting the gavage ware to carry out the oral cavity gavage, slide opening piece to butt in the sacculus earlier, then the animal can carry out the intubate after stinging opening piece, promote the hose promptly and make the hose have the tip of liquid outlet hole slowly enter into the stomach of animal, prevent that the animal from spitting out opening piece. The opening piece can guarantee the opening of the animal and the space in the oral cavity on the premise of not damaging the oral cavity of the animal, fully open the esophagus inlet and provide enough space for the insertion of the hose. The balloon after inflation can avoid the damage caused by the shaking of the hose in the esophagus.

Description

Stomach irrigator

Technical Field

The application relates to the technical field of animal models, in particular to a stomach irrigator.

Background

Oral gavage is used as a noninvasive administration mode, simulates clinical oral drugs, and is used as the most common mode for drugs to enter organisms, and is widely applied to clinical and preclinical researches due to simple operation and high acceptance degree. In the related research of preclinical experimental animals, the administration method does not cause excessive stress to the animals, and can better simulate clinics.

It is difficult to satisfy the operation demand when the animal is baoding in the gavage, may lead to the operation people to be bitten even, consequently the current common mode of gavage to the animal is for adopting independent mouth gag fixer mouth, uses the stomach tube to irritate the stomach again. This may result in failure of the gavage by the animal spitting out or resisting the mouth gag during the gavage process and may cause the operator to be scratched/bitten, or the animal may damage the mucosal lining by resisting the agitation of the tube within the oesophagus.

SUMMERY OF THE UTILITY MODEL

It is an object of embodiments of the present application to provide an intragastric lavage apparatus that can simplify the procedure for administering a drug through the oral gavage.

In a first aspect, embodiments of the present application provide a gastric lavage device, including: a flexible tube, a balloon and an opening member.

The two ends of the hose are respectively provided with a liquid inlet hole and a liquid outlet hole.

The sacculus is arranged at one end of the hose close to the liquid outlet hole in a sleeved mode.

The opening piece is sleeved outside the hose and is in sliding fit with the hose, and when the opening piece slides to one end close to the liquid outlet hole, the opening piece is abutted to the balloon.

In the above-mentioned realization process, hose and opening piece structure as an organic whole in the stomach irrigator of this application, when adopting the stomach irrigator to carry out the oral cavity stomach irrigation, slide to the butt in the sacculus with the opening piece earlier, then the animal can carry out the intubate after stinging the opening piece, promote the hose promptly and make the tip that the hose has the liquid outlet hole slowly enter into the stomach of animal, prevent that the animal from spitting out the opening piece. And the opening piece can guarantee the opening of the animal and the space in the oral cavity on the premise of not damaging the oral cavity of the animal, fully open the esophagus inlet and provide enough space for the insertion of the hose. And then the end part of the hose with the liquid outlet hole extends into the stomach of the animal, the balloon is inflated to expand the balloon, the outer wall of the expanded balloon can be attached to the esophagus of the animal, the damage possibly caused by the shaking of the hose in the esophagus is avoided, and the hose is more stable during gastric lavage.

In one possible embodiment, the material of the mouth piece is rubber.

In the implementation process, the rubber material is soft, so that the animal can feel as comfortable as possible when biting the mouth gag, and the injury to the gum and/or the oral mucosa possibly caused by the animal when biting the mouth gag with force is avoided or reduced.

In a possible embodiment, a pressure-sensitive lamp is arranged inside the mouth piece.

In the implementation process, the mouth piece can emit light when an animal bites the inside of the mouth piece, so that the internal condition of the oral cavity can be observed clearly during gastric lavage, and the possibility of inserting the trachea by mistake is reduced to a great extent or even is eliminated.

In one possible embodiment, the opening member is a truncated cone, a cylinder or a truncated pyramid, the opening member has an axis, and the opening member is sleeved outside the hose along the axis.

In a possible embodiment, the inner diameter of the exit opening is between 1.5mm and 2.5mm.

In one possible embodiment, the stomach irrigator comprises a trachea, which is connected to a hose and one end of which is connected to the balloon and the other end of which has an inflation port provided with a spring valve.

In the implementation process, the air pipe is used for inflating the saccule to enable the saccule to expand, and the spring valve can avoid gas loss in the saccule.

In one possible embodiment, the gastric lavage device further includes an injection push rod configured to mate with the access port.

In the implementation process, the injection push rod can be directly used for intragastric administration after the intubation is finished, so that the step that the intragastric tube is required to be filled with liquid after the injector is connected is simplified.

In one possible embodiment, the outer diameter of the flexible tube is 3mm to 4mm, and the diameter of the balloon is 8mm to 13mm at most after inflation.

In one possible embodiment, the maximum range of the hose is 7mL, the hose is provided with scale marks, and the minimum readable digit is 0.1mL.

In a possible embodiment, the hose has a length of 250mm to 280mm and is provided with a first and a second distance line of 80mm and 180mm, respectively, from the exit opening.

In the implementation process, the distance line enables an operator to conveniently and quickly insert the distance line into a proper position of the esophagus so as to prevent liquid from flowing back into the trachea due to insufficient depth during gastric lavage. Different distance lines are suitable for the lengths of the esophagus of different animals, the first distance line is the length of the esophagus of the tree shrew, and the second distance line is the length of the esophagus of the rabbit.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are required to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present application and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained from the drawings without inventive effort.

FIG. 1 is a schematic view of an embodiment of an intragastric lavage device of the present application;

FIG. 2 is a schematic view of the balloon uninflated insufflator configuration of an embodiment of the present application;

FIG. 3 is a schematic view of the configuration of the gastric lavage device with the mouth piece abutting against the balloon in the embodiment of the present application;

FIG. 4 is a schematic view of the injection plunger and the hose of the embodiment of the present application after being separated;

FIG. 5 is a schematic view of the stomach irrigator of the embodiment of the present application inserted into the stomach of an animal.

Icon: 10-stomach irrigator; 100-a hose; 101-liquid inlet hole; 102-liquid outlet holes; 103-graduation mark; 104-a first distance line; 105-a second distance line; 200-a balloon; 300-an open piece; 310-pressure sensitive lamps; 400-trachea; 401-an inflation port; 410-a spring valve; 420-a first portion; 430-a second portion; 500-an injection push rod; 510-an injection handle; 520-sealing the head.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are some embodiments of the present application, but not all embodiments. The components of the embodiments of the present application, generally described and illustrated in the figures herein, can be arranged and designed in a wide variety of different configurations.

Thus, the following detailed description of the embodiments of the present application, presented in the accompanying drawings, is not intended to limit the scope of the claimed application, but is merely representative of selected embodiments of the application. All other embodiments obtained by a person of ordinary skill in the art based on the embodiments in the present application without making any creative effort belong to the protection scope of the present application.

It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures.

In the description of the present application, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings or orientations or positional relationships that the products of the application usually place when in use, and are used only for convenience in describing the present application and simplifying the description, but do not indicate or imply that the devices or elements being referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present application. Furthermore, the terms "first," "second," "third," and the like are used solely to distinguish one from another, and are not to be construed as indicating or implying relative importance.

Furthermore, the terms "horizontal", "vertical", "overhang" and the like do not imply that the components are required to be absolutely horizontal or overhang, but may be slightly inclined. For example, "horizontal" merely means that the direction is more horizontal than "vertical" and does not mean that the structure must be perfectly horizontal, but may be slightly inclined.

In the description of the present application, it is further noted that, unless expressly stated or limited otherwise, the terms "disposed," "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in this application will be understood to be a specific case for those of ordinary skill in the art.

In preclinical research, only large and small mice in common experimental animals are provided with gastric lavage needles, rabbits are subjected to gastric lavage through clinical human medical gastric tubes at present, tree shrews are used as a new experimental animal, and the gastric lavage method used at present is the same as that of the rabbits.

The inventor finds that the existing technology for gavage of experimental animals mainly comprises a gavage needle for rats and mice and stomach tubes with different specifications, the tree shrew is similar to the rats in body shape, the length and the depth of the esophagus are almost the same as those of the rats, the tree shrew is more active and difficult to fix, and the existing hard gavage needle is easy to damage animals and cause bites of operators. Compared with the esophagus of a big mouse and a small mouse and a tree shrew, the length of the esophagus is about 200mm, the gastric lavage depth of the rabbit needs about 180mm, the opening and closing angle of the mouth of the rabbit is small, the operation requirement is difficult to meet when the animal is fixed by gastric lavage, and even an operator can be bitten, so that the mouth of the independent mouth gag fixer is adopted in the current common mode of gavage for the animal, and then the gastric tube is used for gavage. This may result in failure of the gavage by the animal spitting out or resisting the mouth gag during the gavage process and may cause the operator to be scratched/bitten, or the animal may damage the mucosal lining by resisting the agitation of the tube within the oesophagus.

Based on the above conditions, the inventor designs an integrated gastric lavage device for experimental animals such as rabbits, tree shrews and the like, which can reduce the resistance of the animals, avoid the damage to the animals and ensure the safety of operators while completing the operation conveniently and rapidly.

Referring to fig. 1, the present embodiment provides an intragastric lavage device 10, which includes: a flexible tube 100, a balloon 200 and a split 300.

The hose 100 is a tubular structure made of elastic material, and the two ends of the hose 100 are respectively a liquid inlet hole 101 and a liquid outlet hole 102.

Optionally, the hose 100 has a length of 250 to 280mm.

By way of example, the length of the hose 100 may be 250mm, 255mm, 260mm, 265mm, 270mm, 275mm or 280mm.

Optionally, the hose 100 has a diameter of 3mm to 4mm.

By way of example, the hose 100 may have a diameter of 3mm, 3.2mm, 3.5mm, 3.8mm or 4mm.

Optionally, the diameter of the liquid inlet hole 101 is 1.5 mm-2.5 mm.

As an example, the aperture of the liquid inlet hole 101 may be 1.5mm, 1.8mm, 2mm, 2.2mm, or 2.5mm.

Optionally, the maximum range of the hose 100 is 7mL, the hose 100 is provided with scale marks 103, and the minimum readable digit is 0.1mL.

The graduation mark 103 can ensure the accuracy during the stomach irrigation.

Optionally, the hose 100 is provided with a first line 104 and a second line 105 at a distance of 80mm and 180mm, respectively, from the exit opening 102.

The distance line allows the practitioner to insert it conveniently and quickly into the appropriate location of the esophagus to prevent reflux of liquid into the trachea 400 due to insufficient depth during gastric lavage. Different distance lines are appropriate for different animal esophageal lengths, the first distance line 104 being the length of the esophagus of the tree shrew and the second distance line 105 being the length of the esophagus of the rabbit.

Optionally, the material of the hose 100 is medical polyvinyl chloride.

Referring to fig. 1 and 2, the balloon 200 is a hollow structure that is sleeved on an end of the tube 100 near the exit hole 102.

When the balloon 200 is not filled with gas, the inner wall of the balloon 200 is attached to the outer wall of the hose 100, and the volume occupied by the balloon 200 is small, so that the influence on the part of the hose 100 passing through the esophagus is small; when 5-6.5 mL of gas is filled into the balloon 200, the balloon 200 is completely expanded, the length of the balloon can reach 15-20 mm, and the diameter of the balloon can reach 8-13 mm.

After the end part of the hose 100 with the liquid outlet hole 102 extends into the stomach of the animal, the balloon 200 is inflated to expand the hose, the outer wall of the expanded balloon 200 can be attached to the esophagus of the animal, the hose 100 is prevented from shaking in the esophagus to cause damage, and the hose is more stable during gastric lavage.

Moreover, the size of the balloon 200 can be controlled by controlling whether the balloon 200 is inflated or not, or controlling the inflation amount of the balloon 200, so that the gastric lavage device 10 is suitable for the esophagus of different animals. For example, due to the smaller esophageal diameter of a tree shrew, the balloon 200 is suitable for use in the esophagus of a tree shrew when it is uninflated. However, the diameter of the esophagus of a rabbit is large, about 10mm, and inflation of balloon 200 to expand it as compared to a tree shrew makes it suitable for use in the esophagus of a rabbit.

Optionally, balloon 200 is made of a transparent material. When the intragastric lavage liquid medicine is injected into the hose 100, the scale marks 103 in the partial hose 100 in the saccule 200 can be clearly seen so as to ensure the accuracy of the intragastric lavage liquid medicine.

The stomach irrigator 10 comprises an air tube 400, a part of the air tube 400 is connected with the side wall of a hose 100 by the side wall, one end of the air tube 400 is connected with a balloon 200, the other end of the air tube 400 is provided with an inflation port 401, and the inflation port 401 is provided with a spring valve 410.

The trachea 400 is used to inflate the balloon 200 and the spring valve 410 prevents gas from escaping from the balloon 200. Before inflation, the valve of the spring valve 410 is pressed to the bottom to open the spring valve 410, the balloon 200 is inflated, and after the intragastric administration is completed, the valve of the spring valve 410 is pressed to the bottom to open the spring valve 410, and gas in the balloon 200 is exhausted.

Optionally, gas tube 400 includes a first portion 420 adjacent to exit orifice 102 and a second portion 430 adjacent to entry orifice 101, wherein first portion 420 is attached to the sidewall of hose 100 at its sidewall and second portion 430 is angled away from hose 100 to facilitate inflation.

Referring to fig. 1 and 3, the opening member 300 is disposed outside the flexible tube 100 and is slidably engaged with the flexible tube 100.

When the opening member 300 slides to an end close to the liquid outlet hole 102, the opening member 300 abuts against the balloon 200; when the split member 300 is slid to approach one end of the liquid inlet hole 101, the split member 300 abuts on the end of the second portion 430 of the air pipe 400.

When the stomach irrigator 10 is used for oral gavage, the mouth piece 300 is firstly slid to abut against the balloon 200, then an animal bites the mouth piece 300 and can perform intubation, namely the hose 100 is pushed so that the end part of the hose 100 with the liquid outlet hole 102 slowly enters the stomach of the animal, and the animal is prevented from spitting the mouth piece 300.

Alternatively, the material of the mouth piece 300 is rubber.

The softer rubber material may make the mouth gag bite as comfortable as possible, thereby avoiding or reducing potential gum and/or oral mucosa damage by the animal when biting the mouth gag 300 hard.

Alternatively, the material of the mouth piece 300 is transparent rubber.

The transparent mouth piece 300 makes it possible to ensure accuracy without blocking the graduation marks 103 when drawing the liquid medicine.

Optionally, a pressure-sensitive lamp 310 is provided inside the mouth piece 300.

When an animal bites the opening piece 300, the light can be emitted, so that the internal situation of the oral cavity can be observed clearly during the gastric lavage, and the possibility of mistakenly inserting the trachea 400 is greatly reduced or even eliminated.

Optionally, the opening member 300 is a truncated cone, a cylinder or a truncated pyramid, the opening member 300 has an axis, and the opening member 300 is sleeved outside the hose 100 along the axis.

In the embodiment shown in fig. 1 to 3, the opening member 300 is a truncated cone-shaped structure, which is sleeved outside the hose 100 along the axis, and the top surface (the surface with smaller area) of the truncated cone-shaped structure is close to the liquid inlet hole 101, and the top surface (the surface with larger area) of the truncated cone-shaped structure is close to the liquid outlet hole 102.

Optionally, the length of the mouth piece 300 along the axis is 25mm to 30mm.

By way of example, the length of the mouth piece 300 along the axis may be 25mm, 26mm, 27mm, 28mm, 29mm, or 30mm.

Alternatively, the maximum diameter and the minimum diameter of the cross section of the mouth piece 300 in the axial direction are 15mm and 10mm, respectively.

Referring to fig. 1 and 4, the gastric lavage device 10 further includes an injection push rod 500, the injection push rod 500 is configured to cooperate with the fluid intake 101.

Injection ram 500 includes an injection handle 510 and a sealing head 520, with the end of one end of injection handle 510 being attached to sealing head 520.

After the intubation is finished, the push rod 500 can be directly injected for intragastric administration, and the step that the intragastric tube needs to be filled with liquid after the injector is connected is simplified.

Referring to fig. 1 to 5, before use, the injection push rod 500 is taken out, the intragastric lavage liquid medicine is injected into the hose 100 through the liquid injection hole, and the amount of the intragastric lavage liquid medicine in the hose 100 is determined through the scale mark 103 on the hose 100, so as to ensure the accuracy of the intragastric lavage liquid medicine. Then, the injection push rod 500 is installed through the injection hole so that the sealing head 520 seals the gavage liquid in the tube 100. When the opening member 300 is slid to the end close to the liquid outlet hole 102, the opening member 300 abuts against the balloon 200, the end of the hose 100 with the liquid outlet hole 102 is inserted into the mouth of the animal, so that the animal bites the opening member 300, then the hose 100 is pushed, the liquid outlet hole 102 of the hose 100 moves relative to the opening member 300, the end of the hose 100 with the liquid outlet hole 102 is ensured to be inserted into the stomach of the animal with the aid of the pressure sensing lamp 310 inside the opening member 300, the valve of the spring valve 410 is pressed to the bottom to open the spring valve 410, the balloon 200 is inflated through the inflation port 401 of the air pipe 400, the outer wall of the balloon 200 is expanded to be attached to the esophagus of the animal, the injection handle 510 is pushed, so that the gastric perfusion liquid medicine enters the stomach of the animal, the perfusion treatment is completed, then the valve of the spring valve 410 is pressed to the bottom to open the spring valve 410, the air in the balloon 200 is exhausted through the inflation port 401 of the air pipe 400, and the hose 100 and the opening member 300 are pulled out.

To sum up, hose 100 and opening piece 300 in the gavage apparatus 10 of this application are structure as an organic whole, when adopting gavage apparatus 10 to carry out the oral cavity gavage, slide opening piece 300 earlier to butt in sacculus 200, then the animal can carry out the intubate after biting opening piece 300, promote hose 100 promptly and make hose 100 have the tip of liquid outlet hole 102 slowly enter into the animal's stomach, prevent that the animal from spitting out opening piece 300. And the opening member 300 can ensure the opening of the animal and the space in the oral cavity without damaging the oral cavity of the animal, fully open the entrance of the esophagus, and provide enough space for the insertion of the hose 100. And then the end part of the hose 100 with the liquid outlet hole 102 extends into the stomach of the animal, the balloon 200 is inflated to expand the balloon, the outer wall of the expanded balloon 200 can be attached to the esophagus of the animal, the possible damage caused by the shaking of the hose 100 in the esophagus is avoided, and the hose is more stable during gastric lavage.

The above description is only a preferred embodiment of the present application and is not intended to limit the present application, and various modifications and changes may be made to the present application by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. An intragastric lavage, said lavage comprising:

the two ends of the hose are respectively provided with a liquid inlet hole and a liquid outlet hole;

the balloon is sleeved at one end, close to the liquid outlet hole, of the hose;

the opening piece is sleeved outside the hose and is in sliding fit with the hose, and when the opening piece slides to the position close to one end of the liquid outlet hole, the opening piece is abutted to the balloon.

2. The gastric lavage device of claim 1 wherein the mouth piece is rubber.

3. The gastric lavage device of claim 2 wherein a pressure sensitive light is disposed within the mouth piece.

4. The gastric lavage device of claim 1 wherein the mouth piece is of a truncated cone, cylindrical or truncated pyramid configuration, the mouth piece having an axis, and the mouth piece being sleeved outside the hose along the axis.

5. The gastric lavage device of claim 1 wherein the inner diameter of the exit orifice is 1.5mm to 2.5mm.

6. The gastric lavage device according to claim 1, characterized in that it comprises an air tube connected to the hose and having one end connected to the balloon and the other end provided with an inflation port provided with a spring valve.

7. The intragastric device of claim 1, further comprising an injection push rod configured to mate with the intake aperture.

8. The gastric lavage device of claim 1 wherein the flexible tube has an outer diameter of 3mm to 4mm and the balloon is inflated to a maximum diameter of 8mm to 13mm.

9. The gastric lavage device of claim 1 wherein the hose has a maximum range of 7mL, and the hose has a scale line and a minimum readable digit of 0.1mL.

10. The gastric lavage device of claim 1 wherein the hose has a length of 250mm to 280mm and is provided with first and second lines of distance of 80mm and 180mm, respectively, from the exit orifice.