CN111870385A

CN111870385A - Tree shrew nasal cavity internal drug administration device

Info

Publication number: CN111870385A
Application number: CN202010834162.0A
Authority: CN
Inventors: 夏巍; 唐安洲; 冯一唯
Original assignee: First Affiliated Hospital of Guangxi Medical University
Current assignee: First Affiliated Hospital of Guangxi Medical University
Priority date: 2020-08-18
Filing date: 2020-08-18
Publication date: 2020-11-03

Abstract

The invention discloses a tree shrew nasal cavity internal drug administration device, and mainly relates to the field of nasal drug administration of experimental animals. Comprises a developing device, an outer inserting hose, a medicine injection inner sleeve hose and a flow choking device; the outer inserting hose comprises a middle tube cavity and an annular cleaning cavity, a cleaning through hole is formed in the top surface of a tube head of the outer inserting hose, and a short medicine injection tube is arranged on the side of the tube head of the outer inserting hose; the developing device is arranged in the center of the top surface of the tube head of the outer inserting hose; and a medicine injection port is arranged on the side part of the tube head of the medicine injection inner sleeve hose. The invention has the beneficial effects that: the device is suitable for administration of the tree shrew nasal disease model, can track the position of a cannula in a nasal cavity in real time, determines the position of the cannula, and is more accurate in administration position; in addition, nasal liquid can be cleaned in real time in the propelling process, so that the insertion of the cannula is facilitated; the injection can avoid the injected liquid medicine from flowing into the digestive tract, so that the injection dosage is more accurate.

Description

Tree shrew nasal cavity internal drug administration device

Technical Field

The invention relates to the field of nasal administration of experimental animals, in particular to a tree shrew nasal cavity internal administration device.

Background

The tree shrew is a novel experimental animal which is small in size, fast in reproduction and closer in relationship with primates compared with traditional experimental animals (rats, mice, rabbits and the like), and is considered to be a low-grade primate in the past; therefore, the compound has wide application in the biomedical field, and particularly has more and more attention to the role in animal models of human diseases. For the study of different diseases, it is often necessary to use different routes of administration; for the creation of nasal disease models, the administration site is usually limited to the local part of the nose, so that the ideal model effect can be obtained. However, the tree shrew has a complicated nasal cavity structure, large space occupied by the turbinates and sinuses, narrow nasal passages, thin nasal mucosa and more nasal fluid, so that the administration through the nasal route is difficult. At present, no device for nasal administration of the tree shrews is available, which causes great inconvenience for establishing a tree shrew nasal disease model.

At present, no literature or patent reports about a special nasal administration method for tree shrews. The method used in the industry at present is to use a plastic hose, one end of which is inserted into the inferior nasal passage of the nasal cavity of the tree shrew, and the other end of which is connected with a syringe for administration. The inconvenience lies in:

1. since the hose has no scale and the insertion depth cannot be known, the final administration site cannot be estimated, and the administration site may be inaccurate.

2. The liquid medicine directly output through the hose may flow into the digestive tract through the posterior nostril, and the loss of the liquid medicine causes inaccurate administration amount of local medicine injection.

3. The tree shrew has more nasal fluid in the nasal cavity, the nasal fluid is comparatively and the plastic hose is softer, and the nasal fluid can be pushed inwards to accumulate and increase resistance in the continuous inserting process, so that the plastic hose is blocked from further inserting, and the whole inserting process is difficult.

Disclosure of Invention

The invention aims to provide a tree shrew nasal cavity internal drug administration device which is suitable for administration of a tree shrew nasal disease model, can track the position of a cannula in a nasal cavity in real time, determines the position of the cannula and is more accurate in drug administration position; in addition, nasal liquid can be cleaned in real time in the propelling process, so that the insertion of the cannula is facilitated; the injection can avoid the injected liquid medicine from flowing into the digestive tract, so that the injection dosage is more accurate.

In order to achieve the purpose, the invention is realized by the following technical scheme:

a tree shrew nasal cavity internal drug administration device comprises a developing device, an outer inserting soft tube, an inner drug injecting soft tube and a flow blocking device;

externally inserting a hose:

the outer inserting hose comprises a middle tube cavity and an annular cleaning cavity at the periphery of the middle tube cavity, the cavity diameter of the middle tube cavity is matched with the outer diameter of the medicine injection inner sleeve hose, a plurality of cleaning through holes communicated with the annular cleaning cavity are arranged on the top surface of the head of the outer inserting hose in an annular array mode, and a cleaning pipe joint communicated with the annular cleaning cavity is arranged on a detachable tail cover at the tail of the outer inserting hose;

the side part of the head of the externally-inserted hose is provided with a tapered short medicine injection pipe, and the inner end of the short medicine injection pipe is communicated with the middle lumen; the short medicine injection pipe is not communicated with the annular cleaning cavity;

a developing device:

the developing device is arranged in the center of the top surface of the tube head of the outer inserting hose;

injecting a medicine and sleeving a hose:

the medicine injection inner sleeve hose is inserted in the middle tube cavity, a medicine injection port is arranged on the side part of the tube head of the medicine injection inner sleeve hose, and the position of the medicine injection port is just aligned with the short medicine injection pipe after the medicine injection inner sleeve hose abuts against the inner surface of the tube head of the outer insertion hose.

The device also comprises a flow blocking device; the side surface of the position of the externally-inserted hose head is provided with an annular groove, and the flow resisting device comprises an inflatable air bag and an inflatable inner tube; the inflation air bag is arranged in the annular groove, one end of the inflation inner pipe is communicated with the inflation air bag, the inflation inner pipe is arranged in the annular cleaning cavity, and the other end of the inflation inner pipe penetrates out of the detachable tail cover at the tail of the externally-inserted hose.

The developing device comprises a shell and a contrast agent in the shell, wherein the shell is detachably arranged at the center of the top surface of the tube head of the outer insertion hose.

And the outer insertion hose is provided with scale marks.

The distance between the developing device and the short medicine injection pipe is 5 mm.

Compared with the prior art, the invention has the beneficial effects that:

the device is an accurate drug delivery device based on radiography positioning. The inserting position of the tube head of the external insertion hose in the nasal cavity is tracked by utilizing the characteristic that X-rays cannot penetrate through the developing agent and the image displayed by the developing agent under the X-rays, so that the inserting position of the image of the developing device in the nasal cavity is observed in real time on the image information of a computer. After the developing device reaches the dosing position, the developing device is inserted with a distance of 5mm, so that the dosing short pipe is aligned with the dosing position for dosing, and the dosing position is more accurate.

And, in the outer inserting hose of inner sleeve injection inner sleeve hose advances the in-process, along with the piling up of nasal liquid, can pass through external negative pressure equipment, through clearance coupling, annular clearance chamber, this clearance pipeline of clearance through-hole carries out the negative pressure to accumulational nasal liquid and clears away, make accumulational nasal liquid clear up through clearance through-hole, annular clearance chamber, this passageway of clearance coupling in proper order, thereby guarantee can real-timely clear up the clearance to nasal liquid in advancing the in-process, make things convenient for inserting of intubate.

And the device is also provided with a flow blocking device, after the medicine injection short pipe is aligned with the medicine administration position, the inflating air bag is inflated through the inflating inner pipe by the external inflating device, so that the inflating air bag which is shrunk in the annular groove is inflated, the outer edge of the inflating air bag is in close contact with the inner wall of the nasal cavity, a medicine liquid flow is blocked from entering a channel of the oral cavity, and then medicine injection is performed, so that the injected medicine liquid can be prevented from flowing into the digestive tract through the oral cavity during medicine injection, and the injection dosage is more accurate.

Drawings

FIG. 1 is a schematic structural view of the inflatable air bag when the inflatable air bag is not inflated.

Fig. 2 is a structural schematic diagram of the inflatable air bag after inflation and expansion.

Fig. 3 is a cross-sectional view of the present invention.

Fig. 4 is a structural schematic diagram of the inflatable air bag after inflation and expansion.

Fig. 5 is a schematic view of the structure of the external insertion hose of the present invention.

Fig. 6 is a schematic view of the structure of the medicine-injecting inner sleeve hose of the invention.

FIG. 7 is a schematic view of the inflated balloon inflated to its inflated position during insertion into the nasal cavity.

FIG. 8 is a schematic view of the inflated balloon of the present invention inserted into the nasal cavity after inflation.

FIG. 9 is a schematic diagram of the structure of a tree shrew nasal passage.

Fig. 10 is a state diagram for use in the present invention.

Reference numerals shown in the drawings:

1. a developing device; 2. externally inserting a hose; 3. a flexible pipe is sleeved in the medicine injection device; 4. a middle lumen; 5. an annular cleaning chamber; 6. cleaning the through hole; 7. the tail cover can be disassembled; 8. cleaning the pipe joint; 9. a short medicine injection pipe; 10. a medicine injection port; 11. an annular groove; 12. inflating the air bag; 13. an inflatable inner tube; 14. a housing; 15. a contrast agent.

Detailed Description

The invention will be further illustrated with reference to the following specific examples. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention. Further, it should be understood that various changes or modifications of the present invention may be made by those skilled in the art after reading the teaching of the present invention, and these equivalents also fall within the scope of the present application.

The invention relates to a nasal cavity internal drug delivery device for tree shrews, which comprises a developing device 1, an outer inserting hose 2, an inner medicine injection hose 3 and a flow blocking device. The following detailed structural principle analysis is carried out on the devices in combination with the attached drawings:

the external insertion hose 2:

the external insertion hose 2 is provided with scale marks to roughly predict the insertion position. The externally-inserted hose 2 comprises a middle tube cavity 4 and an annular cleaning cavity 5 at the periphery of the middle tube cavity 4, the middle tube cavity 4 and the annular cleaning cavity 5 are isolated by an inner tube, and the two tube cavities are not communicated. The cavity diameter of the middle cavity 4 is adapted to the outer diameter of the medicine injection inner sleeve hose 3, a plurality of cleaning through holes 6 communicated with the annular cleaning cavity 5 are arranged on the top surface of the tube head of the outer insertion hose 2 in an annular array mode, and a cleaning pipe joint 8 communicated with the annular cleaning cavity 5 is arranged on a detachable tail cover 7 at the tube tail of the outer insertion hose 2;

the lateral part of the tube head of the externally-inserted hose 2 is provided with a cone-shaped short medicine injection tube 9, and the two ends of the diameter of the short medicine injection tube 9 are in a cone shape with a large outside and a small inside, so that the administration area is enlarged. The inner end of the short drug injection pipe 9 is communicated with the middle tube cavity 4; the short medicine injection pipe 9 is not communicated with the annular cleaning cavity 5.

The developing device 1:

the developing device 1 is arranged in the center of the top surface of the tube head of the outer insertion hose 2; the developing device 1 comprises a shell 14 and a contrast medium 15 in the shell 14, wherein the shell 14 is detachably arranged at the center of the top surface of the tube head of the outer inserting hose 2. The distance between the developing device 1 and the medicine injection short pipe 9 is 5 mm.

Medicine injection inner sleeve hose 3:

the medicine injection inner sleeve hose 3 is inserted in the middle tube cavity 4, a medicine injection port 10 is arranged on the side part of the tube head of the medicine injection inner sleeve hose 3, and the position of the medicine injection port 10 is just aligned with the medicine injection short tube 9 after the medicine injection inner sleeve hose 3 abuts against the inner surface of the tube head of the outer insertion hose 2.

The device also comprises a flow blocking device; an annular groove 11 is formed in the side face of the pipe head of the externally-inserted hose 2, and the flow resisting device comprises an inflatable air bag 12 and an inflatable inner pipe 13; the inflatable air bag 12 is arranged in the annular groove 11, one end of the inflatable inner tube 13 is communicated with the inflatable air bag 12, the inflatable inner tube 13 is arranged in the annular cleaning cavity 5, and the other end of the inflatable inner tube 13 penetrates out of the detachable tail cover 7 at the tube tail of the externally-inserted hose 2.

The specific principle and the using method are as follows:

the device is an accurate drug delivery device based on radiography positioning. The inserting position of the tube head of the external insertion hose 2 in the nasal cavity is tracked through the image displayed by the developer under the X-ray by utilizing the characteristic that the X-ray cannot penetrate through the developer, so that the inserting position of the image of the developing device 1 in the nasal cavity is observed in real time on the image information of a computer.

Specifically, because the distance between developing device 1 and injection nozzle stub 9 is 5mm, so developing device 1 arrives and inserts 5mm distance deeply behind the position of dosing again, makes injection nozzle stub 9 and the position of dosing align and dose to make the position of dosing more accurate.

And, in the process of marcing of outer inserting hose 2 of inner sleeve injection inner sleeve hose 3, along with the accumulation of nasal discharge, can be through external negative pressure equipment, through clearance coupling 8, annular clearance chamber 5, this clearance pipeline of clearance through-hole 6 carries out the negative pressure to accumulational nasal discharge and clears away, make accumulational nasal discharge in proper order via clearance through-hole 6, annular clearance chamber 5, this passageway of clearance coupling 8 clears up, thereby guarantee can real-timely clear up the clearance to nasal discharge in advancing the in-process, make things convenient for the inserting of intubate.

Still what is more, in order to avoid the liquid medicine that can avoid injecting when annotating the medicine to flow into the alimentary canal through the oral cavity, this device still is equipped with the choked flow device, annotate the medicine stub pipe 9 with the position alignment back of dosing, at first through external aerating device, inflate gasbag 12 via aerifing inner tube 13, make flat shrink gasbag 12 that rises that inflate in ring channel 11 rise, its outer fringe and nasal cavity inner wall in close contact with block the passageway that the liquid medicine flows into the oral cavity, then annotate the medicine, so, can avoid the liquid medicine of injecting to flow into the alimentary canal through the oral cavity during annotating the medicine, make the injection dosage more accurate.

In addition, since the diameter of the nasopharynx portion at the rear side of the posterior naris is larger than that of the posterior naris, the inflatable air bag 12 having a larger inflation capacity is required to be used when administering the medicine to the nasopharynx portion in order to prevent the injected medicine from flowing into the digestive tract through the oral cavity during injection.

Claims

1. A tree shrew nasal cavity internal drug administration device is characterized in that: comprises a developing device (1), an outer inserting hose (2), a medicine injection inner sleeve hose (3) and a flow choking device;

external insertion hose (2):

the outer inserting hose (2) comprises a middle tube cavity (4) and an annular cleaning cavity (5) at the periphery of the middle tube cavity (4), the cavity diameter of the middle tube cavity (4) is matched with the outer diameter of the medicine injection inner sleeve hose (3), a plurality of cleaning through holes (6) communicated with the annular cleaning cavity (5) are arranged on the top surface of the tube head of the outer inserting hose (2) in an annular array mode, and a cleaning pipe joint (8) communicated with the annular cleaning cavity (5) is arranged on a detachable tail cover (7) at the tube tail of the outer inserting hose (2);

the lateral part of the tube head of the externally-inserted hose (2) is provided with a tapered short medicine injection tube (9), and the inner end of the short medicine injection tube (9) is communicated with the middle tube cavity (4); the short medicine injection pipe (9) is not communicated with the annular cleaning cavity (5);

developing device (1):

the developing device (1) is arranged in the center of the top surface of the tube head of the outer insertion hose (2);

medicine injection inner sleeve hose (3):

the medicine injection inner sleeve hose (3) is inserted in the middle tube cavity (4), a medicine injection port (10) is formed in the side part of the tube head of the medicine injection inner sleeve hose (3), the medicine injection inner sleeve hose (3) abuts against the inner surface of the tube head of the outer insertion hose (2), and the position of the medicine injection port (10) is just aligned with the medicine injection short tube (9).

2. The device for the intranasal administration of tree shrews according to claim 1, wherein: the device also comprises a flow blocking device; an annular groove (11) is formed in the side face of the pipe head of the externally-inserted hose (2), and the flow resisting device comprises an inflatable air bag (12) and an inflatable inner pipe (13); the inflatable air bag (12) is arranged in the annular groove (11), one end of the inflatable inner tube (13) is communicated with the inflatable air bag (12), the inflatable inner tube (13) is arranged in the annular cleaning cavity (5), and the other end of the inflatable inner tube (13) penetrates out of the detachable tail cover (7) at the tube tail of the externally-inserted hose (2).

3. The device for the intranasal administration of tree shrews according to claim 1, wherein: the developing device (1) comprises a shell (14) and a contrast agent (15) in the shell (14), wherein the shell (14) is detachably arranged at the center of the top surface of a tube head of the externally-inserted hose (2).

4. The device for the intranasal administration of tree shrews according to claim 1, wherein: the external insertion hose (2) is provided with scale marks.

5. The device for the intranasal administration of tree shrews according to claim 1, wherein: the distance between the developing device (1) and the medicine injection short pipe (9) is 5 mm.