CN209933060U

CN209933060U - Fistulization tube structure applied to animal transgastric administration experiment

Info

Publication number: CN209933060U
Application number: CN201920482873.9U
Authority: CN
Inventors: 孙勤
Original assignee: Sichuan Provincial Peoples Hospital
Current assignee: Sichuan Provincial Peoples Hospital
Priority date: 2019-04-10
Filing date: 2019-04-10
Publication date: 2020-01-14
Anticipated expiration: 2029-04-10

Abstract

The utility model discloses a fistulization tube structure applied to animal transgastric administration experiments, which comprises a soft catheter and a guide wire; the soft catheter is provided with a through cavity and a ventilation cavity respectively, one end of the guide wire is used for being inserted into the stomach of an animal, the other end of the guide wire is used for penetrating through the through cavity after being inserted into the stomach of the animal so that one end of the soft catheter is also inserted into the stomach of the animal, and the other end of the soft catheter is used for being fixed at the position where the soft catheter can be prevented from being bitten by the animal after the soft catheter is inserted into the stomach of the animal; the outer part of one end of the soft catheter inserted into the animal stomach is provided with an air bag which is communicated with the ventilation cavity and used for leading the air to be filled through the ventilation cavity after the soft catheter is inserted into the animal stomach so as to fix the end of the soft catheter; meanwhile, the end part of the other end of the soft catheter is also provided with a self-sealing surrounding block. Through the design, the utility model discloses a fistulization pipe is convenient for insert and fix in the animal stomach, reduces the operation degree of difficulty that current animal was dosed through the stomach, improves the success rate of animal experiment. Therefore, the method has high use value and popularization value.

Description

Fistulization tube structure applied to animal transgastric administration experiment

Technical Field

The utility model relates to an experimental auxiliary instrument, in particular to a fistulization tube structure applied to the experiment of the animal transgastric administration.

Background

The gastrostomy is a clinical operation performed on a patient who has normal digestive function but cannot take food from the oral cavity due to various reasons, can be called as a percutaneous puncture gastrostomy, and is a minimally invasive operation for inserting a gastrostomy tube through puncture. The use of the gastrostomy tube can help not only the patient with esophageal obstruction (such as tumor or esophageal stenosis) to solve the problem of food intake, but also the patient after abdominal operation to perform gastrointestinal decompression, and furthermore, the gastrostomy tube can be filled with drugs to more conveniently and directly implement a corresponding treatment scheme on the patient.

Similarly, gastrostomy tubes can also be used in animal experiments, and transgastric administration is one of the conventional administration routes in animal experiments, and the most common method at present is to inject a medicament after a gavage needle is inserted into the stomach through mouth. Most experimental animals are small rodents such as big mice, the animals cannot be effectively matched, difficulty is brought to the operation, and if the operation is unskilled or the administration is performed by gastric lavage for a long time, the digestive tract of the animals is often damaged, so that the experimental result is not ideal, and even the experimental failure is caused by the midway death of the animals.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a be applied to animal through stomach and administer fistulization tubular construction of experiment, mainly used reduces current animal through the stomach operation degree of difficulty of dosing, thereby avoids bringing the loss for the experiment because of the operation is not skilled or dose for a long time and cause the damage for the animal.

In order to achieve the above object, the utility model adopts the following technical scheme:

the fistulization tube structure applied to the animal transgastric administration experiment comprises a soft catheter and a guide wire; the soft catheter is provided with a through cavity and a ventilation cavity respectively, one end of the guide wire is used for being inserted into the stomach of an animal, the other end of the guide wire is used for penetrating through the through cavity after being inserted into the stomach of the animal so that one end of the soft catheter is also inserted into the stomach of the animal, and the other end of the soft catheter is used for being fixed at the position where the soft catheter can be prevented from being bitten by the animal after the soft catheter is inserted into the stomach of the animal; the outer part of one end of the soft catheter inserted into the animal stomach is provided with an air bag which is communicated with the ventilation cavity and used for leading the air to be filled through the ventilation cavity after the soft catheter is inserted into the animal stomach so as to fix the end of the soft catheter; meanwhile, the end part of the other end of the soft catheter is also provided with a self-sealing surrounding block.

Preferably, the self-sealing enclosure block is made of solid rubber.

Preferably, the flexible conduit is made of rubber.

Preferably, the guide wire is a solid silica gel rod with the diameter of 0.5-0.7 mm.

Preferably, the inner diameters of the through cavity and the ventilation cavity are both 1 mm.

Compared with the prior art, the utility model discloses following beneficial effect has:

(1) the utility model inserts the guide wire into the animal stomach through the inner cavity of the needle head, and after the needle head is withdrawn, the guide wire is inserted into the animal stomach from one end of the soft catheter to pass through the through cavity, and the soft catheter is inserted into the animal stomach along the guide wire; after the soft catheter inserts in the animal stomach, pour into 0.5 ~ 1ml air through ventilating the chamber and fill the gasbag with little needle tubing, the gasbag fills and draws the soft catheter to outer promotion until can't drag, and soft catheter inserts in the animal stomach one end at this moment and has fixed in the stomach, extracts the seal wire, just realizes that the fistulization pipe inserts in the animal stomach, and is very convenient, doses through the fistulization pipe, reduces the operation degree of difficulty that current animal was dosed through the stomach.

(2) The utility model discloses a set up from closed surrounding block at the outside end of soft pipe, the chamber that runs through of the end department of soft pipe and ventilate the chamber accent and be surrounded and the extrusion is in the closed condition from closed surrounding block, only can push away the accent that is pressed closed when the syringe needle inserts, accomplish and dose and ventilate, can effectively avoid not giving the liquid refluence in the stomach under the medicine state.

Drawings

Fig. 1 is a schematic sectional view of the present invention.

Fig. 2 is a schematic sectional view of the fixed animal stomach after being inserted into the stomach.

Wherein, the names corresponding to the reference numbers are:

1-soft catheter, 2-guide wire, 3-through cavity, 4-ventilation cavity, 5-air bag, 6-self-sealing surrounding block.

Detailed Description

The present invention will be further described with reference to the following description and examples, which include but are not limited to the following examples.

Examples

As shown in fig. 1 and 2, the fistulization tube structure applied to the animal transgastric administration experiment disclosed by the utility model comprises a soft catheter 1 and a guide wire 2 made of rubber; the guide wire 2 is a solid silica gel rod with the diameter of 0.5-0.7 mm, the soft catheter 1 is respectively provided with a through cavity 3 and a ventilation cavity 4, the inner diameters of the through cavity 3 and the ventilation cavity are both 1mm, one end of the guide wire 2 is inserted into the stomach of an animal, the other end of the guide wire 2 is used for penetrating through the through cavity 3 after the guide wire 2 is inserted into the stomach of the animal so that one end of the soft catheter 1 is also inserted into the stomach of the animal, and the other end of the soft catheter 1 is used for being fixed at the position where the soft catheter can be prevented from being bitten; the outer part of one end of the soft catheter 1 inserted into the animal stomach is provided with an air bag 5 which is communicated with the ventilation cavity 4 and used for leading one end of the soft catheter 1 to be fixed through air intake and filling of the ventilation cavity 4 after the soft catheter 1 is inserted into the animal stomach; meanwhile, the other end of the soft catheter 1 is also provided with a self-sealing surrounding block 6 made of solid rubber. The self-sealing surrounding block 6 is arranged to ensure that the mouths of the through cavity 3 and the vent cavity 4 at the end of the soft catheter 1 are surrounded and extruded by the self-sealing surrounding block 6 to be in a closed state, the pressed closed mouths can be pushed open only when the syringe needle is inserted, the administration and the ventilation are completed, the backflow of liquid in the stomach under the non-administration state can be effectively avoided, and the identification site for inserting the syringe needle is marked on the self-sealing surrounding block 6.

The utility model inserts the guide wire into the animal stomach through the inner cavity of the needle, taking a rat as an example, after the rat is anesthetized and fixed, the abdominal wall is cut into a small opening of 1cm to expose the stomach, the stomach pylorus part of the rat stomach is lifted to be slightly pinched to avoid the rich area of the blood vessel, a small hole is pricked on the front wall of the stomach by using a 12g needle (about 2.4mm inside), the guide wire is inserted into the stomach through the inner cavity of the needle, after the needle is withdrawn, the guide wire is inserted into one end of the rat stomach from the soft catheter to pass through the through cavity; after the soft catheter is inserted into the rat stomach, 0.5-1 ml of air is injected into the air filling air bag through the small needle tube for the ventilation cavity, the soft catheter is pulled outwards after the air bag is filled until the air bag cannot be dragged, at the moment, one end of the soft catheter inserted into the rat stomach is fixed in the stomach, and the guide wire is pulled out. The other end of the soft catheter penetrates out of the abdominal front wall of the rat, in order to avoid the phenomenon that the soft catheter falls off due to pulling and the soft catheter is bent or folded, 8-shaped suture is carried out at the position where the soft catheter penetrates out of the peritoneum, the peritoneum and surface muscles are dotted by a suture needle, and the thread crosses the soft catheter to be knotted. The skin of the abdominal wall at the right outer side of the rat is slightly propped open with the skin of the skin under the skin by hemostatic forceps to establish a subcutaneous tunnel, the soft catheter is submerged to the skin under the neck along the subcutaneous tunnel (between two ears, the rat is not easy to turn around to bite the soft catheter), a small opening is cut in the skin, the outer side end of the soft catheter is led out and fixed by a suture. The through cavity of the soft catheter and the orifice of the ventilation cavity are exposed outside the skin, and the abdominal wall is sewn in a layered mode after disinfection. Thus, the utility model can be used for animal experiments and drug administration through stomach, which can reduce the injury of the rat caused by opening the wound on the body of the rat when the fistulization tube is inserted into the stomach of the rat to the maximum extent, and improve the survival rate of the experimental rat; meanwhile, the medicament is administered through the fistulization tube, so that the operation difficulty of the conventional stomach administration of animals is reduced, and the success rate of animal experiments is improved. Therefore, the method has high use value and popularization value.

The above embodiment is only one of the preferred embodiments of the present invention, and should not be used to limit the protection scope of the present invention, but all the insubstantial changes or modifications made in the spirit and the idea of the main design of the present invention, the technical problems solved by the embodiment are still consistent with the present invention, and all should be included in the protection scope of the present invention.

Claims

1. The fistulization tube structure applied to animal transgastric administration experiments is characterized by comprising a soft catheter (1) and a guide wire (2); the soft catheter (1) is respectively provided with a through cavity (3) and a ventilation cavity (4), one end of the guide wire (2) is inserted into the stomach of an animal, the other end of the guide wire is used for penetrating through the through cavity (3) after the guide wire (2) is inserted into the stomach of the animal so that one end of the soft catheter (1) is also inserted into the stomach of the animal, and the other end of the soft catheter (1) is used for being fixed at the position where the soft catheter (1) can avoid the animal from biting after being inserted into the stomach of the animal; the outer part of one end of the soft catheter (1) inserted into the animal stomach is provided with an air bag (5) which is communicated with the ventilation cavity (4) and used for leading the air to be filled through the ventilation cavity (4) after the soft catheter (1) is inserted into the animal stomach so as to fix one end of the soft catheter (1); meanwhile, the end part of the other end of the soft catheter (1) is also provided with a self-sealing surrounding block (6).

2. Ostomy tube structure for the transgastric administration of animals according to claim 1, characterised in that the self-sealing enclosure block (6) is made of solid rubber.

3. Ostomy tube structure for application in transgastric administration experiments in animals according to claim 2, characterised in that the flexible tube (1) is made of rubber.

4. The ostomy tube structure applied to the animal transgastric administration experiment according to claim 3, wherein the guide wire (2) is a solid silicone rod with a diameter of 0.5-0.7 mm.

5. Ostomy tube structure for the transgastric administration experiments in animals according to claim 4, wherein the inner diameter of the through lumen (3) and the vent lumen (4) are both 1 mm.