CN218725836U

CN218725836U - Sample pretreatment instrument

Info

Publication number: CN218725836U
Application number: CN202222255867.4U
Authority: CN
Inventors: 雷名龙; 何建方; 谭林; 张博
Original assignee: Decipher Bioscience Shenzhen Co ltd
Current assignee: Decipher Bioscience Shenzhen Co ltd
Priority date: 2022-08-25
Filing date: 2022-08-25
Publication date: 2023-03-24
Anticipated expiration: 2032-08-25

Abstract

The application discloses preceding processing appearance of sample, including singlechip mainboard circuit and industry control mainboard circuit. The single-chip microcomputer mainboard circuit comprises a peripheral driving circuit, a peripheral bus interface and an industrial control connecting interface, the peripheral driving circuit is used for providing hardware driving for a peripheral of the sample pretreatment instrument, the industrial control connecting interface is used for data communication between the single-chip microcomputer mainboard circuit and the industrial control mainboard circuit, the peripheral bus interface is used for data communication between the single-chip microcomputer mainboard circuit and the peripheral of the sample pretreatment instrument, and the industrial control mainboard circuit is connected with the industrial control connecting interface and used for monitoring and controlling the working flow of the sample pretreatment instrument. Because the singlechip mainboard circuit is adopted to provide drive for the peripheral equipment of the sample pretreatment instrument, the requirement can be met only by designing or upgrading the singlechip mainboard circuit when the peripheral equipment is added or upgraded, the product flexibility of the sample pretreatment instrument is greatly increased, and the production, research and development and maintenance costs are reduced.

Description

Sample pretreatment instrument

Technical Field

The application relates to the technical field of chemical analysis instruments, in particular to a sample pretreatment instrument.

Background

In the development of analytical chemistry, sample pretreatment techniques have not been regarded as important, and compared with the rapid development of modern analytical techniques, the development of sample pretreatment techniques and instruments lags behind and restricts the development of analytical chemistry, which has been focused on the research of analytical methods per se in the past years: how to improve sensitivity, selectivity and analysis speed; how to develop a new analysis method and technology by applying theories in the aspects of physics, chemistry, biology and the like so as to meet the new target and high requirement of the new technology on analytical chemistry; how to adopt the results of the new technology to improve the performance, speed, and degree of automation of analytical instruments. The study of pretreatment methods and techniques has been neglected for a long time, and the sample pretreatment technique becomes a bottleneck restricting the development of analytical chemistry.

The complexity of sample properties faced by modern analytical chemistry is unprecedented, and the objects of analysis include not only all substances in gas, liquid, and solid phases, but also tend to exist in multiphase forms; the composition is not only complex, but also is often interfered with each other during measurement; meanwhile, the concentration requirement of the detected object is lower and lower, and the stability changes at any time, so a series of difficulties are brought to analysis, particularly, the possibility of direct implementation after various environments and biological samples are collected is very low, and the detection can be generally carried out after sample preparation and pretreatment. A complete sample analysis process, from the beginning of sampling to the writing of an analysis report, can be roughly divided into several steps of sample collection, sample pretreatment, analysis and detection, data processing and report results. Statistics show that the sample pretreatment in this step takes considerable time, and some of the samples can even take 70% or more of the whole time, at least about half the time of the detection and analysis of the sample itself. Therefore, in recent years, the research on the sample preprocessing method and apparatus has been increasingly focused.

Referring to fig. 1, a schematic diagram of a hardware framework structure of a sample pretreatment apparatus in the prior art is shown, the sample pretreatment apparatus is controlled and operated by an industrial control motherboard, a peripheral driving circuit is integrated in the industrial control motherboard and directly controlled by a main control IC, and the driving circuit includes a plurality of stepping motor driving circuits, a code scanner serial port driving circuit, an illumination lamp/ultraviolet lamp driving control circuit, a sample rack input switching value detection circuit, a fan peripheral control circuit, and the like. The operation algorithm of the sample pretreatment instrument is also completed by the master control IC, and the operation algorithm comprises a multichannel pipettor independent operation algorithm, a sample number random operation state, consumable material loss recording, operation state pause, operation state stop, operation state error reporting, equipment movement mechanism calibration recording, experiment flow online editing and the like. The hardware execution circuit and the operation algorithm of the sample pretreatment instrument are completed by the industrial control main board IC, the system integration level is high, and meanwhile, the working content of the main control IC is increased. In the prior art, because the pretreatment instrument of sample only includes industrial control mainboard and peripheral hardware, the drive circuit integration of peripheral hardware is on the industrial control mainboard, and industrial control mainboard master control IC directly controls the peripheral hardware, and master control IC accomplishes the algorithm operation of equipment experimentation simultaneously, when needs upgrade or reform transform the partial function of pretreatment instrument of sample, just need upgrade the transformation to the hardware of whole industrial control mainboard, this development cycle that has just so greatly increased the new product. When partial functions of the sample pretreatment instrument are added or upgraded, the main control IC of the industrial control mainboard needs to be programmed on line to realize operation algorithm and deal with various states of the equipment, and the whole industrial control mainboard needs to be subjected to function detection again after programming, so that the development period and the operation risk of the sample pretreatment instrument are greatly increased.

Disclosure of Invention

The technical problem that this application was solved in advance is the poor technical problem of sample pretreatment appearance function update flexibility among the prior art.

According to a first aspect of the present application, an embodiment provides a sample pretreatment instrument, which includes a single chip microcomputer motherboard circuit and an industrial control motherboard circuit;

the single chip microcomputer mainboard circuit is connected between the industrial control mainboard circuit and the peripheral of the sample pretreatment instrument; the single chip microcomputer mainboard circuit comprises a peripheral drive circuit, a peripheral bus interface and an industrial control connecting interface;

the peripheral driving circuit is used for providing hardware driving for the peripheral of the sample pretreatment instrument, the industrial control connecting interface is used for data communication between the single chip microcomputer mainboard circuit and the industrial control mainboard circuit, and the peripheral bus interface is used for data communication between the single chip microcomputer mainboard circuit and the peripheral of the sample pretreatment instrument;

the industrial control mainboard circuit is connected with the industrial control connecting interface and used for monitoring and controlling the working process of the sample pretreatment instrument.

In an embodiment, the sample preprocessing instrument further includes a human-computer interaction module, the human-computer interaction module is connected to the industrial control main board circuit, and the human-computer interaction module is configured to send a control command for controlling the sample preprocessing instrument to the industrial control main board circuit, and is further configured to output and display a working state parameter signal of the sample preprocessing instrument.

In one embodiment, the peripheral bus interface comprises a CAN bus interface.

In one embodiment, the industrial control connection interface is a serial interface.

In one embodiment, the external devices of the sample pretreatment instrument include a scanner, a lighting lamp, an ultraviolet lamp, a sample rack detection passage, a temperature monitoring circuit, a fan, a liquid level detector and/or a limit detector.

In one embodiment, the peripheral driving circuit includes a first RS232 interface, an ADC sampling circuit, a fan driving circuit, a lighting switch circuit, and/or a switch detection circuit;

the first RS232 interface is connected with the scanner;

the ADC sampling circuit is connected with the temperature monitoring circuit and is used for carrying out analog-to-digital conversion on the temperature-related electric signal output by the temperature monitoring circuit so as to realize the display of a temperature value;

the fan driving circuit is connected with the fan and used for providing driving electric energy for the fan;

the illumination switch circuit is connected with the illumination lamp and the ultraviolet lamp and is used for realizing the on-off control of the illumination lamp and the ultraviolet lamp;

the switch detection circuit is connected with a limit detector, a sample frame detection passage and a liquid level detector of the sample pretreatment instrument.

In one embodiment, the sample pretreatment instrument comprises an X-axis motor, a sampling needle Y-axis motor and a sampling needle Z-axis motor.

In one embodiment, the peripheral bus interface includes a CAN motor bus, and the CAN motor bus is connected to the X-axis motor, the sample application needle Y-axis motor, and the sample application needle Z-axis motor.

In one embodiment, the single chip microcomputer mainboard circuit further comprises a buzzer for outputting the warning information of the sample pretreatment instrument.

In one embodiment, the industrial control mainboard circuit comprises a second RS232 interface, a network adapter, a CAN interface, a USB interface circuit, and an LVDS interface;

the second RS232 interface is connected with the singlechip mainboard circuit, and the LVDS interface is connected with the human-computer interaction module.

According to the sample pretreatment instrument of the embodiment, the singlechip mainboard circuit is adopted to provide drive for the peripheral equipment of the sample pretreatment instrument, so that the requirement can be met only by designing or upgrading the singlechip mainboard circuit when the peripheral equipment is added or upgraded, the product flexibility of the sample pretreatment instrument is greatly increased, and the production, research and development and maintenance costs are reduced.

Drawings

FIG. 1 is a schematic diagram of a hardware framework of a sample pre-treatment instrument in the prior art;

FIG. 2 is a diagram of a hardware framework of the sample pre-processor in an embodiment;

FIG. 3 is a schematic diagram of an embodiment of a motherboard circuit of a single chip microcomputer;

FIG. 4 is a schematic diagram of a buzzer in one embodiment;

FIG. 5 is a schematic diagram of an embodiment of an industrial control motherboard circuit;

FIG. 6 is a circuit diagram of a temperature monitoring circuit according to an embodiment.

Detailed Description

The present application will be described in further detail below with reference to the accompanying drawings by way of specific embodiments. Wherein like elements in different embodiments are numbered with like associated elements. In the following description, numerous details are set forth in order to provide a better understanding of the present application. However, those skilled in the art will readily recognize that some of the features may be omitted or replaced with other elements, materials, methods in different instances. In some instances, certain operations related to the present application have not been shown or described in detail in order to avoid obscuring the core of the present application from excessive description, and it is not necessary for those skilled in the art to describe these operations in detail, so that they may be fully understood from the description in the specification and the general knowledge in the art.

In addition, the features, operations, or characteristics described in the specification may be combined in any suitable manner to form various embodiments, and the operation steps involved in the embodiments may be sequentially exchanged or adjusted in a manner that can be obvious to those skilled in the art. Accordingly, the description and drawings are merely for clarity of description of certain embodiments and are not intended to necessarily refer to a required composition and/or order.

The numbering of the components as such, e.g., "first", "second", etc., is used herein only to distinguish the objects as described, and does not have any sequential or technical meaning. The term "connected" and "coupled" when used in this application, unless otherwise indicated, includes both direct and indirect connections (couplings).

The sample pretreatment instrument disclosed in the embodiment of the application shortens the development period of equipment and reduces risks by optimizing the whole hardware architecture. In addition, due to the adjustment of the hardware architecture, the complexity of software design is improved, the complexity is reduced, the occurrence rate of BUG in product development is reduced, the whole software structure of the sample pretreatment instrument is easier and clearer, the maintenance is more convenient and faster, the product development period can be correspondingly shortened, and the risk of function upgrade is reduced.

The first embodiment is as follows:

fig. 2 is a schematic diagram of a hardware framework of a sample preprocessing device in an embodiment, where the sample preprocessing device includes a single-chip microcomputer motherboard circuit 1 and an industrial control motherboard circuit 2. The singlechip mainboard circuit 1 is connected between the industrial control mainboard circuit 2 and the peripheral 4 of the sample pretreatment instrument. The singlechip mainboard circuit 1 comprises a peripheral drive circuit 11, a peripheral bus interface 13 and an industrial control connection interface 12. The peripheral driving circuit 11 is used for providing hardware driving for the peripheral 4 of the sample pretreatment instrument, the industrial control connecting interface 12 is used for data communication between the single chip microcomputer main board circuit 1 and the industrial control main board circuit 2, and the peripheral bus interface 13 is used for data communication between the single chip microcomputer main board circuit 1 and the peripheral 4 of the sample pretreatment instrument. The industrial control mainboard circuit 2 is connected with the industrial control connecting interface 12 and is used for monitoring and controlling the working process of the sample pretreatment instrument. In an embodiment, the sample preprocessing instrument further includes a human-computer interaction module 3, the human-computer interaction module 3 is connected to the industrial control motherboard circuit 2, and the human-computer interaction module 3 is configured to send a control command for controlling the sample preprocessing instrument to the industrial control motherboard circuit 2, and is further configured to output and display a working state parameter signal of the sample preprocessing instrument. In one embodiment, the peripheral bus interface comprises a CAN bus interface. In one embodiment, the industrial control connection interface is a serial interface.

In one embodiment, the external devices of the sample pre-treatment instrument include a scanner 52, an illumination lamp 53, an ultraviolet lamp 54, a sample rack detection path 55, a temperature monitoring circuit 51, a fan 56, a liquid level detector 57 and/or a limit detector 58.

Referring to fig. 3, it is a schematic diagram of an architecture of a motherboard circuit of a single chip microcomputer according to an embodiment, wherein the peripheral driving circuit includes a first RS232 interface 111, an ADC sampling circuit 112, a fan driving circuit 113, an illumination switch circuit 114, and/or a switch detection circuit 115. The first RS232 interface 111 is connected to the scanner 52. The ADC sampling circuit 112 is connected to the temperature monitoring circuit 51, and is configured to perform analog-to-digital conversion on the temperature-related electrical signal output by the temperature monitoring circuit 51, so as to display a temperature value. The fan driving circuit 113 is connected to the fan 56 and supplies driving power to the fan 56. The illumination switch circuit 114 is connected to the illumination lamp 53 and the ultraviolet lamp 54, and is configured to perform on-off control of the illumination lamp 53 and the ultraviolet lamp 54. The switch detection circuit 115 is connected to the limit detector 58, the sample rack detection path 55, and the liquid level detector 57 of the sample pretreatment apparatus.

In one embodiment, the peripheral device 4 of the sample pre-treatment instrument includes an X-axis motor 61, a sample injection needle Y-axis motor 62, and a sample injection needle Z-axis motor 63. The peripheral bus interface comprises a CAN motor bus 131, wherein the CAN motor bus 131 is connected with an X-axis motor 61, a sample adding needle Y-axis motor 62 and a sample adding needle Z-axis motor 63.

Referring to fig. 4, a schematic circuit diagram of a buzzer in an embodiment is shown, in which in an embodiment, the single chip microcomputer main board circuit 1 further includes a buzzer 14 for outputting warning information of the sample pretreatment apparatus.

Fig. 5 is a schematic diagram of an industrial control motherboard circuit in an embodiment, where the industrial control motherboard circuit 2 includes a second RS232 interface 21, a network adapter 22, a CAN interface 23, a USB interface circuit 24, and an LVDS interface 25. The second RS232 interface 21 is connected with the singlechip mainboard circuit 1, and the LVDS interface 25 is connected with the human-computer interaction module 3.

Referring to fig. 6, a schematic circuit diagram of a temperature monitoring circuit in an embodiment is shown, wherein the temperature monitoring circuit is a sampling circuit using an NTC thermistor.

As shown in fig. 3, in an embodiment of the present application, a main control IC of a motherboard circuit of a single chip microcomputer is STM32F107RCT6, and further includes a DC/DC 24V buck circuit, an LDO 3.3V buck circuit, a crystal oscillator circuit, and an EEPROM data saving circuit. The master control IC of the singlechip mainboard circuit receives data through a serial port and analyzes the data sent by the upper computer, and belongs to an actuating mechanism and a reporting transfer node. If the stepping motor is controlled through a CAN motor bus, the stepping motor comprises an X-axis motor, a Y/Z-axis stepping motor 1 of a sample adding needle, a Y/Z-axis stepping motor 2 of the sample adding needle and the like, an illuminating lamp and an ultraviolet lamp CAN be started or closed, and meanwhile, the detection of whether a sample rack detection channel is in place, the detection of liquid capacity, the detection of whether an equipment magnetic rod sleeve exists and the like and the temperature value of a key part of the equipment are detected, and the detection result is reported to an industrial control mainboard circuit.

As shown in fig. 5, in an embodiment of the present application, a core system IC of the industrial control motherboard circuit is an MCIMX6U55EVM10AC with 4 pieces of DDR3 and 1 piece of eMMC, and further includes an LVDS screen interface, a USB HOST interface, a USB OTG download port, an RTC circuit, a Debug circuit, an RS232 serial port circuit, a CAN interface, and other circuits. The functions pre-finished by the industrial control mainboard circuit comprise man-machine interaction through a man-machine interaction module, communication with a singlechip mainboard circuit, equipment running state monitoring, equipment running algorithm calculation, online editing and running test processes and the like.

The application discloses sample pretreatment appearance comprises two parts: industrial control mainboard circuit and singlechip mainboard circuit. The industrial control mainboard circuit is responsible for equipment operation algorithm and man-machine interaction, completes calculation work, and sends calculation results to the single-chip microcomputer mainboard circuit, and the single-chip microcomputer mainboard circuit executes corresponding peripheral equipment according to data types and numerical values after analyzing data. The industrial control mainboard circuit in the application is only responsible for configuration and calculation of equipment experiment operation, and the singlechip mainboard circuit is only responsible for execution and does not participate in experiment operation. Because the hardware architecture function is clear, the functions completed by the industrial control mainboard circuit and the singlechip mainboard circuit are independent, as long as the communication protocol is customized, the development of the industrial control mainboard circuit and the development of the circuit of the singlechip mainboard can be mutually independent, so that the software architecture is clear, the maintenance is also convenient, the complexity of software design is reduced, when the peripheral equipment of the sample pretreatment instrument needs to be replaced or upgraded, the problem can be solved only by adjusting the singlechip mainboard circuit, the development period is further shortened, and the product upgrading risk is reduced.

It should be noted that all software and methods related to the embodiments of the present application are the prior art, and how to execute the specific program and the specific calling step can refer to the contents of the related tool book or the patent document, and the present application does not protect and does not describe the related principle in detail.

It is right to have used specific individual example above the utility model discloses expound, only be used for helping to understand the utility model discloses, not be used for the restriction the utility model discloses. To the technical field of the utility model technical personnel, the foundation the utility model discloses an idea can also be made a plurality of simple deductions, warp or replacement.

Claims

1. A sample pretreatment instrument is characterized by comprising a singlechip mainboard circuit and an industrial control mainboard circuit;

the industrial control main board circuit is connected with the industrial control connecting interface and is used for monitoring and controlling the working process of the sample pretreatment instrument;

the external equipment of the sample pretreatment instrument comprises a scanner, a lighting lamp, an ultraviolet lamp, a sample frame detection passage, a temperature monitoring circuit, a fan, a liquid level detector and/or a limit detector;

the peripheral driving circuit comprises a first RS232 interface, an ADC sampling circuit, a fan driving circuit, an illumination switch circuit and/or a switch detection circuit;

the first RS232 interface is connected with the scanner;

the switch detection circuit is connected with a limit detector, a sample frame detection passage and a liquid level detector of the sample pretreatment instrument;

the sample pretreatment instrument further comprises a human-computer interaction module, the human-computer interaction module is connected with the industrial control mainboard circuit, and the human-computer interaction module is used for sending a control command for controlling the sample pretreatment instrument to the industrial control mainboard circuit and outputting and displaying a working state parameter signal of the sample pretreatment instrument.

2. The pre-sample processor of claim 1, wherein the peripheral bus interface comprises a CAN bus interface.

3. The pre-sample treatment instrument as recited in claim 1, wherein the industrial control connection interface is a serial interface.

4. The pre-sample treatment instrument as recited in claim 1, wherein the sample treatment instrument comprises an X-axis motor, a Y-axis motor for the sample application needle, and a Z-axis motor for the sample application needle.

5. The pre-sample treatment instrument as recited in claim 4, wherein the peripheral bus interface includes a CAN motor bus, and the CAN motor bus is connected to the X-axis motor, the sample-adding needle Y-axis motor, and the sample-adding needle Z-axis motor.

6. The pre-sample treatment instrument as claimed in claim 1, wherein the single chip microcomputer main board circuit further comprises a buzzer for outputting warning information of the pre-sample treatment instrument.

7. The pre-sample treatment instrument according to claim 1, wherein the industrial control motherboard circuit comprises a second RS232 interface, a network adapter, a CAN interface, a USB interface circuit, and an LVDS interface;