CN218641431U - Exosome separation kit - Google Patents

Abstract

The utility model relates to an exosome separation technical field especially relates to exosome separation kit, include: outer box, test tube spare, extending structure, install the fixed plate in the outer box, be provided with a plurality of buttresses on the fixed plate, a plurality of hole grooves have been seted up, a plurality of to the top side range of outer box hole groove and a plurality of the position of collet corresponds each other, it is connected with the bull stick to rotate on the outer box, install splint on the bull stick, test tube spare is placed in the outer box, the top of test tube spare is provided with the enclosing cover, the enclosing cover includes shell and commentaries on classics board, the commentaries on classics board rotates to be connected on the shell, extending structure connects the shell with on the commentaries on classics board, the utility model discloses, reduced the reagent liquid spill's when turning on one's side possibility of reagent, reduced the long-time contact air of reagent possibility, improved the operation of staff when extracting the reagent more portably, also improved the fixed of reagent and deposited stable effect with the reagent.

Description

Exosome separation kit

Technical Field

The utility model relates to an exosome separation technical field especially relates to exosome separation kit.

Background

Exosomes are vesicles containing nucleic acids and proteins, are secreted by various cells, are present in a large amount in body fluids such as blood, saliva, urine, and milk, require addition of a plurality of reagents in separation of exosomes, and can purify extracted exosomes.

Patent publication No. CN212290909U discloses a exosome separation draws kit, and this kit can reach through the support protection of two support protection pieces and carry out effectual protection support to the reagent bottle, but at the in-process of placing of kit, because the mistake collision probably leads to turning on one's side of whole kit, the back reagent of turning on one's side spills the polluted environment, if use the bottle lid to plug up the reagent mouth, it is comparatively troublesome again when operating personnel takes the reagent, exosome separation kit that provides for this reason.

SUMMERY OF THE UTILITY MODEL

The utility model aims at solving the problems in the prior art and providing an exosome separation kit.

In order to realize the purpose, the utility model adopts the following technical scheme:

the utility model provides an exosome separation kit, includes outer box, examination pipe fitting, extending structure, install the fixed plate in the outer box, be provided with a plurality of collet on the fixed plate, a plurality of hole grooves have been seted up to the top side range of outer box, and is a plurality of hole groove and a plurality of the position of collet corresponds each other, it is connected with the bull stick to rotate on the outer box, install splint on the bull stick, examination pipe fitting places in the outer box, the top of examination pipe fitting is provided with the enclosing cover, the enclosing cover includes shell and rotor, rotor rotates to be connected on the shell, extending structure connects the shell with on the rotor, extending structure includes carriage release lever, dead lever and spring, be hollow form in the dead lever, carriage release lever sliding connection is wherein, the spring sets up between carriage release lever and the dead lever.

Preferably, a plurality of holes are formed in the clamping plate, penetrate through the clamping plate and correspond to the hole grooves in position.

Can be spacing in the outside in hole groove with the snap ring through the hole groove, can stretch out the top of examination pipe fitting through the hole groove, press from both sides the snap ring between outer box and splint through splint, more convenient fixing.

Preferably, the test tube spare includes the body, snap ring and first screw thread, the snap ring is fixed on the surface of body, and it is located the port department of body, first screw thread is seted up on the outer wall of body, and it is seted up between the port of first screw thread and body.

Preferably, the test tube spare is provided with a plurality ofly, all sets up the hole inslot, and its bottom all places on the collet, the snap ring all blocks and establishes the hole groove outside, and the snap ring all press from both sides in outer box with between the splint.

Can make the port department of test tube spare more conveniently connect the shell through first screw thread, and the threaded connection of shell and test tube spare can let test tube spare fix on splint, and test tube spare also can not drop from outer box when the outer box side falls.

Preferably, the top end of the outer box is provided with a through hole, a base is arranged at the right lower end of the through hole, the base and the top surface of the bottom support are both semicircular and concave, and a lamp bead and a battery are arranged in the base and are electrically connected.

Can hold the body through collet and base, prevent that it is unsettled for a long time, can carry out observation at any time to the sample when separating the exosome through the base, and can not shelter from light because of outer box.

Preferably, a metal ball is fixed on one side of the moving rod, a second fixing block is arranged on the outer side of the metal ball, a rotating ring is fixed on one side of the fixing rod, and a first fixing block is arranged on the outer side of the rotating ring.

Preferably, the first fixed block with all be provided with the pivot in the second fixed block, the pivot runs through the metal ball with the swivel is the rotation and is connected, the second fixed block is fixed on the commentaries on classics board, first fixed block is fixed on the shell.

Can not receive spacing card when the commentaries on classics board rotates through metal ball, swivel and pivot and pause, the extending structure can freely stretch out and draw back.

Preferably, a plurality of rotating plates are annularly arranged in the shell, the rotating plates are rotatably connected with the shell, a plurality of telescopic structures are connected between the rotating plates and the shell, and the shell is in threaded connection with the first threads.

The beneficial effects of the utility model are that:

the utility model discloses can realize the stability of reagent through hole groove and collet and place, can fix reagent through splint, can control opening and closing of enclosing cover by oneself through extending structure, can observe and deposit the sample when separating through-hole and base.

The utility model discloses, reduced the reagent box reagent liquid spill when turning on one's side the possibility, reduced the long-time contact air of reagent's possibility, improved the operation of staff when extracting reagent more portably, also improved the fixed and deposit stable effect of reagent box to reagent.

Drawings

Fig. 1 is a schematic structural diagram of an exosome-separating kit provided by the present invention;

fig. 2 is a schematic structural diagram of a pilot-scale tube of the exosome-separating kit provided by the present invention;

fig. 3 is a schematic bottom view of the structure of the outer cover of the exosome-separating kit according to the present invention;

FIG. 4 is a schematic view of the telescoping structure of FIG. 3;

fig. 5 is a schematic structural front view of the telescopic structure.

In the figure: 1. an outer box; 11. a fixing plate; 111. a bottom support; 12. a base; 13. a rotating rod; 14. a splint; 15. a through hole; 2. an outer cover; 21. a housing; 22. rotating the plate; 3. a telescopic structure; 31. a metal ball; 32. a travel bar; 33. a fixing rod; 331. a spring; 34. rotating the ring; 35. a first fixed block; 36. a second fixed block; 4. testing the pipe; 41. a pipe body; 42. a snap ring; 43. a first thread.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments.

Example 1:

referring to fig. 1-5, the exosome separation kit includes an outer box 1, a test tube element 4, a telescopic structure 3, a fixing plate 11 is installed in the outer box 1, a plurality of bottom holders 111 are disposed on the fixing plate 11, a plurality of hole grooves are formed in the top side of the outer box 1, the plurality of hole grooves correspond to the plurality of bottom holders 111, a rotating rod 13 is rotatably connected to the outer box 1, a clamping plate 14 is installed on the rotating rod 13, the test tube element 4 is placed in the outer box 1, an outer cover 2 is disposed at the top end of the test tube element 4, the outer cover 2 includes a housing 21 and a rotating plate 22, the rotating plate 22 is rotatably connected to the housing 21, the telescopic structure 3 is connected to the housing 21 and the rotating plate 22, the telescopic structure 3 includes a moving rod 32, a fixing rod 33 and a spring 331, the fixing rod 33 is hollow, the moving rod 32 is slidably connected to the moving rod 32, the spring 331 is disposed between the moving rod 32 and the fixing rod 33, a metal ball 31 is fixed to one side of the moving rod 32, a second fixing block 36 is disposed outside the metal ball 31, a rotating ring 34 is fixed to one side of the fixing rod 33, a first fixing block 35 is disposed outside the rotating ring 34, a first fixing block 35 is disposed on the rotating rod 35, and a second fixing block 35 is disposed on the rotating rod 21, and a second fixing block 35, and a second rotating rod 21 is disposed on the rotating rod 32, and a second rotating plate, and a second fixing block 34.

In this implementation, a plurality of holes have been seted up on splint 14, splint 14 is all run through to the hole, and its position with the hole groove all is mutual correspondence, test tube spare 4 includes body 41, snap ring 42 and first screw thread 43, snap ring 42 is fixed on the surface of body 41, and its port department that is located body 41, first screw thread 43 is seted up on the outer wall of body 41, and it is seted up between the port of first screw thread 43 and body 41, test tube spare 4 is provided with a plurality ofly, all set up at the hole inslot, and its bottom all places on collet 111, snap ring 42 all blocks and establishes in the hole groove outside, and snap ring 42 all presss from both sides between outer box 1 and splint 14, the annular is provided with a plurality of commentaries on classics board 22 in the shell 21, commentaries on classics board 22 all is changeing with shell 21 and connects, all be connected with extending structure 3 between a plurality of commentaries on classics board 22 and the shell 21, shell 21 is threaded connection with first screw thread 43.

The working principle is as follows: when carrying out the exosome separation, add reagent in body 41, turn over splint 14 upwards, put into the hole groove with body 41, make snap ring 42 card in hole notch and body 41 bottom contact collet 111, close splint 14, and with enclosing cover 2 threaded connection on body 41, when needs extraction reagent, insert examination pipe fitting 4 in taking the extraction pipe, when the extraction pipe touches revolving plate 22, revolving plate 22 can rotate, carriage release lever 32 can inwards retract, spring 331 is compressed tightly, after having extracted reagent, take out the extraction pipe, spring 331 can rebound rapidly, carriage release lever 32 stretches out revolving plate 22 and returns the normal position, realize closing the effect.

Example 2:

on the basis of the embodiment 1, the following technical scheme is also provided:

the test tube 4 is provided with a plurality of, all sets up in the hole inslot, and all places on collet 111 its bottom, and snap ring 42 all blocks and establishes in the hole groove outside, and snap ring 42 all presss from both sides between outer box 1 and splint 14.

The working principle is as follows: when carrying out exosome separation experiment, can place the test tube of sample on base 12 through-hole 15, control lamp pearl is opened, can observe the change of sample more clearly, conveniently records.

The above, only be the concrete implementation of the preferred embodiment of the present invention, but the protection scope of the present invention is not limited thereto, and any person skilled in the art is in the technical scope of the present invention, according to the technical solution of the present invention and the utility model, the concept of which is equivalent to replace or change, should be covered within the protection scope of the present invention.

Claims (8)

1. An exosome isolation kit, comprising:

the box comprises an outer box (1), wherein a fixing plate (11) is installed in the outer box (1), a plurality of bottom supports (111) are arranged on the fixing plate (11), a plurality of hole grooves are formed in the top side of the outer box (1) in an arrayed mode, the hole grooves correspond to the bottom supports (111) in position, a rotating rod (13) is connected to the outer box (1) in a rotating mode, and a clamping plate (14) is installed on the rotating rod (13);

the test tube piece (4) is placed in the outer box (1), an outer cover (2) is arranged at the top end of the test tube piece (4), the outer cover (2) comprises a shell (21) and a rotating plate (22), and the rotating plate (22) is rotatably connected to the shell (21);

extending structure (3), extending structure (3) are connected shell (21) with on changeing board (22), extending structure (3) include carriage release lever (32), dead lever (33) and spring (331), be hollow form in dead lever (33), carriage release lever (32) sliding connection is wherein, spring (331) set up between carriage release lever (32) and dead lever (33).

2. An exosome-isolating kit according to claim 1, characterized in that the splint (14) is provided with a plurality of holes, which all penetrate the splint (14) and are positioned corresponding to the slots.

3. An exosome isolation kit according to claim 1, characterized in that the test tube member (4) comprises a tube body (41), a snap ring (42) and a first thread (43), the snap ring (42) being fixed on the outer surface of the tube body (41) and being located at a port of the tube body (41), the first thread (43) being provided on the outer wall of the tube body (41) and being provided between the first thread (43) and the port of the tube body (41).

4. A exosome-isolation kit according to claim 3, wherein the test tube member (4) is provided in plurality, all disposed in the hole groove, and the bottom ends thereof are disposed on the bottom support (111), the snap rings (42) are all snapped outside the hole groove, and the snap rings (42) are all sandwiched between the outer box (1) and the splint (14).

5. An exosome separation kit according to claim 1, wherein a through hole (15) is formed in the top end of the outer box (1), a base (12) is arranged right below the through hole (15), the top surfaces of the base (12) and the bottom support (111) are both semicircular and concave, and a lamp bead and a battery are arranged in the base (12) and are electrically connected.

6. Exosome isolation kit according to claim 1, characterized in that a metal ball (31) is fixed to one side of the moving rod (32), a second fixed block (36) is provided to the outside of the metal ball (31), a swivel (34) is fixed to one side of the fixed rod (33), and a first fixed block (35) is provided to the outside of the swivel (34).

7. An exosome isolation kit according to claim 6, wherein a rotating shaft is arranged in each of the first fixing block (35) and the second fixing block (36), the rotating shaft penetrates through the metal ball (31) and is rotatably connected with the rotating ring (34), the second fixing block (36) is fixed on the rotating plate (22), and the first fixing block (35) is fixed on the housing (21).

8. Exosome-isolation kit according to claim 3, characterized in that a plurality of rotating plates (22) are annularly arranged in the housing (21), the rotating plates (22) are all in rotating connection with the housing (21), a telescopic structure (3) is connected between the plurality of rotating plates (22) and the housing (21), and the housing (21) is in threaded connection with the first thread (43).

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