CN211035888U - Free nucleic acid piece-rate system of pressurization formula - Google Patents
Free nucleic acid piece-rate system of pressurization formula Download PDFInfo
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- CN211035888U CN211035888U CN201921732940.4U CN201921732940U CN211035888U CN 211035888 U CN211035888 U CN 211035888U CN 201921732940 U CN201921732940 U CN 201921732940U CN 211035888 U CN211035888 U CN 211035888U
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- nucleic acid
- free nucleic
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- storage pipe
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Abstract
The utility model relates to a free nucleic acid separation technical field, specifically speaking relates to a free nucleic acid piece-rate system of pressurization formula, including the liquid storage pipe, the liquid storage pipe is inside to be hollow cylinder, the bottom of liquid storage pipe is coniform, and be equipped with the first flow outlet that is linked together with inside at the liquid storage pipe bottom, the liquid storage pipe is inside to be equipped with the bulldozing ware, bulldozing ware includes first cylinder, first cylinder lower surface is equipped with a plurality of backup pads, the lower extreme of backup pad is equipped with the second cylinder, the cover is equipped with free nucleic acid adsorption column on the first flow outlet, free nucleic acid adsorption column is inside to be equipped with silica gel adsorption pad, free nucleic acid adsorption column bottom is equipped with the second flow outlet that is linked together with inside, the cover is equipped with the connector below the second flow outlet, the below; this pressurization formula free nucleic acid piece-rate system sets up liquid storage pipe and bulldozer, and the cooperation is free nucleic acid adsorption column, and under user's applied pressure, the flow of free nucleic acid in silica gel adsorption pad is accelerated, shortens the separation time.
Description
Technical Field
The utility model relates to a free nucleic acid separation technical field, specifically speaking relates to a free nucleic acid piece-rate system of pressurization formula.
Background
The composition difference of blood plasma of different people is large, such as blood fat content, protein content, carbohydrate content and the like, and the composition difference is large after the lysate of the blood plasma is cracked, so that the speed difference is very large when the lysate flows through a silica gel adsorption column for adsorbing free nucleic acid, and the speed difference is different from several minutes to tens of minutes;
in the prior art, the separation speed of free nucleic acid is slow, the waste time is long, and the extraction is inconvenient for users.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a free nucleic acid piece-rate system of pressurization formula to solve the problem that proposes among the above-mentioned background art.
In order to achieve the above object, the utility model provides a following technical scheme:
a pressurized free nucleic acid separation system comprises a liquid storage pipe, wherein the liquid storage pipe is internally hollow cylindrical, the bottom of the liquid storage pipe is conical, a first flow outlet communicated with the inside is arranged at the bottom of the liquid storage pipe, an annular groove is formed in the position, close to the bottom, of the outer wall of the circumference of the first flow outlet, a pushing device is arranged inside the liquid storage pipe and comprises a first cylinder, a plurality of supporting plates are arranged on the lower surface of the first cylinder, a second cylinder is arranged at the lower end of each supporting plate and is in splicing fit with the liquid storage pipe, a free nucleic acid adsorption column is sleeved on the first flow outlet and is internally hollow cylindrical, a silica gel adsorption pad is arranged inside the free nucleic acid adsorption column, a second flow outlet communicated with the inside is arranged at the bottom of the free nucleic acid adsorption column, and a connector is sleeved below the second flow outlet, the liquid collector is arranged below the connector and comprises a collecting column, and the collecting column is in plug-in fit with the connector.
Preferably, the position that the liquid storage pipe circumference outer wall is close to the tip is equipped with first ring, first ring and liquid storage pipe be the integrated into one piece structure, the liquid storage pipe is the integrated into one piece structure with first outfall, first ring provides the effect of supporting force when setting up the manual promotion bulldozer of convenient to use person.
Preferably, the backup pad is the annular equidistant distribution, and quantity has four at least, backup pad, first cylinder and second cylinder three are integrated into one piece structure, the internal diameter looks adaptation of second cylinder diameter and liquid storage pipe, and the user makes by manually pressing down first cylinder, lets the solution of second cylinder extrusion inside, and what more stable carried out the pressurization and use.
As preferredly, the position that free nucleic acid adsorption column circumference outer wall is close to the tip is equipped with the second ring, the second ring is the integrated into one piece structure with free nucleic acid adsorption column, the second outfall is the integrated into one piece structure with free nucleic acid adsorption column, the external diameter looks adaptation of free nucleic acid adsorption column internal diameter and annular, the effect of second ring, convenient to use person dismantles and changes free nucleic acid adsorption column, and whole free nucleic acid adsorption column closely cup joints with the second outfall, makes it more stable.
Preferably, the position that the connector circumference outer wall is close to the tip is equipped with the third ring, the third ring is the integrated into one piece structure with the connector, the internal diameter and the second outflow external diameter looks adaptation of connector, the third ring sets up, and convenient to use person installs and dismantles.
Preferably, the outer diameter of the connector is matched with the inner diameter of the collecting column, and the collecting column and the liquid collector are of an integrally formed structure, so that the finally decomposed solution can be conveniently collected.
Compared with the prior art, the beneficial effects of the utility model are that:
the utility model discloses set up liquid storage tube and bulldozing ware, the quick pressurization separation of convenient to use person, shorten the time of separation, first outflow cup joints the cooperation with free nucleic acid adsorption column, convenient to detach and change, facilitate the use, the inside silica gel adsorption pad that is equipped with of free nucleic acid adsorption column, in order to adsorb free nucleic acid, when the user applys pressure to bulldozing ware, free nucleic acid wears to flow in silica gel adsorption pad with higher speed, it further filters the solution of separation to be equipped with the connector below free nucleic acid adsorption column cover, final solution flows in the liquid collector, under the external condition of applying pressure of user, the decomposition to free nucleic acid is collected with higher speed, the time is shortened.
Drawings
FIG. 1 is a schematic view of the overall structure of a pressurized free nucleic acid separation system according to the present invention;
FIG. 2 is a schematic view of the liquid storage tube of the present invention;
FIG. 3 is a schematic structural view of the pushing device of the present invention;
FIG. 4 is a schematic view of the structure of the free nucleic acid adsorption column of the present invention;
fig. 5 is a schematic view of the connector of the present invention;
fig. 6 is a schematic view of the liquid collector of the present invention.
In the figure:
1. a liquid storage pipe; 10. a first circular ring;
2. a pusher; 20. a first cylinder; 21. a support plate; 22. a second cylinder;
3. a first outflow port; 30. a ring groove;
4. a free nucleic acid adsorption column; 40. a second circular ring; 41. a second outlet; 42. a silica gel adsorption pad;
5. a connector; 50. a third circular ring;
6. a liquid collector; 60. and collecting the column.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and to simplify the description, but do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore should not be construed as limiting the present invention.
Furthermore, the terms "first", "second", "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, features defined as "first", "second", "third" may explicitly or implicitly include one or more of the features. In the description of the present invention, "a plurality" means at least two, e.g., two, three, etc., unless specifically limited otherwise.
Referring to fig. 1-6, the present invention provides a technical solution:
a pressurized free nucleic acid separation system comprises a liquid storage tube 1, the inside of the liquid storage tube 1 is hollow cylindrical, the bottom of the liquid storage tube 1 is conical, a first flow outlet 3 communicated with the inside is arranged at the bottom of the liquid storage tube 1, an annular groove 30 is arranged at the position, close to the bottom, of the circumferential outer wall of the first flow outlet 3, a pushing and pressing device 2 is arranged inside the liquid storage tube 1, the pushing and pressing device 2 comprises a first cylinder 20, a plurality of supporting plates 21 are arranged on the lower surface of the first cylinder 20, a second cylinder 22 is arranged at the lower end of each supporting plate 21, the second cylinder 22 is in splicing fit with the liquid storage tube 1, a free nucleic acid adsorption column 4 is sleeved on the first flow outlet 3, the inside of the free nucleic acid adsorption column 4 is hollow cylindrical, a silica gel adsorption pad 42 is arranged inside the free nucleic acid adsorption column 4, a second flow outlet 41 communicated with the inside is arranged at the bottom of, a liquid collector 6 is arranged below the connector 5, the liquid collector 6 comprises a collecting column 60, and the collecting column 60 is in plug fit with the connector 5.
In this embodiment, the position that 1 circumference outer wall of liquid storage pipe is close to the tip is equipped with first ring 10, and first ring 10 is the integrated into one piece structure with liquid storage pipe 1, and liquid storage pipe 1 is the integrated into one piece structure with first outflow 3, and when first ring 10 set up the manual bulldozer 2 that promotes of convenient to use person, provides the effect of supporting force.
It is specific, backup pad 21 is the equidistant distribution of annular, and quantity has four at least, backup pad 21, first cylinder 20 and second cylinder 22 three are the integrated into one piece structure, the internal diameter looks adaptation of second cylinder 22 diameter and liquid storage pipe 1, the user makes by manually pressing first cylinder 20, let the solution of second cylinder 22 extrusion in inside, the more stable use of pressurizeing, backup pad 21 has the part to cave in being close to second cylinder 22 one, be convenient for let the user carry out the restricted type use, break easily, avoid used repeatedly.
Further, the position that 4 circumference outer walls of free nucleic acid adsorption column are close to the tip is equipped with second ring 40, second ring 40 and free nucleic acid adsorption column 4 are the integrated into one piece structure, second outlet 41 and free nucleic acid adsorption column 4 are the integrated into one piece structure, 4 internal diameters of free nucleic acid adsorption column and the external diameter looks adaptation of annular 30, the effect of second ring 40, convenient to use person dismantles and changes free nucleic acid adsorption column 4, whole free nucleic acid adsorption column 4 and second outlet 41 closely cup joint, make it more stable, silica gel adsorption pad 42 is the cake form, and diameter and 4 internal diameter looks adaptations of free nucleic acid adsorption column.
Secondly, the position that the outer wall of connector 5 circumference is close to the tip is equipped with third ring 50, and third ring 50 and connector 5 be integrated into one piece structure, and the internal diameter of connector 5 and the external diameter looks adaptation of second outflow 41, third ring 50 set up, and convenient to use person installs and dismantles.
In addition, the outer diameter of the connector 5 is matched with the inner diameter of the collecting column 60, and the collecting column 60 and the liquid collector 6 are of an integrally formed structure, so that the finally decomposed solution can be conveniently collected.
When the pressurized free nucleic acid separation system of this embodiment is used, the user first adds the plasma to be separated at an accelerated speed into the reservoir 1, the user inserts the pushing device 2 into the liquid storage tube 1 manually, the second cylinder 22 is tightly attached to the liquid storage tube 1, after the free nucleic acid adsorption column 4 is sleeved in the annular groove 30, the user manually sleeves the connector 5 on the second outlet 41, the lower end of the connector 5 is inserted into the collection column 60, the user manually pushes the pusher 2, the second cylinder 22 extrudes the plasma in the liquid storage tube 1 to extrude the plasma into the free nucleic acid adsorption column 4, when the speed is fast, the free nucleic acid enters the silica gel adsorption pad 42, the plasma mixed liquid which is not adsorbed enters the connector 5 and finally enters the liquid collector 6, and the whole process is carried out the free nucleic acid adsorption in most of the shortened time under the condition that the user applies pressure manually.
The foregoing shows and describes the general principles, essential features, and advantages of the invention. It should be understood by those skilled in the art that the present invention is not limited by the above embodiments, and the description in the above embodiments and the description is only preferred examples of the present invention, and is not intended to limit the present invention, and that the present invention can have various changes and modifications without departing from the spirit and scope of the present invention, and these changes and modifications all fall into the scope of the claimed invention. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (6)
1. A pressurized free nucleic acid separation system comprising a liquid storage tube (1), characterized in that: the inside hollow cylinder that is of liquid storage pipe (1), the bottom of liquid storage pipe (1) is coniform, and is in liquid storage pipe (1) bottom is equipped with first outfall (3) that is linked together with inside, the position that first outfall (3) circumference outer wall is close to the bottom is equipped with annular (30), the inside bulldozing ware (2) that is equipped with of liquid storage pipe (1), bulldoze ware (2) including first cylinder (20), first cylinder (20) lower surface is equipped with a plurality of backup pads (21), the lower extreme of backup pad (21) is equipped with second cylinder (22), second cylinder (22) and liquid storage pipe (1) are pegged graft and are cooperated, the cover is equipped with free nucleic acid adsorption column (4) on first outfall (3), inside hollow cylinder that is of free nucleic acid adsorption column (4), inside silica gel adsorption pad (42) that is equipped with of free nucleic acid adsorption column (4), free nucleic acid adsorption column (4) bottom is equipped with second outlet (41) that is linked together with inside, second outlet (41) below cover is equipped with connector (5), the below of connector (5) is equipped with liquid collector (6), liquid collector (6) are including collecting post (60), it pegs graft the cooperation with connector (5) to collect post (60).
2. The pressurized free nucleic acid separation system according to claim 1, wherein: the liquid storage pipe is characterized in that a first circular ring (10) is arranged at a position, close to the end, of the outer wall of the circumference of the liquid storage pipe (1), the first circular ring (10) and the liquid storage pipe (1) are of an integrally formed structure, and the liquid storage pipe (1) and the first outflow port (3) are of an integrally formed structure.
3. The pressurized free nucleic acid separation system according to claim 1, wherein: the support plate (21) is in annular equidistant distribution, the number of the support plate is at least four, the support plate (21), the first cylinder (20) and the second cylinder (22) are in an integrated structure, and the diameter of the second cylinder (22) is matched with the inner diameter of the liquid storage pipe (1).
4. The pressurized free nucleic acid separation system according to claim 1, wherein: free nucleic acid adsorption column (4) circumference outer wall is equipped with second ring (40) near the position of tip, second ring (40) and free nucleic acid adsorption column (4) are the integrated into one piece structure, second outlet (41) and free nucleic acid adsorption column (4) are the integrated into one piece structure, the external diameter looks adaptation of free nucleic acid adsorption column (4) internal diameter and annular (30).
5. The pressurized free nucleic acid separation system according to claim 1, wherein: the connector (5) circumference outer wall is equipped with third ring (50) near the position of tip, third ring (50) and connector (5) are integrated into one piece structure, the internal diameter and the second outflow (41) external diameter looks adaptation of connector (5).
6. The pressurized free nucleic acid separation system according to claim 1, wherein: the outer diameter of the connector (5) is matched with the inner diameter of the collecting column (60), and the collecting column (60) and the liquid collector (6) are of an integrally formed structure.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921732940.4U CN211035888U (en) | 2019-10-16 | 2019-10-16 | Free nucleic acid piece-rate system of pressurization formula |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921732940.4U CN211035888U (en) | 2019-10-16 | 2019-10-16 | Free nucleic acid piece-rate system of pressurization formula |
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| Publication Number | Publication Date |
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| CN211035888U true CN211035888U (en) | 2020-07-17 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201921732940.4U Active CN211035888U (en) | 2019-10-16 | 2019-10-16 | Free nucleic acid piece-rate system of pressurization formula |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113717837A (en) * | 2021-08-13 | 2021-11-30 | 通用生物(安徽)股份有限公司 | Detachable medicinal nucleic acid purification post |
-
2019
- 2019-10-16 CN CN201921732940.4U patent/CN211035888U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113717837A (en) * | 2021-08-13 | 2021-11-30 | 通用生物(安徽)股份有限公司 | Detachable medicinal nucleic acid purification post |
| CN113717837B (en) * | 2021-08-13 | 2023-10-03 | 通用生物(安徽)股份有限公司 | Detachable medicinal nucleic acid purification column |
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