CN218213043U - Medical portable rapid automatic biochemical analyzer system - Google Patents
Medical portable rapid automatic biochemical analyzer system Download PDFInfo
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- CN218213043U CN218213043U CN202222220545.6U CN202222220545U CN218213043U CN 218213043 U CN218213043 U CN 218213043U CN 202222220545 U CN202222220545 U CN 202222220545U CN 218213043 U CN218213043 U CN 218213043U
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Abstract
The utility model discloses a medical portable rapid automatic biochemical analyzer system, which comprises a detector and a special detection card matched with the detector, wherein the detection card is of a fan-shaped or semicircular structure, and each detection card is provided with more than two first reagent cups, more than two second reagent cups and a sample cup; each reagent cup is used for placing different kinds of reagents, and each sample cup is used for placing a sample; the detector can be simultaneously provided with more than one detection card at one time, namely, more than one sample can be synchronously subjected to the same multiple item detection, or more than one sample can be simultaneously subjected to different multiple item detection; the instrument is internally provided with a detection unit, a sample reagent distribution unit and a detection card tray, and more than one detection card can be loaded on one detection card tray of the instrument at one time.
Description
Technical Field
The utility model relates to a medical science detecting instrument and supporting consumptive material field, especially a medical portable quick automatic biochemical analyzer system.
Background
The biochemical analysis and detection of blood samples (serum, plasma), urine and other body fluids has important value in clinical diagnosis and treatment monitoring. The biochemical analyzer adopted by the existing medical institution is mainly a liquid full-automatic biochemical analyzer, and a large-scale full-automatic biochemical analyzer has the advantages of high speed and high accuracy, but has the defects of large volume, difficult movement, high cost, complex operation, uneconomic operation when the sample amount is small, and the like. The biochemical detection is required to be completed quickly under emergency situations in clinical work, and is extremely inapplicable to a large biochemical analyzer due to small sample amount and limited investment in a basic medical institution, but the biochemical detection is necessary detection equipment of the basic medical institution, so the biochemical analyzer with small investment and convenient operation is also required. However, the existing portable rapid biochemical analyzer is mainly based on a dry test strip or a dry reagent card technology, and the detection result of the portable rapid biochemical analyzer is often inconsistent with that of a liquid biochemical analyzer, the accuracy of the detection result is poor, and the number of detection items is small, so that the development of the portable rapid biochemical analyzer adopting a liquid reagent is very necessary.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a medical portable quick automatic biochemical appearance system can carry out the multinomial examination of more than two samples in step, and detection efficiency is high.
Realize the utility model discloses the technical scheme of purpose does: a medical portable rapid automatic biochemical analyzer system comprises a detector, wherein the detector comprises a detection unit, a sample reagent distribution unit, a detection card tray, a temperature control unit and a cleaning unit;
more than one detection card with a fan-shaped or semicircular plane of depression is synchronously loaded on the detection card tray, namely, more than one sample can be respectively and simultaneously subjected to more than one same or different biochemical project detection each time the instrument runs;
each detection card is provided with a sample cup, more than two first reagent cups and more than two second reagent cups; and each cup on the detection card is opened upwards and is independent and not communicated with each other; the reagent cups on the detection card are used for placing different kinds of reagents, the reagent cups are arranged in an arc shape at equal intervals along the radius of the detection card, and the cups arranged on the detection card are arranged in more than one layer according to different radii.
Furthermore, each reagent cup on the detection card is respectively pre-filled with all reagents required by more than two different biochemical detection items, each detection item is provided with a first reagent cup, and each detection item completes the reaction of the sample and all the reagents participating in the detection of the item in the corresponding first reagent cup and completes the detection in the first reagent cup; each test card is provided with only one sample cup for placing a sample, and each test card is loaded with a sample required by the test of the test card and all various reagents participating in the reaction of the test items.
Furthermore, a first reagent cup of the detection card is positioned at the outermost side of the detection card, a second reagent cup which is distributed in parallel with the first reagent cup is arranged close to the inner side of the first reagent cup, and the sample cup is positioned at the innermost side.
Furthermore, a specific identifier or a chip is arranged on the detection card, the detector is provided with a reading device for automatically identifying the identifier arranged on the detection card, and the detector automatically identifies the information of the detection card through the specific identifier, including the type of the detection card, the detection items, whether the detection card is in the valid period and the sample information loaded by the detection card.
Further, the test card is provided with a reagent cup for loading a third reagent.
Furthermore, the detection card tray is connected with a driving motor through a shaft rod, and the driving motor drives the detection card tray to rotate.
Furthermore, the detection card placing area set on the detection card tray can be suitable for loading one or more detection cards at the same time, so that synchronous detection of a plurality of items of one or more samples can be synchronously executed at one time.
Furthermore, the detector is also provided with a blending device for adding the sample into the first reagent cup and blending the sample with other reagents.
Compared with the prior art, the beneficial effects of the utility model are that: the utility model can conveniently and rapidly complete detection, especially, only one detection unit and one detection card tray structure are adopted, the instrument structure is not enlarged, and the simultaneous detection of a plurality of items can be simultaneously carried out on more than one sample on the premise of not increasing investment, so that one instrument can simultaneously detect more than one detection card, and the detection speed and efficiency are greatly improved; compared with the similar automatic analyzer which has the same detection function level and adopts the liquid reagent, the analyzer has the advantages of smaller volume, simpler structure, more convenient operation and lower production cost.
Drawings
These and other advantages of the invention will become apparent from the following more detailed description of the invention, when taken in conjunction with the accompanying drawings and detailed description.
FIG. 1 is a schematic top view of the detection tray of the instrument system loaded with a plurality of detection cards.
Fig. 2 is a schematic structural diagram of the instrument system of the present invention.
FIG. 3 is a schematic diagram of the liquid suction needle cleaning pool of the instrument.
In the figure, 1-1, 1-2, 1-3 and 1-4 respectively correspond to four same fan-shaped detection cards, 2-a first reagent cup, 3-a second reagent cup, 4-a sample cup, 5-a cleaning reagent cup or a cup loaded with other reagents, 6-a pipette needle, 6-1-a pipette needle connecting diluter empty pipe, 7-a pipette needle movement control device, 8-a diluter, 9-a diluter driving motor, 10-an instrument cup detection card tray, 11-an instrument cup detection card tray motor shaft, 12-an instrument cup detection card tray driving motor, 13-a connecting water storage bottle pipeline, 14-a pipeline connecting the diluter and the pipette needle, 15-a water storage bottle, 16-a detection light source, 17-a detection signal receiver, V1-a liquid path valve on the pipeline connecting the diluter and the cleaning reagent needle, V2-a liquid path valve on the pipeline connecting the diluter and the liquid storage bottle, 18-a cleaning pool, 19-a waste liquid discharge pipe and 20-a cleaning cup.
Detailed Description
The utility model provides a medical portable quick automatic biochemical analyzer system, the liquid reagent and the back beam split detection technique of the large-scale full-automatic biochemical analyzer of mainstream are adopted to this instrument, the instrument possesses the various detection methods that large-scale biochemical analyzer had, dual wavelength, double reagent, deduction sample blank, speed method, two dot methods, terminal point method, therefore executable comprehensive biochemical project detects, and the instrument volume reduces greatly only about 30% of general full-automatic biochemical analyzer volume, and this instrument once can load more than one detection card simultaneously, and do not increase the instrument structure volume because of increasing the detection card, also need not to increase detecting element. The instrument can simultaneously carry out a plurality of different item detections on more than one sample. The instrument can synchronously carry out the same detection on a plurality of items on different samples, and can also synchronously carry out respective detection on a plurality of different items on different samples. More than one detection card with a fan-shaped or semicircular plane of depression can be loaded on the instrument detection card tray at the same time; each detection card is provided with a sample cup, more than two first reagent cups and more than two second reagent cups; and each cup on the detection card is opened upwards and is independent and not communicated with each other; the reagent cups on the detection card are used for placing different kinds of reagents, the reagent cups are arranged in an arc shape with equal distance along the radius of the card, and the cups arranged on the detection card are arranged in more than one layer structure according to different radii. The system can perform detection of a plurality of biochemical items of more than one sample at a time, and the detection items can be the same or different.
The medical portable rapid automatic biochemical analyzer system mainly comprises more than one detection unit, more than one sample reagent distribution unit, more than one detection card tray and a fan-shaped or semicircular detection card arranged on the detection card tray. Each detection card is provided with a sample cup and more than one reagent cup, the reagent cups of the detection cards are divided into a first reagent cup and a second reagent cup, the first reagent cup is positioned at the outermost side of the detection card, the depth of the first reagent cup is deeper, the second reagent cup which is distributed in parallel with the first reagent cup is arranged close to the inner side of the first reagent cup, and the sample cup is positioned at the innermost side. In addition, the detection card can also be provided with more cup-shaped structures with other shapes, which are used for loading other reagents, cleaning agents or water. Other cups may also be provided outside the first reagent cup. The detection card can be also provided with a third reagent cup for storing the reagent 3 which needs three reagents to complete the detection project.
As shown in figure 1, the utility model discloses a each cup all upwards opens and each cup is mutually independent not communicating on the detection card, each reagent cup is pre-installed respectively and is detected the required different reagents of project, and every project all has a first reagent cup, and each first reagent cup is packed into reagent 1 in advance before detecting, and each second reagent cup, sample cup distribute and pack into corresponding reagent 2 and sample in advance. Each item test completes all reagents, sample addition, reaction, and testing in each corresponding first reagent cup. Each test card is provided with a sample cup for placing a sample, which can be whole blood, plasma, serum or other liquid sample. The reagents loaded by the detection card are all liquid reagents, and the detected sample is also liquid. And the reagents required by the detection process of the detection card are loaded in the reagent cups before detection, and the samples are also loaded in the sample cups. During detection, the detection of various items of the designed detection sample of the detection card can be executed only by loading the detection card on a detection card tray of the instrument and fixing the detection card.
The utility model discloses in, be equipped with the second reagent cup on the detection card, prestore reagent 2, after adding the sample in first reagent cup, absorb 2 reagent additions first reagent cups in the second reagent cup, react after the mixing. However, some items only have the first reagent, do not need the reagent 2, and the reaction can be carried out after the first reagent and the sample are uniformly mixed.
The utility model discloses in, the detection card still is equipped with the drinking cup, drinking cup pre-installation distilled water or normal saline for wash the imbibition needle, dilute sample or reaction liquid. The detection card can be further provided with a cleaning agent cup for loading cleaning agents.
The detection unit is used for detecting reactants of the first reagent cups of the detection cards before other reagents are added, samples are added and after the samples and other reagents are added, so as to obtain absorbance change signals of the first reagent cups.
The sample reagent distribution unit comprises a mechanical arm, a liquid suction needle 6, a diluter 8, a pipeline 14 and a valve V1, wherein the liquid suction needle 6, the diluter 8, the pipeline 14 is connected between the diluter and the liquid suction needle, the valve V1 is arranged on the pipeline, the pipeline 13 is connected to a water storage bottle, and the electromagnetic valve V2 is arranged on the pipeline.
The test card tray is used for loading test cards, more than one fan-shaped or semicircular test cards can be loaded on the test card tray at the same time, and each test card performs multi-item test on each sample. A driving motor is connected below a detection card tray of the instrument, the driving motor drives the detection card tray to rotate to realize detection card displacement during detection, a sample reagent distribution unit is matched with the sample reagent distribution unit to realize that appropriate samples and reagents 2 are distributed into first reagent cups and are uniformly mixed, and the detection card tray continuously rotates after the samples and the reagents are distributed until all detection processes are completed;
furthermore, the instrument also comprises a temperature control unit, a cleaning unit and a control and data processing unit.
The temperature control unit is used for maintaining the temperature stability of reagents and reactants in the detection card, and the instrument detection card tray is positioned in a constant temperature bin. The set temperature of the temperature control unit is 25-50 ℃.
The cleaning unit consists of a waste liquid collecting tank and a waste liquid discharge pipeline and is used for collecting waste liquid discharged by the instrument when the liquid suction needle is cleaned and conveying the waste liquid to the outside of the instrument through the pipeline. Fig. 3 shows a cleaning tank 18, which has a through hole at its lower part for connecting a pipe 19 for discharging waste liquid, and a cleaning cup 20 is provided in the cleaning tank 18, and the lower part of the cleaning cup 20 is closed and only the upper part is opened. During cleaning, the liquid suction needle point extends into the cleaning cup, the diluter injects water through the liquid suction needle point, and the injected water also cleans the surface of the needle when cleaning the interior of the needle.
After the uniform mixing reagent and the sample are sucked each time, the sample reagent distribution unit of the instrument moves the pipette needle to the cleaning tank, the diluter sucks cleaning water and discharges the cleaning water through the pipette needle to wash the inner wall of the pipette needle, and the cleaning water is back-flushed in the cleaning tank due to the back flushing of the cleaning tank, so that the outer wall of the pipette needle is synchronously cleaned.
The instrument can also be provided with an additional cleaning pump for specially cleaning the outer wall of the liquid suction needle.
The control and data processing unit is responsible for overall control of the instrument, analysis and calculation of detection data and uploading of detection results.
The present invention will be described in detail with reference to the accompanying drawings and examples.
Example 1
The pipette needle of the system is only one, and is used for sucking and distributing the sample and the reagent. The detection card is pre-loaded with samples and various reagents required by the detection, the reaction detection of each item is completed in the first reagent cup of each item, and other reagents and samples required by each detection item except the first reagent are sucked and transferred to the first reagent cup by the liquid sucking needle from the sample cup and the second reagent cup of the detection card.
The detector comprises a control and data processing unit, a sample reagent distribution unit, a detection card tray, a detection unit and a cleaning unit; the lower part of the detection card tray is connected with a connecting rod and a rotating motor, and the rotating motor rotates to drive the detection card tray and the detection card loaded on the detection card tray to rotate rapidly; the control and data processing unit is used for controlling the coordination work among all units of the instrument, processing the detection data, calculating the detection result and the like;
the sample reagent distribution unit consists of a mechanical arm, a liquid suction needle 6 and a diluter 8 which are fixed on the mechanical arm, wherein the rear part of the liquid suction needle 6 is connected with a pipeline 14, the pipeline is connected with a valve V1 at the rear end and is communicated with the diluter 8, the pipeline is also communicated with another pipeline 13 connected with a water storage bottle 15 after the valve V1, and an electromagnetic valve V2 is also connected on the pipeline 13. Fig. 2 shows a drive motor 9 for the diluter 8.
The pipette needle motion control device 7 can realize horizontal rotation and up-and-down motion of the pipette needle, and is used for adding a sample into the first reagent cup and sucking a quantitative reagent 2 in the second reagent cup and adding the reagent into the corresponding first reagent cup.
The test card tray is used for loading test cards, more than one fan-shaped or semicircular test cards can be loaded on the test card tray at the same time, and each test card carries out multi-item test on each sample. The detection card tray is connected with a driving motor 12 through a shaft lever 11, the driving motor 12 drives the detection card tray to rotate during detection to realize detection card displacement, the sample reagent distribution unit is matched with the sample reagent distribution unit to distribute proper samples and reagents 2 into each first reagent cup and mix the samples and the reagents uniformly, and the detection card tray continuously rotates after the samples and the reagents are distributed until all detection processes are completed.
The detection unit is used for detecting reactants of the first reagent cups of the detection cards before other reagents are added, samples are added and after the samples and other reagents are added, so as to obtain absorbance change signals of the first reagent cups. The detection unit comprises one or more optical detection means arranged at the incubation well of the detector, the optical detection means comprising a light source 16, a photo-electric signal receiver 17, the detection light source illuminating the detector 17 through the first reagent cup. The detection card passes through the detection positions of the first reagent cups in sequence under the driving of the rotating motor, and the instrument detects the first reagent cups one by one repeatedly at regular time in the whole detection process.
The detection card is in the shape of a semicircle or a fan-shaped disc and is arranged on a turntable of the detector during use, and the sample cup is arranged in the most central area of the detection card.
The detection card is attached with a specific identifier, the detector is provided with a reading device for automatically identifying the identifier, and the detector can automatically identify the information of the detection card through the specific identifier, wherein the information comprises parameter information such as the type of the detection card, detection items, the validity period of the detection card, the sample adding amount of each detection item, the sample adding flow, the detection conditions, the standard curve and the like. Specifically, the specific identifier may be a bar code, a two-dimensional code, or a chip; when the detection card is placed in the rotating device, the bar code of the detection card is automatically aligned with the recognition area of the detector, or the bar code of the detection card is manually aligned with the recognition area of the detector.
The cleaning unit comprises a pump, a connecting pipeline, a valve and a cleaning pool and is used for collecting waste liquid discharged when the liquid suction needle is cleaned by the collecting instrument and transmitting the waste liquid to the outside of the instrument through the pipeline.
The detection card can also be provided with a physiological salt water cup.
After the sample and the reagent are sucked and distributed, the motor continuously rotates at a constant speed without stopping until the detection process is finished.
The cleaning mode of the liquid suction needle is as follows: the liquid suction needle moves to the cleaning pool and descends, the needle point enters a cup-shaped structure which is only provided with an opening at the upper part and arranged in the cleaning pool, cleaning water in the water storage bottle is sucked by the diluter and is sprayed into the cup-shaped structure in the cleaning pool through the liquid suction needle during cleaning, and because the water yield is greater than the volume of the cup, the cleaning water not only cleans the inner cavity of the needle, but also cleans the outer surface of the needle.
A sample distribution process: the sample reagent distribution unit adds samples into the first reagent cups one by one according to each detection item through the pipette needle according to the detection flow (corresponding to the corresponding detection card) selected by the user;
and (3) reagent distribution process: the liquid suction needle of the sample reagent distribution unit is respectively transferred to the upper part of each project of second reagent cup, descends and sucks quantitative reagent 2, the displacement of the liquid suction needle is combined with the displacement of the detection chuck, the liquid suction needle reaches the position of the appointed first reagent cup, descends and adds the sucked reagent 2 into the first reagent cup, and sucks and uniformly mixes the reagent 2 with the detection chuck through a diluter, and after the liquid suction needle sucks the reagent 2 into the first reagent cup every time, the liquid suction needle sucks quantitative first cleaning agent from the cleaning agent cup and moves the cleaning agent cup to a cleaning pool for cleaning; or when the detection card is not loaded with cleaning agent, the liquid suction needle directly goes to the cleaning pool for cleaning after the reagent is distributed.
The motor 12 drives the detection card tray to rotate at a constant speed, and pauses for a short time at the position where the sample and the reagent need to be sucked and distributed, the detection device carries out multi-wavelength detection on each reagent cup once in each rotation period, and the detection result is recorded. After the sample and the reagent are sucked and distributed, the detection card continuously rotates at a constant speed until the detection is finished, and the tray driving motor of the instrument detection card stops rotating.
The working process of the medical portable rapid automatic biochemical analyzer system is as follows:
step 1: quantitatively adding reagents required by detection of each item into each first reagent cup and each second reagent cup respectively according to the specified rule of the work of an instrument and quantitatively adding the reagents of different items;
step 2: adding a sufficient amount of sample (serum, plasma, body fluid, urine or whole blood and the like) into a sample cup of the detection card;
and step 3: placing more than one detection card on a detection card tray in sequence and fixing the detection cards;
and 4, step 4: starting the instrument, automatically controlling the detection card tray to rotate in a unidirectional mode and pause in a regular mode in the initial stage, simultaneously matching a sample reagent distribution unit of the instrument with the instrument, respectively sucking a sample and a reagent 2 according to the rotation-pause rhythm of the detection card tray and according to the detection requirement/design, adding the sample and the reagent into a specified first reagent cup, and uniformly mixing a mixture in the first reagent cup to enable the mixture to fully and thoroughly react;
and 5: when a plurality of samples are detected, the instrument completes the distribution and the mixing of the samples and the reagents on one detection card in sequence, and then distributes and mixes the samples and the reagents on a second detection card in sequence until the distribution of the sample reagents of each detection card is completed;
step 6: after the samples and the reagents are distributed, the tray of the detection card keeps rotating in a one-way constant speed until detection of each detection item on each detection card is completed.
In the process, the instrument detection unit continuously performs optical detection on the solution in each first reagent cup by adopting the selected wavelength, wherein the optical detection comprises liquid detection in the first reagent cup before the reagent 2 and the sample are added and detection of a mixture after the reagent and the sample are added.
Example 2
In this embodiment, after the pipette needle dispenses a sample or a reagent, high-pressure air is blown into the first reagent cup, and the liquid in the first reagent cup is agitated by the air pressure to generate disturbance, so that the reaction solution is uniformly mixed.
Example 3
The present example is different from example 1 in that the detection card is provided with a detergent cup, and a detergent is previously added to the detergent cup. After the reaction liquid is distributed and uniformly mixed by the liquid suction needle, a certain amount of cleaning agent is sucked in the cleaning agent cup and then is cleaned in the cleaning tank.
Example 4
This example differs from example 1 in that the test card is provided with a third reagent cup for a project requiring three reagents to complete the test.
Example 5
The difference between the embodiment and the embodiment 1 is that the detection card tray is further arranged in a constant temperature chamber, a heating constant temperature device is arranged in the constant temperature chamber, the temperature is adjustable, and the detection card and the reagent in the reagent cup are in a constant temperature state in the detection process.
The utility model provides a medical portable quick automatic biochemical analyzer system, the method and the way of specifically realizing this technical scheme are many, above only the utility model discloses an preferred embodiment should point out, to the ordinary technical personnel of this technical field, not deviating from the utility model discloses under the prerequisite of principle, can also make a plurality of improvements and moist decorations, these improve and moist decorations should also regard as the utility model discloses a scope of protection. All the components not specified in this embodiment can be implemented by the prior art.
Claims (7)
1. A medical portable rapid automatic biochemical analyzer system comprises a detector, and is characterized in that the detector comprises a detection unit, a sample reagent distribution unit, a detection card tray, a temperature control unit and a cleaning unit;
more than one detection card with a fan-shaped or semicircular plane of depression is synchronously loaded on the detection card tray, namely, more than one sample can be respectively and simultaneously subjected to more than one same or different biochemical project detection each time the instrument runs;
each detection card is provided with a sample cup, more than two first reagent cups and more than two second reagent cups; and each cup on the detection card is opened upwards and is independent and not communicated with each other; the reagent cups on the detection card are used for placing different kinds of reagents, the reagent cups are arranged in an arc shape with equal distance along the radius of the detection card, and the cups arranged on the detection card are arranged in a structure with more than one layer according to different radii.
2. The medical portable rapid automatic biochemical analyzer system according to claim 1, wherein each reagent cup on the detection card is pre-loaded with all reagents required for two or more different biochemical detection items, each detection item has a first reagent cup, and each detection item completes the reaction of the sample with all reagents participating in the detection of the item in the corresponding first reagent cup and completes the detection in the corresponding first reagent cup; each test card is provided with only one sample cup for placing a sample, and each test card is loaded with a sample required by the test of the test card and all various reagents participating in the reaction of the test items.
3. The medical portable rapid automatic biochemical analyzer system according to claim 1 or 2, wherein the first reagent cup of the detection card is located at the outermost side of the detection card, the second reagent cup is located next to the inner side of the first reagent cup and is parallel to the first reagent cup, and the sample cup is located at the innermost side.
4. The medical portable rapid automatic biochemical analyzer system according to claim 3, wherein the detection card is provided with a specific mark or chip, the detector has a reading device for automatically recognizing the mark provided on the detection card, and the detector automatically recognizes the detection card information including the type of the detection card, the detection item, whether the detection card is valid or not and the sample information loaded on the detection card through the specific mark.
5. The medical portable rapid automatic biochemical analyzer system according to claim 4, wherein the detection card is further provided with a reagent cup for loading a third reagent.
6. The medical portable rapid automatic biochemical analyzer system according to claim 4, wherein the detection card tray is connected with a driving motor through a shaft rod, and the driving motor drives the detection card tray to rotate.
7. The medical portable rapid automatic biochemical analyzer system according to claim 1, wherein the analyzer further comprises a blending device for blending the sample and other reagents added into the first reagent cup.
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| CN202222220545.6U CN218213043U (en) | 2022-08-23 | 2022-08-23 | Medical portable rapid automatic biochemical analyzer system |
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| CN202222220545.6U CN218213043U (en) | 2022-08-23 | 2022-08-23 | Medical portable rapid automatic biochemical analyzer system |
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| CN218213043U true CN218213043U (en) | 2023-01-03 |
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