CN109324002A - A kind of full-automatic detector - Google Patents
A kind of full-automatic detector Download PDFInfo
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- CN109324002A CN109324002A CN201811509822.7A CN201811509822A CN109324002A CN 109324002 A CN109324002 A CN 109324002A CN 201811509822 A CN201811509822 A CN 201811509822A CN 109324002 A CN109324002 A CN 109324002A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
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Abstract
A kind of full-automatic detector is made of reaction frame conveying mechanism, multiple reaction frame, reagent disc, sample rack, reaction tray, reaction cup transfer arm, the sample arm with reagent arm and sample arm and optical detection units.Specimen sample is infused in the cuvette of reaction tray by full-automatic detector in a manner of automating sampling, and the reagent reacted required for being added automatically according to the type of specimen sample, after specimen sample reacts with reagent and to form reaction solution, by being set to the optical measurement unit below the cuvette of reaction tray come the detection of the reaction solution progress absorbance in contrastive colours cup, the concentration of specimen sample can be directly obtained.
Description
Technical field
The present invention is to be related to a kind of specimen pattern detection technology, is detected in particular to a kind of full-automatic detector
The concentration of body sample continuously analyzes a large amount of specimen sample without being interrupted to reach.
Background technique
In the analytical equipment of clinical examination, usually it is used to for the spy carried out in the biological samples such as blood or urine
Determine ingredient and carries out qualitative and quantitative measurement.For the general operation of analytical equipment, passing through specimen sample nozzle first will
Sample container is dispensed into reaction vessel.In addition, being dispensed into reagent from reagent container by reagent nozzle has inspection to by dispensing
In the reaction vessel of body sample, and it is stirred.Followed by allowing reagent in reaction vessel and a specimen sample when certain
It is interior to be reacted to form reaction solution.Reaction solution is detected again later, by the result such as absorbance detected and is shone
The information such as amount carry out concentration calculation.
In recent years, occurred in order to prevent with malpractice, i.e. the fill-error of reagent and/or be that examination should be set in script
The place of agent container is provided with the reagent container of sundry item, and leads to subsequent measurement mistake, causes the damage of specimen sample
And the mistake of specimen sample measurement information, this can be easily caused in mistaken diagnosis or medical careless mistake medically.Therefore in order to
Improve above-mentioned missing, each reagent container can be managed by this traceable mark of bar code, also for
It strongly prevents reagent in the case where the resting period is permanent different, goes bad or deteriorate, also do not carried out for the reagent after use
Continue add reagent, but reagent is come in a manner of disposable using.
In general, operator can calculate a specimen for next batch measurement after the specimen sample of a batch completes measurement
Amount of reagent required for sample, and be arranged in analytical equipment.Sometimes each project needs use multiple reagents, therefore try
The confirmation of agent dosage, and it is arranged in analytical equipment in reagent and needs to spend many manpowers and time.In addition, in order to replace
Reagent container afterwards is used for actual inspection, needs to generate lubber-line to each reagent container, to confirm the examination in the reagent container
Whether agent can be checked, therefore during analysis detection, more changing jobs for reagent is very many and diverse.
Summary of the invention
It is a primary object of the present invention to disclose a kind of full-automatic detector, by specimen sample in a manner of automating sampling
The reagent for being infused in the cuvette of reaction tray, and being reacted required for being added automatically according to the type of specimen sample,
After specimen sample reacts with reagent and to form reaction solution, by be set to the optical measurement unit below the cuvette of reaction tray come pair
Reaction solution in cuvette carries out the detection of absorbance, and can immediately arrive at the concentration of specimen sample, to reach full-automatic inspection
The purpose of survey and calculated result.
Another object of the present invention is to disclose a kind of full-automatic detector, needs not move through manual operation and save people
Power, and can by low artificial operation careless mistake and artificially-contaminated factor, so that the detection accuracy of specimen sample improves, and
It is conducive to provide healthcare givers and does correct diagnosis.
Another object of the present invention is to disclose a kind of full-automatic detector, using the reaction tray with multiple channels, and
And multiple reaction trays with multiple channels are provided in reaction disk carrying mechanism, ratio has been preset in each reaction tray
Color cup, after the cuvette in the reaction tray with multiple channels, which has extracted, to be finished, reaction conveying mechanism can be automatically with machinery
In parking lot, the concept that landing can be replaced with vertical direction and left and right directions, by the reaction that extracted cuvette finishes
Disk is moved down by the top, and the reaction tray for being placed with cuvette is moved upward to the top, allows reaction cup transfer arm
It takes, can continuously analyze a large amount of specimen sample whereby, without being interrupted, also do not need to replace or add always reaction
Disk and cuvette.
Another object of the present invention is to disclose a kind of full-automatic detector, optical detection unit, which is set up directly on, have been contained
Below the reaction tray of cuvette, so that the specimen sample for being added with reagent does not need to compare using other mechanical arms
Color cup extracts and is moved to optical assay device to carry out the measurement of absorbance, has been can solve in the prior art whereby, has been
It to measure the absorbance of reaction solution and another mechanical arm is set to extract cuvette, and reduce the system of full-automatic detector
Cheng Chengben, at the same can also to avoid during extracting cuvette, due to the vibration of mechanical arm cause it is anti-in cuvette
It answers liquid to spray and pollute specimen sample or reagent that other to be ready being analyzed, the measurement of specimen sample can be improved whereby
Accuracy.
According to above-mentioned purpose, the present invention discloses a kind of full-automatic detector, by reaction frame conveying mechanism, multiple reaction framves,
Reagent disc, sample rack, reaction tray, reaction cup transfer arm, sample arm and optical detection unit with reagent arm and sample arm
It is formed, wherein each reaction frame is equipped with multiple channels, in being provided with cuvette on each channel；React frame conveyer
Structure, to put multiple reaction framves, reaction frame conveying structure will be will react frame in full-automatic detector with vertical direction and a left side
Right direction is mobile；Reagent disc is provided with the reagent position to put Reagent Tube, identical or not in being placed with respectively in Reagent Tube
Same reagent；Sample rack, to put the sample tube for being loaded with specimen sample；Reaction tray is provided with to put cuvette
Multiple from top to bottom perforative channels；Reaction cup transfer arm, to extract and be moved to the cuvette being arranged on reaction frame
Above reaction tray, then cuvette is seated in the channel in reaction tray；Sample arm, including reagent arm and sample arm, pilot scale
Agent arm draws the reagent in the Reagent Tube on reagent disc using dropper, and the dropper that absorption has reagent is moved to the ratio of reaction tray
On color cup, reagent is flowed into cuvette and sample arm utilizes dropper to draw the specimen in the sample tube on sample rack
Sample, and the dropper for drawing specimen sample is moved to above the cuvette of reaction tray, specimen sample is flowed into colorimetric
In cup, so that reagent and specimen sample are reacted in cuvette to form reaction solution；And optical detection unit, it is set to
Below the channel of reaction tray, wherein optical detection unit, which has, surveys radiant, surveys radiant and is radiated above optical detection unit
Reaction tray channel in cuvette in the reaction solution, to obtain the absorbance of reaction solution.
Detailed description of the invention
Fig. 1 is technology disclosed according to the present invention, indicates the block schematic diagram of full-automatic detector.
Fig. 2A is technology disclosed according to the present invention, indicates the side view of full-automatic detector.
Fig. 2 B is technology disclosed according to the present invention, indicates the top view of full-automatic detector.
Fig. 2 C is technology disclosed according to the present invention, indicates the reaction frame to carry cuvette, and react and have on frame
There is the top view in multiple channels.
Fig. 3 is technology disclosed according to the present invention, indicates the operating procedure flow chart of full-automatic detector.
Specific embodiment
In order to make the purpose of the present invention, technical characteristic and advantage, can more correlative technology field personnel understood, and be able to
Implement the present invention, cooperates appended schema herein, specifically illustrates technical characteristic and embodiment of the invention, and enumerate preferable reality
Apply example further explanation.It is not also needed with the schema hereinafter compareed to express signal related with feature of present invention
It is completely drawn according to practical situation.And the technology well-known to those skilled in the art involved in the explanation of this case embodiment
Content is also no longer stated.
It please refers to Fig. 1 and cooperates Fig. 2A, Fig. 2 B and Fig. 2 C simultaneously.Fig. 1 be indicate disclosed herein full-automatic detection
The block schematic diagram of instrument, Fig. 2A be indicate disclosed herein the side diagram of full-automatic detector, Fig. 2 B be to indicate the present invention
Full-automatic detector top view and Fig. 2 C indicate the reaction frame to carry cuvette, and react on frame have it is multiple logical
The top view in road.
In Fig. 1, full-automatic detector 1 includes at least reaction frame conveying mechanism 12, reaction frame 10, reagent disc 30, sample
Frame 40, reaction tray 20, reaction cup transfer arm 14, the sample arm as composed by reagent arm 60 and sample arm 42 and optical detection list
Member 70, is stated in detail below for the function of each above-mentioned component.
Frame 10 is reacted, is a kind of carrier for carrying multiple cuvettes 102, is equipped with multiple channels on reaction frame 10
101, the quantity for reacting the channel on frame can be 16,25,36,64 or 96, can be according to user's demand
To design, that is to say, that when user need a large amount of sample (sample) is tested and analyzed when, in order to save the time and
Human cost can carry corresponding number of cuvette 102 using the reaction frame 10 of high channel quantity.
Frame conveying mechanism 12 is reacted, to put multiple reaction framves 10, and transmits and carries in full-automatic detector 1
The reaction frame 10 of multiple cuvettes 102, to provide reaction cup transfer arm 14 for cuvette 102 by being extracted on reaction frame 10 to reaction
Give on disk 20 using.
In an embodiment of the present invention, the operating concept for reacting frame conveying mechanism 12 is similar to the general of mechanical vehicle parking system
It reads, reaction frame conveying mechanism 12 is equipped with carrier (not shown in the figure) (landing that can be considered as mechanical parking ground),
Carrier can be in a side in the board of full-automatic detector 1 with upper and lower, (i.e. Y coordinate direction in Fig. 2A and Fig. 2 B)
The mode in left and right (i.e. Z coordinate in Fig. 2A and Fig. 2 B) direction moves, that is to say, that is loaded with multiple cuvettes for multiple
102 reaction frame 10 is arranged on the carrier of reaction frame conveying mechanism 12, and is loaded with the reaction frame 10 of multiple cuvettes 102
Can with reaction frame conveying mechanism 12 carrier in a side of the board of full-automatic detector 1 with upper and lower, left and right
Mode move.Herein it is noted that upper and lower, left and right are the reaction frame conveyings with subscriber station in full-automatic detector 1
12 front of mechanism, relative position when in face of entire full-automatic detector 1.
In the present invention, it puts back the carrier quantity of frame 10 is answered to can be 4 or 6 built in reaction frame conveying mechanism 12
It is a, that is, indicate that reaction conveying mechanism 12 can carry 4 or 6 reaction framves 10.In more preferably embodiment of the invention,
Be then 4 reaction framves 10 are carried using 4 carriers, but can also depending on user need, install additional carrier, to carry
More reaction framves 10.And this 4 reaction framves 10 are then to be arranged respectively with upper and lower, forward and backward position in full-automatic detector 1
Board a side in.The cuvette 102 in reaction frame 10 above the platform in full-automatic detector 1, which is all taken, to be finished
Later, when continuing to take next cuvette 102, reaction frame conveying mechanism 12 just be will start, by the empty reaction frame 10 of carrying
The carrier of (i.e. cuvette 102, which has all been drawn, finishes) is mobile towards the lower section (Y coordinate direction) of full-automatic detector 1,
The direction of platform far from full-automatic detector 1 is mobile, and (will be faced entirely certainly with user on the right of full-automatic detector 1
The relative position in the direction of the reaction frame conveying mechanism 12 of dynamic detector 1) (Z coordinate direction), it is loaded with the reaction of cuvette 102
Frame 10 is moved by the left direction (Z coordinate direction) of carrier towards the user of reaction frame conveying mechanism 12, therefore,
The transmission direction of carrier in reaction conveying mechanism 12 is then to be carried out with direction counterclockwise, that is, taken colorimetric
The reaction frame 10 of cup 102 can be transferred into the lower section in the board of full-automatic detector 1, on the platform of full-automatic detector 1 all
It can be the reaction frame 10 for carrying cuvette 102, until the cuvette 102 that carries on all reaction framves 10 has all extracted
Finish, just needs again to be placed in cuvette 102 again on reaction frame 10.
The reaction frame 10 for carrying cuvette 102 is transmitted using reaction conveying mechanism 12 in full-automatic detector 1
Advantage is: can be disposable, the quantity of required cuvette 102 is seated on reaction frame 10, in addition to can be with
It avoids during detection, except cuvette 102 is by artificial pollution, a large amount of inspection can also be handled in a manner of batch
Body sample has timeliness.
In another embodiment of the invention, alarming device (the not table in figure is additionally provided in reaction conveying mechanism 12
Show), this alarming device is all to take to finish it when the cuvette 102 on all reaction framves 10 in reaction conveying mechanism 12
Afterwards, that is, it indicates extract for reaction cup transfer arm 14 without any cuvette, alarming device can issue information at this time
Remind the user on reaction frame 10 without cuvette 102, and the operation of entire full-automatic detector 1 can also suspend,
It avoids in the case where no cuvette 102, other components continue to operate, and cause the waste of specimen sample, reagent.?
In preferred embodiment, alarming device can be buzzer, remind user to need to carry out replacement reaction to make a sound
Disk 10.
Reaction tray 20 is provided with multiple channels 202 (as shown in Figure 2 B) to put cuvette 102.Wherein reaction tray
20 be a disk, and multiple channels 202 are equipped on disk, these channels 202 are in rectangle, is more preferably square,
The shape in channel 202 is mainly to cooperate the shape of cuvette 102.In the present invention, the perimeter in channel 202 is slightly larger than cuvette
102 perimeter is put into cuvette 102 in the channel 202 of reaction tray 20, and from the bottom of cuvette 102 toward up to
The height of few 1cm can be exposed to the lower section (Y coordinate direction) in channel 202, in the present invention more preferably embodiment, by colorimetric
102 bottom-exposeds of cup are in the 202 lower section at least purpose of 1cm of the channel of reaction tray 20, also set up in the lower section of reaction tray 20
There is optical detection unit 70, the survey radiant that optical detection unit 70 is launched need pass through the reaction solution ability of at least 1cm height
The measurement of absorbance can be carried out, and the height of cuvette 102 being open towards reaction tray 20 is come compared with the depth in channel 202
Height, its purpose is to allow reaction cup transfer arm 14 by cuvette 102 rim of a cup crawl, and can be convenient by cuvette 102 into
Row is extracted and is put.
Reagent disc 30 has multiple reagent positions 302 to put Reagent Tube 310, wherein stores in Reagent Tube 310
It is identical or is different reagent, it is to be noted that, inspection of the full-automatic detector 1 disclosed in this invention in addition to being directed to protein
Except survey, it can also be carried out for the specimen sample of liver function, renal function, myocardium enzyme, diabetes, blood lipid, pancreatitis, ionic species
Analysis detection, therefore correspond to different detection projects and can be set and contain the Reagent Tube 310 of identical or different reagents and trying
On the reagent position 302 of agent disk 30.
Sample rack 40, to put the sample tube 402 for being loaded with specimen sample, and sample rack 40 is to be seated in sample introduction mechanism
On 50, sample rack 40 is moved on sample introduction mechanism 50 with the direction in forward and backward (X-coordinate direction), and allows sample arm
42 can be by extracting the specimen sample being contained in sample tube 402 on sample rack 40.Herein it is noted that sample rack 40 exists
Moving direction on sample introduction mechanism 50 is to react the opposite of frame conveying mechanism 12 facing to full-automatic detector 1 with user
The direction of position indicates, that is to say, that sample introduction mechanism 50 drives sample rack 40 to be moved forward or rearward and refers to sample introduction mechanism
50 on the platform of full-automatic detector 1 with X-coordinate direction, be moved forward or rearward.
In the operation of sample introduction mechanism 50, user is by required detection, and the sample tube 402 for being loaded with specimen sample is first set
It is placed on sample rack 40, then sample rack 40 is seated on sample introduction mechanism 50, sample introduction mechanism 50 is allowed to drive sample rack 40
It is moved on the platform of full-automatic detector 1, when sample arm 42 needs to extract specimen sample, sample introduction mechanism 50 drives sample rack
40, which are moved to anchor point (not shown in the figure), allows sample arm 42 to extract the specimen sample in sample tube 402, and sample
When arm 42 will extract next specimen sample, then sample introduction mechanism 50 drives sample rack 40 to be moved to anchor point, and at this time to certainly
Site is next sample tube 402 with specimen sample, rather than the previous extracted sample tube for crossing specimen sample
402, the sample introduction operation through sample introduction mechanism 50 can be to avoid to the specimen sample repeated sampling in the same sample tube 402, weight
It operates again and causes the repetition in data, avoid the waste of reagent or specimen sample.
In addition, in an embodiment of the present invention, sensing device is further respectively had between sample arm 42 and sample introduction mechanism 50 (not
Shown in the figure).When sample introduction mechanism 50 drives sample rack 40 to anchor point, it is fixed that the sensing device on sample introduction mechanism 50 can transmit
Position signal specifically after the sample tube 402 of analysis to be sampled reaches anchor point, is arranged in sample to sample arm 42
Sensing device (not shown in the figure) in this arm 42 is after receiving location signal, i.e., initially towards anchor point is arranged in
Sample tube 402 moves, and the dropper in sample arm 42 422 will be arranged in the top of the sample tube 402 from top to bottom (Y
Coordinate direction) it is inserted into sample tube 402, to draw the specimen sample of sufficient amount (volume), a specimen has been drawn in sample arm 42
After sample, from bottom to top (Y coordinate direction) separate sample tube 40 is understood, then, absorption is had specimen sample again by sample arm 42
Dropper 422 is moved to the cuvette 102 in reaction tray 20, and specimen sample is injected into colorimetric cylinder 102, to reach automatic sampling
Purpose.
Sample arm is made of reagent arm 60 and sample arm 42, and sample arm 42 is stated in front, is just no longer added herein
Statement.And the purpose of reagent arm 60 is to draw the reagent for the Reagent Tube 310 being set in reagent disc 30 using dropper 602, and
And the reagent after absorption is injected into the cuvette 102 that reaction tray 20 is arranged in, and according to aforementioned, sample arm 42 is by specimen sample
This by sample tube 402 draw after be infused in the cuvette 102 of reaction tray 20, at this time cuvette 102 be loaded with reagent and
Specimen sample, so that specimen sample and reagent can form reaction solution in cuvette 102.
Optical detection unit 70 is set to the lower section of reaction tray 20, and optical detection unit 70, which has, surveys radiant, this surveys light
The reaction solution in cuvette 102 in the channel 202 of reaction tray 20 of the light source to be radiated at 70 top of optical detection unit, by
The absorbance of this available reaction solution.
In the present invention, optical detection unit 70 is to be divided brightness devices, wave-length coverage 340nm-800nm, and
The wavelength for measuring absorbance can be set according to project to be detected, therefore user also need not be because of preceding primary batch institute
The project of detection is different from next batch project detected, and needs replacing the fluorescence detector 70 with different wave length, only
Need to adjust the wavelength of the survey radiant of fluorescence detector 70 before being detected.
In an embodiment of the present invention, full-automatic detector 1 further includes having mixing arm 80, this mixing arm 80 is in Y coordinate side
To being connected with stirring rod 802, so that after aforementioned agents and specimen sample all inject cuvette 102, in order to allow reagent and inspection
Body sample reacts completely, can using mixing arm 80 drive stirring rod 802 be stirred in cuvette 102, with accelerate reagent and
Specimen sample is reacted.Herein it is noted that in more preferably embodiment of the invention, the surface of stirring rod 802 is
Smooth surface does not have the surface that liquid is attached to stirring rod 802 when being stirred to reagent and specimen sample, to avoid
The reduction of reaction solution volume.
In addition, full-automatic detector 1 further includes having rinse bath 90 in another more preferably embodiment of the invention, this
Rinse bath 90 be remain in stirring rod 802 in order to which stirring rod 802 can be cleaned to avoid previous reaction solution, and
Influence the accuracy of next reaction solution.Likewise, the surface due to stirring rod 802 is smooth surface, in stirring rod 802
After being cleaned, the surface that cleaning solution remains in stirring rod 802 there will not be.In an embodiment of the present invention, cleaning solution can
To be ethyl alcohol, deionized water or distilled water.Also, this rinse bath 90 (is not being schemed in another more preferably embodiment with water pipe
Middle expression) it is connect with sink (not shown in the figure), using water pipe and sink, timing and automatically by cleaning solution in rinse bath 90
It is replaced, so that when carrying out large batch of specimen pattern detection, it can be ensured that stirring rod 802 will not remain previous reaction
Liquid and pollute except next reaction solution, stirring rod 802 is also ensured after the washing, does not have cleaning solution and remains in and stir
On the surface for mixing stick 802.
And then Fig. 3 is please referred to.Fig. 3 indicates the operating procedure flow chart of full-automatic detector.It is walked in the operation of explanatory diagram 3
When rapid flow chart, while cooperating Fig. 1 together, Fig. 2A, Fig. 2 B and Fig. 2 C illustrate.Step 902: starting reaction cup transfer frame is by anti-
It answers and a certain number of cuvettes is taken to be placed in reaction tray on frame.In this step, user needs that colorimetric will be carried in advance
The reaction frame 10 of cup 102 is seated in respectively on reaction frame conveying mechanism 12, and in an embodiment of the present invention, carry cuvette
102 reaction frame 10 is usually directly to be provided by manufacturer, certainly, also has user voluntarily to load, but the latter is to using for end
It is artificial and time-consuming compared with taking, it generally still allows manufacturer to provide the reaction frame 10 for having contained cuvette 102 and directly uses.
Then, step 904: starting sample arm is extracted on sample introduction mechanism, the specimen sample being contained in sample tube 402,
It is placed in the cuvette in reaction tray.In this step, it is connected with dropper 422 using sample arm 42, to draw sample
Specimen sample in pipe 402 recycles sample arm 42 to transmit specimen sample and is flowed into cuvette 102.
Step 906: starting reagent arm extracts the reagent in the Reagent Tube on reagent disc, and reagent is placed in reaction tray
Cuvette in reagent is reacted with specimen sample to form reaction solution.
Step 908: starting mixing arm is stirred the reaction solution in the cuvette in reaction tray using stirring rod
So that reagent and specimen sample are reacted and are uniformly mixed.The step of this step alternative, but in order to allow reagent and specimen sample
It can react and be uniformly mixed completely, still can execute this step in the present invention, stirring rod 802 is in cuvette 102
Mixing time is about 1-3 seconds, and due to the bore of cuvette 102 and little, when stirring rod 802 is placed in cuvette 102 also
Consider the problems of that the solution in cuvette 102 can overflow, thus stirring rod 802 will not whole branch all protrude into cuvette 102, only
The stirring rod 802 of part, which protrudes into cuvette 102, touches solution, is then stirred under the mixing speed of the slow-speed of revolution, in
The purpose of the mixing speed of this step middle and slow speed of revolution is too fast also for mixing speed is avoided, and allows the reaction in cuvette 102
Liquid sprays, and stirring rod 802 and cuvette 102 is in addition also avoided to collide, and cause cuvette 102 and or stirring rod 802 it is broken
Or fracture.
Step 910: carrying out extinction for the reaction solution in cuvette using the optical detection unit being located at below reaction tray
Degree detection, and will test result and exported.In this step, the survey radiant (not shown in the figure) of optical detection unit 70
Irradiation is loaded with the cuvette 102 of reaction solution, and the absorbance of the available reaction solution, and utilizes optical detection unit 70
In computing module (not shown in the figure) calculating of the absorbance of specimen sample is converted into concentration, and its concentration can be core
Acid concentration or protein concentration.And the concentration value being calculated can be via the output device connecting with full-automatic detector 1
(not shown in the figure) is come the step of executing output.Specifically, output device is to connect with optical detection unit 70, and export
Device includes printer, external connection type memory apparatus, calculator or server.
Then step 912: the cuvette extraction Jing Guo absorbance detection is placed in waste liquid time by starting reaction cup transfer arm
It receives and is collected in bucket.In this step, when the reaction solution in the cuvette 102 in reaction tray 20 complete absorbance detection it
Afterwards, it recycles reaction cup transfer arm 14 towards moving above reaction tray 20, and grabs the colorimetric for having completed absorbance test
Cup 102, then the cuvette 102 for being loaded with reaction solution is placed in waste liquor recycling bin (not shown in the figure).
Therefore full-automatic detector 1 can be according to the duplicate operation of above-mentioned steps 902- step 912, either in specimen sample
Sheet, the extraction of reagent, the extraction of cuvette 102, reaction solution absorbance detection, by complete detection cuvette 102 lost
It abandons and the output of testing result with full-automatic, high-volume and can be completed in a continuous manner, can not only save people
The operation of power can more be reduced in artificial operation for the cross contamination of a specimen sample a possibility that.
Optionally, in another embodiment of the present invention, increase a step between step 904 and step 906
905: (being not yet added at this time anti-using the optical detection unit being located at below reaction tray for the specimen sample in cuvette 102
Answer liquid) absorbance detected, obtain the blank absorbency data of specimen sample.It has further included and has deposited in optical detection unit 70
It stores up module (not shown in the figure), has pre-set blank absorbency threshold value in memory module.In optical detection unit 70
The blank absorbency data that will test of computing module (not shown in the figure) be compared with blank absorbency threshold value, sentence
Whether the blank absorbency data of disconnected specimen sample exceed preset blank absorbency threshold value, and by this result via with it is complete
The output device (not shown in the figure) that automatic tester 1 connects executes output.It helps testing staff to judge, excludes different
Often detection sample, further increases the accuracy of testing result.
The foregoing is merely the preferred embodiments of the invention, the interest field that is not intended to limit the invention；More than simultaneously
Description, the special personage of correlative technology field should can be illustrated and be implemented, thus other without departing from it is disclosed it
The lower equivalent change or modification completed of spirit, should be included in claim.
Claims (8)
1. a kind of full-automatic detector characterized by comprising
Multiple reaction framves, each reaction frame are equipped with multiple channels, are equipped with cuvette in each channel；
React frame conveying mechanism, to put multiple reaction framves, the reaction frame conveying mechanism to by the reaction frame in institute
It states mobile with vertical direction and left and right directions in full-automatic detector；
Reagent disc is provided with the reagent position to put Reagent Tube, identical or different in being placed with respectively in the Reagent Tube
Reagent；
Sample rack, to put the sample tube for being loaded with specimen sample；
Reaction tray is provided with multiple channels to put the cuvette；
Reaction cup transfer arm, to extract and be moved in the reaction tray by the cuvette being arranged on the reaction frame
Side, then the cuvette is seated in the channel in the reaction tray；
Sample arm, including reagent arm and sample arm, the reagent arm are drawn in the Reagent Tube on the reagent disc using dropper
Reagent, and there is the dropper of the reagent to be moved on the cuvette of the reaction tray absorption, the reagent is infused
Enter in the cuvette and described in the sample arm drawn using dropper in the sample tube on the sample rack
Specimen sample, and the dropper for drawing the specimen sample is moved to above the cuvette of the reaction tray,
The specimen sample is flowed into the cuvette, so that the reagent and the specimen sample carry out in the cuvette
Reaction is to form reaction solution；And
Optical detection unit is set to the lower section of the reaction tray, wherein the optical detection unit, which has, surveys radiant, it is described
It surveys radiant and is radiated at the institute in the cuvette in the channel of the reaction tray above the optical detection unit
Reaction solution is stated, to obtain the absorbance of the reaction solution.
2. full-automatic detector as described in claim 1, which is characterized in that further include sample introduction mechanism, the sample introduction mechanism is used
To carry the sample rack, and make the sample rack on the sample introduction mechanism in the same plane with front, rear, left and right side
To movement.
3. full-automatic detector as described in claim 1, which is characterized in that further include mixing arm, the mixing arm is connected with
Stirring rod, so that the mixing arm can use the stirring rod and be stirred in the cuvette for being loaded with the reaction solution
It mixes.
4. full-automatic detector as described in claim 1, which is characterized in that the optical detection unit further includes computing module
The absorbance calculating of the specimen sample is converted into concentration.
5. the full-automatic detector as described in right 4, which is characterized in that the concentration is nucleic acid concentration or protein concentration.
6. full-automatic detector as described in claim 1, which is characterized in that further include output device and the optical detection list
Member connection, to export the absorbance as detected by the optical detection unit.
7. full-automatic detector as claimed in claim 6, which is characterized in that the output device includes printer, circumscribed
Storage device, calculator or server.
8. the full-automatic detector as described in claim 1,4,5 or 6, which is characterized in that the optical detection unit is light splitting
Brightness devices.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811509822.7A CN109324002A (en) | 2018-12-11 | 2018-12-11 | A kind of full-automatic detector |
| CN201910670895.2A CN110412306A (en) | 2018-12-11 | 2019-07-24 | A kind of full-automatic detector |
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| CN110387322A (en) * | 2018-04-09 | 2019-10-29 | 恺硕生物科技(厦门)有限公司 | Automatic nucleic acid extracts detection system |
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| CN110387322A (en) * | 2018-04-09 | 2019-10-29 | 恺硕生物科技(厦门)有限公司 | Automatic nucleic acid extracts detection system |
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