CN218047998U - Multi-specification chromatographic column clamping device - Google Patents
Multi-specification chromatographic column clamping device Download PDFInfo
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- CN218047998U CN218047998U CN202220790400.7U CN202220790400U CN218047998U CN 218047998 U CN218047998 U CN 218047998U CN 202220790400 U CN202220790400 U CN 202220790400U CN 218047998 U CN218047998 U CN 218047998U
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Abstract
The utility model discloses a multi-specification chromatographic column clamping device, which comprises two clamping plates which are arranged in bilateral symmetry and used for clamping a plurality of specification chromatographic columns, a fixed slide block used for fixedly connecting one end part of the two clamping plates, and a detachable fixed component used for fixedly connecting the other end parts of the two clamping plates; a plurality of fixing grooves which are matched with the specifications of the plurality of chromatographic columns one by one are formed in the inner side walls of the two clamping plates, and an elastic anti-slip pad which is attached to the inner walls of the fixing grooves is arranged on each fixing groove; the utility model has the advantages of, can be simultaneously with the chromatography column phase-match of multiple specification, fixed effectual, convenient to use, and be applicable to the protein purification appearance that needs multiple specification chromatography column, saved the loaded down with trivial details of changing the clip, reduce the clip and damage, through the elasticity slipmat on the fixed slot simultaneously, can reach the purpose of protection chromatography column.
Description
Technical Field
The utility model belongs to the technical field of laboratory instrument and device, especially, relate to a many specifications chromatography column clamping device.
Background
The protein purifier is a device for separating and purifying samples by utilizing a chromatographic column, and the main devices of the protein purifier comprise an infusion pump, a sample injection valve, a detector, a fraction collector and the like. The kit can be used for rapidly detecting, separating and purifying various biological samples such as protein, polysaccharide, biological acid, alkaloid, natural micromolecule and the like, can be used for effectively purifying and separating specific biological micromolecule aiming at various samples (plants, animals and human organisms), and has wide application.
The specifications of the chromatographic columns commonly used in the research and development laboratory at present are 10mm, 25mm, 35mm and 50mm. When the chromatographic column is delivered from a factory, the chromatographic column is generally matched with only one clamp with a corresponding specification, the number is small, the service life is short, the chromatographic column is easy to damage, and the shortage of the clamps is caused. Also need change rather than assorted clip in changing the chromatography column in the experiment, complex operation, and cause the damage of clip easily in the change process to frequently change the clip and cause destruction to the shaft of chromatography column more easily, the experiment cost is higher. Meanwhile, in the using process of the chromatographic column, the iron support is not fixed due to frequent movement, so that the balance of the chromatographic column can be damaged, and the experimental error is larger. Therefore, in order to solve the problems, the multi-specification chromatographic column clamping device is designed, can be matched with chromatographic columns of various specifications, and is convenient to operate.
Disclosure of Invention
The utility model aims at providing a many specifications chromatography post clamping device, solve the current complex operation that above-mentioned background art mentioned, quantity is limited, frequent change easily causes the broken ring scheduling problem to clip and chromatography post.
The technical scheme of the utility model is that: a multi-specification chromatographic column clamping device comprises two clamping plates which are arranged in bilateral symmetry and used for clamping a plurality of specification chromatographic columns, a fixed sliding block used for fixedly connecting one end part of the two clamping plates, and a detachable fixed assembly used for fixedly connecting the other end parts of the two clamping plates;
be provided with the fixed slot that a plurality of matches the setting with a plurality of chromatography column specification one by one respectively on the inside wall of two grip blocks, all be provided with simultaneously on every fixed slot with the elasticity slipmat that the laminating of fixed slot inner wall set up.
As a preferable technical scheme, a longitudinal through hole for adjusting the upper position and the lower position of the fixed sliding block and a transverse threaded hole communicated with the longitudinal through hole are arranged on the fixed sliding block, and a positioning screw is arranged in the transverse threaded hole.
As a preferred technical scheme, the detachable fixing component comprises a screw rod and two screw caps matched with the screw rod; and meanwhile, connecting holes matched with the outer diameters of the screws are formed in the end parts of the two clamping plates, the screws are inserted into the connecting holes in the two clamping plates, and the two ends of each screw are respectively fixed by the two nuts in a rotating mode.
According to a preferable technical scheme, the positioning screw is made of stainless steel, the length of the positioning screw is 0.5-1cm, the inner diameters of the longitudinal through hole and the transverse threaded hole are both 0.5-1cm, and the thickness of the fixed sliding block is 1-2cm.
As a preferable technical scheme, the screw and the nut are both made of stainless steel materials, the length of the screw is 3-4cm, the outer diameter of the screw is 0.5-1cm, and the inner diameter of the connecting hole is 0.5-1cm.
As the preferred technical scheme, four fixing grooves which are sequentially arranged from small to big are formed in the inner side walls of the two clamping plates, and the fixing grooves are arc-shaped grooves.
As a preferable technical scheme, the inner diameter of the arc-shaped groove is 22.5mm, 35mm, 46mm and 57mm from left to right in sequence.
As a preferred technical scheme, the elastic anti-skid pad is made of rubber, and a plurality of anti-skid flanges which are longitudinally arranged are arranged on the inner surface of the elastic anti-skid pad.
Preferably, the clamping plate is made of stainless steel, PEEK, PE or PVC, and the length of the clamping plate is 20-25cm.
The utility model has the advantages that:
1. the utility model discloses a many specifications chromatography column clamping device can be simultaneously with the chromatography column phase-match of multiple specification, fixed effectual, convenient to use, and be applicable to the protein purification appearance that needs multiple specification chromatography column, has saved the loaded down with trivial details of changing the clip, reduces the clip and damages, simultaneously through the elasticity slipmat on the fixed slot, can reach the purpose of protection chromatography column.
2. The utility model discloses among the many specifications chromatography post clamping device, two grip blocks can centre gripping 10mm, 25mm, 35mm, the chromatography post of four kinds of specifications of 50mm, have reduced clip figure, practice thrift the cost, and convenient operation, practicality height.
3. The utility model discloses two grip blocks front end have the hole, can fix the grip block on protein purification appearance or iron stand platform, convenient to use, and can guarantee the equilibrium of chromatography post.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required to be used in the description of the embodiments are briefly introduced below, the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.
The invention will be further described with reference to the following drawings and examples:
FIG. 1 is a schematic structural view of a single clamping plate and an elastic anti-slip mat of the utility model;
FIG. 2 is a schematic structural view of the multi-specification chromatographic column clamping device of the utility model;
FIG. 3 is a schematic structural view of a screw and a nut of the present invention;
FIG. 4 is a schematic structural view of a set screw of the utility model;
FIG. 5 is a schematic structural view of the elastic anti-slip mat of the utility model;
fig. 6 is a diagram illustrating a state of use of the multi-standard chromatography column holding device and the gantry in example 1;
wherein: 1, clamping a plate, 2, fixing a sliding block, 21, longitudinally perforating and 22, wherein the transverse threaded hole is formed in the sliding block;
3 chromatography columns, 4 fixing grooves, 5 elastic anti-slip pads, 6 screw rods, 7 screw caps, 8 connecting holes, 9 anti-slip flanges, 10 positioning screws and 11 positioning rods.
Detailed Description
In order to make the aforementioned objects, features and advantages of the present invention more comprehensible, the present invention is described in detail with reference to the following embodiments.
First, reference herein to "one embodiment" or "an embodiment" means that a particular feature, structure, or characteristic described in connection with at least one implementation of the invention is included. The appearances of the phrase "in one embodiment" in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments.
Secondly, the utility model discloses utilize structural schematic diagram etc. to carry out the detailed description, when detailing the embodiment of the utility model, for the convenience of explanation, show that a schematic diagram that is used for fixed bolt can not do local amplification according to general proportion, moreover the schematic diagram is the example only, and it should not limit the scope of the utility model protection here. In addition, the actual fabrication process should include three-dimensional space of length, width and depth.
Example 1:
as shown in fig. 1 to 5, the multi-specification chromatography column clamping device of the present invention comprises two clamping plates 1, a screw rod 6, two screw caps 7, a fixed slider 2, and a set screw 10.
The two clamping plates 1 are 20-25cm in length and made of stainless steel, PEEK, PE or PVC, the PEEK is preferably selected, four fixing grooves 4 which are sequentially arranged from small to large are formed in the inner side wall of each clamping plate, the fixing grooves 4 are arc-shaped grooves, and the inner diameters of the fixing grooves are 22.5mm, 35mm, 46mm and 57mm respectively; each fixing groove 4 is provided with an elastic anti-skid pad 5 which is attached to the inner wall of the fixing groove, the inner surface of the elastic anti-skid pad 5 is provided with anti-skid flanges 9 which are longitudinally distributed, and the material is rubber;
the screw 6 is 3-4cm in length, 0.5-1cm in diameter and made of stainless steel; connecting holes 8 matched with the outer diameters of the screws 6 are formed in the end parts of the two clamping plates 1, the screws 6 are inserted into the connecting holes 8 in the two clamping plates 1, and the two ends of each screw 6 are rotationally fixed through two nuts 7;
the fixed sliding block 2 is 1-2cm thick, a longitudinal through hole 21 used for adjusting the upper position and the lower position of the fixed sliding block 2 and a transverse threaded hole 22 communicated with the longitudinal through hole 21 are arranged on the fixed sliding block, a positioning screw 10 is arranged in the transverse threaded hole 22, the positioning screw 10 is made of stainless steel, the length is 0.5-1cm, and the inner diameters of the longitudinal through hole 21 and the transverse threaded hole 22 are both 0.5-1cm.
Referring to fig. 6, the operation process of the clamping device of the embodiment 1: the elastic anti-skid pad 5 is fixed in a fixing groove 4 matched with the elastic anti-skid pad 5, the fixing slide block 2 is used for fixing and connecting the front ends of the two clamping plates 1, the two clamping plates 1 and the fixing slide block 2 are in rigid connection, the tightness of the clamping device is adjusted by utilizing the elastic deformation of metal so as to achieve the purposes of fixing and adjusting the whole clamping device, then the clamping device is fixed on a positioning rod 11 of an iron support table or a protein purification instrument through the matching of a longitudinal through hole 21 on the fixing slide block 2 and a positioning screw 10, chromatography columns 3 with different specifications are clamped in corresponding arc-shaped grooves on the two clamping plates 1, after the clamping device is adjusted to a proper position, a screw 6 is inserted into a connecting hole 8 at the rear ends of the two clamping plates 1, the two clamping plates 1 are screwed and fixed through the two screw caps 7, the elastic anti-skid pad 5 can protect the chromatography columns 3, the chromatography columns 3 are prevented from being damaged when the screw 6 and the two screw caps 7 are screwed, the screw 6 and the two screw caps 7 are matched with the two clamping plates 1 so as to adjust the closing degree, and the positioning screw cap 10 on the fixing slide block 2 can enable the whole clamping device to be contained on the positioning rod 11 on the iron support table and the protein purification instrument, and the upper and the lower position of the clamping device can be adjusted. The whole device is simple to operate, convenient to use and wide in application.
It should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting, and although the present invention is described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention can be modified or substituted by equivalents without departing from the spirit and scope of the technical solutions of the present invention, which should be covered by the scope of the claims of the present invention.
Claims (9)
1. A multi-specification chromatographic column clamping device is characterized by comprising two clamping plates which are arranged in bilateral symmetry and used for clamping a plurality of specification chromatographic columns, a fixed sliding block used for fixedly connecting one end parts of the two clamping plates, and a detachable fixed assembly used for fixedly connecting the other end parts of the two clamping plates;
the inner side walls of the two clamping plates are provided with a plurality of fixing grooves which are matched with the specifications of the plurality of chromatographic columns one by one, and meanwhile, each fixing groove is provided with an elastic anti-slip pad which is attached to the inner wall of the corresponding fixing groove.
2. The multi-specification chromatography column clamping device according to claim 1, wherein a longitudinal through hole for adjusting the up-and-down position of the fixed slide block and a transverse threaded hole communicated with the longitudinal through hole are formed in the fixed slide block, and a set screw is arranged in the transverse threaded hole.
3. The multi-format chromatography column clamping device of claim 1, wherein the detachable fixing component comprises a screw and two nuts arranged to match with the screw; and meanwhile, connecting holes matched with the outer diameters of the screws are formed in the end parts of the two clamping plates, the screws are inserted into the connecting holes in the two clamping plates, and the two ends of each screw are respectively fixed by the two nuts in a rotating mode.
4. The multi-format chromatography column clamping device according to claim 2, wherein the set screw is made of stainless steel, the length of the set screw is 0.5-1cm, the inner diameters of the longitudinal through hole and the transverse threaded hole are both 0.5-1cm, and the thickness of the fixing slide block is 1-2cm.
5. The multi-specification chromatographic column clamping device according to claim 3, wherein the screw and the nut are made of stainless steel, the screw is 3-4cm long, the outer diameter of the screw is 0.5-1cm, and the inner diameter of the connecting hole is 0.5-1cm.
6. The multi-specification chromatography column clamping device according to claim 1, wherein four fixing grooves are arranged in sequence from small to large on the inner side walls of the two clamping plates, and the fixing grooves are arc-shaped grooves.
7. The multi-format chromatography column clamping device of claim 6, wherein the inner diameter of the arc-shaped groove is 22.5mm, 35mm, 46mm, 57mm from left to right in sequence.
8. The multi-format chromatography column clamping device of claim 1, wherein the elastic non-slip mat is made of rubber, and a plurality of longitudinally arranged non-slip flanges are arranged on the inner surface of the elastic non-slip mat.
9. The multi-format chromatography column clamping device of claim 1, wherein the clamping plate is made of stainless steel, PEEK, PE or PVC and has a length of 20-25cm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220790400.7U CN218047998U (en) | 2022-04-07 | 2022-04-07 | Multi-specification chromatographic column clamping device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220790400.7U CN218047998U (en) | 2022-04-07 | 2022-04-07 | Multi-specification chromatographic column clamping device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN218047998U true CN218047998U (en) | 2022-12-16 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202220790400.7U Active CN218047998U (en) | 2022-04-07 | 2022-04-07 | Multi-specification chromatographic column clamping device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN218047998U (en) |
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2022
- 2022-04-07 CN CN202220790400.7U patent/CN218047998U/en active Active
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