CN217909041U

CN217909041U - Beta-nicotinamide mononucleotide's recrystallization device

Info

Publication number: CN217909041U
Application number: CN202222196569.2U
Authority: CN
Inventors: 聂助星; 李爽; 李婷婷
Original assignee: Jilin Baiao Biotechnology Co ltd
Current assignee: Jilin Baiao Biotechnology Co ltd
Priority date: 2022-08-19
Filing date: 2022-08-19
Publication date: 2022-11-29
Anticipated expiration: 2032-08-19

Abstract

The utility model provides a beta-nicotinamide mononucleotide's recrystallization device, including a dissolving kettle, a crystallization kettle and a solvent collector, still include a cooling body. The dissolving kettle is used for dissolving the material in the solvent to obtain a mixed solution to be crystallized, the crystallizing kettle cools the mixed solution to be crystallized to separate out beta-nicotinamide mononucleotide crystals, the solution at the separation part is conveyed to the solvent collector, the solution in the solvent collector is treated to obtain the solvent, the solvent is returned to the dissolving kettle again to realize recycling, and the utilization rate of the solvent is effectively improved. Simultaneously, the dissolving kettle is equipped with the zone of heating, is favorable to improving the speed that the material dissolved, and the crystallization kettle is equipped with cooling layer and cooling coil, has improved crystallization kettle's cooling efficiency greatly, and crystallization efficiency is high. The cooling medium in the cooling layer is heated and then conveyed to the heating layer to be used for increasing the temperature of the solvent in the dissolving kettle, so that the full utilization of energy is realized.

Description

Beta-nicotinamide mononucleotide's recrystallization device

Technical Field

The utility model relates to a nicotinamide mononucleotide production technical field, concretely relates to beta-nicotinamide mononucleotide's recrystallization device.

Background

NMN (Nicotinamide mononuleotide): the full name of beta-nicotinamide mononucleotide is naturally-occurring bioactive nucleotide. NMN has 2 forms of irregularity, α and β; the beta isomer is the active form of NMN and has a molecular weight of 334.221g/mol. Because niacinamide belongs to vitamin B3, NMN belongs to the category of vitamin B derivatives, and is widely involved in various biochemical reactions of human bodies and closely related to immunity and metabolism. NMN plays an important role in the generation of human body cell energy, is a synthetic intermediate of intracellular NAD (nicotinamide adenine dinucleotide, an important coenzyme for cell energy conversion), plays a key role in the energy metabolism of cells, and has great application value in the field of medicines. NMN has obvious anti-aging effect, and NMN has obvious effect on prevention of diabetes, alzheimer disease, heart failure and other diseases and improvement of symptoms. In the prior art, the nicotinamide mononucleotide product obtained by crystallization is usually crystallized by adopting a cooling crystallization method, and further purification can be carried out by adopting a recrystallization mode in order to further obtain high-purity nicotinamide mononucleotide crystals, wherein recrystallization is a process of dissolving crystals in a solvent or melting the crystals and then recrystallizing the crystals from the solution or the melt, and the recrystallization can purify impure substances or separate salts mixed together. The traditional recrystallization kettle operation procedure is discontinuous operation, and has the defects of discontinuous materials, easy blockage of the materials, unsmooth circulation, incapability of recycling a recrystallization solvent, long cooling time, high energy consumption and low working efficiency.

Disclosure of Invention

The utility model aims to provide a beta-nicotinamide mononucleotide's recrystallization device, it is effectual to cool down, and crystallization efficiency is high, and the solvent can recycle, but coolant liquid cyclic utilization, make full use of heat energy reduction energy consumption, and crystallization effect is good.

The utility model provides a beta-nicotinamide mononucleotide's recrystallization device, including a dissolving kettle, a crystallization kettle and a solvent collector. The dissolving kettle comprises an outer shell and an inner cavity, wherein a material feeding hole and a solvent feeding hole are formed in the top of the inner cavity, a discharging hole is formed in the bottom of the inner cavity, a heating layer is arranged between the outer shell and the inner cavity, and a first inlet and a first outlet are formed in the heating layer. The crystallization kettle comprises an outer wall and a kettle inner cavity, wherein a liquid inlet is arranged at the top of the kettle inner cavity, a liquid outlet is arranged at the bottom of the kettle inner cavity, a cooling layer is arranged between the outer wall of the crystallization kettle and the kettle inner cavity, a cooling coil is arranged in the kettle inner cavity, a second inlet and a second outlet are arranged on the cooling layer, the inlet of the cooling coil is communicated with the second inlet, and the outlet of the cooling coil is communicated with the second outlet. The solvent collector is provided with a third inlet and a third outlet. Wherein the first entry of zone of heating links to each other with the second export on cooling layer, the discharge gate with the inlet links to each other, the liquid outlet with the third entry links to each other, the third export with the solvent feed inlet links to each other.

Preferably, the cooling device further comprises a cooling mechanism, the first outlet is connected with the inlet of the cooling mechanism, and the outlet of the cooling mechanism is connected with the second inlet.

Preferably, a filter plate is arranged in the inner cavity and arranged above the discharge hole.

Preferably, the inner cavity is provided with an ultrasonic generator.

Preferably, a heating wire is arranged in the heating layer.

Preferably, a crystal discharge port is formed in the bottom of the outer side wall of the crystallization kettle, a filter is arranged in the inner cavity of the kettle, the crystal discharge port is communicated with the upper plane of the filter, and the filter is used for separating crystals and solution.

Further preferably, a scraper is arranged on the upper plane of the filter, and the scraper is connected with a transmission mechanism.

Preferably, a purification mechanism is arranged in the solvent collector and used for separating impurities from the solution flowing out of the crystallization kettle.

The utility model has the advantages that: the utility model provides a beta-nicotinamide mononucleotide's recrystallization device, including dissolving the cauldron, crystallization kettle and solvent collector, dissolving the cauldron and being arranged in dissolving the material and obtaining in the solvent and waiting to crystallize mixed solution, the crystallization kettle will be this to wait to crystallize mixed solution cooling and appear beta-nicotinamide mononucleotide crystal to carry the solution of junction to the solvent collector, the solution among the solvent collector obtains the solvent after handling and returns once more to dissolving the cauldron and realizes recycling, effectively improves the utilization ratio of solvent. Simultaneously, the dissolving kettle is equipped with the zone of heating, is favorable to improving the speed that the material dissolved, and the crystallization kettle is equipped with cooling layer and cooling coil, has improved crystallization kettle's cooling efficiency greatly, and crystallization efficiency is high. The cooling medium in the cooling layer is heated and then conveyed to the heating layer to be used for increasing the temperature of the solvent in the dissolving kettle, so that the full utilization of energy is realized.

Drawings

FIG. 1 is a schematic structural diagram of a recrystallization apparatus for beta-nicotinamide mononucleotide of the present invention.

In the figure: 1-a dissolving kettle, 2-a material inlet, 3-a solvent inlet, 4-a liquid inlet, 5-a crystallizing kettle, 6-a second inlet, 7-a cooling coil, 8-a third inlet, 9-a solvent collector, 10-a first outlet, 11-a heating wire, 12-an ultrasonic generator, 13-a filter plate, 14-the first inlet, 15-a discharge outlet, 16-the second outlet, 17-a transmission mechanism, 18-a filter, 19-a liquid outlet, 20-a scraper, 21-a crystallized material discharge outlet, 22-a third outlet, 23-a cooling mechanism and 24-a purification mechanism.

Detailed Description

In order to make the technical field better understand the technical scheme of the invention, the invention is further described in detail with reference to the attached drawings. The described embodiments are only some, but not all embodiments of the invention. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

The embodiment provides a beta-nicotinamide mononucleotide recrystallization device, which comprises a dissolving kettle 1, a crystallization kettle 5 and a solvent collector 9, wherein the dissolving kettle 1, the crystallization kettle 5 and the solvent collector 9 are sequentially connected through pipelines, and the solvent collector 9 is connected with the dissolving kettle 1 through a pipeline to form a circulating path. Specifically, dissolving kettle 1 includes shell and inner chamber, the inner chamber top is equipped with material feed inlet 2 and solvent feed inlet 3 respectively, and the inner chamber bottom is equipped with discharge gate 15, is equipped with the zone of heating between its shell and the inner chamber, the zone of heating is equipped with first entry 14 and first export 10. Crystallization kettle 5 includes outer wall and cauldron inner chamber, cauldron inner chamber top is equipped with inlet 4, and cauldron inner chamber bottom is equipped with liquid outlet 19, the cauldron inner chamber is equipped with cooling coil 7, is equipped with the cooling layer between crystallization kettle 5's outer wall and the cauldron inner chamber, the cooling layer is equipped with second entry 6 and second export 16, cooling coil 7's entry with 6 intercommunications of second entry, cooling coil 7's export with 16 intercommunications of second export. Through add cooling coil 7 in the cauldron inner chamber, the cooling effect of treating the mixed liquid of crystallization can effectively be improved to the cooperation cooling layer, improves the efficiency of crystallization. The solvent collector 9 is provided with a third inlet 8 and a third outlet 22. Wherein the first entry 14 of zone of heating links to each other with the second export 16 of cooling layer, discharge gate 15 with inlet 4 links to each other, liquid outlet 19 with third entry 8 links to each other, third export 22 with solvent feed inlet 3 links to each other. That is to say, the cooling medium enters through the second inlet 6, a part of the cooling medium flows to the second outlet 16 through the cooling coil 7, the other part of the cooling medium flows to the second outlet 16 through the cooling layer, and as the temperature of the cooling medium after flowing out of the second outlet 16 is increased, the cooling medium flows into the heating layer through the first inlet 14 for the second heat exchange, the temperature of the liquid in the dissolution kettle 1 is increased, and the dissolution rate is accelerated. The cooling medium may be water, air or other substances. It should be noted that valves are disposed on the connecting pipelines of the dissolving kettle 1, the crystallizing kettle 5 and the solvent collector 9, and are used for controlling the on-off of the solution, so as to facilitate the mechanical operation.

Preferably, the device further comprises a cooling mechanism 23, the first outlet 10 is connected with an inlet of the cooling mechanism 23, and an outlet of the cooling mechanism 23 is connected with the second inlet 6. By providing the cooling mechanism 23, the cooling medium whose heating layer has completed the second heat exchange is further lowered in temperature and circulated to the second inlet 6 again, so that the cooling medium can be recycled.

Preferably, a filter plate 13 is arranged in the inner cavity, and the filter plate 13 is arranged above the discharge hole 15. The filter plate 13 is arranged, so that a part of impurities can be separated from the mixed liquid to be crystallized before crystallization, and the quality of the product after recrystallization is improved.

Preferably, the inner cavity is provided with an ultrasonic generator 12. Ultrasonic vibration can accelerate the dissolution rate of the material, and the time is saved.

Preferably, a heating wire 11 is arranged in the heating layer. Preferably, 2-3 groups of heating wires 11 are arranged in the heating layer, so that the heating wires 11 can be electrified to release heat energy when the temperature of liquid in the dissolving kettle 1 is not high enough according to actual requirements.

Preferably, a crystal material outlet 21 is arranged at the bottom of the outer side wall of the crystallization kettle 5, a filter 18 is arranged in the kettle inner cavity, the crystal material outlet 21 is communicated with the upper plane of the filter 18, and the filter 18 is used for separating crystal materials from solution. It is further preferred that a scraper 20 is disposed on the upper plane of the filter 18, and the scraper 20 is connected to a transmission mechanism 17. The crystals are separated from the solution by the filter 18, wherein the separated solution flows from the outlet 19 to the solvent collector 9, the separated crystals remain on the upper surface of the filter 18, the crystal outlet 21 is opened, and the scraper 20 is activated to discharge the crystals. The driving mechanism 17 connected to the scraper 20 is prior art and not shown in detail, but it is easy to know by those skilled in the art that the scraper 20 can be driven by the driving mechanism 17 to reciprocate to press the crystals remained on the upper surface of the filter 18 to the crystal discharge port 21. The transmission mechanism 17 can adopt worm gear and worm transmission.

Preferably, a purification mechanism 24 is arranged in the solvent collector 9, and the purification mechanism 24 is used for separating impurities from the solution flowing out of the crystallization kettle 5. Preferably, the purification mechanism 24 may be filled with activated carbon to adsorb and filter impurities in the solution, and the treated solution may be recycled to the solvent feed port 3 as a solvent. It should be noted that the solvent collector 9 is further provided with a waste liquid outlet through which the solvent can be discharged when the solvent is circulated for a certain number of times and cannot be used continuously.

The whole process for the recrystallization of beta-nicotinamide mononucleotide is as follows:

1) The material and the solvent enter a dissolving kettle 1, the temperature of the solvent is raised through heat exchange, ultrasonic vibration is combined, and the material is completely dissolved in the solvent to obtain a mixed solution to be crystallized;

2) Conveying the mixed solution to be crystallized to the inner cavity of the crystallization kettle 5 through a discharge hole 15, cooling the mixed solution to be crystallized through a cooling layer and a cooling coil 7, separating out crystals, retaining crystals on the upper surface of a filter 18 through the filter 18, and allowing the separated solution to flow into a solvent collector 9 through a liquid outlet 19;

3) Opening a crystal discharge port 21, and starting a scraper 20 to discharge the crystals;

4) The solution is processed by a solvent collector 9 to obtain a new solvent which is returned to the solvent feed port 3;

5) The cooling medium of the cooling layer and the cooling coil 7 flows out through the second outlet 16, flows into the heating layer through the first inlet 14, flows to the cooling mechanism 23 through the first outlet 10, and returns to the second inlet 6 for recycling after being processed by the cooling mechanism 23.

The utility model provides a beta-nicotinamide mononucleotide's recrystallization device, cooling layer and zone of heating intercommunication can make coolant realize twice heat exchange, make full use of heat energy, and crystallization kettle is equipped with cooling coil, and cooling coil and cooling layer collocation use improve crystallization rate greatly. The crystal and the solution are separated by the filter, and the separated solution is treated to obtain the solvent for recycling, so that the cost can be effectively saved

The preferred embodiments of the present invention disclosed above are only for the purpose of helping to explain the present invention, and do not limit the present invention to the specific embodiments described above. Obviously, other modifications and variations are possible in light of the above teachings. The embodiment that this specification chose and specifically described is in order to explain the principle and the practical application of the utility model better to make the technical field personnel that belong to understand well and utilize the utility model discloses, it is not right the utility model discloses a limit, it is any right the scheme after simply warping the utility model discloses a protection scope.

Claims

1. A beta-nicotinamide mononucleotide's recrystallization plant, including a dissolving kettle, a crystallization kettle and a solvent collector, characterized by, the said dissolving kettle includes outer casing and cavity, the top of said cavity has supplies feed inlet and solvent feed inlet, the cavity bottom has discharge gates, there are heating layers between its outer casing and cavity, the said heating layer has first entrance and first outlet; the crystallization kettle comprises an outer wall and a kettle inner cavity, wherein a liquid inlet is formed in the top of the kettle inner cavity, a liquid outlet is formed in the bottom of the kettle inner cavity, a cooling layer is arranged between the outer wall of the crystallization kettle and the kettle inner cavity, a cooling coil is arranged in the kettle inner cavity, the cooling layer is provided with a second inlet and a second outlet, the inlet of the cooling coil is communicated with the second inlet, and the outlet of the cooling coil is communicated with the second outlet; the solvent collector is provided with a third inlet and a third outlet; wherein the first entry of zone of heating links to each other with the second export on cooling layer, the discharge gate with the liquid inlet links to each other, the liquid outlet with the third entry links to each other, the third export with the solvent feed inlet links to each other.

2. The apparatus for recrystallizing beta-nicotinamide mononucleotide as claimed in claim 1, further comprising a cooling mechanism, wherein said first outlet is connected to an inlet of said cooling mechanism, and wherein an outlet of said cooling mechanism is connected to said second inlet.

3. The apparatus for recrystallizing beta-nicotinamide mononucleotide as claimed in claim 1, wherein a filter plate is disposed in said internal chamber, and said filter plate is disposed above said discharge port.

4. The apparatus for recrystallizing beta-nicotinamide mononucleotide according to claim 1, characterized in that said lumen is provided with an ultrasound generator.

5. The apparatus for recrystallizing beta-nicotinamide mononucleotide according to claim 1, characterized in that a heating wire is provided in said heating layer.

6. The apparatus for recrystallizing beta-nicotinamide mononucleotide as claimed in claim 1, wherein said crystallization vessel has a crystal outlet at the bottom of its outer wall, and a filter in the inner cavity of said vessel, said crystal outlet being connected to the upper surface of said filter, said filter being used for separating the crystal from the solution.

7. The apparatus for recrystallizing beta-nicotinamide mononucleotide as claimed in claim 6, wherein said filter is provided with a scraper on the upper surface, and said scraper is connected to a driving mechanism.

8. The apparatus for recrystallizing beta-nicotinamide mononucleotide as claimed in claim 1, wherein said solvent collector is provided with a purification mechanism for separating impurities from the solution flowing out of the crystallization kettle.