CN212941509U - Reduced pressure concentration device for metoprolol production - Google Patents
Reduced pressure concentration device for metoprolol production Download PDFInfo
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- CN212941509U CN212941509U CN202021338843.XU CN202021338843U CN212941509U CN 212941509 U CN212941509 U CN 212941509U CN 202021338843 U CN202021338843 U CN 202021338843U CN 212941509 U CN212941509 U CN 212941509U
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Abstract
A pressure-reducing concentration device for metoprolol production comprises a concentration tank, wherein a steam pipe is arranged at the top of the concentration tank and connected to an input end of a cooler, a temporary storage tank is further arranged at the top of the concentration tank, a liquid discharge pipe of the cooler is connected to the top of the temporary storage tank, a circulating liquid delivery pipe connected with the concentration tank is arranged at the bottom of the temporary storage tank, and a feeding pipe is arranged on the circulating liquid delivery pipe; a vertical rotating shaft is arranged in the concentration tank, a scraping frame is arranged on the rotating shaft, a material guide mechanism is arranged at the lower end of the rotating shaft, a motor is arranged at the top of the concentration tank, a shaft of the motor vertically and downwards penetrates through the top surface of the concentration tank, and the rotating shaft is connected with the motor shaft; the side wall of the concentration tank is provided with a negative pressure pipe which is connected to a negative pressure pump. This novel adopt above-mentioned structure, can effectively solve current concentrated operation in-process, the problem of middle solid product is remained to concentrated jar wall and concentrated jar tank bottoms, makes the produced solid product of decompression concentration can realize discharging fast.
Description
Technical Field
The utility model relates to a metoprolol production field, specificly is a metoprolol production is with decompression enrichment facility.
Background
Metoprolol is a drug used to treat various types of hypertension (combined with diuretics and vasodilators) and angina pectoris. It is also effective for treating arrhythmia, especially supraventricular arrhythmia by intravenous injection.
In the production process of metoprolol, the synthesis of 4-benzyloxy benzaldehyde is the first step, which mainly comprises the following steps: p-hydroxybenzaldehyde, anhydrous potassium carbonate, tetrabutylammonium bromide (TBAB) and DMF are added into a reaction bottle, benzyl chloride is dripped at room temperature, and the temperature is raised to 65 ℃ for reaction for 3 hours after dripping. Cooling to room temperature, vacuum-filtering, pouring the filtrate into water, extracting with ethyl acetate, washing the organic layer with 5% sodium bicarbonate solution and water respectively, and concentrating under reduced pressure to obtain white solid.
Wherein concentration under reduced pressure is used as the last step, which determines the quality and yield of the final intermediate product.
In the existing decompression concentration process, in the process of continuous evaporation of solution, precipitated solid products are easily adhered to the inner wall of a tank body of a concentration tank, so that output product quantity has certain loss, in addition, the tank bottom of the concentration tank generally adopts a bowl-shaped structure, and in the concentration process, the solid products are also easily accumulated, so that the solid products are not discharged timely, and the raw material quantity of chemical reaction is determined after calculation according to the yield demand, and the residual quantity per se belongs to uncertain factors, so that the control of accurate yield cannot be realized.
Disclosure of Invention
The utility model aims to solve the technical problem that a decompression enrichment facility is used in metoprolol production is provided, can effectively solve current concentrated operation in-process, the problem of middle solid product is remained to concentrated jar tank wall and concentrated jar tank bottoms, makes the produced solid product of decompression concentration can realize discharging fast.
In order to solve the technical problem, the utility model discloses the technical scheme who adopts is: a pressure-reducing concentration device for metoprolol production comprises a concentration tank, wherein a steam pipe is arranged at the top of the concentration tank and connected to an input end of a cooler, a temporary storage tank is further arranged at the top of the concentration tank, a liquid discharge pipe of the cooler is connected to the top of the temporary storage tank, a circulating liquid delivery pipe connected with the concentration tank is arranged at the bottom of the temporary storage tank, and a feeding pipe is arranged on the circulating liquid delivery pipe;
a vertical rotating shaft is arranged in the concentration tank, a scraping frame is arranged on the rotating shaft, a material guide mechanism is arranged at the lower end of the rotating shaft, a motor is arranged at the top of the concentration tank, a shaft of the motor vertically and downwards penetrates through the top surface of the concentration tank, and the rotating shaft is connected with the motor shaft;
the side wall of the concentration tank is provided with a negative pressure pipe, and the negative pressure pipe is connected to a negative pressure pump.
In a preferable scheme, a first butterfly valve is arranged on the steam pipe.
In a preferable scheme, a second butterfly valve is arranged on the circulating liquid conveying pipe.
In the preferred scheme, the scraping frame is of a rectangular frame structure, the vertical sections of the two sides of the scraping frame are tightly attached to the inner wall of the concentration tank, and the vertical sections of the scraping frame are provided with scraping plates.
In a preferred scheme, the outer wall of the concentration tank is coated with a heating jacket.
In a preferable scheme, a discharge pipe is arranged at the bottom of the concentration tank.
In the preferred scheme, the material guiding mechanism comprises an arc-shaped material guiding rod, the arc-shaped material guiding rod is tightly attached to the inner wall of the bottom of the bowl of the concentration tank, a horizontal connecting rod is arranged on the arc-shaped material guiding rod, one end of the horizontal connecting rod is fixedly connected to the arc-shaped material guiding rod, and the other end of the horizontal connecting rod is fixedly connected to the lower end of the rotating shaft.
In a preferable scheme, a reinforcing connecting rod is further arranged between the arc-shaped material guide rod and the horizontal connecting rod.
The utility model provides a metoprolol production is with concentrated device that reduces pressure through adopting above-mentioned structure, has following beneficial effect:
(1) the problem that the existing concentration tank is easy to form adhered solids on the tank wall in the process of reduced pressure concentration is solved, and the solid products on the tank wall are quickly removed and discharged;
(2) the solid product formed on the bottom of the tank can be guided to be discharged, so that the error between the final yield and the calculated value is reduced as much as possible.
Drawings
The invention will be further explained with reference to the following figures and examples:
fig. 1 is a schematic view of the overall structure of the present invention.
Fig. 2 is a schematic view of the structure of the scraping frame of the present invention.
Fig. 3 is a schematic structural view of the material guiding mechanism of the present invention.
In the figure: the device comprises a concentration tank 1, a steam pipe 2, a cooler 3, a liquid discharge pipe 4, an exhaust pipe 5, a temporary storage tank 6, a circulating liquid feeding pipe 7, a first butterfly valve 8, a second butterfly valve 8', a motor 9, a rotating shaft 10, a scraping frame 11, a scraping plate 111, a material guiding mechanism 12, an arc-shaped material guiding rod 121, a horizontal connecting rod 122, a reinforcing connecting rod 123, a heating jacket 13, a discharge pipe 14, a negative pressure pipe 15, a negative pressure pump 16 and a feed pipe 17.
Detailed Description
As shown in fig. 1-3, a reduced pressure concentration device for metoprolol production comprises a concentration tank 1, wherein a steam pipe 2 is arranged at the top of the concentration tank 1, the steam pipe 2 is connected to the input end of a cooler 3, a temporary storage tank 6 is further arranged at the top of the concentration tank 1, a liquid discharge pipe 4 of the cooler 3 is connected to the top of the temporary storage tank 6, a circulating liquid delivery pipe 7 connected with the concentration tank 1 is arranged at the bottom of the temporary storage tank 6, and a feeding pipe 17 is arranged on the circulating liquid delivery pipe 7;
a vertical rotating shaft 10 is arranged in the concentration tank 1, a scraping frame 11 is arranged on the rotating shaft 10, a material guide mechanism 12 is arranged at the lower end of the rotating shaft 10, a motor 9 is arranged at the top of the concentration tank 1, a shaft of the motor 9 vertically penetrates through the top surface of the concentration tank 1 downwards, and the rotating shaft 10 is connected with the motor 9;
the side wall of the concentration tank 1 is provided with a negative pressure pipe 15, and the negative pressure pipe 15 is connected to a negative pressure pump 16.
In a preferable scheme, a first butterfly valve 8 is arranged on the steam pipe 2.
In a preferable scheme, a second butterfly valve 8' is arranged on the circulating liquid sending pipe 7.
In the preferred scheme, the scraping frame 11 is a rectangular frame structure, the vertical sections at two sides of the scraping frame 11 are arranged close to the inner wall of the concentration tank 1, and the vertical section of the scraping frame 11 is provided with a scraping plate 111.
In a preferred scheme, the outer wall of the concentration tank 1 is coated with a heating jacket 13.
In a preferred scheme, the bottom of the concentration tank 1 is provided with a discharge pipe 14.
In a preferred embodiment, the material guiding mechanism 12 includes an arc-shaped material guiding rod 121, the arc-shaped material guiding rod 121 is disposed closely to the inner wall of the bowl-shaped bottom of the concentrating tank 1, a horizontal connecting rod 122 is disposed on the arc-shaped material guiding rod 121, one end of the horizontal connecting rod 122 is fixedly connected to the arc-shaped material guiding rod 121, and the other end of the horizontal connecting rod 122 is fixedly connected to the lower end of the rotating shaft 10.
In a preferable scheme, a reinforcing connecting rod 123 is further arranged between the arc-shaped material guiding rod 121 and the horizontal connecting rod 122.
When the device is used:
solution after the suction filtration reaction is sent into the concentration tank 1 through the feeding pipe 17, the negative pressure pipe 15 is opened simultaneously in the suction filtration process, negative pressure is formed in the concentration tank 1, and filtered solution enters the concentration tank 1, after the operation is completed, the second butterfly valve 8' is closed, then the concentration tank 1 is heated through the heating jacket 13, the first butterfly valve 8 is opened, in the heating process, generated steam enters the cooler 3, after the cooling, condensed liquid enters the temporary storage tank 6, cooled air is discharged through the exhaust pipe 5, in the whole pressure reduction concentration process, the motor 9 continuously keeps the running state, the solution in the tank is stirred, the evaporation is accelerated, solid products gradually separated out from the tank wall and the tank bottom are cleaned and guided, after the operation is completed, the discharging pipe 14 is opened, and the solid products are guided and output by the material guiding mechanism 12.
Claims (8)
1. The utility model provides a metoprolol production is with concentrated device of decompression, includes concentrated jar (1), its characterized in that: the top of the concentration tank (1) is provided with a steam pipe (2), the steam pipe (2) is connected to the input end of the cooler (3), the top of the concentration tank (1) is also provided with a temporary storage tank (6), a liquid discharge pipe (4) of the cooler (3) is connected to the top of the temporary storage tank (6), the bottom of the temporary storage tank (6) is provided with a circulating liquid delivery pipe (7) connected with the concentration tank (1), and the circulating liquid delivery pipe (7) is provided with a feeding pipe (17);
a vertical rotating shaft (10) is arranged in the concentration tank (1), a scraping frame (11) is arranged on the rotating shaft (10), a material guide mechanism (12) is arranged at the lower end of the rotating shaft (10), a motor (9) is arranged at the top of the concentration tank (1), a shaft of the motor (9) vertically penetrates through the top surface of the concentration tank (1) downwards, and the rotating shaft (10) is connected with the motor (9) through a shaft;
the side wall of the concentration tank (1) is provided with a negative pressure pipe (15), and the negative pressure pipe (15) is connected to a negative pressure pump (16).
2. The reduced-pressure concentration device for metoprolol production according to claim 1, which is characterized in that: the steam pipe (2) is provided with a first butterfly valve (8).
3. The reduced-pressure concentration device for metoprolol production according to claim 1, which is characterized in that: and a second butterfly valve (8') is arranged on the circulating liquid feeding pipe (7).
4. The reduced-pressure concentration device for metoprolol production according to claim 1, which is characterized in that: scrape material frame (11) be rectangular frame structure, scrape the vertical section of material frame (11) both sides and hug closely concentrated jar (1) inner wall setting, be equipped with on scraping the vertical section of material frame (11) and scrape flitch (111).
5. The reduced-pressure concentration device for metoprolol production according to claim 1, which is characterized in that: the outer wall of the concentration tank (1) is coated with a heating jacket (13).
6. The reduced-pressure concentration device for metoprolol production according to claim 1, which is characterized in that: the bottom of the concentration tank (1) is provided with a discharge pipe (14).
7. The reduced-pressure concentration device for metoprolol production according to claim 1, which is characterized in that: guide mechanism (12) include arc guide bar (121), arc guide bar (121) hug closely the bowl form bottom inner wall setting of concentrated jar (1), be equipped with horizontally horizontal connecting rod (122) on arc guide bar (121), horizontal connecting rod (122) one end fixed connection is on arc guide bar (121), other end fixed connection is at pivot (10) lower extreme.
8. The reduced-pressure concentration device for metoprolol production according to claim 7, which is characterized in that: and a reinforcing connecting rod (123) is also arranged between the arc-shaped material guide rod (121) and the horizontal connecting rod (122).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021338843.XU CN212941509U (en) | 2020-07-09 | 2020-07-09 | Reduced pressure concentration device for metoprolol production |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021338843.XU CN212941509U (en) | 2020-07-09 | 2020-07-09 | Reduced pressure concentration device for metoprolol production |
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| Publication Number | Publication Date |
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| CN212941509U true CN212941509U (en) | 2021-04-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202021338843.XU Active CN212941509U (en) | 2020-07-09 | 2020-07-09 | Reduced pressure concentration device for metoprolol production |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113713408A (en) * | 2021-08-26 | 2021-11-30 | 上海精日新材料科技有限公司 | Multifunctional vacuum decompression concentration tank |
-
2020
- 2020-07-09 CN CN202021338843.XU patent/CN212941509U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113713408A (en) * | 2021-08-26 | 2021-11-30 | 上海精日新材料科技有限公司 | Multifunctional vacuum decompression concentration tank |
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