CN212941586U - Washing device is used in metoprolol production - Google Patents
Washing device is used in metoprolol production Download PDFInfo
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- CN212941586U CN212941586U CN202021351115.2U CN202021351115U CN212941586U CN 212941586 U CN212941586 U CN 212941586U CN 202021351115 U CN202021351115 U CN 202021351115U CN 212941586 U CN212941586 U CN 212941586U
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Abstract
A washing device for metoprolol production comprises a washing tank, wherein a horizontal partition plate is arranged in the washing tank, a detergent tank is arranged on one side of the washing tank, a vertical partition plate is arranged in the detergent tank, and two detergent bins are respectively communicated with the two washing bins in the washing tank through a first detergent pipe and a second detergent pipe; the side wall of the washing bin positioned above the washing tank is provided with a solution input pipe and a liquid discharge pipe, the horizontal partition plate is provided with a first solution output pipe communicated with the two washing bins, the bottom of the washing tank is provided with a second solution output pipe and a third solution output pipe, the second solution output pipe is connected to the transfer tank, the transfer tank is further provided with a circulating pipe, and the circulating pipe extends to the top of the washing tank. This is novel adopts above-mentioned structure, washes organic solvent through dividing batch, can effectively get rid of the impurity in the organic solvent, guarantees the purity of the organic solvent of output to promote product quality.
Description
Technical Field
The utility model relates to a metoprolol production field, specific is a washing device is used in metoprolol production.
Background
Metoprolol is a drug used to treat various types of hypertension (combined with diuretics and vasodilators) and angina pectoris. It is also effective for treating arrhythmia, especially supraventricular arrhythmia by intravenous injection.
In the production process of metoprolol, the synthesis of 4-benzyloxy benzaldehyde is the first step, which mainly comprises the following steps: p-hydroxybenzaldehyde, anhydrous potassium carbonate, tetrabutylammonium bromide (TBAB) and DMF are added into a reaction bottle, benzyl chloride is dripped at room temperature, and the temperature is raised to 65 ℃ for reaction for 3 hours after dripping. Cooling to room temperature, vacuum-filtering, pouring the filtrate into water, extracting with ethyl acetate, washing the organic layer with 5% sodium bicarbonate solution and water respectively, and concentrating under reduced pressure to obtain white solid.
Wherein, the extraction is carried out by ethyl acetate, the organic layer is respectively washed by sodium bicarbonate solution with mass fraction of 5% and water, and the sodium bicarbonate solution and the water are respectively fed into a common washing tank for washing, so that the problem that the efficiency of the washing operation cannot be controlled exists, and other impurities such as ethyl acetate to be washed and the like still remain in the solution output after washing.
Disclosure of Invention
The utility model aims to solve the technical problem that a washing device is used in metoprolol production is provided, washes organic solvent through the batch, can effectively get rid of the impurity in the organic solvent, guarantees the purity of the organic solvent of output to promote product quality.
In order to solve the technical problem, the utility model discloses the technical scheme who adopts is: a washing device for metoprolol production comprises a washing tank, wherein a horizontal partition plate is arranged in the washing tank and divides an inner cavity of the washing tank into an upper washing bin and a lower washing bin;
and a solution input pipe and a liquid discharge pipe are arranged on the side wall of the washing bin above the washing tank, a first solution output pipe for communicating the two washing bins is arranged on the horizontal partition plate, a second solution output pipe and a third solution output pipe are arranged at the bottom of the washing tank, the second solution output pipe is connected to the transfer tank, a circulating pipe is further arranged on the transfer tank, and the circulating pipe extends to the top of the washing tank.
In the preferred scheme, the top of the washing tank is provided with a motor, a rotating shaft penetrating through the horizontal partition plate is arranged in the washing tank, the rotating shaft is connected with a motor shaft, a first stirring blade is arranged on the rotating shaft positioned in the washing bin above, and a second stirring blade is arranged on the rotating shaft positioned in the washing bin below.
In a preferable scheme, one end of a first detergent pipe is positioned in a detergent bin, the other end of the first detergent pipe is connected to a second detergent pipe outside a detergent tank, a first three-way regulating valve is arranged at the connecting position of the first detergent pipe and the second detergent pipe, one end of the first detergent pipe is positioned in the detergent bin, and the other end of the first detergent pipe is connected to a detergent conveying pump at the top of the detergent tank;
the output of the detergent conveying pump is provided with a first conveying pipe, the first conveying pipe is connected to a washing bin above the inside of the washing tank, the middle part of the first conveying pipe is connected with a second conveying pipe, the second conveying pipe is connected to the washing bin below the inside of the washing tank, and a second three-way regulating valve is arranged at the connecting position of the first conveying pipe and the second conveying pipe.
In a preferable scheme, an inclined baffle is arranged on the inner wall of the washing tank above the solution input pipe.
In a preferred scheme, the top of the washing tank is provided with an air escape pipe.
In a preferable scheme, a transparent plate is arranged on the side wall of the washing bin above the washing tank, and the connecting position of the liquid discharge pipe and the washing tank is arranged on the transparent plate.
In a preferable scheme, a circulating pump is arranged in the transfer tank, and the circulating pipe is connected to the circulating pump.
The utility model provides a washing unit is used in metoprolol production through adopting above-mentioned structure, has following beneficial effect:
(1) the purpose that the washing operation of the solvent and different detergents is carried out in different washing bins is achieved, so that the washing effect is ensured, and the condition that the output solvent still contains impurities is avoided;
(2) the solvent is circularly washed, and the washing quality is ensured;
(3) the washing parameters of different washing steps can be respectively controlled, so that the washing operation of the solvent needing to be washed for multiple times can be accurately controlled.
Drawings
The invention will be further explained with reference to the following figures and examples:
fig. 1 is a schematic view of the overall structure of the present invention.
In the figure: the device comprises a washing tank 1, a horizontal partition plate 2, a detergent tank 3, a vertical partition plate 4, a first detergent pipe 5, a second detergent pipe 5 ', a first three-way regulating valve 6, a second three-way regulating valve 6 ', a detergent delivery pump 7, a first delivery pipe 8, a second delivery pipe 8 ', a motor 9, a rotating shaft 10, a first stirring blade 11, a second stirring blade 11 ', a solution input pipe 12, a first solution output pipe 13, a second solution output pipe 13 ', a liquid discharge pipe 14, a transparent plate 15, a third solution output pipe 16, a transfer box 17, a circulating pump 18, a circulating pipe 19, an air escape pipe 20 and an inclined baffle 21.
Detailed Description
As shown in fig. 1, a washing device for metoprolol production comprises a washing tank 1, wherein a horizontal partition plate 2 is arranged in the washing tank 1, the horizontal partition plate 2 divides an inner cavity of the washing tank 1 into an upper washing bin and a lower washing bin, a detergent tank 3 is arranged on one side of the washing tank 1, a vertical partition plate 4 is arranged in the detergent tank 3, the vertical partition plate 4 divides the inner cavity of the detergent tank 3 into a left washing bin and a right washing bin, and the two washing bins are respectively communicated with the two washing bins in the washing tank 1 through a first detergent pipe 5 and a second detergent pipe 5';
a solution input pipe 12 and a liquid discharge pipe 14 are arranged on the side wall of the washing bin positioned at the upper part in the washing tank 1, a first solution output pipe 13 for communicating the two washing bins is arranged on the horizontal partition plate 2, a second solution output pipe 13 'and a third solution output pipe 16 are arranged at the bottom of the washing tank 1, the second solution output pipe 13' is connected to a transfer box 17, a circulating pipe 19 is further arranged on the transfer box 17, and the circulating pipe 19 extends to the top of the washing tank 1.
In the preferred scheme, a motor 9 is arranged at the top of the washing tank 1, a rotating shaft 10 penetrating through the horizontal partition plate 2 is arranged in the washing tank 1, the rotating shaft 10 is connected with the motor 9 through a shaft, a first stirring blade 11 is arranged on the rotating shaft 10 positioned in the upper washing bin, and a second stirring blade 11' is arranged on the rotating shaft 10 positioned in the lower washing bin.
In a preferable scheme, one end of a first detergent pipe 5 is positioned in a detergent bin, the other end of the first detergent pipe is connected to a second detergent pipe 5 'outside a detergent tank 3, a first three-way regulating valve 6 is arranged at the connecting position of the first detergent pipe 5 and the second detergent pipe 5', one end of the first detergent pipe 5 is positioned in the detergent bin, and the other end of the first detergent pipe 5 is connected to a detergent conveying pump 7 at the top of the detergent tank 3;
the delivery outlet of the detergent delivery pump 7 is provided with a first delivery pipe 8, the first delivery pipe 8 is connected to the washing bin at the upper part in the washing tank 1, the middle part of the first delivery pipe 8 is connected with a second delivery pipe 8 ', the second delivery pipe 8' is connected to the washing bin at the lower part in the washing tank 1, and the connecting position of the first delivery pipe 8 and the second delivery pipe 8 'is provided with a second three-way regulating valve 6'.
In a preferred scheme, an inclined baffle plate 21 is arranged on the inner wall of the washing tank 1 above the solution input pipe 12.
In a preferred scheme, the top of the washing tank 1 is provided with an air escape pipe 20.
In a preferable scheme, a transparent plate 15 is arranged on the side wall of the upper washing bin in the washing tank 1, and the connection position of the liquid discharge pipe 14 and the washing tank 1 is arranged on the transparent plate 15.
In a preferable scheme, a circulating pump 18 is arranged in the transit box 17, and a circulating pipe 19 is connected to the circulating pump 18.
When the device is used:
adding a pretreated organic solvent into a solution input pipe 12, starting a motor 9, pre-stirring the organic solvent in an upper washing bin, adjusting a first three-way adjusting valve 6 and a second three-way adjusting valve 6 'to enable washing liquid in one of the washing agent bins to enter the upper washing bin while stirring, washing the organic solvent for the first time, enabling gas generated by washing to escape from an air escape pipe 20, layering the washing liquid and the solvent after reaction, opening a liquid discharge pipe 14, observing the output condition of lower-layer liquid through a transparent plate 15, discharging the liquid to a washing tank 1, only leaving the organic solvent, then opening a first solution output pipe 13 to enable the solvent to enter a lower washing bin, then adjusting the first three-way adjusting valve 6 and the second three-way adjusting valve 6' to enable the washing liquid in one of the washing agent bins to enter the lower washing bin to perform a second washing operation, and (3) the washed solvent enters the transfer box 17 by opening the second solution output pipe 13', is conveyed back to the upper washing bin by the circulating pump 18, is repeatedly washed for multiple times, opens the third solution output pipe 16, outputs the washed solvent, and is dried.
Claims (7)
1. The utility model provides a washing device is used in metoprolol production, includes washing jar (1), its characterized in that: the washing tank (1) is internally provided with a horizontal partition plate (2), the horizontal partition plate (2) divides the inner cavity of the washing tank (1) into an upper washing bin and a lower washing bin, one side of the washing tank (1) is provided with a detergent tank (3), a vertical partition plate (4) is arranged in the detergent tank (3), the vertical partition plate (4) divides the inner cavity of the detergent tank (3) into a left washing bin and a right washing bin, and the two washing bins are communicated with the two washing bins in the washing tank (1) through a first detergent pipe (5) and a second detergent pipe (5') respectively;
the washing tank is characterized in that a solution input pipe (12) and a liquid discharge pipe (14) are arranged on the side wall of the washing bin at the upper part in the washing tank (1), a first solution output pipe (13) communicated with the two washing bins is arranged on the horizontal partition plate (2), a second solution output pipe (13 ') and a third solution output pipe (16) are arranged at the bottom of the washing tank (1), the second solution output pipe (13') is connected to a transfer case (17), a circulating pipe (19) is further arranged on the transfer case (17), and the circulating pipe (19) extends to the top of the washing tank (1).
2. The washing device for metoprolol production according to claim 1, characterized in that: washing jar (1) top be equipped with motor (9), be equipped with pivot (10) that pass horizontal baffle (2) in washing jar (1), pivot (10) and motor (9) hub connection are located and are equipped with first stirring leaf (11) in pivot (10) in the washing storehouse of top, are located and are equipped with second stirring leaf (11') in pivot (10) in the washing storehouse of below.
3. The washing device for metoprolol production according to claim 1, characterized in that: one end of the first detergent pipe (5) is positioned in the detergent bin, the other end of the first detergent pipe is connected to a second detergent pipe (5 ') outside the detergent tank (3), a first three-way regulating valve (6) is arranged at the connecting position of the first detergent pipe (5) and the second detergent pipe (5'), one end of the first detergent pipe (5) is positioned in the detergent bin, and the other end of the first detergent pipe is connected to a detergent conveying pump (7) at the top of the detergent tank (3);
the delivery outlet of the detergent delivery pump (7) is provided with a first delivery pipe (8), the first delivery pipe (8) is connected to the interior of the washing tank (1) at the upper part of the washing tank, the middle part of the first delivery pipe (8) is connected with a second delivery pipe (8 '), the second delivery pipe (8') is connected to the interior of the washing tank (1) at the lower part of the washing tank, and the connecting position of the first delivery pipe (8) and the second delivery pipe (8 ') is provided with a second three-way regulating valve (6').
4. The washing device for metoprolol production according to claim 1, characterized in that: an inclined baffle (21) is arranged on the inner wall of the washing tank (1) above the solution input pipe (12).
5. The washing device for metoprolol production according to claim 1, characterized in that: the top of the washing tank (1) is provided with an air escape pipe (20).
6. The washing device for metoprolol production according to claim 1, characterized in that: in the washing tank (1), a transparent plate (15) is arranged on the side wall of the washing bin above the washing tank (1), and the connecting position of the liquid discharge pipe (14) and the washing tank (1) is positioned on the transparent plate (15).
7. The washing device for metoprolol production according to claim 1, characterized in that: a circulating pump (18) is arranged in the transit box (17), and a circulating pipe (19) is connected to the circulating pump (18).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021351115.2U CN212941586U (en) | 2020-07-10 | 2020-07-10 | Washing device is used in metoprolol production |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021351115.2U CN212941586U (en) | 2020-07-10 | 2020-07-10 | Washing device is used in metoprolol production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN212941586U true CN212941586U (en) | 2021-04-13 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202021351115.2U Active CN212941586U (en) | 2020-07-10 | 2020-07-10 | Washing device is used in metoprolol production |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN212941586U (en) |
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2020
- 2020-07-10 CN CN202021351115.2U patent/CN212941586U/en active Active
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