CN217578900U - Nucleic acid detection tube plug and nucleic acid mixing detection tube - Google Patents

Abstract

The utility model relates to the technical field of experimental containers, in particular to a nucleic acid detection tube plug and a nucleic acid mixed detection tube, wherein the nucleic acid detection tube plug comprises a plug body; the latter includes nucleic acid detection plugs and detection tubes. The utility model has reasonable and compact structure and convenient use, can simply and rapidly break the cotton swab head through the swab breaking port, and is always positioned in the nucleic acid detection pipe plug in the breaking process of the cotton swab head, thereby reducing the contact time between the sample and the outside air and effectively preventing the sample from being polluted; the liquid splashed in the falling process of the cotton swab head can be shielded by the nucleic acid detection pipe plug and the detection pipe, so that the iatrogenic pollution of infectious disease sources caused by the overflow of aerosol in the pipe due to the fact that the liquid carrying the sample splashes out of the pipe or the air flow at the pipe orifice is disturbed by the action of breaking the cotton swab head is prevented, and the iatrogenic cross infection risk of the infectious disease sources is further avoided; even if the strength of the broken label opening is damaged after sampling, the nucleic acid detection tube plug is not influenced to be plugged into the detection tube, and the detection tube can still be reliably plugged by the nucleic acid detection tube plug.

Description

Nucleic acid detection tube plug and nucleic acid mixing detection tube

Technical Field

The utility model relates to an experiment container technical field is a nucleic acid detection stopcock and nucleic acid mix the detecting tube.

Background

Nucleic acid diagnostics is one of the most active segments in the future IVD (in vitro diagnostics) industry. The increasing of the prevention and treatment of infectious diseases, the popularization of blood screening nucleic acid detection and the development of individualized medical treatment in China are the main motivations for the development of nucleic acid diagnosis in China. Driven by the factors, the future speed increase of domestic nucleic acid diagnosis is 25-30%, which obviously exceeds the average speed increase of domestic IVD industry. The nucleic acid diagnosis can realize early, rapid, specific and high-flux detection of pathogens, genopathy and the like.

In the population suffering from infectious virus, such as infected patients of new coronavirus and the like, nucleic acid detection is required, in order to improve the detection efficiency, a mixed detection mode can be adopted, and the current mixed detection has two modes: firstly, when sampling, put into same sampling pipe after sampling respectively many people, this kind of mode is also called "mixed sampling" or called "mixed sampling", secondly when laboratory detection, with many people's sample get the same volume wait to examine the solution mix together, also called "sample mix". However, in the large-scale sampling process, especially in the process of breaking off the cotton swab head of the existing nucleic acid detection tube, the tube opening is open, the aerosol at the tube opening of each nucleic acid detection tube may carry viruses, the viruses are accumulated in the air at the tube opening of the collection tube, which is very easy to cause iatrogenic transmission of infectious diseases, and more harm can be caused without cutting off the iatrogenic transmission of the infectious diseases.

The 10 mix 1 detection technology can greatly improve the detection efficiency and save the detection cost compared with a single sampling mode by mixing 10 detection samples for detection. The mixed collection needs to collect swab samples of a plurality of persons (generally 10 persons) into the same test tube, the swab head is difficult to break in the using process, and the swab head is required to clamp a bottle mouth and repeatedly bend to break; in the process, the gloves are easy to contact with the cotton swabs, so that samples are polluted, and the strength of the bottle mouth is easy to damage; the liquid in the test tube carrying the cotton swab can be splashed out sometimes because the liquid level is too high; the cover of the test tube needs to be unscrewed by both hands, and the operation is inconvenient.

Chinese patent document No. CN213085978U discloses a high-sealability virus sampling bottle, which comprises a bottle cap and a bottle body, wherein a first-stage inner diameter sealing ring is bonded to the top of the inner side wall of the bottle body, a second-stage top sealing ring is bonded to the top of the bottle body, a third-stage outer diameter sealing ring is bonded to the top of the outer side wall of the bottle body, an outer thread is formed on the outer side wall of the bottle body, the outer thread is located at the bottom of the third-stage outer diameter sealing ring, an inner thread matched with the outer thread is formed on the inner side wall of the bottle cap, and a sealing plug is fixedly connected to the top of the inner cavity of the bottle cap. Through the inner chamber of twisting bottle body with bottle lid cooperation external screw thread and internal thread into, get into sealed position, rely on certain external force, overcome the interference volume to reached sealed effectual purpose, this high leakproofness virus sampling bottle possesses sealed effectual advantage, it is sealed only to lean on the sealing washer of bottle lid bottom generally to have solved current partial sampling bottle, also has the structure of leaning on hard seal, but sealed effect is not especially ideal, and the cost is higher, adorn the problem of waterproof circle inefficiency. The operation is inconvenient and the cotton swab head is difficult to break in the using process.

Therefore, the existing mixed detection bottle for nucleic acid detection has the following defects in the actual use process: the cotton swab is difficult to break, the operation is complex, the collected sample is easy to be polluted when the breaking time is too long, and the strength of the bottle mouth is easy to damage in the breaking process; the opening size of the pipe orifice is large, so that liquid carrying a sample in the bottle is easy to splash out when the cotton swab head falls off, or aerosol in the pipe overflows due to disturbance of air flow of the pipe orifice in the process of breaking the cotton swab, so that iatrogenic pollution of infectious disease sources is caused.

Disclosure of Invention

The utility model provides a nucleic acid detecting pipe plug and a nucleic acid mixing detecting pipe, which overcome the defects of the prior art and can effectively solve the problems that the cotton swab of the existing nucleic acid detecting sampling bottle is difficult to break and complex to operate, the collected sample is easy to be polluted when the breaking time is overlong, and the bottle mouth strength is easy to be damaged in the breaking process; the opening size of the pipe orifice is large, so that liquid carrying a sample in the bottle is easy to spill out when the cotton swab head falls off, or aerosol in the pipe overflows due to disturbance of air flow of the pipe orifice in the process of breaking the cotton swab, thereby causing the problem of iatrogenic pollution of infectious disease sources.

The technical scheme of the utility model first realize through following measure: the utility model provides a nucleic acid detection stopcock, includes the cock body, and the cock body can and the nucleic acid detection mouth of pipe adaptation rather than being connected can be with its shutoff, the internal blind hole that is equipped with the opening downwards of cock, the blind hole can communicate with each other rather than the nucleic acid detection pipe inner chamber of being connected, and the cock body middle part is equipped with the disconnected sign mouth that is linked together with the blind hole, and disconnected sign mouth department is equipped with can be with its shutoff and can be under the exogenic action the part of opening seal the part.

The following is a further optimization or/and improvement of the first technical scheme of the utility model:

preferably, the label breaking opening is a horizontal through hole with an axis perpendicular to an axis of the plug body, and a label breaking blade is integrally formed inside the horizontal through hole.

As a second preferred aspect, the label breaking opening may be an inclined hole inclined in a low-inside and high-outside manner.

The sealing component can be a sealing film, a sealing film mounting groove with an outward opening is formed in the outer side of the plug body corresponding to the position of the label breaking opening, and the sealing film is fixedly mounted in the sealing film mounting groove.

The outer side of the middle part of the sealing film can be provided with an auxiliary open slot with an outward opening.

The above may further comprise a stopper opening device which is an outer annular table disposed outside the upper end of the stopper body or a pull ring disposed at the upper end of the stopper body.

The technical scheme of the utility model second realize through following measure: a nucleic acid mixing detection tube comprises a nucleic acid detection tube plug and a detection tube, wherein the detection tube is sleeved outside the lower end of the nucleic acid detection tube plug.

The following is further optimization or/and improvement of the second technical scheme of the utility model:

the detection device also comprises a first sealing ring and a second sealing ring, wherein at least one first sealing ring is arranged between the lower part of the nucleic acid detection tube plug and the detection tube from top to bottom; at least one second sealing ring is arranged between the upper part of the nucleic acid detecting tube plug and the detecting tube from top to bottom.

The first sealing ring and the second sealing ring can be O-shaped sealing rings or lip-shaped sealing rings.

The outer side of the upper part of the detection tube can be provided with a breaking groove with an outward opening and a triangular section.

The utility model has reasonable and compact structure and convenient use, can simply and quickly break the cotton swab head through the swab breaking port, and is always positioned in the nucleic acid detection pipe plug in the breaking process of the cotton swab head, thereby reducing the contact time between the sample and the outside air and effectively preventing the sample from being polluted; the liquid splashed in the falling process of the cotton swab head can be shielded by the nucleic acid detection tube plug and the detection tube, so that the liquid carrying the sample is prevented from splashing out of the tube to cause the iatrogenic pollution of the infectious disease source, and in addition, the small-caliber swab breaking opening arranged on the side wall of the plug body can further prevent the iatrogenic pollution of the infectious disease source caused by the overflow of aerosol in the tube due to the action of breaking the cotton swab head to stir the airflow at the opening, so that the risk of iatrogenic cross infection of the infectious disease source is greatly reduced; because can impress the cock body upper end in the test tube after the sampling is accomplished, and there is the certain distance between disconnected sign mouth and the cock body upper end, and is provided with at least one second sealing washer between cock body upper portion and the test tube, even consequently disconnected sign mouth intensity is destroyed, the protection liquid that carries the sample also can not be followed disconnected sign mouth and is revealed.

Drawings

Fig. 1 is a schematic front view structure diagram of embodiments 1 to 9 of the present invention.

Fig. 2 is a schematic perspective view of fig. 1.

Fig. 3 is a left side view cross-sectional structure diagram of embodiment 2 of the present invention.

Fig. 4 is a left side view cross-sectional structure diagram of embodiment 3 of the present invention.

The codes in the figures are respectively: 1 is the cock body, 2 is the blind hole, 3 is the sealing membrane, 4 is horizontal through-hole, 5 is disconnected sign sword, 6 is the inclined hole, 7 is supplementary open slot, 8 is the detection tube, 9 is first sealing washer, 10 is the second sealing washer.

Detailed Description

The utility model discloses do not receive the restriction of following embodiment, can be according to the utility model discloses a technical scheme and actual conditions determine concrete implementation.

In the present invention, for convenience of description, the description of the relative position relationship of each component is described according to the layout mode of the attached drawing 1 in the specification, such as: the positional relationship of front, rear, upper, lower, left, right, etc. is determined in accordance with the layout direction of the drawings of the specification.

The invention will be further described with reference to the following examples and drawings:

example 1: as shown in the attached figures 1, 2, 3 and 4, the nucleic acid detecting pipe plug comprises a plug body 1, wherein the plug body 1 can be matched with a nucleic acid detecting pipe orifice connected with the plug body and can plug the nucleic acid detecting pipe orifice, a blind hole 2 with a downward opening is arranged in the plug body 1, the blind hole 2 can be communicated with an inner cavity of the nucleic acid detecting pipe connected with the blind hole 2, a label breaking orifice communicated with the blind hole 2 is arranged in the middle of the plug body 1, and a sealing part which can plug the label breaking orifice and can be opened under the action of external force is arranged at the label breaking orifice. According to the requirement, the nucleic acid detecting tube will keep the state as shown in FIG. 1 when it leaves factory, in order to prevent the leakage of the protecting liquid in the tube, the protecting liquid needs to be prevented from flowing out from the label breaking port by the sealing component, and the sealing component can adopt the prior known technology; when the device is used, the sealing component is firstly opened through external force, the cotton swab head after sampling can be plugged into the blind hole 2 from the cotton swab breaking port, and the cotton swab breaking port is positioned on the side wall of the plug body 1, so that the shearing force in the vertical direction can be applied to the cotton swab head; after sampling is finished, the plug body 1 is pressed into the nucleic acid detection tube, and then the broken label port can be effectively blocked; the swab breaking opening is a lateral opening, so that the size of the swab breaking opening can be conveniently plugged by a swab head, and the swab breaking opening can be far smaller than the nucleic acid detection pipe opening, so that liquid containing a sample in a pipe can be prevented from splashing or aerosol in the pipe from diffusing when the swab head falls, and the iatrogenic pollution of infectious disease sources can be effectively avoided. The utility model has reasonable and compact structure and convenient use, and can form a complete nucleic acid detecting tube by directly loading the cock body 1 into the opening of the existing nucleic acid detecting tube, thereby saving the processing cost; the operation of breaking the cotton swab head through the swab breaking opening is simple, the breaking efficiency of the cotton swab head can be effectively improved, the sampling time is saved, and the sampling work efficiency is improved; in addition, the small-caliber label breaking port can effectively prevent liquid in the pipe from splashing out of the pipe to cause iatrogenic pollution of infectious disease sources, prevent the iatrogenic pollution of the infectious disease sources caused by the fact that air flow at the pipe opening is stirred by breaking the cotton swab head to cause aerosol in the pipe to overflow, and greatly reduce the risk of iatrogenic cross infection of the infectious disease sources.

The nucleic acid detection pipe plug can be further optimized or/and improved according to actual needs:

example 2: as shown in the attached figure 3, the label breaking opening is a horizontal through hole 4 with the axis vertical to the axis of the plug body 1, and a label breaking blade 5 is integrally formed on the inner side of the horizontal through hole 4. By the arrangement, the horizontal through hole 4 can reduce the escape of aerosol in the tube; the swab breaking blade 5 can effectively improve the cutting speed of the swab head and accelerate the sampling speed.

Example 3: as shown in figure 4, the label breaking opening is an inclined hole 6 which is inclined in a low-inside and high-outside shape. Through setting up like this, inclined hole 6 is more convenient for insert the cotton-wool head in the cock body 1, and the inside upper end of inclined hole 6 can make cock body 1 form the cutting edge, supplementary broken of cotton-wool head.

Example 4: as shown in fig. 1, 2, 3 and 4, the sealing member is a sealing film 3, a sealing film mounting groove with an outward opening is formed on the outer side of the plug body 1 corresponding to the position of the label breaking opening, and the sealing film 3 is fixedly mounted in the sealing film mounting groove. Through such an arrangement, the sealing component is low in production cost and easy to process. According to the requirement, the sealing film 3 can be realized by tinfoil paper, a silicon film or a rubber film in the prior art.

Example 5: as shown in fig. 3, an auxiliary opening groove 7 with an outward opening is formed in the outer side of the middle part of the sealing film 3. The thickness of the local position of the sealing film 3 is reduced through the auxiliary open slot 7, so that the sealing film 3 can reliably shield a broken swab opening and the resistance of a cotton swab head to poke the sealing film 3 can be reduced; in addition, if the sealing film 3 is made of elastic materials such as silica gel, the broken shape of the sealing film 3 is generally consistent with that of the auxiliary open slot 7, so that the broken part of the sealing film 3 can be restored to the original shape after the cotton swab head penetrates through the sealing film 3, the broken swab opening can be better shielded, and the sample can be prevented from being polluted by external aerosol. The shape of the auxiliary open slot 7 can be a straight line shape, a three-fork shape, a cross shape, a fire shape, a star shape, a meter shape and the like according to requirements.

Example 6: the plug opening device is an outer annular table arranged on the outer side of the upper end of the plug body 1 or a pull ring arranged at the upper end of the plug body 1. Through setting up like this, be convenient for when the analysis detects, follow the sampling in the test tube after taking out cock body 1.

Example 7: as shown in FIGS. 1, 2, 3 and 4, the nucleic acid mixing detection tube comprises a nucleic acid detection tube plug and a detection tube 8, wherein the detection tube 8 is sleeved outside the lower end of the nucleic acid detection tube plug. Through setting up like this, nucleic acid detecting stopcock and detecting tube 8 can be in the same place better cooperatees, and it is more convenient to use, is favorable to improving the product added value.

The nucleic acid mixing detection tube can be further optimized or/and improved according to actual needs:

example 8: as shown in the attached figures 1, 2, 3 and 4, the detection tube also comprises a first sealing ring 9 and a second sealing ring 10, and at least one first sealing ring 9 is arranged between the lower part of the nucleic acid detection tube plug and the detection tube 8 from top to bottom; at least one second sealing ring 10 is arranged between the upper part of the nucleic acid detecting tube plug and the detecting tube 8 from top to bottom. By such arrangement, the sample protection solution in the detection tube 8 can be prevented from seeping and evaporating from the gap between the lower part of the nucleic acid detection tube plug and the detection tube 8 in the storage process to cause the failure of the nucleic acid mixing detection tube; after sampling, the liquid containing the sample to be detected can be prevented from leaking out from the gap between the upper part of the nucleic acid detection pipe plug and the detection pipe 8 through the broken label port to cause pollution.

Example 9: as shown in fig. 1, 2, 3 and 4, the first seal ring 9 and the second seal ring 10 are O-ring or lip-ring seals. Through the arrangement, the O-shaped sealing ring and the lip-shaped sealing ring with the upward opening can achieve a better sealing effect and are easy to purchase; in addition, when the plug body 1 is processed by injection molding, the lip-shaped sealing ring and the plug body 1 can be integrally molded by two matched molds (the sealing ring is usually made of rubber or silica gel), so that the assembly steps can be saved, the assembly time can be shortened, and the production operation efficiency can be improved. According to the requirement, the lip-shaped sealing ring can be a V-shaped sealing ring or a Y-shaped sealing ring in the prior art.

Example 10: the outer side of the upper part of the detection tube 8 is provided with a breaking groove with an outward opening and a triangular section. Through setting up like this, through the mode sample with 8 upper ends rupture of test tube, can avoid the cork-pulling operation, improve sample detection efficiency.

Above technical feature constitutes the utility model discloses an embodiment, it has stronger adaptability and implements the effect, can increase and decrease unnecessary technical feature according to actual need, satisfies the demand of different situation.

Claims (10)

1. The utility model provides a nucleic acid detection stopcock which characterized in that includes the cock body, and the cock body can be rather than the nucleic acid detection mouth of pipe adaptation of being connected and can be with its shutoff, is equipped with the downward blind hole of opening in the cock body, the blind hole can communicate with each other with the nucleic acid detection pipe inner chamber of being connected with it, and the cock body middle part is equipped with the disconnected sign mouth that is linked together with the blind hole, and disconnected sign mouth department is equipped with can be with its shutoff and can be under the exogenic action the seal part of opening.

2. The nucleic acid detecting stopcock of claim 1, wherein the label breaking opening is a horizontal through hole having an axis perpendicular to the axis of the stopcock body, and a label breaking blade is integrally formed inside the horizontal through hole.

3. The nucleic acid detecting plug according to claim 1, wherein the label breaking port is an inclined hole having a low inside and a high outside.

4. The nucleic acid detecting stopcock of claim 1, 2 or 3, wherein the sealing member is a sealing film, a sealing film mounting groove with an outward opening is provided on the outer side of the stopcock body corresponding to the position of the label breaking opening, and a sealing film is fixedly mounted in the sealing film mounting groove.

5. The nucleic acid detecting plug according to claim 4, wherein the sealing membrane has an auxiliary opening groove formed at an outer side of a middle portion thereof.

6. The nucleic acid detecting stopcock according to claim 1, 2, 3 or 5, further comprising a stopper means, wherein the stopper means is an outer annular platform disposed outside the upper end of the stopper body or a pull ring disposed at the upper end of the stopper body.

7. The nucleic acid detecting stopcock according to claim 4, further comprising an opening means, wherein the opening means is an outer annular table disposed outside the upper end of the stopcock body or a pull ring disposed on the upper end of the stopcock body.

8. A nucleic acid mixing detecting tube using the nucleic acid detecting plug according to any one of claims 1 to 7, comprising a nucleic acid detecting plug and a detecting tube, wherein the detecting tube is attached to the outside of the lower end of the nucleic acid detecting plug.

9. The nucleic acid mixing detection tube according to claim 8, further comprising a first sealing ring and a second sealing ring, wherein at least one first sealing ring is arranged between the lower part of the nucleic acid detection tube plug and the detection tube from top to bottom; at least one second sealing ring is arranged between the upper part of the nucleic acid detection tube plug and the detection tube from top to bottom.

10. The tube according to claim 8 or 9, wherein the outer side of the upper portion of the detection tube is provided with a break groove having a triangular cross section and opening outward.

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