CN217466676U - Portable capillary tube integral column-SERS detection device - Google Patents
Portable capillary tube integral column-SERS detection device Download PDFInfo
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- CN217466676U CN217466676U CN202221519985.5U CN202221519985U CN217466676U CN 217466676 U CN217466676 U CN 217466676U CN 202221519985 U CN202221519985 U CN 202221519985U CN 217466676 U CN217466676 U CN 217466676U
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Abstract
The utility model discloses a portable capillary monolithic column-SERS detection device, its characterized in that: including transparent sample platform and a plurality of perforation ways of parallel arrangement at sample bench, the perforation is said the inside plug and is equipped with the integral column of capillary, the upper surface of sample platform is equipped with the slide that the perpendicular to perforated the axial lead, be equipped with the supporting seat that can follow this slide and slide on the slide, be equipped with the laser probe towards the integral column lasing of capillary in the supporting seat, the sense terminal of laser probe connection SERS optic fibre, the transmission end and the portable Raman spectrometer of SERS optic fibre are connected. The portable capillary tube monolithic column-SERS detection device can realize on-site rapid determination, and has the advantages of simple structure and low manufacturing cost.
Description
Technical Field
The utility model belongs to the technical field of analytical chemistry, more specifically relates to a portable capillary monolithic column-SERS detection device.
Background
With the continuous progress of scientific technology, the on-site rapid and high-sensitivity analysis of trace or trace substances in a sample is realized, and the on-site rapid and high-sensitivity analysis becomes an important research content in the current analysis scientific field; at present, the on-site rapid detection technology is widely applied to the fields of clinical inspection, food safety, inspection and quarantine, drug inspection and the like.
In recent years, with the continuous and rapid development of high and new technologies such as micro nano-fabrication technology, biotechnology, new materials and the like, the field rapid detection technology is continuously developed towards real-time detection, quantitative detection and equipment miniaturization, and meanwhile, a corresponding detection device is expected to be capable of rapidly completing the detection of batch samples in a high-throughput manner.
At present, the quantitative analysis of trace analytes still mainly depends on a large-scale liquid chromatography-mass spectrometry instrument for analysis, and the pretreatment of samples is often needed to improve the detection sensitivity, the consumption of samples in the traditional pretreatment is large, and the problems of expensive equipment, complex operation process, long detection time consumption, special requirement of a specially-assigned person and the like of the large-scale liquid chromatography-mass spectrometry instrument are solved, so that the rapid determination requirement on the site is difficult to meet.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a portable capillary monolithic column-SERS detection device, this portable capillary monolithic column-SERS detection device can realize on-the-spot short-term test, and simple structure, cost of manufacture are low.
The utility model discloses portable capillary monolithic column-SERS detection device, its characterized in that: including transparent sample platform and a plurality of perforation ways of parallel arrangement at sample bench, the perforation is said the inside plug and is equipped with the integral column of capillary, the upper surface of sample platform is equipped with the slide that the perpendicular to perforated the axial lead, be equipped with the supporting seat that can follow this slide and slide on the slide, be equipped with the laser probe towards the integral column lasing of capillary in the supporting seat, the sense terminal of laser probe connection SERS optic fibre, the transmission end and the portable Raman spectrometer of SERS optic fibre are connected.
Furthermore, the support seat body is internally provided with a through hole channel, the side wall of the through hole channel is vertically screwed with a screw, and the laser probe is installed in the through hole channel and is locked and fixed through the screw.
Furthermore, a seam road is arranged at the bottom of the slideway, and the seam road extends from the bottom of the slideway to the perforated road.
Further, the laser emitted by the laser probe travelling along the slideway falls in a first plane, and the seam way is coincided with the first plane.
Furthermore, the wavelength of the laser is 633 nm or 785 nm, and the laser energy is 50-150 w.
Further, the transparent sample stage is a plastic plate or a glass plate, and has a rectangular parallelepiped shape.
Furthermore, the outer diameter of the capillary monolithic column is 300-700 microns, and the inner diameter of the capillary monolithic column is 50-550 microns.
Furthermore, the perforation channels are in clearance fit with the capillary monolithic column, and the number of the perforation channels is 3-20.
The utility model discloses portable capillary monolithic column-SERS detection device's operating method, during each perforation way of packing into the capillary monolithic column that will make, pack the supporting seat in the slide, install laser probe on the supporting seat after that to adjust the interval of laser probe and capillary monolithic column, adjust and fix laser probe locking on the supporting seat through the screw after suitable.
The utility model discloses a show the advantage:
1. the utility model adopts the portable Raman with high sensitivity as the detection end, compared with the conventional detection by the combination of liquid chromatography and mass spectrometry, the detection device is simplified, the detection cost is greatly reduced, and the operation is more simple, convenient, rapid, efficient and sensitive;
2. the capillary monolithic column is used as an SERS active substrate and consists of continuous through holes from nanometer to micrometer, and has the advantages of controllable aperture, uniform distribution, good permeability, larger specific surface area, abundant active sites and capability of uniformly modifying metal nanoparticles; based on the high specific surface area of the monolithic column and abundant metal nanoparticle binding sites, more SERS 'hot spots' can be obtained, so that the detection of trace substances has higher sensitivity;
3. compared with conventional detection, the sampling mode is more convenient and fast by inserting the capillary tube monolithic column serving as an SERS substrate into the perforation channel, the required sample amount is small, and the field sampling requirement is better met;
4. the utility model is convenient to carry, easy operation realize high flux sample test through the mobile probe position during detection, and sample test is consuming time shorter, can satisfy the demand of on-the-spot short-term test, easily promotes by a large scale.
Drawings
FIG. 1 is a schematic view of the front cross-section structure of the present invention;
FIG. 2 is a schematic side view of the cross-sectional structure of the present invention;
FIG. 3 is a schematic view of a top view configuration of the sample stage;
FIG. 4 is a schematic front sectional view of another embodiment of the present invention;
FIG. 5 is a schematic side view cross-sectional configuration of another embodiment of the present invention;
fig. 6 is a schematic perspective view of the present invention;
Detailed Description
In order to make the technical problem, technical solution and advantageous effects to be solved by the present invention clearer and more obvious, the following description of the present invention with reference to the accompanying drawings and embodiments is provided for further details. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the invention.
The utility model discloses portable capillary monolithic column-SERS detection device: the transparent sample platform can be a plastic plate or a glass plate, the shape of the transparent sample platform is cuboid, and the perforated channels 2 are straight cylindrical channels.
The capillary monolithic column 3 is arranged in the perforation channel 2, the outer diameter of the capillary monolithic column is 300-700 microns, the inner diameter of the capillary monolithic column is 50-550 microns, the diameter of the perforation channel 2 is 330-730 microns, the outer diameter of the capillary monolithic column is 365 microns, the inner diameter of the capillary monolithic column is 100 microns, the diameter of the perforation channel 2 is 400 microns, and the number of the perforation channels is 3-20; the upper surface of the sample stage 1 is provided with a slideway 4 vertical to the axial lead of the perforated channel, the slideway is arranged along the radial direction of the perforated channel, the section of the slideway 4 can be rectangular or dovetail-shaped, the slideway 4 is provided with a supporting seat 5 capable of sliding along the slideway, the supporting seat 5 can be made of plastic and other materials, and has the functions of fixing a laser probe 6, the supporting seat is a slide block, the outer side surface of the supporting seat is matched with the slideway, the supporting seat 5 is internally provided with a laser probe 6 emitting laser towards the capillary monolithic column, the wavelength of the laser emitted by the laser probe 6 is preferably 785 nm, the laser energy is 100 w, and the laser emitted by the laser probe 6 irradiates on the capillary monolithic column through the transparent sample stage 1; the laser probe is connected with the detection end of the SERS optical fiber 7, and the transmission end of the SERS optical fiber 7 is connected with the portable Raman spectrometer 8.
The laser probe 6, the SERS optical fiber 7 and the portable raman spectrometer 8 are commercially available products, and will not be described herein.
In order to realize the better installation of the laser probe on the supporting seat, the supporting seat body is internally provided with a through hole channel 11, the side wall of the through hole channel is vertically screwed with a screw 9, the laser probe is installed in the through hole channel and is locked and fixed through the screw, after the laser probe is installed in the through hole channel, the distance between the laser probe and the capillary tube integral column 3 needs to be finely adjusted, and the laser probe is locked and fixed through the screw when to be adjusted and integrated.
In order to achieve a good detection effect, a slot 10 may be formed at the bottom of the slideway, the length direction of the slot 10 is along the length direction of the slideway, the depth direction of the slot extends from the bottom of the slideway to the perforated channel, the depth of the slot may reach the upper end of the perforated channel (as shown in fig. 1 and 2) or the middle thereof (as shown in fig. 4 and 5), and the laser emitted by the laser probe travelling along the slideway falls within a first plane, the slot coincides with the first plane (the coincidence here does not mean that the width of the slot is equal to the laser line diameter, the slot may be obtained by cutting during processing and manufacturing, and the width of the cutting slot is greater than the laser line diameter).
The utility model discloses a show the advantage:
1. the utility model adopts the portable Raman with high sensitivity as the detection end, compared with the conventional liquid chromatogram-mass spectrum combined detection, the detection device is simplified, the detection cost is greatly reduced, and the operation is more simple, convenient, rapid, efficient and sensitive;
2. the capillary monolithic column is used as an SERS active substrate and consists of continuous through holes from nanometer to micrometer, and has the advantages of controllable aperture, uniform distribution, good permeability, larger specific surface area, abundant active sites and capability of uniformly modifying metal nanoparticles; based on the high specific surface area of the monolithic column and abundant metal nanoparticle binding sites, more SERS 'hot spots' can be obtained, so that the detection of trace substances has higher sensitivity;
3. compared with conventional detection, the sampling mode is more convenient and fast by inserting the capillary tube monolithic column serving as an SERS substrate into the perforation channel, the required sample amount is small, and the field sampling requirement is better met;
4. the utility model discloses convenient to carry, easy operation realizes high flux sample detection through the removal probe position during the detection, and sample detection is consuming time shorter, can satisfy on-the-spot short-term test's demand, easily promotes by a large scale.
The capillary monolithic column can be an existing alkylamine silica gel capillary monolithic column, an existing immobilized liposome capillary monolithic column, and the like (for example, an alkylamine silica gel capillary monolithic column disclosed in CN200810073436.8, a preparation method and an application thereof, and for example, a preparation method and an application of an immobilized liposome capillary monolithic column disclosed in cn201810397945. x).
The present invention has been described in detail with reference to the accompanying drawings, and it is apparent that the present invention is not limited to the above embodiments, and it is within the scope of the present invention to adopt various insubstantial modifications of the method concept and technical solution of the present invention, or to directly apply the concept and technical solution of the present invention to other occasions without modification.
Claims (8)
1. The utility model provides a portable capillary monolithic column-SERS detection device which characterized in that: including transparent sample platform and a plurality of perforation ways of parallel arrangement at sample bench, the perforation is said the stopper and is equipped with the integral column of capillary, the upper surface of sample platform is equipped with the slide of perpendicular to perforation way axial lead, be equipped with the supporting seat that can follow this slide and slide on the slide, be equipped with the laser probe towards integral column lasing of capillary in the supporting seat, the sense terminal of laser probe connection SERS optic fibre, the transmission end and the portable Raman spectrometer of SERS optic fibre are connected.
2. The portable capillary monolithic column-SERS detection device according to claim 1, wherein: the laser probe is arranged in the through hole channel and is locked and fixed through the screw.
3. A portable capillary monolithic column-SERS detection device according to claim 1 or 2, wherein: a seam way is arranged at the bottom of the slideway, and the seam way extends from the bottom of the slideway to the perforated way.
4. A portable capillary monolithic column-SERS detection device according to claim 3, wherein: the laser emitted by the laser probe travelling along the slideway falls on a first plane, and the seam way is superposed with the first plane.
5. A portable capillary monolithic column-SERS detection device according to claim 1 or 2, wherein: the wavelength of the laser is 633 nm or 785 nm, and the laser energy is 50-150 w.
6. A portable capillary monolithic column-SERS detection device according to claim 1 or 2, wherein: the transparent sample stage is a plastic plate or a glass plate and is in a cuboid shape.
7. A portable capillary monolithic column-SERS detection device according to claim 1 or 2, wherein: the outer diameter of the capillary tube monolithic column is 300-700 microns, and the inner diameter of the capillary tube monolithic column is 50-550 microns.
8. The portable capillary monolithic column-SERS detection apparatus according to claim 7, wherein: the perforation channels are in clearance fit with the capillary monolithic column, and the number of the perforation channels is 3-20.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202221519985.5U CN217466676U (en) | 2022-06-17 | 2022-06-17 | Portable capillary tube integral column-SERS detection device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202221519985.5U CN217466676U (en) | 2022-06-17 | 2022-06-17 | Portable capillary tube integral column-SERS detection device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN217466676U true CN217466676U (en) | 2022-09-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202221519985.5U Active CN217466676U (en) | 2022-06-17 | 2022-06-17 | Portable capillary tube integral column-SERS detection device |
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| CN (1) | CN217466676U (en) |
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2022
- 2022-06-17 CN CN202221519985.5U patent/CN217466676U/en active Active
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