CN207894869U - The system taken drugs using saliva detection - Google Patents
The system taken drugs using saliva detection Download PDFInfo
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- CN207894869U CN207894869U CN201720794241.7U CN201720794241U CN207894869U CN 207894869 U CN207894869 U CN 207894869U CN 201720794241 U CN201720794241 U CN 201720794241U CN 207894869 U CN207894869 U CN 207894869U
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- Prior art keywords
- saliva
- detection
- detection zone
- drugs
- transfer unit
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- 238000001514 detection method Methods 0.000 title claims abstract description 73
- 210000003296 saliva Anatomy 0.000 title claims abstract description 53
- 239000003814 drug Substances 0.000 title claims abstract description 43
- 229940079593 drug Drugs 0.000 title claims abstract description 43
- 238000004458 analytical method Methods 0.000 claims abstract description 14
- 238000005070 sampling Methods 0.000 claims abstract description 13
- 230000005540 biological transmission Effects 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 4
- 239000000463 material Substances 0.000 claims abstract description 3
- 238000002347 injection Methods 0.000 claims description 10
- 239000007924 injection Substances 0.000 claims description 10
- 230000002209 hydrophobic effect Effects 0.000 claims description 5
- 239000012188 paraffin wax Substances 0.000 claims description 2
- 239000004575 stone Substances 0.000 claims 1
- 239000001993 wax Substances 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 abstract description 4
- 230000008901 benefit Effects 0.000 abstract description 3
- 150000002500 ions Chemical class 0.000 description 16
- 239000000243 solution Substances 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 238000002203 pretreatment Methods 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 238000001819 mass spectrum Methods 0.000 description 3
- 239000002207 metabolite Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000004698 Polyethylene Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000002117 illicit drug Substances 0.000 description 2
- 239000011261 inert gas Substances 0.000 description 2
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- -1 polyethylene Polymers 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 230000009897 systematic effect Effects 0.000 description 2
- 206010013654 Drug abuse Diseases 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 125000004494 ethyl ester group Chemical group 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000006920 protein precipitation Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
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- 239000006228 supernatant Substances 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
The utility model provides a kind of system taken drugs using saliva detection, and the detecting system includes sampling device and detection device；The sampling device includes：Load-bearing part, the load-bearing part is for carrying transfer unit；Transfer unit, the transfer unit include using detection zone and transmission range made of water wetted material, and one end of the transmission range connects the detection zone, and the other end gos deep into container；Filter layer, the filter layer are used to filter out the stickum in saliva, and filter layer is distributed in the transverse direction of the detection zone, and the saliva of transmission range is only capable of by passing through filter layer just to enter detection zone；Container, the inner containment saliva to be measured of the container；Content of the detection device by drugs in the saliva that the detection zone is known in analysis.The utility model has many advantages, such as good accuracy, high sensitivity, high efficiency, low cost.
Description
Technical field
The utility model is related to illicit drugs inspection analyses, more particularly to the system for utilizing saliva detection to take drugs.
Background technology
In recent years, abuse of the drugs in worldwide gradually penetrates into the various aspects of daily life, such as takes drugs
After drive, in public place of entertainment workplace drug abuse etc. in one's power.The quick and accurate detection of drugs has become the emphasis of research
And focus.
Drugs are analyzed in urine and blood sample relative to traditional, drugs are analyzed in saliva has many advantages.
The common practices of illicit drugs inspection is in saliva：Protein deposition agent such as acetonitrile is added in saliva, is used for protein precipitation, divides after filtering
Supernatant is taken to carry out LC-MS analyses after analysis or centrifugation.This analysis method has many deficiencies, such as：
1. pre-treatment is more complicated, and is required for repeating pre-treatment for different samples；
2.LC-MS analyses can only analyze single sample every time, be unable to continuous sample introduction, cannot achieve fast and automatically change and height
Flux distribution.
Utility model content
For the deficiency for solving in above-mentioned prior art, the utility model provides a kind of automatic sampling, sensitivity
High, the high system taken drugs using saliva detection of detection efficiency.
The purpose of this utility model is achieved through the following technical solutions：
A kind of system taken drugs using saliva detection, the system taken drugs using saliva detection includes sampling device and inspection
Survey device；The sampling device includes：
Load-bearing part, the load-bearing part is for carrying transfer unit；
Transfer unit, the transfer unit include using detection zone and transmission range, the transmission range made of water wetted material
One end connect the detection zone, the other end gos deep into container；
Filter layer, the filter layer are used to filter out the stickum in saliva, and filter layer is distributed in the cross of the detection zone
To the saliva of transmission range is only capable of by passing through filter layer just to enter detection zone；
Container, the inner containment saliva to be measured of the container；
Content of the detection device by drugs in the saliva that the detection zone is known in analysis.
Compared with prior art, the utility model have the advantage that for：
1. using filter paper is obtained added with the porous filter layer after chemical treatment, to realize paper substrate automatic sampling, it is not necessarily to
Sample pre-treatments can reduce ambient noise, improve sensitivity for analysis；
Further, it is furnished with mobile platform, is accurately controlled caused by sample introduction can eliminate human factor and interfered by motor,
Precision of analysis is improved, can realize fast and automatically change and high throughput analysis to the saliva sample that Different Individual obtains；
2. can ensure that hydrophilic area moistens for a long time in the analysis process, be conducive to the ionization of sample to be tested, ensure and divide
The sensitivity of analysis and repeatability；
3. device is simple, it is not necessarily to liquid chromatogram and artificial pre-treatment；It is easy to operate simultaneously, detection efficiency can be promoted.
Description of the drawings
With reference to attached drawing, the disclosure of the utility model will be easier to understand.Skilled addressee readily understands that
It is：These attached drawings are used only for illustrating the technical solution of the utility model, and are not intended to the protection to the utility model
Range is construed as limiting.In figure：
Fig. 1 is the structure diagram according to the system taken drugs using saliva detection of the utility model embodiment 1；
Fig. 2 is the structure diagram according to the sampling device of the utility model embodiment 1；
Fig. 3 is the corresponding mass spectrogram of saliva according to No. 1 drug abstainer in the utility model embodiment 3；
Fig. 4 is the corresponding mass spectrogram of saliva according to No. 1 non-drug addict in the utility model embodiment 3；
Fig. 5 is the corresponding mass spectrogram of saliva according to No. 2 drug abstainers in the utility model embodiment 4；
Fig. 6 is the corresponding mass spectrogram of saliva according to No. 2 non-drug addicts in the utility model embodiment 4.
Specific implementation mode
Fig. 1-6 and following description describe the optional embodiments of the utility model how to instruct those skilled in the art
Implement and reproduce the utility model.In order to instruct technical solutions of the utility model, some conventional aspects are simplified or have been omitted.This
Field technology personnel should be appreciated that modification from these embodiments or replacement will be in the scope of the utility model.This field
Technical staff should be appreciated that following characteristics can be combined in various ways to form multiple modifications of the utility model.As a result, originally
Utility model is not limited to following optional embodiments, and is only limited by the claims and their equivalents.
Embodiment 1：
Fig. 1 schematically illustrates the structure diagram of the system taken drugs using saliva detection of the utility model embodiment,
As shown in Figure 1, the system taken drugs using saliva detection includes：
Ion source, mass spectrograph, the ion source, mass spectrograph are separately positioned on the both sides of sampling device；
Fig. 2 schematically illustrates the structure diagram of the sampling device of the utility model embodiment, as shown in Fig. 2, described
Sampling device includes：
Guide rail 11, the guide rail are horizontally disposed；
Load-bearing part 21, the load-bearing part is arranged on the guide rail, including horizontal component and vertical portion；
Transfer unit, the upper end of transfer unit are fixed on the horizontal component of the load-bearing part, and lower end is goed deep into container；It is described
Transfer unit uses filter paper, and is divided into hydrophobic region 31 and hydrophilic detection zone 32 by printing paraffin in the above and passes
Area 33 is sent, on the operative orientation of detection device such as horizontal direction, load-bearing part is unable to occlusion detection area namely detection zone is in water
The lower part of flat part；Wherein, hydrophobic region is in detection zone and transmits the one or both sides in area, namely periphery；Transmit the one end in area
Connecting detection area, the other end are deep into container；
Filter layer 34, the filter layer are used to filter out the stickum in saliva, such as mucin；Filter layer is poly- for cellular
Ethyl ester filter layer uses after the solution drying that 0.1% Tween-20 and PH7.2 phosphate buffer solutions are made into；Filter layer is arranged
In transmission area so that the saliva in container has to pass through the filter layer and gets to detection zone；
Container 41, the container are arranged on the guide rail, inner containment saliva to be measured；
Drive module (not shown), such as stepper motor, the drive module drive the load-bearing part to be moved on guide rail, make
It obtains the line between the nozzle and mass spectrograph injection port of the ion source and passes through the detection zone, such as detect district center.
The course of work of the above-mentioned system taken drugs using saliva detection of the utility model embodiment：
Using capillarity, the saliva sample in container reaches filter layer by transmitting area；
Stickum in saliva is stopped by filter layer；
Enter detection zone by the saliva of filtering；
Driving load-bearing part moves on guide rail so that the plasma that the ion source projects is mapped to one of detection
Area, sample are ionized；
Spectrometer analysis ion, to obtain the content of drugs or metabolite in the corresponding saliva of the detection zone, to
It knows whether to take drugs；
Previous step is repeated, so as to adjust the relative position of ion source and detection zone, is corresponded to obtain another detection zone
Saliva in the content of drugs or metabolite.
Embodiment 2：
The system taken drugs using saliva detection of the utility model embodiment, as different from Example 1：
Ion source and mass spectrograph are arranged on guide rail, so as to adjust the relative position of ion source and detection zone.
Embodiment 3：
The systematic difference example taken drugs using saliva detection described in the utility model embodiment 1.
In the application examples, detection zone is circle, a diameter of 3-5mm, such as 4mm；The width for transmitting area is 1-1.5mm, such as
1.5mm, a length of 10-20mm, such as 20mm；Container is 2mL polyethylene centrifuge tubes；Ion source nozzle is with mass spectrograph injection port distance
2cm；Transfer unit is 0.2mm, ion source apart from mass spectrograph injection port distance between ion source nozzle and mass spectrum injection port
Nozzle, the circle detection area center of circle and mass spectrograph injection port are located in same horizontal line.Mass Spectrometer Method m/z ranges are set as 50-500,
Ion source heating temperature is set as 100 DEG C, and inert gas flow velocity is set as 4L/min, detection sample be the saliva and one of a drug abstainer not
The saliva of drug addict is as shown in Figure 3 and Figure 4 respectively.It can obviously observe that m/z is 100 signal peak, signal strength from Fig. 3
1.90e5, and corresponding signal peak is not observed in Fig. 4, thus speculate that this feature peak may be drugs or the matter of its metabolite
Compose peak-to-peak signal.Four measured value relative standard deviations obtained by mobile motor are 7.93%.
Embodiment 4：
The systematic difference example taken drugs using saliva detection described in the utility model embodiment 1.
In the application examples, detection zone is circle, a diameter of 3-5mm, such as 3mm；The width for transmitting area is 1-1.5mm, such as
1mm, a length of 10-20mm, such as 10mm；Container is 2mL polyethylene centrifuge tubes；Ion source nozzle is with mass spectrograph injection port distance
2cm；Transfer unit is 0.2mm, ion source apart from mass spectrograph injection port distance between ion source nozzle and mass spectrum injection port
Nozzle, the circle detection area center of circle and mass spectrograph injection port are located in same horizontal line.Mass Spectrometer Method m/z ranges are set as 50-500,
Ion source heating temperature is set as 100 DEG C, and inert gas flow velocity is set as 4L/min, and detection sample is a drug abstainer and a non-drug addict
Saliva, show respectively such as Fig. 5 and Fig. 6.Can obviously be observed from Fig. 5 m/z be 121 signal peak, signal strength 4.26e5, and
Observe that m/z is 121 signal peak in Fig. 6, thus signal strength e3 speculates that this feature peak may be drugs or its metabolism production
The mass spectrum of object goes out peak-to-peak signal.Measured value relative standard deviation is 8.65% three times obtained by mobile motor.
Claims (7)
1. a kind of system taken drugs using saliva detection, the system taken drugs using saliva detection includes sampling device and detection
Device；It is characterized in that：The sampling device includes：
Load-bearing part, the load-bearing part is for carrying transfer unit；
Transfer unit, the transfer unit include using detection zone and transmission range made of water wetted material, and the one of the transmission range
End connects the detection zone, and the other end gos deep into container；
Filter layer, the filter layer are used to filter out the stickum in saliva, and filter layer is distributed in the transverse direction of the detection zone, passes
The saliva in defeated area is only capable of by passing through filter layer just to enter detection zone；
Container, the inner containment saliva to be measured of the container；
Content of the detection device by drugs in the saliva that the detection zone is known in analysis.
2. the system according to claim 1 taken drugs using saliva detection, it is characterised in that：The transfer unit also wraps
It includes：
Hydrophobic region, the hydrophobic region are distributed in the one or both sides of the detection zone and transmission range.
3. the system according to claim 2 taken drugs using saliva detection, it is characterised in that：By printing stone on filter paper
Wax and form hydrophobic region, non-paraffin region forms detection zone and transmission range.
4. the system according to claim 1 taken drugs using saliva detection, it is characterised in that：The detection device includes：
Ion source, the ion source is for launching plasma；
Mass spectrograph, the line between the nozzle of the ion source and mass spectrometric injection port pass through the detection zone.
5. the system according to claim 1 taken drugs using saliva detection, it is characterised in that：The detection zone is diameter 3-
The circle of 5mm, transmission range are the strip of width 1-1.5mm, long 10-20mm.
6. the system according to claim 1 taken drugs using saliva detection, it is characterised in that：The transfer unit is at least
Two, the container is corresponded with transfer unit.
7. the system according to claim 4 taken drugs using saliva detection, it is characterised in that：The sampling device is further
Including：
Guide rail, the load-bearing part and container are arranged on the guide rail or the detection device is arranged on the guide rail；
Drive module, the drive module drive guide rail so that the load-bearing part is relatively moved with detection device, the company
Line passes through the detection zone.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720794241.7U CN207894869U (en) | 2017-07-03 | 2017-07-03 | The system taken drugs using saliva detection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720794241.7U CN207894869U (en) | 2017-07-03 | 2017-07-03 | The system taken drugs using saliva detection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207894869U true CN207894869U (en) | 2018-09-21 |
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ID=63547297
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720794241.7U Active CN207894869U (en) | 2017-07-03 | 2017-07-03 | The system taken drugs using saliva detection |
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| Country | Link |
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| CN (1) | CN207894869U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107356659A (en) * | 2017-07-03 | 2017-11-17 | 宁波华仪宁创智能科技有限公司 | The system and method taken drugs by saliva detection |
-
2017
- 2017-07-03 CN CN201720794241.7U patent/CN207894869U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107356659A (en) * | 2017-07-03 | 2017-11-17 | 宁波华仪宁创智能科技有限公司 | The system and method taken drugs by saliva detection |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address |
Address after: West side of 1st floor, 1st floor, Building A, No. 288 Jingu Middle Road (East), Yinzhou District, Ningbo City, Zhejiang Province, 315000 Patentee after: CHINA INNOVATION INSTRUMENT Co.,Ltd. Country or region after: China Address before: Room 304, D Building, Kexin Building, 655 Xueshi Road, Yinzhou District, Ningbo City, Zhejiang Province, 315000 Patentee before: CHINA INNOVATION INSTRUMENT Co.,Ltd. Country or region before: China |
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| CP03 | Change of name, title or address |