CN217007339U

CN217007339U - Bubble elimination system and sample analyzer

Info

Publication number: CN217007339U
Application number: CN202123028153.1U
Authority: CN
Inventors: 钟伟源; 侯敬生; 李洋; 董钊夺
Original assignee: Edan Instruments Inc
Current assignee: Edan Instruments Inc
Priority date: 2021-12-02
Filing date: 2021-12-02
Publication date: 2022-07-19
Anticipated expiration: 2031-12-02

Abstract

The application relates to a bubble elimination system and a sample analyzer. The bubble elimination system includes: a first drive member for containing and dispensing a liquid, the first drive member having a first opening and a second opening; and a second driving member connected to the first opening; wherein the second driver is configured to expel liquid within the first driver through the second opening based on the communication of the second driver with the first driver; the first driving part is configured to be refilled with liquid so as to eliminate bubbles in the liquid in the first driving part, avoid the bubbles in the first driving part from generating adverse effects on the detection result, improve the quantitative precision of the first driving part, and improve the accuracy and repeatability of the test result.

Description

Bubble elimination system and sample analyzer

Technical Field

The application relates to the technical field of medical equipment, in particular to a bubble eliminating system and a sample analyzer.

Background

In a sample analyzer, such as a blood cell analyzer, a certain amount of blood sample is generally extracted, and then mixed and reacted with a relevant reagent in a certain proportion, and then the mixture is detected in different ways. The sample adding and dispensing quantification of the existing sample analyzer is usually provided by a syringe, and if air bubbles exist in the syringe, the dispensing precision of the syringe is adversely affected, so that the accuracy of a test result is reduced, and the repeatability is poor.

SUMMERY OF THE UTILITY MODEL

The technical problem that this application mainly solved provides a bubble elimination system to eliminate the bubble of liquid in the first driving piece, thereby improve the accuracy and the repeatability of test result.

In order to solve the above technical problem, an aspect of the present application provides a bubble removing system, including: a first driving member for containing and dispensing a liquid, having a first opening and a second opening; and a second driving member connected to the first opening; wherein the second driver is configured to expel liquid within the first driver through the second opening based on the communication of the second driver with the first driver; the first drive member is configured to be refilled with liquid to eliminate air bubbles from the liquid in the first drive member.

Optionally, the first valve is connected between the first opening and the second driver for controlling a communication state between the first driver and the second driver.

Optionally, the second drive member comprises: a container connected with the first driving member; and the air pressure source is connected with the container and is configured to control the container to be in a negative pressure state or a positive pressure state.

Optionally, the bubble elimination system further comprises: and the liquid containing device is connected with the second opening and is configured to contain the liquid discharged by the second driving part or provide the liquid for injecting into the first driving part.

Optionally, the bubble elimination system further comprises: a first pipeline connected between the first opening and the second driving member; a second pipeline connected between the liquid containing device and the second opening; and the second valve is arranged on the second pipeline and used for controlling the communication state between the first driving piece and the liquid containing device.

Optionally, the air pressure source comprises an inlet end and an outlet end; the gas pressure source is configured to inject gas into the container based on the communication between the gas outlet end and the container and the closing of the first valve, so that the container is controlled to be in a positive pressure state; the gas pressure source is configured to suck gas in the container based on the communication between the gas inlet end and the container and the closing of the first valve, so that the container is controlled to be in a negative pressure state.

Optionally, the second driving member is configured to, when the container is in a positive pressure state, press the liquid in the first driving member into the liquid containing device through the second opening based on the communication between the second driving member and the first pipeline, the first driving member, the second pipeline and the liquid containing device, so that the first driving member is inflated with air; the second driving member is configured to, when the container is in a negative pressure state, suck the liquid in the liquid containing device from the second opening to refill the first driving member based on the communication between the second driving member and the first pipeline, the first driving member, the second pipeline and the liquid containing device, so as to refill the first driving member.

Optionally, the second driver further comprises: the third valve is connected between the air outlet end and the container and is used for controlling the communication state between the air outlet end and the container; and a fourth valve connected between the gas inlet end and the container for controlling the communication state between the gas inlet end and the container.

Optionally, the second driver further comprises: the third pipeline is connected between the first valve and the second driving piece; a fourth line connected between the container and the third valve; the fifth pipeline is connected between the third valve and the air outlet end; and the sixth pipeline is connected between the air inlet end and the container, and the fourth valve is arranged on the sixth pipeline.

Optionally, the second driver further comprises: a seventh pipeline connected to the container so that the container is communicated with the outside through the seventh pipeline; the fifth valve is arranged on the seventh pipeline and used for controlling the communication state between the container and the outside; and a ninth pipeline connected with the third valve so that the third valve is communicated with the outside through the ninth pipeline.

Optionally, the third valve is a three-way solenoid valve comprising: a first terminal connected to the fourth pipe; a second terminal connected to the fifth pipe and disposed opposite to the first terminal; and a third terminal connected to the ninth pipe and located at a side of the second terminal.

Optionally, the first and second drive members are hydrodynamic devices.

Optionally, the first drive member comprises: the first main body is provided with an accommodating cavity, one end wall of the first main body is provided with a first opening, the side wall of the other end opposite to the first opening is provided with a second opening, and the first opening and the second opening are communicated with the accommodating cavity; and the first plunger is at least partially arranged in the accommodating cavity and can move in the accommodating cavity, and the movement of the first plunger is towards or away from the first opening along a direction perpendicular to the end wall of the first opening.

Another aspect of the present application provides a sample analyzer, comprising: a housing; the accommodating device is arranged in the shell and used for accommodating a sample; the detection system is arranged in the shell and used for detecting the sample; and the bubble removal system described above, disposed within the housing, for removing the sample from the containment device and dispensing the sample into the detection system.

The second driving piece is arranged in the bubble eliminating system and is communicated with the first opening of the first driving piece, and the second driving piece can discharge liquid in the first driving piece through the second opening; the first driving part is configured to be refilled with liquid so as to eliminate bubbles in the liquid in the first driving part, thereby avoiding adverse effects of the bubbles in the first driving part on the detection result, improving the quantitative precision of the first driving part and further improving the accuracy and repeatability of the test result.

Drawings

The present application will explain embodiments in conjunction with the accompanying drawings. The drawings in the present application are for the purpose of illustrating embodiments only. Other embodiments can be readily made by those skilled in the art from the following description of the steps described without departing from the principles of the present application.

FIG. 1 is a schematic structural diagram of a bubble abatement system provided by an embodiment of the present application;

FIG. 2 is a schematic representation of the initial state of the bubble elimination system in the embodiment of FIG. 1 of the present application;

FIG. 3 is a schematic illustration of bubble elimination in the first drive member of the embodiment of FIG. 1 of the present application;

FIG. 4 is a schematic view of the embodiment of FIG. 1 of the present application showing the second driving member displacing air towards the fluid containing device and displacing fluid drawn from the first driving member;

FIG. 5 is a schematic view of the embodiment of FIG. 1 illustrating the second driving member exhausting air to the outside;

FIG. 6 is a schematic view of the embodiment of FIG. 1 of the present application wherein the second driving member draws fluid from the fluid containing means for injection into the first driving member;

FIG. 7 is a schematic view of the second driving member re-injecting the liquid drawn by the second driving member into the first driving member, the first pipeline and the sampler in the embodiment of FIG. 1;

FIG. 8 is a schematic view of the embodiment of FIG. 1 of the present application in which the second drive member re-injects the extracted fluid into the first drive member;

FIG. 9 is a schematic diagram of a bubble elimination system according to another embodiment of the present application;

FIG. 10 is a schematic representation of the initial state of the bubble elimination system in the embodiment of FIG. 9 of the present application;

FIG. 11 is a schematic illustration of the elimination of air bubbles in the first drive member in the embodiment of FIG. 9 of the present application;

FIG. 12 is a schematic view of the embodiment of FIG. 9 of the present application showing the second driving member displacing air towards the fluid containing device and displacing fluid drawn from the first driving member;

FIG. 13 is a schematic view of the embodiment of the present application shown in FIG. 9 with the fluid contained therein being refilled into the first drive member;

FIG. 14 is a schematic diagram of a bubble elimination system according to another embodiment of the present application;

FIG. 15 is a schematic illustration of the embodiment of FIG. 14 showing a positive pressure condition in the container of the second driving member;

FIG. 16 is a schematic view of the embodiment of FIG. 14 of the present application showing the injection of liquid by the first driving member;

FIG. 17 is a schematic illustration of bubble elimination in the first drive member of the embodiment of FIG. 14 of the present application;

FIG. 18 is a schematic illustration of the elimination of air bubbles in the first drive member of the embodiment of FIG. 14 of the present application;

FIG. 19 is a schematic view of the embodiment of FIG. 14 showing a negative pressure condition in the container of the second driving member;

FIG. 20 is a schematic view of the embodiment of the present application illustrated in FIG. 14 showing refilling of the first actuating member with fluid from the fluid containing device;

FIG. 21 is a schematic view of the embodiment of FIG. 14 of the present application showing the first drive member expelling refill liquid;

fig. 22 is a schematic diagram of a sample analyzer in an embodiment of the present application.

Detailed Description

The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. It is to be understood that the specific embodiments described herein are merely illustrative of and not restrictive on the broad application. It should be further noted that, for the convenience of description, only some of the structures related to the present application are shown in the drawings, not all of the structures. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

The terms "first", "second", etc. in this application are used to distinguish between different objects and not to describe a particular order. Furthermore, the terms "include" and "have," as well as any variations thereof, are intended to cover non-exclusive inclusions. For example, a process, method, system, article, or apparatus that comprises a list of steps or elements is not limited to only those steps or elements listed, but may alternatively include other steps or elements not listed, or inherent to such process, method, article, or apparatus.

Reference herein to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment can be included in at least one embodiment of the application. The appearances of the phrase in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. It is explicitly and implicitly understood by one skilled in the art that the embodiments described herein can be combined with other embodiments.

Referring to fig. 1, fig. 1 is a schematic diagram illustrating a bubble elimination system according to an embodiment of the present disclosure. The bubble removing system 100 may include a sampler 10, a first driving member 20 communicating with the sampler 10 through a first line T1, a first valve 30 connected with the first driving member 20 through a second line T2, and a second driving member 40 connected with the first valve 30 through a third line T3, wherein the first valve 30 is used for controlling the communication state between the first driving member 20 and the second driving member 40; the second driving member 40 is configured to discharge all of the liquid in the first driving member 20 based on the communication of the second driving member 40, the third line T3, the second line T2, the first driving member 20, the first line T1 and the sampler 10; the first driver 20 is configured to be refilled with liquid to eliminate bubbles of liquid in the first driver 20.

In some embodiments, the bubble abatement system 100 may include a first drive member 20, a first valve 30, and a second drive member 40, the first valve 30 being directly connected between the first drive member 20 and the second drive member 40 without connection through the third line T3 and the second line T2. Also, the first drive member 20 may directly aspirate a sample without the sampler 10.

Further, the bubble removing system 100 of the present embodiment may further include a fluid container 50 connected to the second driving member 40 via a fourth line T4 and the first valve 30, wherein the fluid container 50 is configured to contain the fluid discharged from the second driving member 40 or provide the fluid for injecting into the first driving member 20.

With continued reference to fig. 1, the sampler 10 may be used to aspirate a biological sample and dispense a quantity, and in one embodiment, the sampler 10 may be a sampling needle or a reagent needle, which may be affixed to a sample application mechanism and a reagent needle, respectively, in a sample analyzer. Alternatively, the detailed structure of the sampler 10 can refer to the prior art, and is not described in detail in this application.

As shown in fig. 1, the first driving member 20 can be used to contain and dispense a liquid, and can include: a first body 22 and a first plunger 24 movably connected to the first body 22.

Specifically, the first body 22 defines a containing cavity for containing liquid. A first opening 26 is opened on one end wall of the first main body 22, a second opening 28 is opened on the side wall of the other end opposite to the first opening 26, and both the first opening 26 and the second opening 28 are communicated with the accommodating cavity. The first port 26 is connected to the sampler 10 via a first line T1, and the second port 28 is connected to the first valve 30 via a second line T2. It will be appreciated that in another embodiment, the first drive member 20 may also be provided with a plurality of openings, namely: the first body 22 is not only provided with the first opening 26 and the second opening 28, but also provided with other openings on the end wall or the side wall of the first body 22, and the like, which can be selected according to the practical application.

At least a portion of the first plunger 24 is disposed within the receiving cavity and is movable relative to the first body 22 within the receiving cavity. The movement of the first plunger 24 is movement toward or away from the first opening 26 in a direction perpendicular to the end wall of the first opening 26. When the first plunger 24 is moved away from the first opening 26, liquid is drawn from the first opening 26 into the receiving cavity. When the first plunger 24 moves in the direction of the first opening 26, the liquid in the receiving chamber is expelled from the first opening 26 out of the receiving chamber.

When the first plunger 24 is moved furthest away from the first opening 26, it is at a greater distance from the first opening 26 than the second opening 28 is at the first opening 26, so that in this condition the first plunger 24 does not separate the liquid in the first drive member 20 from the second opening 28, so that the liquid in the first drive member 20 can circulate from the second opening 28. Also, the second opening 28 is opened near an end of the receiving chamber away from the first opening 26, for example, a surface of the first plunger 24 closest to the first opening 26 is flush with the second opening 28, so that the liquid in the receiving chamber can completely flow out through the second opening 28.

Specifically, the first driving member 20 is a fluid power device, and may be one of a syringe, a fixed displacement pump, a syringe pump, etc. for applying a fixed pressure to the fluid therein, or the fluid in the first pipeline T1 or the sampler connected thereto, so as to dispense the fluid in a fixed amount. Of course, the first driving member 20 may be other hydraulic power device capable of outputting a constant pressure. When the first driving member 20 is one of a syringe, a fixed displacement pump, a syringe pump, etc., the specific structure thereof may be other existing structures, and the present application is not limited thereto. The present application is described below with the first drive member 20 being an injector.

As shown in fig. 1, the first driving member 20 is connected to the sampler 10 through a first line T1, and liquid can be sucked or discharged through the sampler 10 by the sucking or discharging action of the first driving member 20, and the movement of the first plunger 24 in a direction away from the first opening 26 or in a direction close to the first opening 26. It will be appreciated that in some embodiments the sampler 10 may be omitted and the first drive member 20 may draw or expel liquid directly through the first line T1.

As shown in fig. 1, the communication state of the connection lines in the bubble removing system 100 can be realized by controlling the first valve 30, for example, the first valve 30 can be used for controlling the communication state between the first driving member 20 and the second driving member 40, and the first valve 30 can also be used for controlling the communication state between the second driving member 40 and the fourth line T4 and the liquid containing device 50. Optionally, the first valve 30 is connected between the second opening 28 and the second driver 40 such that the second driver 40 can expel the liquid in the first driver 20 through the second opening 28. It is understood that the connection state of the connection lines in the bubble elimination system 100 is specifically the connection of the connection lines or the disconnection of the connection lines. Specifically, the first valve 30 may be a three-way solenoid valve, which may include: a first terminal a connected to the third pipe T3, a second terminal b connected to the second pipe T2 and disposed opposite to the first terminal a, and a third terminal c connected to the fourth pipe T4 and located on the second terminal side. The first terminal a is a common terminal, and can be selectively connected to the second terminal b and the third terminal c. When it is necessary to communicate the second line T2 and the third line T3, the first terminal a is connected to the second terminal b, so that the third line T3 communicates with the second line T2, and the third line T3 communicates with the first driver 20, the first line T1, and the sampler 10 through the second line T2, and at this time, the first terminal a is not connected to the third terminal c, and the third line T3 and the fourth line T4 are cut off. When it is necessary to communicate the third pipe T3 and the fourth pipe T4, the first terminal a is connected to the third terminal c, and at this time, the first terminal a is not connected to the second terminal b, and the second pipe T2 and the third pipe T3 are disconnected from each other. It is understood that the first valve 30 may be other types of valves, and the valve structure having the function of changing the flow direction of the medium may be used, which is not limited in the present application.

As shown in fig. 1, second driving member 40 may be used to contain a liquid, and may include: a second body 42 and a second plunger 44 movably connected to the second body 42.

Specifically, the second body 42 is opened with a containing cavity for containing liquid. A third opening 46 is formed in an end wall of the second body 42, and the third opening 46 is in communication with the receiving cavity. The third opening 46 is connected to the first valve 30 through a third line T3.

At least a portion of the second plunger 44 is disposed within the receiving cavity and is movable relative to the second body 42 within the receiving cavity. The movement of the second plunger 44 is a movement toward or away from the third opening 46 in a direction perpendicular to the end wall of the third opening 46. When the second plunger 44 moves away from the third opening 46, liquid is drawn from the third opening 46 into the receiving cavity. When the second plunger 44 moves in the direction of the third opening 46, the liquid in the accommodation chamber is discharged from the third opening 46 out of the accommodation chamber.

The second driving member 40 is connected to the first terminal a of the first valve 30 through the third pipeline T3, and when the first terminal a is connected to the second terminal b, the second driving member 40 is communicated with the third pipeline T3, the second pipeline T2, the first driving member 20, the first pipeline T1 and the sampler 10 to form a communication pipeline, so that the second driving member 40 can suck the liquid in the sampler 10, the first pipeline T1, the first driving member 20, the second pipeline T2, the first valve 30 and the third pipeline T3, or the second driving member 40 can inject the liquid into the above components.

Wherein the maximum suction volume of the second drive member 40 is the volume of the housing chamber between the second plunger 44 and the end wall of the housing chamber in which the third opening 46 is located when the second plunger 44 moves from the third opening 46 to the furthest extent from the third opening 46 (i.e. the other end of the housing chamber opposite the third opening 46). It is noted that the maximum suction volume of the second driving member 40 is larger than the sum of the containing volumes of the sampler 10, the first pipe T1 and the first driving member 20, so that when the second plunger 44 moves from one end to the other end of the third opening 46, the liquid in the sampler 10, the first pipe T1 and the first driving member 20 can be sucked into the containing cavity completely, and the liquid in the second driving member 40 can refill the first driving member 20, the first pipe T1 and the sampler 10. In another embodiment, the maximum suction volume of the second driving member 40 may also be larger than the sum of the containing volumes of the sampler 10, the first pipe T1, the first driving member 20, the second pipe T2, the first valve 30 and the third pipe T3, so that when the second plunger 44 moves from one end of the third opening 46 to the other end, all of the liquid in the sampler 10, the first pipe T1, the first driving member 20, the second pipe T2, the first valve 30 and the third pipe T3 can be sucked into the containing cavity, and the liquid in the second driving member 40 can refill the third pipe T3, the first valve 30, the second pipe T2, the first driving member 20, the first pipe T1 and the sampler 10.

Similarly, the second drive member 40 is also a fluid powered device, and may specifically be one of a syringe, a fixed displacement pump, a syringe pump, a plunger pump, a pressure source, and the like.

As shown in fig. 1, the liquid containing device 50 is a device capable of containing liquid, and may include a liquid container 52 having a receiving cavity and a conduit 54 located in the receiving cavity, wherein the conduit 54 is connected to a fourth pipeline T4. When the first terminal a of the first valve 30 is connected to the third terminal c, the second driving member 40, the third line T3, the fourth line T4 and the liquid container 50 form a communication line, and the second driving member 40 can suck the liquid from the liquid container 52 through the conduit 54 and can discharge the liquid into the liquid container 52 through the conduit 54. Specifically, the liquid container 52 may contain pure water or a diluent.

Alternatively, in some embodiments, the fluid containing device 50 may be omitted (as shown in fig. 5), and the third terminal c of the first valve 30 is directly connected to the atmosphere through the fourth line T4, so that the second driving member 40 may also be directly connected to the external atmosphere.

In order to make the above description clearer, fig. 2 to 8 of the present application also show schematic diagrams of a process of eliminating bubbles in the first driving member in the bubble eliminating system according to the embodiment of the present application. The working process in an embodiment of the present application is described below with reference to fig. 2 to 8, specifically as follows:

fig. 2 shows the initial state of the bubble elimination system, namely: the first plunger 24 of the first drive member 20 is driven in a direction away from the first opening 26 to prime the first drive member 20 with a liquid, which may alternatively be pure water. Alternatively, the first plunger 24 may be movable to a bottommost position away from the first opening 26, i.e.: furthest from the first opening 26 to maximize the volume of liquid poured into the first drive member 20. However, although the first plunger 24 of the first drive member 20 has moved to the lowermost position, the liquid poured into the first drive member 20 at this time is not a full condition, since the liquid poured into the first body 22 may contain bubbles (as shown in fig. 2) due to a number of factors, for example: the liquid injected into the first main body 22 may have bubbles due to various factors such as the analyzer itself, the long time for placing the liquid for pumping, and the long time for placing the injected liquid, and the bubbles may have a great influence on the quantitative accuracy of the first driving member 20, thereby reducing the accuracy and repeatability of the test result of the apparatus. Therefore, it is necessary to eliminate the existing air bubbles to improve the accuracy and repeatability of the test results.

Figure 3 shows a schematic view of bubble elimination in the first drive member. As shown in fig. 3, the first terminal a of the first valve 30 is connected to the second terminal b, and at this time, the sampler 10, the first pipeline T1, the first driving member 20, the second pipeline T2, the third pipeline T3 and the second driving member 40 form a second communication pipeline, based on the second communication pipeline, the second plunger 44 of the second driving member 40 moves in a direction away from the third opening 46 to suck out all the liquid injected in the first driving member 20, so that the sampler 10, the first pipeline T1 and the first driving member 20 in the second communication pipeline are all filled with air to eliminate air bubbles in the first driving member 20. Optionally, in some embodiments, based on the above-mentioned second communication pipeline, after the second driving element 40 is driven to suck out all the liquid injected in the first driving element 20, so that the sampler 10, the first pipeline T1, and the first driving element 20 in the second communication pipeline are all filled with air, in addition, the second pipeline T2, the first valve 30, and the third pipeline T3 may also be filled with air at the same time, or the second pipeline T2 may also be filled with air at the same time, and the first valve 30 and the third pipeline T3 are not filled with air.

It will be appreciated that in other embodiments, the first driver 20, the second line T2, the third line T3, and the second driver 40 may also form a second communication line, and based on the second communication line, the second plunger 44 of the second driver 40 moves away from the third opening 46 to draw the liquid injected in the first driver 20 out of the second opening 28, thereby filling the first driver 20 in the second communication line with air to eliminate air bubbles in the first driver 20.

Fig. 4 shows a schematic view of the second driving member expelling air to the fluid-containing means and fluid sucked out of the first driving member. As shown in fig. 4, when the first terminal a of the first valve 30 is connected to the third terminal c, the second driving member 40, the third pipeline T3, the fourth pipeline T4 and the liquid container 50 form a third communication pipeline, and the second plunger 44 of the second driving member 40 is driven to move toward the third opening 46 based on the third communication pipeline, so that the second driving member 40 can discharge the sucked air into the liquid container 50 and discharge the liquid sucked from the first driving member 20.

In other embodiments, the second driving member 40 can also discharge air to the outside, and referring to fig. 5, fig. 5 shows a schematic view of the second driving member discharging air to the outside. As shown in fig. 5, when the first terminal a of the first valve 30 is connected to the third terminal c, the second driving member 40, the third pipeline T3 and the fourth pipeline form a fourth communication pipeline, and the fourth communication pipeline is directly communicated with the external atmosphere through the fourth pipeline T4. Similarly, the second plunger 44 of the second driving member 40 is driven to move toward the third opening 46 based on the fourth communication line, and the second driving member 40 can directly discharge the sucked air to the external atmosphere, thereby completing the exhaust process. It will be appreciated that in some embodiments, based on the fourth communication line, the second driving member 40 may discharge part of the liquid during the air discharging process, and the discharge amount of the liquid may be only for eliminating air bubbles, or may discharge all of the liquid, for example, the liquid may be discharged into other accommodating devices in the sample analyzer, which may be selected according to actual situations.

Fig. 6 shows a schematic view of the second driving member sucking up liquid from the liquid containing means for injection into the first driving member. As shown in fig. 6, when the first terminal a of the first valve 30 is connected to the third terminal c, the second driving member 40, the third pipeline T3, the fourth pipeline T4 and the liquid containing device 50 form a fifth communication pipeline, and based on the fifth communication pipeline, the second plunger 44 of the second driving member 40 is driven to move away from the third opening 46, so that the liquid in the liquid containing device 50 is output from the conduit 54 and is delivered to the second driving member 40 through the fifth communication pipeline.

Figure 7 shows a schematic view of the second drive member re-injecting the aspirated liquid into the first drive member. As shown in fig. 7, the first terminal a of the first valve 30 is connected to the second terminal b, the second driving member 40, the third pipeline T3, the second pipeline T2, the first driving member 20, the first pipeline T1 and the sampler 10 form a sixth communication pipeline, based on which the second plunger 44 of the second driving member 40 is driven to move toward the third opening 46, and the second driving member 40 can also refill the sucked liquid into the first driving member 20, the first pipeline T1 and the sampler 10 through the second opening 28, so that the first driving member 20, the first pipeline T1 and the sampler 10 are all refilled with liquid. (it will be appreciated that in other embodiments, based on the sixth communication path described above, the second plunger 44 of the second drive member 40 is driven in a direction towards the third opening 46, and the second drive member 40 can refill the first drive member 20 with the drawn liquid via the second opening 28, so that the first drive member 20 is refilled with liquid (as shown in figure 8)).

In the embodiment of the present application, the operation of eliminating the bubbles in the first driving member is described with reference to fig. 2 to 8, and the second driving member 40 is disposed in the connecting pipeline of the bubble eliminating system 100, and the communication state of the connecting pipeline is controlled by the first valve 30, so that the second driving member 40 can be selectively communicated with the first driving member 20 and the sampler 10, selectively communicated with the liquid containing device 50, and selectively communicated with the external atmosphere. Specifically, when the second driving member 40 is in communication with the first driving member 20 and the sampler 10, on one hand, the second plunger 44 of the second driving member 40 is driven to move away from the third opening 46, so that the second driving member 40 sucks the liquid in the first driving member 20 and discharges the liquid from the second opening 28 to fill the first driving member 20 with air, and on the other hand, the second plunger 44 of the second driving member 40 is driven to move close to the third opening 46, so that the second driving member 40 can refill the liquid sucked from the liquid containing device 50 into the first driving member 20 through the second opening 28 to eliminate air bubbles in the liquid in the first driving member 20; when the second driving member 40 is in communication with the fluid container 50, on the one hand, the second plunger 44 of the second driving member 40 is driven to move in a direction approaching the third opening 46, the second driving member 40 can discharge the sucked air and the sucked fluid from the first driving member 20 into the fluid container 50, and on the other hand, the second plunger 44 of the second driving member 40 is driven to move in a direction away from the third opening 46, the second driving member 40 can suck the fluid from the fluid container 50; when the second driving member 40 is communicated with the external atmosphere, the second plunger 44 of the second driving member 40 is driven to move towards the third opening 46, and the second driving member 40 can discharge the sucked air into the external atmosphere. Therefore, the second driving member 40 is provided in the bubble removing system of the present application, so that bubbles in the liquid in the first driving member 20 can be removed, adverse effects of bubbles in the first driving member 20 on the detection result are avoided, and the quantitative accuracy of the first driving member 20 is improved, thereby improving the accuracy and repeatability of the test result.

Further, the present application provides another structure of the bubble elimination system, as shown in fig. 9, which is different from the above-described embodiment in that it further includes a second valve 60a provided on the first line T1, a fifth line T5 connected to the second line T2 and the fourth line T4, respectively, and a third valve 60b provided on the fifth line T5.

A second valve 60a may be used to control the communication between the sampler 10 and the first drive member 20. Optionally, the second valve 60a is a two-way solenoid valve. Of course, the second valve 60a can be other types of valves, and the communication or disconnection between the sampler 10 and the first driving member 20 can be controlled, which is not limited in this application.

One end of the fifth pipeline T5 is connected with the second pipeline T2, and the other end is connected with the fourth pipeline T4 to form a communicated connecting pipeline. In some embodiments, the ends of the fifth pipe T5 are connected to the second pipe T2 and the fourth pipe T4 respectively by means of a tee, namely: one end of the fifth line T5 is connected to the second line T2 via a tee 70a, and the other end is connected to the fifth line T5 via a tee 70 b.

The state of communication between the fifth line T5 and the second and fourth lines T2, T4 can be controlled by opening or closing the third valve 60b, that is: when the third valve 60b is opened, a communication line is formed among the second line T2, the fifth line T5 and the fourth line T4 such that the first driving member 20 can communicate with the fluid containing device 50 through the communication line; when the third valve 60b is closed, the second line T2, the fifth line T5, and the fourth line T4 are disconnected. Specifically, the third valve 60b and the second valve 60a have the same structure, and alternatively, the third valve 60b may be a two-way solenoid valve.

Fig. 10 to 13 are schematic diagrams illustrating a process of removing air bubbles in the first driving member in the air bubble removing system according to another embodiment of the present application. The method comprises the following specific steps:

fig. 10 shows the initial state of the bubble elimination system, namely: the first plunger 24 of the first drive member 20 is driven in a direction away from the first opening 26 to prime the first drive member 20 with a liquid, which may alternatively be pure water. Alternatively, the first plunger 24 may be movable to a bottommost position away from the first opening 26, i.e.: furthest from the first opening 26 to maximize the volume of liquid poured into the first drive member 20. Similar to the embodiment shown in fig. 2, the liquid sucked by the first driving member 20 at this time is not full, and may contain bubbles (as shown in fig. 10), which are the same as the embodiment shown in fig. 2, and also cause the accuracy and repeatability of the test result of the apparatus to be reduced. Therefore, it is necessary to eliminate the existing air bubbles to improve the accuracy and repeatability of the test results.

Figure 11 shows a schematic view of bubble elimination in the first drive member. Specifically, as shown in fig. 11, the second valve 60a and the third valve 60b are closed, and the first valve 30 is opened, that is: the first terminal a and the second terminal b of the first valve 30 are connected to form a second communication line through the first driving member 20, the second line T2, the third line T3 and the second driving member 40, and based on the second communication line, the second plunger 44 of the second driving member 40 moves in a direction away from the third opening 46 to perform suction, so as to suck the liquid injected in the first driving member 20 out of the second opening 28 to eliminate the air bubbles in the first driving member 20. At this time, since the second valve 60a is closed, no air enters the first driver 20, so that the first driver 20 in the second communication line is in a state of being close to vacuum.

Fig. 12 shows a schematic view of the second driving member expelling air to the liquid containing means and liquid sucked out of the first driving member. As shown in fig. 12, the second valve 60a and the third valve 60b are closed, and the first valve 30 is opened, that is: the first terminal a of the first valve 30 is connected to the third terminal c, so that the second driving member 40, the third pipeline T3, the fourth pipeline T4 and the liquid containing device 50 form a third communication pipeline, based on which the second plunger 44 of the second driving member 40 is driven to move toward the third opening 46, and the second driving member 40 can discharge the sucked air into the liquid containing device 50 and discharge the liquid sucked from the first driving member 20. It will be appreciated that in some embodiments, based on the third communication pipeline, the second driving member 40 may discharge a part of the liquid or all of the liquid during the process of discharging the air, and the discharge amount of the liquid is selected to eliminate the air bubbles.

Fig. 13 shows a schematic view of the refilling of the first drive member with liquid in the liquid containing device. Specifically, as shown in fig. 13, the second valve 60a, the first valve 30 are closed, and the third valve 60b is opened, at this time, the second pipeline T2, the fifth pipeline T5 and the fourth pipeline T4 are communicated, so that the liquid-containing device 50, the fourth pipeline T4, the fifth pipeline T5, the second pipeline T2 and the first driving member 20 form a fourth communication pipeline, and at this time, the first driving member 20 is in a state close to vacuum, that is: when the first driving member 20 is in a negative pressure state, a pressure difference exists between the first driving member 20 and the liquid containing device 50, and the liquid in the liquid containing device 50 can be refilled into the first driving member 20 through the fourth communication pipeline by the pressure difference based on the fourth communication pipeline, so that the first driving member 20 is refilled with the liquid (as shown in fig. 13).

In comparison with the bubble elimination system 100 of the embodiment shown in fig. 1-8, in the embodiment shown in fig. 9-13, the second valve 60a, the third valve 60b and the fifth pipeline T5 are further disposed in the connecting pipeline of the bubble elimination system 100, and the communication state of the connecting pipeline in the bubble elimination system 100 is controlled by opening or closing the first valve 30, the second valve 60a and the third valve 60b, and different communication pipelines are formed, so that the first driving member 20 can selectively communicate with only the sampler 10, only the second driving member 40 and only the liquid containing device 50. Specifically, when the first drive member 20 is in communication with the sampler 10 only, the first plunger 24 is driven to move away from the first opening 26, allowing liquid to be injected into the first drive member 20; disconnecting the sampler 10 from the first driving member 20, connecting the first driving member 20 with the second driving member 40, and driving the second plunger 44 of the second driving member 40 to move in a direction away from the third opening 46, so that the second driving member 40 sucks the liquid in the first driving member 20 to make the first driving member 20 in a state close to vacuum; disconnecting the second driving member 40 from the first driving member 20 and connecting the second driving member 40 to the liquid containing device 50, driving the second plunger 44 of the second driving member 40 to move in a direction close to the third opening 46, the second driving member 40 discharging the sucked air and the liquid sucked from the first driving member 20 into the liquid containing device 50; the second driving element 40 is disconnected from the liquid containing device 50, the sampler 10 is disconnected from the first driving element 20, the first driving element 20 is connected to the liquid containing device 50, and pressure difference exists between the first driving element 20 and the liquid containing device 50 based on the first driving element 20 being in a negative pressure state, so that liquid in the liquid containing device 50 can be injected into the first driving element 20 again. Therefore, by providing the second driving member 40 in the bubble removing system 100 of the present application, bubbles in the liquid in the first driving member 20 can be removed, thereby avoiding adverse effects of bubbles in the first driving member 20 on the detection result, improving the quantitative accuracy of the first driving member 20, and improving the accuracy and repeatability of the test result.

Still further, the present application provides yet another configuration of a bubble elimination system, as shown in fig. 14. The air bubble removing system 100 may include a first driving member 20, a second driving member 11 connected to the first driving member 20 through a first line T1, and a liquid containing device 50 connected to the first driving member 20 through a second line T2. The first driving member 20 is used for containing and dispensing liquid and has a first opening 26 and a second opening 28. Further, the first pipeline T1 is connected between the first opening 26 of the first driver 20 and the second driver 11. The second line T2 is connected between the fluid containing device 50 and the second opening 28 of the first drive member 20.

Further, the bubble elimination system 100 further includes a first valve 80 provided on the first line T1 and a second valve 90 provided on the second line T2. Wherein, by opening or closing the first valve 80, the communication state between the first driving member 20 and the second driving member 11 can be controlled. By opening or closing the second valve 90, the communication state between the first driving member 20 and the liquid containing device 50 can be controlled. Alternatively, the first valve 80 and the second valve 90 may be two-way solenoid valves. Similarly, the first valve 80 and the second valve 90 can be other types of valves, and the connection between the sampler 10 and the second driving member 20 can be controlled or cut off, which is not limited in this application.

Optionally, the first valve 80 of the bubble removal system 100 is connected between the first opening 26 of the first driving member 20 and the second driving member 11, such that the second driving member 11 can discharge the liquid in the first driving member 20 through the second opening 28 of the first driving member 20. The fluid containing device 50 of the bubble elimination system 100 is connected to the second opening 28 of the first driving member 20 and is configured to contain fluid discharged from the first driving member 20 or to provide fluid for refilling the first driving member 20.

Referring again to fig. 14, the second driving member 11 of the bubble removing system 100 may include: a container 111 connected to the first drive member 20 via a third line T3 and the first valve 80, a third valve 112 connected to the container 111 via a fourth line T4, an air pressure source 113 connected to the third valve 112 via a fifth line T5, and a fourth valve 114 connected between the third line T3 and the air pressure source 113. The air pressure source 113 can control the container 111 to be in a negative pressure state or a positive pressure state.

Further, the second driving member 11 may further include a seventh pipeline T7 and an eighth pipeline T8 connected to the container 111 and spaced apart from each other, a fifth valve 115 connected to the seventh pipeline T7, and a pressure sensor 116 connected to the eighth pipeline T8. The fifth valve 115 can be used to control the communication state of the container 111 with the outside. The pressure sensor 116 may be used to sense the air pressure within the container 111. Optionally, in some embodiments, the seventh conduit T7 may be connected to other devices in the sample analyzer, such as: the sampler, the waste liquid discharge device and the like can be selected according to the practical application condition.

Alternatively, the third valve 112 may also be a three-way solenoid valve, and the structure thereof may be the same as that of the first valve 30 in fig. 1 to 13, which is not described herein again. In some embodiments, the third valve 112 is connected to the fourth line T4, the fifth line T5. In other embodiments, the third valve 112 is connected to the fourth line T4, the fifth line T5, and may be connected to the outside through a ninth line T9, specifically, may be connected to the atmosphere, and may be connected to other devices. Alternatively, the fourth valve 114 may be a two-way solenoid valve.

It is understood that the structure of the first driving member 20 and the liquid containing device 50 in the embodiment shown in fig. 14 is the same as that of the corresponding components in the embodiment shown in fig. 1 to 13, and the description thereof is omitted. Compared with the second driving member 11 in the embodiment shown in fig. 1 to 13, the second driving member 11 in the embodiment shown in fig. 14 drives the liquid in the first driving member 20 to flow out of the second opening 28 thereof by using the pressure difference between the second driving member 11 and the first driving member 20, so as to fill the first driving member 20 with air, but the structure and the connection manner with the first driving member 20 are different.

Specifically, the container 111 in the second driving member 11 may be a closed container having a receiving cavity to receive the gas provided by the gas pressure source 113, so that the receiving cavity may be in a positive pressure state or a negative pressure state.

The air pressure source 113 may include an inlet port 113a connected to the sixth pipe T6 and an outlet port 113b spaced apart from the inlet port 113a and connected to the fifth pipe T5. Wherein the gas inlet 113a may be configured to extract gas from the container 111 such that the container 111 is in a negative pressure state. Gas outlet 113b may be configured to inject a gas into vessel 111 such that vessel 111 is at a positive pressure. Alternatively, the air pressure source 113 may be a liquid pump, and the specific structure thereof may refer to the prior art, which is not described in detail in this application.

In order to make the above description clearer, fig. 15 to 20 of the present application also show schematic diagrams of a bubble elimination process in the first driving member in the bubble elimination system according to another embodiment of the present application. The method comprises the following specific steps:

fig. 15 shows the second driver in a positive pressure state, i.e.: the gas pressure source 113 injects gas into the container 111 through the gas outlet port 113 b. Specifically, as shown in fig. 15, the first valve 80, the second valve 90, the fourth valve 114, and the fifth valve 115 are closed, and the third valve 112 is opened, that is: the first terminal a of the third valve 112 is connected to the second terminal b, so that the gas outlet 113b of the gas pressure source 113, the fifth pipeline T5, the fourth pipeline T4 and the container 111 form a first communication pipeline, and the gas outlet 113b of the gas pressure source 113 can provide gas to the container 111 based on the first communication pipeline, so that the container 111 is in a positive pressure state.

Alternatively, the container 111 may control the amount of intake air by the pressure sensor 116 connected to the eighth pipeline T8, and the container 111 may be filled with gas or a part of gas by the sensing of the pressure sensor 116, as long as the container 111 is in the required positive pressure state and the liquid in the first driving member 20 can be discharged, which may be selected according to the actual situation. Alternatively, the container 111 may be at a desired positive pressure to displace a portion of the liquid from the first drive member 20 (as shown in FIG. 17) or the entire liquid (as shown in FIG. 18).

Figure 16 shows a schematic view of the first drive member injecting liquid. Namely: the first plunger 24 of the first drive member 20 is driven in a direction away from the first opening 26 to prime the first drive member 20 with a liquid, which may alternatively be pure water. Optionally, the first plunger 24 is movable to a bottom-most position away from the first opening 26, i.e.: furthest from the first opening 26 to maximize the volume of liquid poured into the first drive member 20. Similar to the embodiment shown in fig. 2 and 10, there may be air bubbles in the liquid poured into the first driving member 20, and therefore, it is necessary to eliminate the air bubbles to improve the accuracy and repeatability of the test results.

Figures 17 and 18 show schematic views of bubble elimination in the first drive member. Specifically, as shown in fig. 17 and 18, the third valve 112, the fourth valve 114, and the fifth valve 115 are closed, and the first valve 80 and the second valve 90 are opened. At this time, the second driving member 11, for example, the container 111, the third line T3, the first line T1, the first driving member 20, the second line T2 and the liquid-containing device 50 form a third communicating line. Based on the third communication line and the container 111 in the positive pressure state, the second driving member 11, such as the container 111, can be used as a positive pressure source to press the liquid in the first driving member 20 into the liquid containing device 50 through the second opening 28, so that the first driving member 20 is filled with air to eliminate air bubbles in the first driving member 20, and optionally, the first line T1 can be filled with air at the same time, or the second line T2 and the second valve 90 can be filled with air at the same time. It will be appreciated that when the container 111 in the positive pressure state displaces a portion of the liquid in the first driving member 20, correspondingly, the container 111 in the positive pressure state also causes a portion of the air to be filled in the first driving member 20, as shown in fig. 17; when the container 111 in the positive pressure state discharges all the liquid in the first driving member 20, accordingly, the container 111 in the positive pressure state fills the first driving member 20 with air, as shown in fig. 18.

Figure 19 shows a schematic view of the second driving member in a negative pressure condition. Namely: the gas pressure source 113 draws gas from the container 111 through the gas inlet port 113 a. Specifically, as shown in fig. 19, the first valve 80, the second valve 90, the third valve 112 and the fifth valve 115 are closed, and the fourth valve 114 is opened, so that the inlet port 113a of the air pressure source 113, the fourth pipe T4, the third pipe T3 and the container 111 form a fourth communication pipe. Based on the fourth communication line, the gas inlet end 113a of the gas pressure source 113 may draw the gas inside the container 111, so that the container 111 is in a negative pressure state.

Alternatively, the container 111 may control the degree of negative pressure by the pressure sensor 116 connected to the eighth pipeline T8, which is selected according to the actual situation, as long as the container 111 is under a certain negative pressure and the liquid in the liquid containing device 50 can be refilled into the first driving member 20.

Fig. 20 shows a schematic view of the refilling of the first drive member with liquid in the liquid containing device. Specifically, as shown in fig. 20, the third valve 112, the fourth valve 114, and the fifth valve 115 are closed, and the first valve 80 and the second valve 90 are opened. At this time, the second driving member 11, such as the container 111, the third pipeline T3, the first pipeline T1, the first driving member 20, the second pipeline T2 and the liquid containing device 50 form a fifth communication pipeline, and based on the fifth communication pipeline and the container 111 in a negative pressure state, the second driving member 11, such as the container 111, can be used as a negative pressure source, so as to suck the liquid in the liquid containing device 50 from the second opening 28 of the first driving member 20 to refill the first driving member 20, so as to refill the first driving member 20, thereby eliminating bubbles in the liquid in the first driving member 20.

Optionally, in one embodiment, the present application also provides a first driver 20 drain process that refills with liquid. Specifically, as shown in fig. 21, first, the first valve 80, the second valve 90, the third valve 112, and the fourth valve 114 are closed, and the fifth valve 115 is opened, so that the container 111 is communicated with the outside, and the container 111 is depressurized. The first valve 80 is then opened, and at this time, the second valve 90, the third valve 112 and the fourth valve 114 are still in a closed state, so that the first driving member 20, the first pipeline T1, the third pipeline T3, the container 111 and the seventh pipeline T7 form a sixth communication pipeline, and the sixth communication pipeline is directly communicated with the outside. Based on the sixth communication line, the first plunger 24 is driven to move toward the first opening 26, so that the refilled liquid in the first driving member 20 can flow out through the first opening 26, the second line T2, the third line T3, the container 111 and the seventh line T7 in sequence, and the dispensing process is completed.

In the embodiment shown in fig. 15-21, the second driving member 11 of the bubble removing system 100 may include an air pressure source 113 for providing the required air pressure so that there is a pressure difference between the container 111 of the second driving member 11 and the first driving member 20, thereby driving the liquid in the first driving member 20 to be discharged from the second opening 28, and also pumping the liquid and refilling the first driving member 20 through the second opening 28 to refill the first driving member 20, thereby removing bubbles in the liquid in the first driving member 20. Therefore, by providing the second driving member 11 in the bubble removing system 100 of the present application, bubbles in the liquid in the first driving member 20 can be removed, so that adverse effects of bubbles in the first driving member 20 on the detection result are avoided, and the quantitative accuracy of the first driving member 20 is improved, thereby improving the accuracy and repeatability of the test result.

Fig. 22 shows a schematic diagram of a sample analyzer in an embodiment of the present application. As shown in fig. 22, a sample analyzer 200 of the present disclosure includes: a housing 210; a holding device 220 disposed in the housing 210 for holding a sample; a detection system 230 disposed within the housing 210 for detecting a sample; and the bubble removal system 100 described above, the bubble removal system 100 is disposed within the housing 210 for taking a sample from the holding device 220 and dispensing the sample into the detection system 230. The sample analyzer 200 of this embodiment has the same advantages as the bubble elimination system 100 provided in this embodiment, and the description thereof is omitted here.

The above description is only for the purpose of illustrating the preferred embodiments of the present application and is not intended to limit the scope of the present application, which is defined by the appended claims and their equivalents, and all changes that can be made therein without departing from the spirit and scope of the invention.

Claims

1. A bubble abatement system, comprising:

a first drive member for containing and dispensing a liquid, having a first opening and a second opening; and

the second driving piece is connected with the first opening;

wherein the second driver is configured to expel liquid within the first driver through the second opening based on the second driver communicating with the first driver;

the first drive member is configured to be re-injected with liquid to eliminate bubbles of the liquid in the first drive member.

2. The bubble elimination system of claim 1,

and the first valve is connected between the first opening and the second driving piece and is used for controlling the communication state between the first driving piece and the second driving piece.

3. The bubble elimination system of claim 2, wherein the second drive member comprises:

a container connected to the first driving member;

and the air pressure source is connected with the container and is configured to control the container to be in a negative pressure state or a positive pressure state.

4. The bubble elimination system of claim 3, further comprising:

a fluid containing device connected to the second opening and configured to contain fluid discharged from the first driving member or to provide fluid for refilling the first driving member.

5. The bubble elimination system of claim 4, further comprising:

a first conduit connected between the first opening and the second driver;

a second conduit connected between the liquid containing means and the second opening; and

and the second valve is arranged on the second pipeline and used for controlling the communication state between the first driving piece and the liquid containing device.

6. The bubble elimination system of claim 3, wherein the gas pressure source comprises a gas inlet end and a gas outlet end;

wherein the gas pressure source is configured to inject gas into the container based on the communication of the gas outlet end with the container and the closing of the first valve, thereby controlling the container to be in a positive pressure state;

the air pressure source is configured to suck the gas in the container based on the communication between the air inlet end and the container and the closing of the first valve, so that the container is controlled to be in a negative pressure state.

7. The bubble elimination system of claim 5,

the second driving element is configured to, when the container is in a positive pressure state, press the liquid in the first driving element into the liquid containing device through the second opening based on the communication of the second driving element with the first pipeline, the first driving element, the second pipeline and the liquid containing device, so that the first driving element is inflated with air;

the second driving member is configured to, when the container is in a negative pressure state, suck the liquid in the liquid containing device from the second opening to refill the first driving member based on the communication between the second driving member and the first pipeline, the first driving member, the second pipeline and the liquid containing device, so as to refill the first driving member.

8. The bubble elimination system of claim 6, wherein the second drive member further comprises:

the third valve is connected between the air outlet end and the container and is used for controlling the communication state between the air outlet end and the container; and

and the fourth valve is connected between the air inlet end and the container and is used for controlling the communication state between the air inlet end and the container.

9. The bubble elimination system of claim 8, wherein the second drive member further comprises:

a third line connected between the first valve and the second driver;

a fourth line connected between the vessel and the third valve;

the fifth pipeline is connected between the third valve and the air outlet end;

and the sixth pipeline is connected between the air inlet end and the container, and the fourth valve is arranged on the sixth pipeline.

10. The bubble elimination system of claim 9, wherein the second drive member further comprises:

a seventh pipeline connected to the container so that the container communicates with the outside through the seventh pipeline;

a fifth valve, disposed on the seventh pipeline, for controlling a communication state between the container and the outside; and

and a ninth pipeline connected with the third valve so that the third valve is communicated with the outside through the ninth pipeline.

11. The bubble elimination system of claim 10, wherein the third valve is a three-way solenoid valve comprising:

a first terminal connected to the fourth pipe;

a second terminal connected to the fifth pipe and disposed opposite to the first terminal; and

and a third terminal connected to the ninth pipe and located at a side of the second terminal.

12. The bubble elimination system of claim 1, wherein the first drive member and the second drive member are hydrodynamic devices.

13. The bubble elimination system of claim 1, wherein the first drive member comprises:

the first body is provided with an accommodating cavity, one end wall of the first body is provided with a first opening, the side wall of the other end opposite to the first opening is provided with a second opening, and the first opening and the second opening are both communicated with the accommodating cavity; and

and at least one part of the first plunger is arranged in the accommodating cavity and can move in the accommodating cavity, and the movement of the first plunger is towards or away from the first opening along the direction vertical to the end wall of the first opening.

14. A sample analyzer, comprising: the method comprises the following steps:

a housing;

the accommodating device is arranged in the shell and used for accommodating a sample;

the detection system is arranged in the shell and is used for detecting the sample; and

the bubble elimination system of any one of claims 1-13, disposed within the housing for removing a sample from the containment device and dispensing the sample into a detection system.