CN114307828B - Puncture liquid feeding method and device and puncture liquid feeding blending equipment - Google Patents
Puncture liquid feeding method and device and puncture liquid feeding blending equipment Download PDFInfo
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- CN114307828B CN114307828B CN202111493282.XA CN202111493282A CN114307828B CN 114307828 B CN114307828 B CN 114307828B CN 202111493282 A CN202111493282 A CN 202111493282A CN 114307828 B CN114307828 B CN 114307828B
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Abstract
The invention belongs to the technical field of liquid adding methods, and particularly relates to a puncture liquid adding method, a puncture liquid adding device and puncture liquid adding and mixing equipment, wherein the puncture liquid adding method comprises the following steps: communicating the puncture needle with the fluid path; filling liquid filling pipeline and puncture needle of liquid path with liquid; sucking back liquid with a preset volume to the liquid path, wherein the preset volume is larger than the volume of the inner cavity of the puncture needle; driving a puncture needle to puncture the sealing cover of the container; balancing the internal and external air pressure of the container; refilling liquid with a preset volume into the liquid adding liquid pipeline and the puncture needle; a target volume of liquid is injected into the container. The liquid adding process is automatic in the whole process, high in efficiency, free of manual participation and capable of saving labor cost, and therefore large-scale application can be achieved.
Description
Technical Field
The invention belongs to the technical field of liquid adding methods, and particularly relates to a puncture liquid adding method and device and puncture liquid adding and mixing equipment.
Background
In the solid-liquid and liquid-liquid mixing process, solid or liquid is placed in a container, the liquid is added into the container, and the container is shaken to realize the solid-liquid mixing or the liquid-liquid mixing. In this case, it concerns the operations of filling the inside of the container.
At present, the commonly used liquid adding operation is to manually operate clamping tools such as tweezers and the like to lift the container sealing cover. After the container sealing cover is opened, atmospheric pressure can enter the container instantly, and balance of internal and external air pressure of the container is realized. After the air pressure is balanced, a manual operator holds the liquid transferring gun by hand or adopts the electronic liquid transferring gun to add liquid into the container. However, the manual operation of filling liquid into the container has low efficiency and high labor cost, and cannot be applied on a large scale.
Disclosure of Invention
The invention provides a puncturing liquid feeding method, and aims to solve the technical problems that the efficiency is low, the labor cost is high and the large-scale application cannot be realized in an operation mode of manually feeding liquid into a container.
The embodiment of the invention is realized in such a way, and provides a puncturing liquid adding method, which comprises the following steps:
communicating the puncture needle with the fluid path;
filling a liquid feeding liquid path pipeline of the liquid path and the puncture needle with liquid;
drawing back a predetermined volume of fluid into the fluid path, said predetermined volume being greater than the volume of the interior chamber of said needle;
driving the puncture needle to puncture the sealing cover of the container;
balancing the internal and external air pressure of the container;
re-injecting the predetermined volume of liquid into the liquid feeding liquid path pipeline and the puncture needle;
a target volume of liquid is injected into the container.
Further, the step of balancing the internal and external air pressures of the container specifically comprises:
switching the puncture needle from a communicating liquid path to a communicating gas path through a multi-way valve;
and switching the puncture needle from a communicating gas path to a communicating liquid path through the multi-way valve.
Still further, after the step of injecting the target volume of liquid into the container, the method further comprises the steps of:
a target volume of gas is aspirated from the container.
Furthermore, one end of the multi-way valve communicated with the air passage is provided with a filter membrane.
Further, the step of balancing the internal and external air pressures of the container specifically includes:
the puncture mechanism connected with the puncture needle is separated from the puncture needle.
Further, the step of filling the liquid feeding liquid path pipeline of the liquid path and the puncture needle with liquid specifically includes:
a liquid feeding path pipe for feeding liquid into the liquid path and the puncture needle;
collecting waste liquid dripping from the puncture needle;
and until full volume of liquid is injected into the liquid feeding liquid path pipeline and the puncture needle, wherein the full volume is larger than the sum of the volumes of the liquid feeding liquid path pipeline and the puncture needle.
Further, the step of collecting waste liquid dripping from the puncture needle specifically includes:
collecting waste liquid dripping from the puncture needle through a swab structure.
Still further, the swab structure is disposed in the path of the penetration.
The embodiment of the invention also provides a puncture liquid feeding device, which comprises:
a liquid path;
a puncture needle communicating with the fluid path;
the puncture mechanism is used for driving the puncture needle to puncture the sealing cover of the container;
the air pressure balancing mechanism is used for balancing the internal air pressure and the external air pressure of the container;
the liquid adding mechanism is used for filling liquid into a liquid adding liquid path pipeline and the puncture needle of the liquid path, sucking liquid with a preset volume back to the liquid path, re-injecting the liquid with the preset volume into the liquid adding liquid path pipeline and the puncture needle after the air pressure inside and outside the container is balanced, and injecting liquid with a target volume into the container;
wherein the predetermined volume is greater than the lumen volume of the puncture needle.
Furthermore, the air pressure balancing mechanism comprises a multi-way valve, the puncture needle is switched from a communication liquid path to a communication air path through the multi-way valve, and then the puncture needle is switched from the communication air path to the communication liquid path through the multi-way valve, so that the balance between the internal air pressure and the external air pressure of the container is realized.
The embodiment of the invention also provides puncturing liquid feeding and mixing equipment, which comprises:
a piercing filling device as described above;
the blending mechanism is used for driving the container which is subjected to puncture liquid feeding to move so as to blend the objects in the container
The invention has the advantages that after the liquid fills the liquid feeding pipeline and the puncture needle of the liquid path, the liquid with the preset volume is sucked back to the liquid path to empty the liquid in the inner cavity of the puncture needle, then the puncture needle is driven to puncture the sealing cover of the container, and the internal and external air pressures of the container are balanced. The liquid adding process is automatic in the whole process, high in efficiency, free of manual participation and capable of saving labor cost, and therefore large-scale application can be achieved.
Drawings
FIG. 1 is a block diagram of a process for filling liquid by piercing according to an embodiment of the present invention;
FIG. 2 is a schematic diagram of a piercing liquid feeding device provided by an embodiment of the invention;
FIG. 3 is a flow chart of a piercing liquid feeding method according to a second embodiment of the present invention;
FIG. 4 is a flow chart of a piercing liquid feeding method according to a third embodiment of the present invention;
FIG. 5 is a block flow diagram of a liquid adding method for piercing provided by the fifth embodiment of the invention;
FIG. 6 is a flow chart of a piercing liquid feeding method according to a sixth embodiment of the present invention;
FIG. 7 is a flow chart of a piercing liquid feeding method according to a seventh embodiment of the present invention;
FIG. 8 is a schematic view of a needle provided in accordance with an embodiment of the present invention;
FIG. 9 is a cross-sectional view of a swab provided in accordance with an embodiment of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and do not limit the invention.
The invention provides a puncture liquid feeding method, which is characterized in that a puncture needle and a liquid path are communicated, liquid is filled in a liquid feeding liquid path pipeline and the puncture needle of the liquid path, liquid with a preset volume is sucked back to the liquid path to empty the liquid in an inner cavity of the puncture needle, the puncture needle is driven to puncture a sealing cover of a container, the internal air pressure and the external air pressure of the container are balanced, and then the liquid with the preset volume can be smoothly re-injected into the liquid feeding liquid path pipeline and the puncture needle, and the liquid with a target volume is injected into the container to finish the liquid feeding process. The liquid adding process is automatic in the whole process, high in efficiency, free of manual participation and capable of saving labor cost, and therefore large-scale application can be achieved.
Example one
Referring to fig. 1, this embodiment provides a piercing liquid feeding method, which includes the following steps:
s1, communicating a puncture needle with a liquid path;
s2, filling a liquid feeding liquid path pipeline of the liquid path and the puncture needle with liquid;
s3, sucking back liquid with a preset volume to a liquid path, wherein the preset volume is larger than the volume of an inner cavity of the puncture needle;
s4, driving the puncture needle to puncture the sealing cover of the container;
s5, balancing the internal and external air pressure of the container;
s6, re-injecting the liquid with the preset volume into the liquid feeding liquid path pipeline and the puncture needle;
and S7, injecting liquid with a target volume into the container.
In this embodiment, referring to fig. 2, the puncture needle 3 and the fluid path are communicated, the fluid filling fluid path pipeline of the fluid path and the puncture needle 3 are filled with fluid, then a predetermined volume of fluid is sucked back to the fluid path, the predetermined volume is larger than the volume of the inner cavity of the puncture needle 3, and after the predetermined volume of fluid is sucked back to the fluid path, the fluid in the inner cavity of the puncture needle 3 can be emptied. The puncture needle 3 is driven to puncture the sealing cover of the container 1 and balance the internal and external air pressure of the container 1. The predetermined volume of liquid can then be successfully refilled into the priming line and the needle 3 due to the equalized air pressure. After the predetermined volume of the liquid is injected, it is known that the puncture needle 3 has been refilled with the liquid, then the target volume of the liquid is injected into the container 1, and the next injected target volume of the liquid can be completely injected into the container 1, thereby achieving the controllability of the volume of the liquid injected into the container 1. The liquid adding process is automatic in the whole process, high in efficiency, free of manual participation and capable of saving labor cost, and therefore large-scale application can be achieved.
After the liquid adding process is finished, the puncture needle 3 is driven to be separated from the sealing cover of the container 1, the container 1 which is added with liquid is moved away through a manual mode or a mechanical automatic mode, the next container 1 which is not added with liquid is moved to a liquid adding position, and liquid adding operation is carried out on the container 1 which is not added with liquid.
When the puncture needle 3 is used, the user can know the model and specification of the puncture needle 3, and therefore, the volume of the inner chamber of the puncture needle 3 can be known, and a predetermined volume can be set according to the volume of the inner chamber of the puncture needle 3. The predetermined volume set is greater than the volume of the lumen of the needle 3, ensuring that the lumen of the needle 3 has been emptied after the predetermined volume of fluid has been aspirated back. When the container 1 is used, a user can know the model and specification of the container 1, so that the volume of the container 1 can be known, and the volume of the liquid to be injected into the container 1, that is, the target volume of the liquid can be set according to the volume of the container 1.
For example, knowing that the volume of the lumen of the puncture needle 3 is 100ul, the volume of the liquid to be injected into the container 1 is 1ml. After the puncture needle 3 and the liquid path are communicated, liquid is filled in a liquid feeding liquid path pipeline of the liquid path and the puncture needle 3, then liquid with the volume of 120ul is sucked back to the liquid path, and at the moment, the liquid in the inner cavity of the puncture needle 3 is emptied. The puncture needle 3 is driven to puncture the sealing cover of the container 1 and balance the internal and external air pressure of the container 1. Then, the 120ul volume of liquid is re-injected into the liquid feeding channel and the puncture needle 3, at this time, the puncture needle 3 is refilled with liquid, and the liquid injected into the puncture needle 3 is then completely injected into the container 1, so that the liquid feeding operation is completed by injecting 1ml volume of liquid into the container 1.
The puncture liquid feeding method is realized by a puncture liquid feeding device.
Referring to fig. 2, the puncturing liquid adding device includes a liquid adding mechanism, and the liquid adding mechanism includes a first two-way valve 51, a liquid sucking pump 52 connected to the first two-way valve 51, a second two-way valve 53 connected to the liquid sucking pump 52, and a liquid storage piece 541 connected to the second two-way valve 53. Since the liquid suction pump 52 does not have a function of selectively sucking or discharging in any direction, the flow direction of the liquid needs to be controlled by closing and opening the first two-way valve 51 and the second two-way valve 53.
Specifically, when the liquid suction pump 52 needs to suck the liquid in the liquid storage component 541, the first two-way valve 51 is closed, the second two-way valve 53 is opened, and the liquid suction pump 52 smoothly sucks the liquid in the liquid storage component 541. When the liquid sucking pump 52 sucks liquid, a little more liquid can be sucked to be stored inside. When the liquid suction pump 52 needs to inject the liquid toward the puncture needle 3, the first two-way valve 51 is opened, the second two-way valve 53 is closed, and the liquid suction pump 52 smoothly injects the liquid toward the puncture needle 3.
The liquid suction pump 52 may be a plunger pump, the maximum flow rate of which is 10ml, and the plunger pump depends on the reciprocating motion of a plunger in a cylinder body, so that the volume of the sealed working cavity is changed to realize liquid suction and liquid discharge. The fluid reservoir 541 may be a fluid bag filled with fluid.
Referring to fig. 2, the liquid charging mechanism further includes a cross valve 542 disposed on the liquid storage member 541, and a quick coupling 543 connected to the cross valve 542. After the cross valve 542 is opened, the liquid sucking pump 52 can suck the liquid in the liquid storage member 541. The quick joint 543 is a switching joint, and realizes the connection between the cross valve 542 and the fluid path.
The puncture liquid feeding device also comprises a puncture mechanism which is used for driving the puncture needle 3 to move so that the puncture needle 3 punctures the sealing cover of the container 1. The puncture mechanism comprises a clamping piece and a driving mechanism, and under the driving of the driving mechanism, the clamping piece clamps the puncture needle 3 and drives the puncture needle 3 to move so as to realize the sealing of the puncture needle 3 puncturing the container 1.
Further, the driving mechanism comprises a first driving part and a second driving part, the first driving part is used for driving the clamping part to clamp the puncture needle 3, and the second driving part is used for driving the clamping part to drive the puncture needle 3 to puncture the sealing cover of the container 1. The first driving part and the second driving part are driving motors, output shafts of the driving motors are connected with the clamping pieces, and the clamping pieces are driven to move through movement of the output shafts.
It should be noted that, referring to fig. 2, the liquid feeding pipeline includes a pipeline between the quick coupling 543 and the first two-way valve 51 (but does not include the lumen pipeline of the quick coupling 543).
In this embodiment, the container 1 may be a vial of penicillin. The penicillin bottle is also called borosilicate glass or soda-lime glass tube (or molded) injection bottle, which is a bottle with a rubber plug and an aluminum-plastic combined cover for sealing. The container 1 may be other than the above container, as long as it has a lid and can hold an object therein.
Example two
Referring to fig. 3, on the basis of the first embodiment, the step of balancing the internal and external air pressures of the container 1 in the second embodiment specifically includes:
s51, switching the puncture needle from a communication liquid path to a communication gas path through a multi-way valve;
and S52, switching the puncture needle from a communication air path to a communication liquid path through the multi-way valve.
In this embodiment, the puncturing liquid adding device further comprises an air pressure balancing mechanism, the air pressure balancing mechanism comprises a multi-way valve 4, and the multi-way valve 4 is respectively connected with the liquid path, the air path and the puncturing needle 3.
In the present embodiment, the multi-way valve 4 may be a three-way valve.
When the container 1 is sealed by the closure, the inside thereof is in a negative pressure state compared with the outside environment. Firstly, the multi-way valve 4 is controlled to communicate the puncture needle 3 with the liquid path, then the liquid feeding liquid path pipeline of the liquid path and the puncture needle 3 are filled with liquid, and then liquid with a preset volume is sucked back to the liquid path, so that the liquid in the inner cavity of the puncture needle 3 is emptied. Then the puncture needle 3 is driven to puncture the sealing cover of the container 1, and the multi-way valve 4 is controlled to switch the puncture needle 3 from a communication liquid path to a communication gas path, at the moment, the external atmospheric pressure is greater than the internal atmospheric pressure of the container, so the external atmospheric pressure enters the container 1, and the balance of the internal and external atmospheric pressures of the container 1 is realized. After the air pressure inside and outside the container 1 is balanced, the multi-way valve 4 is operated to switch the puncture needle 3 from the communicating air path to the communicating liquid path, then the liquid with the preset volume is injected into the liquid adding path pipeline and the puncture needle 3 again, and the liquid with the target volume is injected into the container 1, thereby completing the liquid adding process.
Referring to fig. 2, multi-way valve 4 is provided with port K1, port K2, and port K3. When the port K1 and the port K2 are opened and the port K3 is closed, the puncture needle 3 is communicated with the liquid path; when the port K1 and the port K3 are opened and the port K2 is closed, the puncture needle 3 is communicated with the air passage.
In the air path, the puncture needle can be directly connected with the external environment, and after the puncture needle 3 is switched from the communicating liquid path to the communicating air path through the multi-way valve 4, the atmosphere of the external environment can enter the container 1 through the air path, so that the balance of the internal air pressure and the external air pressure of the container 1 is realized. The puncture liquid feeding device comprises an air conveying mechanism which is an air conveying pump, and after the puncture needle 3 is switched from a communication liquid path to a communication air path through the multi-way valve 4, the air conveying pump conveys air into the container 1, so that the balance of the air pressure inside and outside the container 1 is realized.
Referring to fig. 2, when the multi-way valve 4 is connected to the puncture needle 3, a predetermined length of a transfer tube is left between the multi-way valve 4 and the puncture needle 3, and the transfer tube can be used for transferring liquid or gas. The liquid feeding pipeline comprises a pipeline between the quick joint 543 and the multi-way valve 4 (but does not comprise an inner cavity pipeline of the quick joint 543).
When a predetermined volume of liquid is required to be sucked back into the liquid path, the predetermined volume being greater than the sum of the volume of the inner cavity of the puncture needle 3 and the volume of the delivery tube, after the predetermined volume of liquid is sucked back into the liquid path, the liquid is sucked between the multi-way valve 4 and the liquid suction pump 52, and if the liquid is sucked back to above the multi-way valve 4 as shown in fig. 2, no liquid remains in the delivery tube and the inner cavity of the puncture needle 3. Then, the multi-way valve 4 is operated to switch the puncture needle 3 from the communication liquid path to the communication gas path, and then the gas enters the container 1 along the conveying pipeline and the puncture needle 3, and no liquid is left in the inner cavities of the conveying pipeline and the puncture needle 3, so that no liquid enters the container 1 along with the gas.
It should be noted that S51 and S52 in this embodiment and S4 in the first embodiment are only pronouns of steps, and do not represent a sequence. Specifically, the step of switching the puncture needle from the communication liquid path to the communication gas path by the multi-way valve may be performed before the step of driving the puncture needle to puncture the cap of the container or after the step of driving the puncture needle to puncture the cap of the container.
EXAMPLE III
Referring to fig. 4, on the basis of the second embodiment, after the step of injecting the target volume of liquid into the container in the third embodiment, the method further includes the following steps:
s8, sucking the gas with the target volume from the container.
After the target volume of liquid is injected into the container 1, the interior of the container 1 is already at a positive pressure. If the positive pressure is greater, this may result in a bulging of the closure of the container 1. In order to balance the positive pressure inside the container 1, after the liquid with the target volume is injected into the container 1, the gas with the target volume is sucked from the inside of the container 1, so that the internal and external air pressures of the container 1 are consistent, and the condition that the sealing cover of the container 1 is raised is avoided.
In this embodiment, the target volume of gas may be directly withdrawn from the container. Specifically, the liquid pump 52 is controlled to suck a target volume of liquid from the container 1, and the inside of the container 1 is in a positive pressure state, so that after the target volume of liquid is sucked from the container 1, the container 1 delivers a target volume of gas to the upper side of the port K2 of the multi-way valve.
After the gas of the target volume is sucked back, the puncture needle 3 can be switched from the communication liquid path to the communication gas path through the multi-way valve 4, and the inside of the container 1 is communicated with the external atmosphere environment, so that the container 1 is further balanced with the external atmosphere pressure. The mode of switching the puncture needle 3 from the liquid communication path to the air communication path has another advantage that if the container sucks the gas with the volume larger than the target volume, the container 1 can be communicated with the external atmosphere environment through the inside of the container 1, so that the container 1 is further balanced with the external atmosphere pressure.
Further, one end of the gas path can be provided with a suction pump, and gas in the container 1 can be pumped away in a working mode of the suction pump so as to realize the air pressure balance of the container 1, and the mode can improve the controllability of the scheme.
Example four
On the basis of the second embodiment, a filter membrane is arranged at one end of the multi-way valve 4 of the fourth embodiment, which is communicated with the air path. After the puncture needle 3 is switched to the communicating gas circuit from the communicating liquid circuit by controlling the multi-way valve 4, the atmospheric gas enters the container 1 along the gas circuit, and the atmospheric gas can pass through the filter membrane which can filter the impurities of the atmospheric gas, thereby ensuring that the atmospheric gas introduced into the container 1 has no impurities.
When the air pressure inside and outside the container 1 is balanced, impurities in atmospheric gas are filtered through the filter membrane, and the impurities can be prevented from polluting objects inside the container 1, so that the puncture liquid adding method can be applied to the fields needing to isolate the impurities, such as the field of medicine mixing, the field of blood mixing and the like.
In this embodiment, the filter membrane is a filter membrane for filtering at least one of microorganisms, such as mycoplasma, and dust. Wherein the aperture of the filter membrane is equal to or less than 0.22 μm, and the filter membrane can meet the requirement of 99.99% of sterilization specified by GMP or pharmacopoeia.
EXAMPLE five
Referring to fig. 5, on the basis of the first embodiment, the step of balancing the internal and external air pressures of the container 1 in the fifth embodiment specifically includes:
and S53, the puncture mechanism connected with the puncture needle is separated from the puncture needle.
The puncture needle 3 is connected with a puncture mechanism, and the puncture mechanism can drive the puncture needle 3 to move. When the puncture mechanism is detached from the puncture needle 3, the through hole of the puncture needle 3 is exposed to the external environment, so that the atmospheric gas of the external environment is introduced into the puncture needle 3.
When the container 1 is sealed by the closure, the inside thereof is in a negative pressure state compared with the outside environment. Firstly, the puncture needle 3 is communicated with the liquid path, then the liquid feeding liquid path pipeline of the liquid path and the puncture needle 3 are filled with liquid, and then the liquid with the preset volume is sucked back to the liquid path, so that the liquid in the inner cavity of the puncture needle 3 is emptied. Then the puncture needle 3 is driven to puncture the sealing cover of the container 1, the puncture mechanism connected with the puncture needle 3 is separated from the puncture needle 3, at the moment, the through hole of the puncture needle 3 is exposed in the external environment, and the atmospheric gas in the external environment enters the container 1 through the puncture needle 3, so that the balance of the internal and external air pressures of the container 1 is realized. After the air pressure inside and outside the container 1 is balanced, the multi-way valve 4 is operated to switch the puncture needle 3 from the communicating air passage to the communicating liquid passage, then the liquid with the preset volume is injected into the liquid adding liquid passage pipeline and the puncture needle 3 again, and the liquid with the target volume is injected into the container 1, so that the liquid adding process is completed.
Because the puncture mechanism is a necessary device for moving the puncture needle 3, the mode of balancing the air pressure inside and outside the container 1 does not need to add an additional device, the puncture mechanism is directly operated to be separated from the puncture needle 3, and atmospheric air instantly enters the container 1 through the puncture needle 3, so that the balance of the air pressure inside and outside the container 1 is realized.
Example six
Referring to fig. 6, on the basis of the first embodiment, the step of filling the liquid feeding path pipeline of the liquid path and the puncture needle 3 with the liquid in the sixth embodiment specifically includes:
s21, injecting liquid into a liquid adding pipeline of the liquid path and the puncture needle;
s22, collecting waste liquid dropping from the puncture needle;
and S23, injecting liquid with a full volume to the liquid adding liquid path pipeline and the puncture needle, wherein the full volume is larger than the sum of the volumes of the liquid adding liquid path pipeline and the puncture needle.
In this embodiment, with liquid feeding liquid way pipeline and pjncture needle 3 on the liquid injection liquid way earlier, at the in-process of injecting liquid gradually, if there is liquid to drip from pjncture needle 3, this part of liquid that drips is the waste liquid, need collect the waste liquid in step, avoid waste liquid dripping container 1, fill liquid to liquid feeding liquid way pipeline and pjncture needle 3 of volume up to the injection, and fill the volume for being greater than the volume sum of liquid feeding liquid way pipeline and pjncture needle 3 to guarantee to fill liquid feeding liquid way pipeline and pjncture needle 3.
EXAMPLE seven
Referring to fig. 7, on the basis of the sixth embodiment, the step of collecting the waste liquid dripping from the puncture needle 3 in the seventh embodiment specifically includes:
and S221, collecting waste liquid dropping from the puncture needle through a swab structure.
Referring to fig. 8, the puncture needle 3 is provided with a side aperture 31.
Referring to fig. 2 and 9, the swab structure 2 includes a swab 41, a drain pump 61, and a waste liquid collecting member 62 connected to the drain pump 61, and the swab 41 is provided inside with an insertion port 411 through which the puncture needle 3 passes, and a drain port 412 communicating with the side hole 31 of the puncture needle 3 and the drain pump 61, respectively.
Before charging, the puncture needle 3 is moved so that the puncture needle 3 passes through the insertion port 411 of the swab 41 and the side hole 31 of the puncture needle 3 communicates with the liquid discharge port 412 of the swab 41.
When filling liquid way pipeline and pjncture needle 3 with liquid injection liquid way, start flowing back pump 61, if there is the waste liquid from the side aperture 31 drippage of pjncture needle 3, flowing back pump 61 can siphon away the waste liquid to the waste liquid can get into waste liquid collection piece 62, realizes the collection to the waste liquid. Until the full volume of liquid is injected to the liquid feeding liquid path pipeline and the puncture needle 3.
Wherein the waste liquid collector 62 may be a waste liquid bucket.
Example eight
In addition to the seventh embodiment, the swab structure 2 of the eighth embodiment is disposed in the path of the puncture.
Specifically, the swab 41 of the swab structure 2 is arranged on the puncture path, and in the liquid filling process, the liquid is injected into the container 1 through the puncture needle 3, so that the puncture and the liquid filling are in the same path, the volume of the whole puncture liquid filling device can be simplified, and the device cost is reduced.
Example nine
This embodiment nine provides a puncture liquid feeding device, puncture liquid feeding device includes:
a liquid path;
a puncture needle 3 communicating with the liquid path;
the puncture mechanism is used for driving the puncture needle 3 to puncture the sealing cover of the container 1;
the air pressure balancing mechanism is used for balancing the internal air pressure and the external air pressure of the container 1;
the liquid adding mechanism is used for filling liquid into a liquid adding pipeline of the liquid path and the puncture needle 3, sucking liquid with a preset volume back to the liquid path, refilling the liquid with the preset volume into the liquid adding pipeline and the puncture needle 3 after the internal and external air pressure of the container 1 is balanced, and filling liquid with a target volume into the container 1;
wherein the predetermined volume is greater than the lumen volume of the puncture needle 3.
In this embodiment, referring to fig. 2, the liquid filling mechanism fills the liquid filling channel of the liquid channel and the puncture needle 3 with liquid, and then sucks back a predetermined volume of liquid to the liquid channel, the predetermined volume being larger than the volume of the inner cavity of the puncture needle 3, so that the liquid in the inner cavity of the puncture needle 3 can be emptied after sucking back the predetermined volume of liquid to the liquid channel. Then the puncture needle 3 is driven by the puncture mechanism to puncture the sealing cover of the container 1, and the internal and external air pressures of the container 1 are balanced by the air pressure balancing mechanism. Because the air pressure has been equalized, the priming mechanism can then successfully refill the priming fluid line conduit and the needle 3 with a predetermined volume of fluid. After the predetermined volume of liquid is injected, the piercing needle 3 is known to be refilled with liquid, then the filling mechanism injects the target volume of liquid into the container 1, and then the injected target volume of liquid can be completely injected into the container 1, thereby achieving the controllability of the volume of liquid injected into the container 1. The liquid adding process is automatic in the whole process, high in efficiency, free of manual participation and capable of saving labor cost, and therefore large-scale application can be achieved.
After the liquid adding process is finished, the puncture needle 3 is driven by the puncture mechanism to be separated from the sealing cover of the container 1, the container 1 which is added with liquid is moved away in a manual mode or a mechanical automatic mode, the next container 1 which is not added with liquid is moved to a liquid adding position, and liquid adding operation is carried out on the container 1 which is not added with liquid.
When the puncture needle 3 is used, since the user can know the model and specification of the puncture needle 3, the volume of the inner chamber of the puncture needle 3 can be known, and a predetermined volume can be set according to the volume of the inner chamber of the puncture needle 3. The predetermined volume is set to be greater than the volume of the lumen of the puncture needle 3, and after the predetermined volume of liquid is sucked back, it is ensured that the lumen of the puncture needle 3 is emptied of liquid. When the container 1 is used, a user can know the model and specification of the container 1, so that the volume of the container 1 can be known, and the volume of the liquid to be injected into the container 1, that is, the target volume of the liquid can be set according to the volume of the container 1.
For example, knowing that the volume of the lumen of the puncture needle 3 is 100ul, the volume of the liquid to be injected into the container 1 is 1ml. The liquid feeding mechanism fills the liquid feeding pipeline of the liquid path and the puncture needle 3 with liquid, and then sucks liquid with the volume of 120ul back to the liquid path, and the liquid in the inner cavity of the puncture needle 3 is emptied at the moment. Then the puncture needle 3 is driven by the puncture mechanism to puncture the sealing cover of the container 1, and the air pressure inside and outside the container 1 is balanced by the air pressure balance mechanism. The filling mechanism then re-injects a volume of 120ul of liquid into the filling fluid line and the puncture needle 3, at which point the puncture needle 3 is refilled with liquid, and then the liquid injected into the puncture needle 3 will be all injected into the container 1, so the filling mechanism then injects a volume of 1ml of liquid into the container 1, completing the filling operation.
Referring to fig. 2, the puncture liquid adding device includes a liquid adding mechanism, and the liquid adding mechanism includes a first two-way valve 51, a liquid suction pump 52 connected to the first two-way valve 51, a second two-way valve 53 connected to the liquid suction pump 52, and a liquid storage 541 connected to the second two-way valve 53. Since the liquid suction pump 52 does not have a function of selectively sucking or discharging in any direction, the flow direction of the liquid needs to be controlled by closing and opening the first two-way valve 51 and the second two-way valve 53.
Specifically, when the liquid suction pump 52 needs to suck the liquid in the liquid storage component 541, the first two-way valve 51 is closed, the second two-way valve 53 is opened, and the liquid suction pump 52 smoothly sucks the liquid in the liquid storage component 541. When the liquid suction pump 52 sucks liquid, a little more liquid can be sucked to be stored inside. When the liquid suction pump 52 needs to inject the liquid toward the puncture needle 3, the first two-way valve 51 is opened, the second two-way valve 53 is closed, and the liquid suction pump 52 smoothly injects the liquid toward the puncture needle 3.
The liquid suction pump 52 may be a plunger pump, the maximum flow rate of which is 10ml, and the plunger pump depends on the reciprocating motion of a plunger in a cylinder body, so that the volume of the sealed working cavity is changed to realize liquid suction and liquid discharge. The fluid reservoir 541 may be a fluid bag filled with fluid.
Referring to fig. 2, the liquid charging mechanism further includes a cross valve 542 disposed on the liquid storage member 541, and a quick coupling 543 connected to the cross valve 542. After the cross valve 542 is opened, the liquid sucking pump 52 can suck the liquid in the liquid storage member 541. The quick connector 543 is a switching connector, and realizes connection of the cross valve 542 and the fluid path.
The puncture mechanism comprises a clamping piece and a driving mechanism, and under the driving of the driving mechanism, the clamping piece clamps the puncture needle 3 and drives the puncture needle 3 to move so as to realize that the puncture needle 3 punctures the seal cover of the container 1.
Further, the driving mechanism comprises a first driving part and a second driving part, the first driving part is used for driving the clamping part to clamp the puncture needle 3, and the second driving part is used for driving the clamping part to drive the puncture needle 3 to puncture the sealing cover of the container 1. The first driving piece and the second driving piece are driving motors, output shafts of the driving motors are connected with the clamping pieces, and the clamping pieces are driven to move through movement of the output shafts.
It should be noted that, referring to fig. 2, the liquid feeding pipeline includes a pipeline between the quick coupling 543 and the first two-way valve 51 (but does not include the lumen pipeline of the quick coupling 543).
In this embodiment, the container 1 may be a vial of penicillin. The penicillin bottle is also called borosilicate glass or soda-lime glass tube (or molded) injection bottle, which is a bottle with a rubber plug and an aluminum-plastic combined cover for sealing. The container 1 may be other than the above container as long as it has a lid and can hold an object therein.
Example ten
On the basis of the ninth embodiment, the air pressure balancing mechanism of the tenth embodiment includes a multi-way valve 4, the puncture needle 3 is switched from the communication liquid path to the communication air path through the multi-way valve 4, and then the puncture needle 3 is switched from the communication air path to the communication liquid path through the multi-way valve 4, so that the balance of the internal and external air pressures of the container 1 is realized.
In this embodiment, the multi-way valve 4 is connected to the fluid path, the air path, and the puncture needle 3.
When the container 1 is sealed by the closure, the inside thereof is in a negative pressure state compared with the outside environment. Firstly, the multi-way valve 4 is controlled to communicate the puncture needle 3 with the liquid path, then the liquid feeding liquid path pipeline of the liquid path and the puncture needle 3 are filled with liquid, and then liquid with a preset volume is sucked back to the liquid path, so that the liquid in the inner cavity of the puncture needle 3 is emptied. Then the puncture needle 3 is driven to puncture the sealing cover of the container 1, and the multi-way valve 4 is controlled to switch the puncture needle 3 from a communication liquid path to a communication gas path, at the moment, the external atmospheric pressure is greater than the internal atmospheric pressure of the container, so the external atmospheric pressure enters the container 1, and the balance of the internal and external atmospheric pressures of the container 1 is realized. After the air pressure inside and outside the container 1 is balanced, the multi-way valve 4 is operated to switch the puncture needle 3 from the communicating air path to the communicating liquid path, then the liquid with the preset volume is injected into the liquid adding path pipeline and the puncture needle 3 again, and the liquid with the target volume is injected into the container 1, thereby completing the liquid adding process.
Referring to fig. 2, multi-way valve 4 is provided with port K1, port K2, and port K3. When the port K1 and the port K2 are opened and the port K3 is closed, the puncture needle 3 is communicated with the liquid path; when the port K1 and the port K3 are opened and the port K2 is closed, the puncture needle 3 is communicated with the air passage.
In the gas circuit, can the external environment of lug connection, then switch pjncture needle 3 from communicating the liquid way to communicating the gas circuit through multi-ported valve 4 after, the atmosphere of external environment can get into inside container 1 through the gas circuit, realizes the equilibrium of inside and outside atmospheric pressure of container 1. The puncture liquid feeding device comprises a gas conveying mechanism which is a gas conveying pump, and after the puncture needle 3 is switched from a communication liquid path to a communication gas path through the multi-way valve 4, the gas conveying pump conveys gas into the container 1 to realize the balance of the internal and external air pressures of the container 1.
It should be noted that, referring to fig. 2, when the multi-way valve 4 is connected to the puncture needle 3, a transfer tube having a predetermined length is left between the multi-way valve 4 and the puncture needle 3, and the transfer tube can be used for transferring liquid or gas. The liquid feeding pipeline comprises a pipeline between the quick joint 543 and the multi-way valve 4 (but does not comprise an inner cavity pipeline of the quick joint 543).
When a predetermined volume of liquid is required to be aspirated back into the fluid path, which is greater than the sum of the volume of the interior chamber of the puncture needle 3 and the volume of the delivery conduit, after the predetermined volume of liquid has been aspirated back into the fluid path, the liquid will be aspirated between the multi-way valve 4 and the aspiration pump 52, e.g., above the multi-way valve 4 as shown in fig. 2, with no residual liquid remaining in the delivery conduit and the interior chamber of the puncture needle 3. Then, the multi-way valve 4 is operated to switch the puncture needle 3 from the communication liquid path to the communication gas path, and then the gas enters the container 1 along the conveying pipeline and the puncture needle 3, and no liquid is left in the inner cavities of the conveying pipeline and the puncture needle 3, so that no liquid enters the container 1 along with the gas.
EXAMPLE eleven
This embodiment eleven provides a puncture liquid feeding mixing equipment, puncture liquid feeding mixing equipment includes:
the piercing liquid feeding device as described in example nine and example ten;
and the blending mechanism is used for driving the container which finishes puncturing and liquid adding to move so as to blend the objects in the container.
Firstly, the puncture needle 3 is communicated with the liquid path, then the liquid feeding liquid path pipeline of the liquid path and the puncture needle 3 are filled with liquid, then liquid with a preset volume is sucked back to the liquid path, the preset volume is larger than the volume of the inner cavity of the puncture needle 3, and the liquid in the inner cavity of the puncture needle 3 can be emptied after the liquid with the preset volume is sucked back to the liquid path. The puncture needle 3 is driven to puncture the sealing cover of the container 1 and balance the internal and external air pressure of the container 1. The predetermined volume of liquid can then be smoothly re-injected into the feeding liquid channel and the puncture needle 3 due to the equalized air pressure. After the predetermined volume of liquid has been injected, the piercing needle 3 is known to be refilled with liquid, and the target volume of liquid is then injected into the container 1, completing the piercing priming operation. Subsequently, the blending mechanism drives the container 1 to move (the movement mode can be rotation, turnover, swing and the like), and artificial blending operation is simulated, so that objects in the container 1 are blended.
The puncture liquid feeding and mixing equipment can be used for mixing various articles (such as various chemicals and blood).
The puncture liquid feeding blending equipment can be applied to redissolution equipment, and batch and automatic redissolution blending operation is realized. Reconstitution means that a solvent is added to a powder reagent such as frozen dry powder, and the powder reagent is dissolved in a former solution state. For example, in order to store some protein substances for a long time, manufacturers freeze-dry the protein substances into powder and store the powder in glass bottles; if used, a solvent is added to the protein material lyophilized to a powder form so that the protein material is dissolved to a previous state.
In this embodiment, the blending mechanism is not specifically limited, and any mechanical module that can drive the container that has been punctured and filled with liquid to move so as to blend the objects in the container is within the protection scope of the present invention.
The above description is intended to be illustrative of the preferred embodiment of the present invention and should not be taken as limiting the invention, but rather, the intention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the invention.
Claims (8)
1. The puncture liquid adding method is characterized by comprising the following steps:
communicating the puncture needle with the fluid path;
filling a liquid feeding liquid path pipeline of the liquid path and the puncture needle with liquid;
drawing back a predetermined volume of fluid to the fluid path, the predetermined volume being greater than the volume of the interior chamber of the needle;
driving the puncture needle to puncture the seal cover of the container;
balancing the internal and external air pressure of the container;
refilling said predetermined volume of liquid into said priming fluid line and said needle;
injecting a target volume of liquid into the container;
the step of balancing the internal and external air pressures of the container specifically comprises:
switching the puncture needle from a communicating liquid path to a communicating gas path through a multi-way valve;
switching the puncture needle from a communicating gas path to a communicating liquid path through the multi-way valve;
or, the step of balancing the internal and external air pressures of the container specifically includes:
the puncture mechanism connected with the puncture needle is separated from the puncture needle.
2. The piercing refill method of claim 1, wherein the step of injecting the target volume of liquid into the container is followed by the steps of:
a target volume of gas is aspirated from the container.
3. The piercing liquid adding method according to claim 1, wherein a filter membrane is arranged at one end of the multi-way valve communicated with the gas path.
4. The method for filling liquid by puncturing according to claim 1, wherein the step of filling the liquid filling path pipe of the liquid path and the puncturing needle with liquid comprises:
injecting liquid into the liquid feeding liquid path pipeline of the liquid path and the puncture needle;
collecting waste liquid dripping from the puncture needle;
and until full volume of liquid is injected into the liquid feeding liquid path pipeline and the puncture needle, wherein the full volume is larger than the sum of the volumes of the liquid feeding liquid path pipeline and the puncture needle.
5. The method for adding liquid by puncture as claimed in claim 4, wherein the step of collecting waste liquid dripping from the puncture needle comprises:
collecting waste liquid dripping from the puncture needle through a swab structure.
6. The puncture priming method of claim 5, wherein said swab structure is disposed in a puncture path.
7. The utility model provides a puncture liquid feeding device which characterized in that, puncture liquid feeding device includes:
a liquid path;
a puncture needle communicating with the fluid path;
the puncture mechanism is used for driving the puncture needle to puncture the sealing cover of the container;
the air pressure balancing mechanism is used for balancing the internal air pressure and the external air pressure of the container;
the liquid adding mechanism is used for filling liquid into a liquid adding liquid path pipeline and the puncture needle of the liquid path, sucking liquid with a preset volume back to the liquid path, re-injecting the liquid with the preset volume into the liquid adding liquid path pipeline and the puncture needle after the air pressure inside and outside the container is balanced, and injecting liquid with a target volume into the container;
wherein the predetermined volume is greater than the lumen volume of the needle;
the air pressure balancing mechanism comprises a multi-way valve, the puncture needle is switched from a communicating liquid path to a communicating air path through the multi-way valve, and then the puncture needle is switched from the communicating air path to the communicating liquid path through the multi-way valve, so that the balance of the internal air pressure and the external air pressure of the container is realized.
8. The utility model provides a puncture liquid feeding mixing equipment, its characterized in that, puncture liquid feeding mixing equipment includes:
the piercing liquid adding device of claim 7;
and the blending mechanism is used for driving the container which is subjected to puncture liquid feeding to move so as to blend the objects in the container.
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| CN202111493282.XA CN114307828B (en) | 2021-12-08 | 2021-12-08 | Puncture liquid feeding method and device and puncture liquid feeding blending equipment |
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| CN202111493282.XA CN114307828B (en) | 2021-12-08 | 2021-12-08 | Puncture liquid feeding method and device and puncture liquid feeding blending equipment |
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| CN114307828B true CN114307828B (en) | 2022-10-04 |
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Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6474375B2 (en) * | 2001-02-02 | 2002-11-05 | Baxter International Inc. | Reconstitution device and method of use |
| US7900659B2 (en) * | 2006-12-19 | 2011-03-08 | Carefusion 303, Inc. | Pressure equalizing device for vial access |
| CA2678198A1 (en) * | 2009-09-08 | 2011-03-08 | Duoject Medical Systems Inc. | Ez-linking device for fluid transfer |
| CN204909936U (en) * | 2015-03-27 | 2015-12-30 | 李坚毅 | Desk -top semi -automatic machine of dispensing |
| CN109475467A (en) * | 2016-09-26 | 2019-03-15 | 泰尔茂株式会社 | Medical fluid filling device and medical fluid fill method |
| JP6389230B2 (en) * | 2016-11-28 | 2018-09-12 | カルメル ファルマ アクチボラゲット | Medical connection device |
| CN207352028U (en) * | 2017-09-21 | 2018-05-11 | 莫纳（苏州）生物科技有限公司 | The liquid feeding system of full-automatic Western blotting instrument |
| CN111467231A (en) * | 2020-04-27 | 2020-07-31 | 四川大学华西医院 | Closed preparation device for antitumor drugs and use method thereof |
| CN112180106A (en) * | 2020-10-15 | 2021-01-05 | 珠海科域生物工程股份有限公司 | Puncture liquid feeding mixing machine |
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