CN212275400U - Biological fluid sample preparation mixing device - Google Patents
Biological fluid sample preparation mixing device Download PDFInfo
- Publication number
- CN212275400U CN212275400U CN202022112778.5U CN202022112778U CN212275400U CN 212275400 U CN212275400 U CN 212275400U CN 202022112778 U CN202022112778 U CN 202022112778U CN 212275400 U CN212275400 U CN 212275400U
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- Prior art keywords
- valve
- pump
- diluent
- communicated
- gun
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- 238000002156 mixing Methods 0.000 title claims abstract description 35
- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- 239000013060 biological fluid Substances 0.000 title claims abstract description 10
- 239000007788 liquid Substances 0.000 claims abstract description 58
- 239000003085 diluting agent Substances 0.000 claims abstract description 43
- 238000002347 injection Methods 0.000 claims abstract description 41
- 239000007924 injection Substances 0.000 claims abstract description 41
- 239000012452 mother liquor Substances 0.000 claims abstract description 18
- 238000004891 communication Methods 0.000 claims abstract description 17
- 239000000523 sample Substances 0.000 claims description 55
- 238000004140 cleaning Methods 0.000 claims description 9
- 230000002572 peristaltic effect Effects 0.000 claims description 6
- 239000002699 waste material Substances 0.000 claims description 6
- 239000000243 solution Substances 0.000 claims description 5
- 239000012470 diluted sample Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 abstract description 9
- 238000012864 cross contamination Methods 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000005070 sampling Methods 0.000 description 5
- 238000001514 detection method Methods 0.000 description 4
- 238000011049 filling Methods 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000011086 high cleaning Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000010413 mother solution Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
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Abstract
本实用新型提供一种生物体液样本制备混匀装置，包括稀释液注射泵、母液注射泵、多通道切换连通阀、枪头适配器以及稀释液容器，母液注射泵的泵嘴处通过三通切换阀与稀释液注射泵以及多通道切换连通阀的主阀门相接，所述多通道切换连通阀上还设有枪阀门以及稀释液阀门，分别连通至枪头适配器以及稀释液容器，所述枪头适配器被一个移动装置驱动而能够移动。本实用新型在进行生物体液样本制备混匀工作的过程中，样本母液仅进入枪头，因此不会污染管路、阀门以及泵，只要每完成一次制备过程后更换一个枪头即可，不需要对管路、发明以及泵进行清洗，因此制备效率大大提高，并且不会发生交叉污染的问题。
The utility model provides a biological fluid sample preparation and mixing device, which comprises a diluent injection pump, a mother liquor injection pump, a multi-channel switching communication valve, a gun head adapter and a diluent container. The pump nozzle of the mother liquor injection pump passes through a three-way switching valve. It is connected with the diluent injection pump and the main valve of the multi-channel switching communication valve. The multi-channel switching communication valve is also provided with a gun valve and a diluent valve, which are respectively connected to the gun head adapter and the diluent container. The adapter is moved by a moving device. In the process of preparing and mixing biological fluid samples in the present invention, the sample mother liquid only enters the pipette tip, so it will not pollute the pipeline, valve and pump, as long as one pipette tip is replaced after each preparation process is completed, no need The pipeline, invention and pump are cleaned, so the production efficiency is greatly improved, and the problem of cross-contamination does not occur.
Description
Technical Field
The utility model relates to a batch processing device capable of preparing, mixing and sampling biological fluid samples.
Background
In the preparation and mixing of biological fluid samples, a certain amount of sample mother solution is generally sucked and discharged into a container, then a certain amount of diluted solution is sucked and discharged into the container, and then mixing is performed. And the sample solution is easy to adhere to the pipeline to cause loss, so that the detection result is misaligned.
Moreover, due to the large number of biological samples, repeated work is required. Between each repetition, the equipment (including pipes, valves, pumps, etc.) often needs to be cleaned to prevent sample contamination from affecting the accuracy of the detection result.
Therefore, the prior art has the problem of high cleaning cost on one hand, and on the other hand, the working time is forced to be prolonged, and the time cost is increased.
SUMMERY OF THE UTILITY MODEL
The utility model aims at providing an organism liquid sample preparation mixing device avoids cross contamination for detection speed improves detection efficiency.
In order to achieve the above object, the utility model adopts the following technical scheme:
the utility model provides an organism liquid sample preparation mixing device which characterized in that includes:
a diluent injection pump;
the pump nozzle of the mother liquor injection pump is connected with one port of a three-way switching valve, and the other port of the three-way switching valve is communicated with the pump nozzle of the diluent injection pump;
the main valve of the multi-channel switching communication valve is communicated with a public port of the three-way switching valve, a gun valve and at least one diluent valve are further arranged on the multi-channel switching communication valve, and the main valve, the gun valve and the at least one diluent valve can be independently opened and closed;
one end of the gun pipeline is communicated with the gun valve, the other end of the gun pipeline is communicated to a gun head adapter, and the gun head adapter is driven by a moving device to move;
the liquid storage container is arranged at the position where the gun head adapter can move, part of the liquid storage container is used for storing sample mother liquid, and the other part of the liquid storage container is used for bearing diluted sample solution;
and the diluent container is communicated with the diluent valve.
Organism liquid sample preparation mixing device, wherein: the moving device can at least drive the gun head adapter to move horizontally, transversely and vertically, and the liquid storage container is arranged below the gun head adapter.
Organism liquid sample preparation mixing device, wherein: multichannel switches intercommunication valve still has the needle valve that can open and close alone and the pump valve that can open and close alone, wherein:
the needle valve is communicated with one end of the needle pipeline, the other end of the needle pipeline is communicated with one port of a three-way valve, the other port of the three-way valve can be connected to an analysis instrument, and a common port of the three-way valve is communicated to the sample injection needle device;
the pump valve is communicated to the waste liquid container through a pump pipeline, and a cleaning peristaltic pump is arranged on the pump pipeline.
Organism liquid sample preparation mixing device, wherein: and a quantitative pipeline is also arranged on the needle tube.
Organism liquid sample preparation mixing device, wherein: the sample injection needle device is driven by the moving device to move synchronously with the gun head adapter.
Compared with the prior art, the utility model discloses the beneficial effect who has is:
the utility model discloses at the in-process of carrying out organism liquid sample preparation mixing work, sample mother liquor only gets into the rifle head, consequently can not pollute pipeline, valve and pump, as long as once accomplish the preparation process after change a rifle head can, need not wash pipeline, invention and pump, consequently preparation efficiency improves greatly to cross contamination's problem can not take place.
Furthermore, the utility model discloses at the in-process that carries out organism liquid sample preparation mixing work, need not frequently move the rifle head, after the rifle head reachs the target container position, the removal of rifle head is few in subsequent diluent emission and mixing operation, consequently preparation speed can accelerate greatly.
Additionally, the utility model discloses at the in-process of carrying out organism liquid sample preparation mixing work, can fill remaining sample mother liquor on the rifle head into the target container together during the loading diluent to guarantee that the organism liquid sample of different viscosities shifts completely, can obtain higher adaptability, accuracy and parallelism.
Drawings
Fig. 1 is a schematic structural diagram of the biological fluid sample preparation and mixing device provided by the present invention.
Description of reference numerals: a diluent injection pump 1; an on-off valve 2; a mother liquor injection pump 3; a three-way switching valve 4; a multi-channel switching communication valve 5; a main valve 51; a needle valve 52; the gun valve 53; a pump valve 54; a diluent valve 55; a needle line 6; a dosing line 61; a three-way valve 7; an analysis instrument 8; a sample injection needle device 9; a gun tube 10; a gun head adapter 11; a lance head 111 moving device 12; a mother liquor container 13; a target container 14; cleaning the peristaltic pump 15; a pump line 16; a waste liquid container 17; a gun head filling position A; discarding the lance tip position B.
Detailed Description
As shown in fig. 1, the utility model provides a living body liquid sample preparation mixing device (still have and advance kind, cleaning function), include:
a pump nozzle of the diluent injection pump 1 is connected with a switch valve 2;
a mother liquor injection pump 3, wherein a pump nozzle of the mother liquor injection pump is connected with one port of a three-way switching valve 4, and the other port of the three-way switching valve 4 is communicated with the switch valve 2 (the switch valve 2 is normally open);
a main valve 51 of the multi-channel switching communication valve 5 is communicated with a common port of the three-way switching valve 4, the multi-channel switching communication valve 5 is further provided with a needle valve 52, a gun valve 53, a pump valve 54 and at least one diluent valve 55, and the main valve 51, the needle valve 52, the gun valve 53, the pump valve 54 and the at least one diluent valve 55 can be opened and closed independently;
a needle line 6, one end of which is communicated with the needle valve 52, and the other end of which is communicated with one port of a three-way valve 7, wherein the other port of the three-way valve 7 can be connected to an analysis instrument 8, and a common port of the three-way valve 7 is communicated to a sample injection needle device 9; a quantitative pipeline 61 can be arranged on the needle pipeline 6, so that the sampling accuracy is improved;
one end of the gun pipeline 10 is communicated with the gun valve 53, and the other end of the gun pipeline is communicated to the gun head adapter 11; in this embodiment, the sample injection needle device 9 and the lance head adapter 11 are driven by the same moving device 12 (e.g., a three-dimensional mechanical arm or a two-dimensional mechanical arm) to be capable of synchronously moving at least in a horizontal transverse direction and a vertical direction, and even in a horizontal longitudinal direction; in practical situations, the sample injection needle device 9 and the lance head adapter 11 can be driven by different moving devices 12 and can respectively and freely move;
the liquid storage containers are arranged below the sample injection needle device 9 and the gun head adapter 11, so that the sample injection needle device 9 and the gun head adapter 11 can move downwards and then carry out liquid taking and liquid discharging operations on the liquid storage containers, wherein some liquid storage containers can store sample mother liquid and are called mother liquid containers 13, and other liquid storage containers are used for bearing diluted sample solution and are called target containers 14;
the cleaning peristaltic pump 15 is arranged on the pump pipeline 16, one end of the pump pipeline 16 is communicated with the pump valve 54, and the other end of the pump pipeline is communicated to the waste liquid container 17;
a diluent container in communication with the diluent valve 55.
The utility model discloses when needing to accomplish living body liquid sample preparation mixing work, its operation process is as follows:
a main valve 51 and a diluent valve 55 of the multi-channel switching communication valve 5 are opened, the three-way switching valve 4 is switched to the mother liquor injection pump 3 to be communicated with the main valve 51, and the mother liquor injection pump 3 is pulled to enable a pipeline between the mother liquor injection pump 3 and the main valve 51 to be filled with diluent;
the gun head adapter 11 runs to a gun head filling position A, and a new gun head 111 is taken;
the moving device 12 moves the lance head 111 to the upper part of the mother liquid container 13, and then the moving device 12 drives the lance head 111 to descend until reaching the sampling position; at the moment, the main valve 51 and the gun valve 53 of the multi-channel switching communication valve 5 are opened, other valves are closed, the mother liquor injection pump 3 is pulled, and sampling of sample mother liquor with the required volume is completed according to the size of the gun head 111;
after sampling, the moving device 12 drives the gun head 111 to ascend, then move to the position above the target container 14 and descend to the liquid discharge position, the main valve 51 and the gun valve 53 of the multi-channel switching communication valve 5 are opened, other valves are closed, and the mother liquid injection pump 3 is pushed, so that the sample mother liquid in the gun head 111 is completely extruded into the target container 14;
the three-way switching valve 4 is switched to the diluent injection pump 1 to be communicated with the main valve 51, the main valve 51 and the diluent valve 55 of the multi-channel switching communication valve 5 are opened, other valves are closed, the diluent injection pump 1 is pulled, and diluent with the required volume is sucked;
the main valve 51 and the gun valve 53 of the multi-channel switching communication valve 5 are opened, other valves are closed, the diluent injection pump 1 is pushed, diluent in the diluent injection pump 1 is discharged into the target container 14, and in the process, the diluent can flush residual sample mother liquid on the inner wall of the gun head 111 into the target container 14;
after sample mother liquor and diluent all got into target container 14, still need carry out the mixing, and the utility model provides a two kinds of mixing modes: mixing air and liquid; wherein, the air mixing means that the gun head 111 is lifted to a position above the liquid level of the target container 14, the diluent injection pump 1 is pulled to suck air, the gun head 111 is lowered to a position below the liquid level of the target container 14 (preferably to a position close to the bottom), then the diluent injection pump 1 is pushed to discharge air, and the liquid in the target container 14 is mixed by means of air flow stirring and bubble stirring; the liquid mixing means that the gun head 111 is kept at a position below the liquid level of the target container 14, then the diluent injection pump 1 is pulled to suck the liquid, then the diluent injection pump 1 is pushed to discharge the liquid, and the liquid in the target container 14 is mixed by liquid convection;
after the mixing, the gun head adapter 11 moves to the waste gun head position B and discards the gun head 111, and the moving device 12 resets.
The utility model discloses need to accomplish the autoinjection during operation, its step is as follows:
the sample injection needle device 9 moves to the sample injection position of the target container 14, the three-way valve 7 is switched to the position where the sample injection needle device 9 is communicated with the analyzer 8, and the liquid sample in the target container 14 can be absorbed through a peristaltic pump or negative pressure of the analyzer 8;
after the sample introduction is finished, the sample introduction needle device 9 moves to a cleaning position, the three-way valve 7 is switched to a position where the sample introduction needle device 9 is communicated with the needle tube path 6, the pump valve 54 of the multi-channel switching communication valve 5 is opened, other valves are closed, then the cleaning peristaltic pump 15 is cleaned, and the cleaning solution flows into the waste liquid container 17 through the sample introduction needle device 9 and the needle tube path 6, so that the cleaning of the sample introduction needle device 9 is completed.
In addition, the utility model discloses still can utilize needle pipeline 6 to carry out the work of advancing a kind, specific step is not repeated here.
According to the above description, the utility model discloses at the in-process of carrying out organism liquid sample preparation mixing work, sample mother liquor only gets into the rifle head, consequently can not pollute pipeline, valve and pump, as long as once accomplish preparation process after change a rifle head can, need not wash pipeline, invention and pump, consequently preparation efficiency improves greatly to cross contamination's problem can not take place.
Furthermore, the utility model discloses at the in-process that carries out organism liquid sample preparation mixing work, need not frequently move the rifle head, after the rifle head reachs 14 positions of target container, the removal of rifle head is very little in subsequent diluent discharges and the mixing operation, consequently preparation speed can accelerate greatly.
Additionally, the utility model discloses at the in-process of carrying out organism liquid sample preparation mixing work, can fill remaining sample mother liquor on the rifle head into target container 14 together during the loading diluent to guarantee that the organism liquid sample of different viscosities shifts completely, can obtain higher adaptability, accuracy and parallelism.
The foregoing description is intended to be illustrative rather than limiting, and it will be appreciated by those skilled in the art that many modifications, variations or equivalents may be made without departing from the spirit and scope of the invention as defined in the appended claims.
Claims (5)
1. The utility model provides an organism liquid sample preparation mixing device which characterized in that includes:
a diluent injection pump;
the pump nozzle of the mother liquor injection pump is connected with one port of a three-way switching valve, and the other port of the three-way switching valve is communicated with the pump nozzle of the diluent injection pump;
the main valve of the multi-channel switching communication valve is communicated with a public port of the three-way switching valve, a gun valve and at least one diluent valve are further arranged on the multi-channel switching communication valve, and the main valve, the gun valve and the at least one diluent valve can be independently opened and closed;
one end of the gun pipeline is communicated with the gun valve, the other end of the gun pipeline is communicated to a gun head adapter, and the gun head adapter is driven by a moving device to move;
the liquid storage container is arranged at the position where the gun head adapter can move, part of the liquid storage container is used for storing sample mother liquid, and the other part of the liquid storage container is used for bearing diluted sample solution;
and the diluent container is communicated with the diluent valve.
2. The apparatus for preparing and mixing a biological fluid sample according to claim 1, wherein: the moving device can at least drive the gun head adapter to move horizontally, transversely and vertically, and the liquid storage container is arranged below the gun head adapter.
3. The apparatus for preparing and mixing a biological fluid sample according to claim 1, wherein: multichannel switches intercommunication valve still has the needle valve that can open and close alone and the pump valve that can open and close alone, wherein:
the needle valve is communicated with one end of the needle pipeline, the other end of the needle pipeline is communicated with one port of a three-way valve, the other port of the three-way valve can be connected to an analysis instrument, and a common port of the three-way valve is communicated to the sample injection needle device;
the pump valve is communicated to the waste liquid container through a pump pipeline, and a cleaning peristaltic pump is arranged on the pump pipeline.
4. The apparatus for preparing and mixing a biological fluid sample according to claim 3, wherein: and a quantitative pipeline is also arranged on the needle tube.
5. The apparatus for preparing and mixing a biological fluid sample according to claim 3, wherein: the sample injection needle device is driven by the moving device to move synchronously with the gun head adapter.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202022112778.5U CN212275400U (en) | 2020-09-23 | 2020-09-23 | Biological fluid sample preparation mixing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202022112778.5U CN212275400U (en) | 2020-09-23 | 2020-09-23 | Biological fluid sample preparation mixing device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN212275400U true CN212275400U (en) | 2021-01-01 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202022112778.5U Withdrawn - After Issue CN212275400U (en) | 2020-09-23 | 2020-09-23 | Biological fluid sample preparation mixing device |
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| Country | Link |
|---|---|
| CN (1) | CN212275400U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112051127A (en) * | 2020-09-23 | 2020-12-08 | 北京莱伯泰科仪器股份有限公司 | Organism liquid sample preparation and mixing device and method |
| CN114705527A (en) * | 2022-04-26 | 2022-07-05 | 北京莱伯泰科仪器股份有限公司 | Assembled Filter Adapters for Urine Protein Preservation |
-
2020
- 2020-09-23 CN CN202022112778.5U patent/CN212275400U/en not_active Withdrawn - After Issue
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112051127A (en) * | 2020-09-23 | 2020-12-08 | 北京莱伯泰科仪器股份有限公司 | Organism liquid sample preparation and mixing device and method |
| CN112051127B (en) * | 2020-09-23 | 2024-11-19 | 北京莱伯泰科仪器股份有限公司 | Biological fluid sample preparation and mixing device and method |
| CN114705527A (en) * | 2022-04-26 | 2022-07-05 | 北京莱伯泰科仪器股份有限公司 | Assembled Filter Adapters for Urine Protein Preservation |
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
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| AV01 | Patent right actively abandoned |
Granted publication date: 20210101 Effective date of abandoning: 20241119 |
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| AV01 | Patent right actively abandoned |
Granted publication date: 20210101 Effective date of abandoning: 20241119 |
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| AV01 | Patent right actively abandoned | ||
| AV01 | Patent right actively abandoned |