CN216823426U - Light path system for photoacoustic tomography - Google Patents

Light path system for photoacoustic tomography Download PDF

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CN216823426U
CN216823426U CN202123304666.0U CN202123304666U CN216823426U CN 216823426 U CN216823426 U CN 216823426U CN 202123304666 U CN202123304666 U CN 202123304666U CN 216823426 U CN216823426 U CN 216823426U
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laser
optical path
annular
path system
light
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刘凯
刘民
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Wuhan Heshiguang Sound Technology Co ltd
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Wuhan Heshiguang Sound Technology Co ltd
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Abstract

The utility model provides an optical path system for optoacoustic tomography, include: a band switching optical path system and an annular optical path forming system; the annular light path forming system comprises a conical top concave lens, an annular prism and an ultrasonic transducer array; the wave band switching optical path system can emit infrared light with different wavelengths and sequentially penetrates through the conical top concave lens and the annular prism to reach a measured object, and a photoacoustic signal generated by the measured object reaches the ultrasonic transducer array; the conical top concave lens is used for converting infrared light into annular light beams; the annular prism is used for reflecting the annular light beam to a measured object; the ultrasonic transducer array is used for acquiring photoacoustic signals generated by a measured object and converting the photoacoustic signals into electric signals. Prior art realizes converting the infrared light into annular beam through convex lens, nevertheless can lead to the physics damage because of convex lens long-term spotlight is in self inner region, the utility model discloses replace convex lens with the concave lens in conical top and realize annular beam's conversion to the lens damage that the spotlight leads to has been avoided.

Description

Light path system for photoacoustic tomography
Technical Field
The utility model relates to an optoacoustic tomography image technical field especially relates to an optical path system for optoacoustic tomography.
Background
Photoacoustic Imaging (PAI) is a new biomedical Imaging method developed in recent years, both non-invasive and non-ionizing. When pulsed laser light is irradiated into biological tissue, the light-absorbing domain of the tissue will generate an ultrasonic signal, which we call the ultrasonic signal generated by light excitation a photoacoustic signal. The photoacoustic signal generated by the biological tissue carries the light absorption characteristic information of the tissue, and the light absorption distribution image in the tissue can be reconstructed by detecting the photoacoustic signal. The photoacoustic imaging combines the advantages of high selection characteristic in pure optical tissue imaging and deep penetration characteristic in pure ultrasonic tissue imaging, can obtain a tissue image with high resolution and high contrast, avoids the influence of light scattering in principle, breaks through the high-resolution optical imaging depth soft limit (-1 mm), and can realize deep in-vivo tissue imaging of 50 mm.
In order to realize laser irradiation of 360 degrees without dead angles in an existing optical path system of photoacoustic tomography, infrared light needs to be converted into annular light beams, and the conversion is realized through a convex lens.
However, the high temperature generated by the convex lens condensing light in the inner region of the convex lens for a long time may cause physical damage to the convex lens itself, thereby seriously affecting the service life and safety of the system.
Different wavelengths of light may excite different molecules/biological tissues/materials to produce photoacoustic signals. However, the wavelength band switching optical path in the existing optical path system for photoacoustic tomography is difficult to realize continuous switching of the wavelength of 670nm to 2300nm, and the optical path structure design of the wavelength band switching optical path is complex and not simple enough.
SUMMERY OF THE UTILITY MODEL
To at least one defect or improvement demand of prior art, the utility model provides an optical path system for optoacoustic tomography for solve the physical damage problem of annular beam conversion lens.
In order to solve the technical problem, the utility model provides an optical path system for optoacoustic tomography, include: a band switching optical path system and an annular optical path forming system;
the annular light path forming system comprises a conical top concave lens, an annular prism and an ultrasonic transducer array;
the wave band switching optical path system can emit infrared light with different wavelengths, the infrared light sequentially penetrates through the conical-top concave lens and the annular prism and then reaches a measured object, and a photoacoustic signal generated by the measured object reaches the ultrasonic transducer array;
the conical top concave lens is used for converting the infrared light into an annular light beam;
the annular prism is used for reflecting the annular light beam to the measured object;
the ultrasonic transducer array is used for collecting photoacoustic signals generated by the object to be measured and converting the photoacoustic signals into electric signals.
According to the utility model provides an optical path system for optoacoustic tomography, the wave band switches optical path system and includes YAG laser instrument, optical parametric oscillator, first switching mirror, second switching mirror, a plurality of laser recoverer and a plurality of speculum;
the YAG laser can emit laser with a first preset wavelength, and can also generate laser with a first preset waveband and laser with a second preset waveband, the wavelengths of which are continuously adjustable, through the combined action of the frequency doubling module and the optical parametric oscillator;
the first switching mirror is used for switching laser with a preset wavelength and laser with a preset waveband;
the second switching mirror is used for switching the laser of the first preset waveband and the laser of the second preset waveband;
the laser recoverer is used for blocking laser with a certain wavelength which is temporarily unnecessary;
the first switching mirror and the second switching mirror are adjusted to enable the waveband switching optical path system to output only one of the laser with the first preset wavelength, the laser with the first preset waveband and the laser with the second preset waveband at a time.
According to the utility model provides an optical path system for optoacoustic tomography, first preset wavelength is 1064 nm.
According to the utility model provides an optical path system for optoacoustic tomography, first predetermined wave band is [670nm, 980nm ].
According to the utility model provides an optical path system for optoacoustic tomography, the second is preset the wave band and is [1190nm, 2350nm ].
According to the utility model provides an optical path system for optoacoustic tomography, optical path system is switched to wave band still includes the guide laser instrument, the guide laser instrument can send visible guide laser, guide laser with the infrared light collineation is realized right the guide of infrared light.
According to the utility model provides an optical path system for optoacoustic tomography, first switching mirror is the speculum, and its back mounted has the potsherd to be used for retrieving the laser of first predetermined wavelength.
According to the utility model provides an optical path system for optoacoustic tomography, cyclic annular optical path formation system is still including transferring ring lens, it is in to transfer ring lens the conical top concave lens with between the annular prism, be used for the adjustment annular light beam's annular size of measurement.
According to the utility model provides an optical path system for optoacoustic tomography, annular prism is used for reflecting the annular beam after the annular size adjustment to on the testee of ultrasonic transducer array's focal plane.
According to the utility model provides an optical path system for optoacoustic tomography, annular prism's the light facing surface is dull polish form.
In the existing similar technology in the technical field, infrared light is converted into annular light beams through a convex lens, but the convex lens condenses in the inner area of the convex lens for a long time, so that the high temperature generated by the convex lens can cause physical damage to the convex lens. The utility model discloses replace convex lens with the concave lens in conical top and realize the conversion of annular beam to avoid the lens damage that the spotlight leads to, prolonged the life of system, security when having increased the system and using.
In addition, due to the simple optical path design of the band switching optical path system comprising the two switching mirrors, when the positions of the two switching mirrors are adjusted, the continuous adjustable switching output of the light with the wavelength of about 670nm-2300nm can be realized. On the basis of the wave band switching, the simplicity of the design of the optical path of the system is improved.
Drawings
In order to more clearly illustrate the technical solutions of the present invention or the prior art, the drawings required for the embodiments or the prior art descriptions will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
Fig. 1 is a schematic diagram of an optical path and a structure of an annular optical path forming system according to an embodiment of the present invention;
FIG. 2 is a schematic diagram comparing transmission astigmatism of a convex lens used in the prior art for generating a ring beam and a conical-top concave lens provided by an embodiment of the present invention;
FIG. 3 is a diagram of the optical path state of the optical path system for laser output with 1064nm wavelength and laser recycling with IR-I and IR-II band wavelengths provided by the embodiment of the present invention;
FIG. 4 is a diagram of the optical path state of the optical path system for laser output at IR-I band wavelength, laser recovery at 1064nm wavelength and IR-II band wavelength provided by the embodiment of the present invention;
FIG. 5 is a diagram of the optical path state of the optical path system for laser output at IR-II band wavelength, laser recovery at 1064nm wavelength and IR-I band wavelength provided by the embodiment of the present invention;
reference numerals:
in fig. 1: 13 is a right-angle prism, 14 is a conical top concave lens, 15 is a ring adjusting lens, 16 is an annular prism, 17 is an ultrasonic transducer array, and 18 is a measured object;
in fig. 3: 1 is a first switching mirror, 2 is a second switching mirror, 3 is an annular optical path forming system, 4 is a guiding laser, 5 is a second laser recoverer, 6 is a first laser recoverer, 7 is a first reflecting mirror, 8 is a second reflecting mirror, 9 is a convex lens, 10 is a light parametric oscillator, 11 is a YAG laser, and 12 is a frequency doubling module.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention clearer, the drawings of the present invention are combined to clearly and completely describe the technical solutions of the present invention, and obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by a person of ordinary skill in the art without creative efforts belong to the protection scope of the present invention.
As shown in fig. 1, in one embodiment, the present invention provides an optical path system for photoacoustic tomography, comprising: a band-switching optical path system (not shown in fig. 1, and laser light emitted from the left side in the upper part of fig. 1 is generated by the band-switching optical path system) and a ring-shaped optical path forming system (i.e., the whole structure shown in fig. 1, i.e., 3 in fig. 3);
the annular optical path forming system 3 includes a conical-top concave lens 14, an annular prism 16, and an ultrasonic transducer array 17.
The waveband switching optical path system can emit infrared light with different wavelengths, the infrared light sequentially penetrates through the conical-top concave lens 14 and the annular prism 16 and then reaches a measured object 18, and a photoacoustic signal generated by the measured object 18 reaches the ultrasonic transducer array 17.
The conical top concave lens 14 is used for converting the infrared light into an annular light beam. The concave part of the concave lens of vertex of a cone can be the cone (right-angled triangle rotates 360 degrees swept space round this right-angled triangle a right-angle side and is the cone), owing to the cone (change the straight line of above-mentioned right-angled triangle's hypotenuse into the arc line sunken to two right-angled sides, other operations are the same, should owing to the swept space of triangle be owing to the cone) or sufficient to the cone (change the straight line of above-mentioned right-angled triangle's hypotenuse into the bellied arc line of keeping away from two right-angled sides, other operations are the same, should be sufficient to the swept space of triangle and be sufficient to the cone promptly). Preferably, when the concave part is a cone, the toroidal beam conversion effect of the conical top concave lens is the best.
As shown in fig. 2, the left two diagrams of fig. 2 show the optical path of the conventional annular beam conversion lens when it is a convex lens. It is easy to see that if the plane is exposed to light, part of the reflected light can be converged in the convex lens; if the convex surface is exposed to light, the transmitted light can be converged in the convex lens, and the conical convex lens is easily physically damaged due to the long-time high-intensity converged light in both cases. In contrast, as shown in the two right drawings of fig. 2, no matter the conical-top concave lens provided by the present application is plane light-facing or concave light-facing, light cannot or cannot be largely transmitted or reflected to the inside of the conical-top concave lens, so that lens damage caused by light condensation is avoided, the service life of the system is prolonged, and the safety of the system during use is increased. Preferably, a conical top concave lens placement scheme with a concave light-facing surface as shown in the lower right corner of fig. 2 is adopted.
The annular prism 16 is used to reflect the annular beam to the object 18 to be measured.
The ultrasonic transducer array 17 is used for collecting photoacoustic signals generated by the object to be measured 18 and converting the photoacoustic signals into electric signals.
Preferably, the annular optical path forming system 3 further includes a ring adjusting lens 15, and the ring adjusting lens 15 is located between the conical-top concave lens 14 and the annular prism 16, and is used for adjusting the annular size of the annular light beam.
Preferably, the annular prism 16 is used for reflecting the annular light beam after the annular size adjustment to a measured object 18 (which may be biological tissue, organic and inorganic materials, etc.) on the focal plane of the ultrasonic transducer array 17, and when the measured object 18 is placed on the focal plane of the ultrasonic transducer array 17, the ultrasonic transducer array 17 can collect the most photoacoustic signals.
Preferably, the light-facing surface of the annular prism 16 is frosted. The light facing surface of the annular prism 16 is frosted and can be used for scattering annular laser to a certain extent, so that light irradiated into a focal plane area of the ultrasonic transducer array 17 is spread to a certain distance in the vertical direction, and therefore the photoacoustic signal is optimal.
Preferably, as shown in fig. 3, the wavelength band switching optical path system includes a YAG laser 11, an optical parametric oscillator 10, a first switching mirror 1, a second switching mirror 2, a plurality of laser recoverers, and a plurality of mirrors.
The YAG laser 11 may emit laser light of a first preset wavelength, or may generate laser light of a first preset wavelength band (IR-I band laser light) and laser light of a second preset wavelength band (IR-II band laser light) with continuously adjustable wavelengths through the combined action of the frequency doubling module 12 and the optical parametric oscillator 10.
YAG laser, one of lasers. YAG is an abbreviation for yttrium aluminum garnet crystal (Y3Al5O12) and is a laser matrix with excellent combination of properties (optics, mechanics and thermal).
An Optical Parametric Oscillator (Optical Parametric Oscillator) is a Parametric Oscillator that oscillates at an Optical frequency. It converts the input laser light (so-called pump light) into two output lights (signal light and idler light) of lower frequency by second-order nonlinear optical interaction, and the sum of the frequencies of the two output lights is equal to the input optical frequency.
The frequency doubling module can double the frequency of the laser light with a first preset wavelength emitted by the YAG laser, for example, two photons with a 1064nm wavelength can be combined into one photon with a 532nm wavelength, and the generated laser light with the 532nm wavelength can be used as a pump light of an OPO (optical parametric oscillator) to further generate an infrared laser light with an IR-I band and an infrared laser light with an IR-II band.
The first switching mirror 1 is used for switching laser with a preset wavelength and laser with a preset waveband.
The second switching mirror 2 is configured to switch the laser in the first preset waveband and the laser in the second preset waveband.
The laser recovery device is used for recovering (blocking) laser light of a certain wavelength which is temporarily unnecessary.
The first switching mirror 1 and the second switching mirror 2 are adjusted to enable the waveband switching optical path system to output only the laser with one wavelength of the laser with the first preset wavelength, the laser with the first preset waveband and the laser with the second preset waveband at a time. The specific adjustment method is as follows:
(1) laser output at a first predetermined wavelength, and laser recovery at IR-I and IR-II band wavelengths.
As shown in fig. 3, the first switching mirror 1 is moved away from the optical path (from the imaginary position to the real position), so that the laser light of either the first predetermined wavelength band or the second predetermined wavelength band reflected from the second reflecting mirror 8 is recovered by the first laser recoverer 6, and the laser light of the first predetermined wavelength can be incident into the annular optical path forming system 3 through the right-angle prism 13 from the upper left side of fig. 3 after various reflections.
(2) The output of the laser with the IR-I waveband, the recovery of the laser with the first preset wavelength and the laser with the IR-II waveband.
As shown in fig. 4, the first switching mirror 1 and the second switching mirror 2 are both moved to the optical path position (as shown in fig. 4), and at this time, the first switching mirror 1 reflects the laser light with the first preset wavelength to the first laser light recoverer 6, and the laser light with the first preset wavelength is recovered. The second switching mirror 2 reflects the laser light of the wavelength of the IR-II band to the second laser recoverer 5, and the laser light of the wavelength of the IR-II band is recovered. The laser beam with the wavelength of IR-I band passes through the second switching mirror 2, the convex lens 9, the second reflecting mirror 8 and the first switching mirror 1 in sequence and then enters the annular optical path forming system 3.
(3) The output of the laser with the IR-II wave band wavelength, the recovery of the laser with the first preset wavelength and the laser with the IR-I wave band wavelength.
As shown in fig. 5, the first switching mirror 1 is moved to the optical path position (from the virtual position to the real position), the second switching mirror 2 is moved to the optical path position (from the virtual position to the real position), and the laser light of the IR-I band wavelength is just emitted to and recovered by the second laser recoverer 5; the first switching mirror 1 reflects the laser with the first preset wavelength to the first laser recoverer 6, and the laser with the first preset wavelength is recovered; the laser with the wavelength of the IR-II wave band is emitted into the annular light path forming system 3 after passing through a certain reflector, the convex lens 9, the second reflector 8 and the first switching mirror 1 in sequence.
Since the two IR lights have a certain divergence angle, the convex lens 9 can be used to converge the IR lights, and preferably, a concave mirror can be used instead of the combination of the convex lens 9 and the second reflecting mirror 8.
Preferably, the first preset wavelength is 1064 nm. A common pump light source is a 1064nm or 532nm doped yttrium aluminum garnet laser.
YAG is currently used for solid-state lasers, fiber lasers, and the like, and laser light of almost any wavelength between 1047nm and 1319nm can be obtained by doping and changing the YAG material.
Nd, YAG (Neodymium-doped yttrium aluminum garnet crystal; Nd: Y3Al5O12) or yttrium aluminum garnet crystal is called as an active substance, the content of Nd atoms in the crystal is about 0.6-1.1%, the crystal belongs to solid laser, and the crystal can excite pulse laser or continuous laser, and the emitted laser has the infrared wavelength of 1064 nm. YAG lasers operated at 1064nm, but almost all materials capable of producing laser gain can be realized at many different wavelengths under different conditions.
Preferably, the first predetermined wavelength band is [670nm, 980nm ].
Preferably, the second preset wave band is [1190nm, 2350nm ].
An OPO (optical parametric oscillator) converts input 532nm pump light into two output lights with lower frequencies, i.e., two output lights with larger wavelengths, through second-order nonlinear optical interaction. The wavelength ranges of the two output lights may be [670nm, 980nm ] and [1190nm, 2350nm ].
Preferably, as shown in fig. 3, the band-switching optical path system further includes a guiding laser 4, and the guiding laser 4 can emit visible guiding laser, and the guiding laser is transmitted through a first reflecting mirror 7 (which is a 1064nm dielectric mirror, and can reflect 1064nm laser, and transmit guiding laser (visible band)), and then is collinear with the infrared light to guide the infrared light.
Preferably, the first switching mirror 1 is a reflecting mirror, and a ceramic plate (the strip on the back of the first switching mirror 1) is mounted on the back of the first switching mirror for further recovering the laser light with the first preset wavelength.
It will be understood by those skilled in the art that the foregoing is only a preferred embodiment of the present invention and is not intended to limit the scope of the invention, and that any modifications, equivalents, improvements and the like which come within the spirit and principle of the invention are intended to be included within the scope of the invention.

Claims (10)

1. An optical path system for photoacoustic tomography, comprising: a band switching optical path system and an annular optical path forming system;
the annular light path forming system comprises a conical top concave lens (14), an annular prism (16) and an ultrasonic transducer array (17);
the wave band switching optical path system can emit infrared light with different wavelengths, the infrared light sequentially penetrates through the conical-top concave lens (14) and the annular prism (16) and then reaches a measured object (18), and a photoacoustic signal generated by the measured object (18) reaches the ultrasonic transducer array (17);
the conical top concave lens (14) is used for converting the infrared light into an annular light beam;
the annular prism (16) is used for reflecting the annular light beam to the measured object (18);
the ultrasonic transducer array (17) is used for collecting photoacoustic signals generated by the measured object (18) and converting the photoacoustic signals into electric signals.
2. The optical path system for photoacoustic tomography according to claim 1, characterized in that the band-switched optical path system comprises a YAG laser (11), an optical parametric oscillator (10), a first switching mirror (1), a second switching mirror (2), a plurality of laser retrievers, and a plurality of mirrors;
the YAG laser (11) can emit laser with a first preset wavelength, and can also generate laser with a first preset waveband and laser with a second preset waveband, the wavelengths of which are continuously adjustable, through the combined action of the frequency doubling module (12) and the optical parametric oscillator (10);
the first switching mirror (1) is used for switching laser with a preset wavelength and laser with a preset waveband;
the second switching mirror (2) is used for switching the laser of the first preset waveband and the laser of the second preset waveband;
the laser recoverer is used for blocking laser with a certain wavelength which is temporarily not needed;
the wave band switching optical path system can only output the laser with one wavelength of the laser with the first preset wavelength, the laser with the first preset wave band and the laser with the second preset wave band at one time by adjusting the first switching mirror (1) and the second switching mirror (2).
3. The optical path system for photoacoustic tomography according to claim 2, characterized in that the first preset wavelength is 1064 nm.
4. The optical path system for photoacoustic tomography according to claim 2, characterized in that the first preset wavelength band is [670nm, 980nm ].
5. The optical path system for photoacoustic tomography according to claim 2, characterized in that the second preset wavelength band is [1190nm, 2350nm ].
6. Optical path system for photoacoustic tomography according to claim 2, characterized in that the band-switched optical path system further comprises a guiding laser (4), the guiding laser (4) emitting visible guiding laser light, which is collinear with the infrared light to achieve the guiding of the infrared light.
7. Optical path system for photoacoustic tomography according to claim 2, characterized in that the first switching mirror (1) is a mirror with a ceramic plate mounted on its back for recovering the laser light of the first preset wavelength.
8. The optical path system for photoacoustic tomography according to claim 1, characterized in that the annular optical path forming system further comprises a ring adjusting lens (15), the ring adjusting lens (15) being located between the conical-topped concave lens (14) and the annular prism (16) for adjusting the annular size of the annular beam.
9. Optical path system for photoacoustic tomography according to claim 8, characterized in that the ring prism (16) is used to reflect the ring-shaped beam after ring-size adjustment onto the object under test (18) on the focal plane of the ultrasound transducer array (17).
10. Optical path system for photoacoustic tomography according to claim 1, characterized in that the light facing side of the annular prism (16) is frosted.
CN202123304666.0U 2021-12-25 2021-12-25 Light path system for photoacoustic tomography Active CN216823426U (en)

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