CN101424667A - Light acoustic imaging method and device based on pulse xenon light excite - Google Patents
Light acoustic imaging method and device based on pulse xenon light excite Download PDFInfo
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- CN101424667A CN101424667A CNA2008102198312A CN200810219831A CN101424667A CN 101424667 A CN101424667 A CN 101424667A CN A2008102198312 A CNA2008102198312 A CN A2008102198312A CN 200810219831 A CN200810219831 A CN 200810219831A CN 101424667 A CN101424667 A CN 101424667A
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Abstract
The invention provides an optical-acoustic imaging method and a device thereof based on the activation of pulse-xenon lamp light. The method comprises the following steps: steps 1, pulse lights emitted by a pulsed-xenon lamp tube are outputted in parallel after reflection; step 2, the lights irradiate a light absorbing sample after light filtration, convergence or direct combination, and an absorbing body absorbs optical energy to generate an optical-acoustic effect and generate ultrasonic waves; step 3, an ultrasonic detector fixedly, rotationally or linearly scans and collects optical-acoustic signals which are transmitted by a collecting component and stored in a computer; step 4, after the signals are filtered and deposited, the light absorbing arrangement is rebuilt and displayed on a display. The device comprises a pulse power source, a xenon lamp, an optical path adjusting component, a filtering switcher, a sample scanning platform, an ultrasonic collecting component and a signal processing and image rebuilding component. The invention uses the pulse-xenon lamp for activating optical-acoustic signals and realizing optical-acoustic imaging. The xenon lamp high optical source energy, simple structure, small size and abundant spectrum, and can effectively lower the cost of the optical-acoustic imaging system and promote the optical-acoustic imaging market development.
Description
Technical field
The present invention relates to the physical optics imaging technique, particularly a kind of based on light activated acousto-optic imaging method of pulse xenon lamp and device.
Background technology
The photoacoustic imaging principle is that absorber of light absorbs pulse luminous energy, inner moment produces temperature rise and causes thermal expansion and produce pressure wave (ultrasound wave), it is photic ultrasonic effect, by surveying absorber photoacoustic signal on every side, can obtain the testee interior lights as calculated behind the machine image reconstruction and absorb situation about distributing.The condition that can produce effective optoacoustic effect is that enough weak point (nanosecond or microsecond magnitude) and enough big (every square centimeter reach little burnt magnitude) of incident optical energy metric density are wanted in the light pulse of incident.
At present, the excitation source of all photoacoustic imaging systems all is to utilize the modulated laser of high power pulsed laser or continuous wave laser outgoing to realize.Laser energy height, directivity go with coherence, but the cost height of laser instrument, volume is big, safeguards and use all inconveniences.And laser instrument can select the wave spectrum scope very limited, for example to seek out near infrared spectrum and then will use solid precious stone laser device or dye laser, the market price of these laser instruments all more than 500,000 Renminbi, and some spectrum be present laser instrument can not cover.Use laser instrument just to suppress the technical development of photoacoustic imaging and the miniaturization and the marketization of photoacoustic signal measurement and photoacoustic imaging system greatly like this as the photo-acoustic excitation source.
Summary of the invention
The objective of the invention is to defective and deficiency, a kind of acousto-optic imaging method that replaces laser excitation based on the short pulse xenon lamp is provided at prior art.
Another object of the present invention is to provide a kind of device of realizing said method.
Purpose of the present invention realizes by following technical scheme: a kind of based on the light activated acousto-optic imaging method of pulse xenon lamp, comprise the steps:
(1) the pulsed xenon fluorescent tube parallel after reflection output of pulsed light of sending;
(2) pulsed light of parallel output through after optical filtering and converging, after perhaps directly converging, shines on the light absorption sample successively, and absorbent body luminous energy produces optoacoustic effect, sends ultrasound wave;
(3) photoacoustic signal is gathered in ultrasonic detector fixed point scanning, rotation sweep or rectilinear scanning, by the acquisition component transmission and be stored in the computing machine;
(4) signal is carried out filtering and integration after, rebuild light absorption by backprojection algorithm dorsad or linear projection's algorithm and distribute and be shown in display screen.
In the step (1), described pulsed xenon fluorescent tube is the high power pulse light pipe, and the optical wavelength scope that it sends is 250nm～2200nm.
In the step (1), described reflection is realized by the cylinder reflection cavity.Described elliptic cylinder reflection cavity is to be made by stainless steel material, and inwall is silver-plated after polishing, and the xenon lamp pipe is positioned on the focal line of elliptic cylinder, makes pulsed light parallel output behind intracavity reflecting.
In the step (2), described optical filtering realizes that by the optical filter switch wavestrip scope of described optical filter is 250-2200nm, can freely switch between the different optical filters.
In the step (2), described converging by optical cylindrical lens realized.
In the step (3), be full of ultrasonic couplant between the sample of described ultrasonic detector and its scanning, described ultrasonic couplant is ultrasonic coupling liquid.
A kind of above-mentioned device based on the light activated acousto-optic imaging method of pulse xenon lamp comprises the pulse power, xenon lamp, light path adjustment assembly, optical filtering switch, sample scanning platform, ultrasound acquisition assembly and signal Processing image reconstruction assembly;
Wherein, the pulse power is connected with xenon lamp; Light path is adjusted assembly and is connected with the optical filtering switch; The ultrasound acquisition assembly is connected with signal Processing image reconstruction assembly;
Described light path is adjusted assembly and is comprised elliptic cylinder reflection cavity and cylindrical lens;
Described ultrasound acquisition assembly comprises ultrasonic probe, signal amplifier/oscillograph and the data acquisition card that connects successively;
Described signal Processing image reconstruction assembly comprises computing machine, I/O card, data transmission card, LABVIEW software and matlab software.
In the said apparatus, described sample scanning platform is driven by the computer control step actuator, but oscilaltion and 360 degree rotations.
In the said apparatus, described ultrasonic probe comprises single-element detector or multiunit detector and corresponding acquisition component thereof.
In the said apparatus, the direction of illumination of pulsed light and the detection direction of ultrasonic probe are that the homonymy emission oppositely receives, the Vertical Launch side direction receives or the subtend emission receives.In the step (2), described cylindrical lens is to be used for pulsed light is further converged to improve the power density of irradiated area.
In the said apparatus, described optical filter converter is provided with the optical filter of the logical scope 250-2200nm of band, can freely change between the different optical filters, and the all-pass state can satisfy the not requirement of needs optical filtering in the method down.
The present invention compared with prior art has following beneficial effect:
(1) the inventive method is utilized pulse xenon lamp phot-luminescence acoustical signal, realize photoacoustic imaging, with respect to greatly reducing imaging system production cost (ten thousand yuan of about 1-2 of pulse xenon lamp system as the photo-acoustic excitation source with pulsed laser, and ten thousand yuan of about 15-20 of high power pulsed laser), help the marketing development and the scale production of photoacoustic imaging.
(2) the pulse xenon lamp system architecture is simple, and volume is little, helps the miniaturization of photoacoustic imaging, densification; Be convenient to move handled easily.
(3) pulse xenon lamp has the SPECTRAL REGION of enriching, and can characteristic per sample utilize optical filter to select the light wave of specificity wavelength to carry out the imaging detection, improves detection efficiency and accuracy.For example, can select for use the nearly ruddiness (800nm) that green is absorbed by force to excite for the train of thought imaging of blade and obtain high signal to noise ratio (S/N ratio); Can select for use short wavelength's laser to come 532nm, 460nm to wait to excite for the imaging of surface/inferior surface structure and obtain high resolution.
Description of drawings
The structural representation of the opto-acoustic imaging devices that Fig. 1 excites for short pulse xenon lamp of the present invention,
Wherein: pulse xenon lamp power supply 1; Xenon lamp emitting module 2 comprises: high power xenon lamp pipe 3, elliptic cylinder reflection cavity 4, optical filter switch 5, optical cylindrical lens 6; Example platform 7; Sample rotation sweep platform 8; Ultrasound acquisition probe 9; Signal amplifier/oscillograph and data acquisition card 10; Computing machine 11; Image display 12;
The light path of dotted line signal xenon lamp among the figure.
Fig. 2 is the sample photo, and two parallel burying of carbon-point are placed in the agar.
Fig. 3 is the signal excitation receiving mode synoptic diagram among the embodiment 1.
Fig. 4 is the light activated fixed point optoacoustic of a pulse xenon lamp reconstructed image among the embodiment 1, and reconstructed image is the xsect of carbon-point.
Fig. 5 is the signal excitation receiving mode synoptic diagram among the embodiment 2.
Fig. 6 is the optoacoustic rotation sweep reconstructed image among the embodiment 2, and reconstructed image is the xsect of agar sample.
Embodiment
Below in conjunction with drawings and Examples the present invention is further described, but embodiments of the present invention are not limited thereto.
Embodiment
1, the opto-acoustic imaging devices that excites of short pulse xenon lamp of the present invention
In Fig. 1, pulse xenon lamp power supply 1 sends the high power pulse xenon lamp 3 in the short pulse signal instant igniting xenon lamp emitting module 2, pulsed xenon light converges parallel output after elliptic cylinder reflection cavity 4 internal reflections of metal, after shine on the sample behind optical filter 5 and the cylindrical lens 6.Described pulse xenon lamp power supply is that the SSL-CP solid-state laser power supply transformation that cubic company is innovated in Beijing forms, and output power is more than the 3KW, and output pulse width is: 0.02-0.3ms, frequency of operation: 1-200Hz; And the high power pulse xenon lamp is supporting customized by the good new LASER Light Source in Shanghai company limited, and its monopulse ceiling capacity reaches 450J, and the output spectrum scope is: 250nm～2200nm.Optical filter is selected the bandpass filter of U.S. Asahi Spectra co.Ltd company for use, is respectively: ZBPA530/ZBPA600/ZBPA800/ZBPA850/ZBPA900.Cylindrical lens self-control processing causes and is used to focus on the light velocity.
Rotation sweep platform 7 and sample article carrying platform 8 are to link to each other control step driven by motor scanning platform rotation sweep or oscilaltion by computing machine with the two-phase stepper motor driver by its digital I/O card.
The photoacoustic signal that xenon lamp irradiation sample produces is gathered by ultrasound acquisition probe 9 and is received, signal is stored in computing machine 11 behind ultrasound acquisition transmission assembly (signal amplifier/oscillograph and data acquisition card) 10, the back is by software matlab in the computing machine 11 and self-editing filtered back projection programmed algorithm reconstructed image and be presented on the display screen 12.Signal is carried out amplification earlier in the ultrasound acquisition assembly, removed noise by bandpass filtering again, and to be carried out the dynamic focusing wave beam by phase delay synthetic for multiple signals wherein then, at last by data acquisition card (NI-PCI6541) transmission and store computing machine 11.The experiment use ultrasonic detector as the multiple linear detector array (SIUI, L2L50A), its centre frequency is 7.5MHz, bandwidth is 70%, probe size is 5 * 2cm.Detector and sample room are coupled with ultrasonic coupling liquid.
2, with the inventive method and device to the analog sample photoacoustic tomography of fixing a point
Sample photoabsorption cross-section body photo as shown in Figure 2, the carbon-point that two diameters are 0.7mm, be about 4mm is embedded in dark approximately 7mm place in the agar.System's pulse repetition rate is 20Hz, selects for use the ZBPA530 optical filter to make the pulsed xenon light of outgoing 530nm.Difference per sample, excite with drainage pattern as shown in Figure 3, multiunit detector is vertically downward over against the absorption of sample body, detector and sample room are full of ultrasonic coupling liquid, xenon lamp is by through cylindrical lens focus, its focal line is aimed at the sample absorber of light, and the cross section of detector collection acoustical signal as shown in phantom in Figure 2.Fig. 4 is a pulse xenon lamp phot-luminescence acoustic image.Reconstructed image clearly reflects the xsect of carbon-point, and its size conforms to actual conditions.
3, with the inventive method and device analog sample is rotated the scan light acoustic imaging
Excite with drainage pattern as shown in Figure 5, xenon lamp shines directly into sample surfaces without cylindrical lens focus behind optical filter, and detector is vertical with incident light and be close to sample surfaces, the centre is full of ultrasonic coupling liquid.Control step driven by motor scanning platform rotation images acquired is gathered 20 positions in the 360 degree scopes altogether, the image reconstruction image as shown in Figure 6, reconstructed image is the morphosis of inverting absorber clearly, and is very identical with the sample photo.
In addition, difference per sample can be without filtering or using respective filter to obtain the emergent light of 250-2200nm scope in the method for the present invention; The optical filter converter can be in the all-pass state or use the optical filter of the logical scope of band at 250-2200nm in the corresponding system and device.
The foregoing description is a preferred implementation of the present invention; but embodiments of the present invention are not restricted to the described embodiments; other any do not deviate from change, the modification done under spirit of the present invention and the principle, substitutes, combination, simplify; all should be the substitute mode of equivalence, be included within protection scope of the present invention.
Claims (10)
1, a kind of based on the light activated acousto-optic imaging method of pulse xenon lamp, it is characterized in that comprising the steps:
(1) the pulsed xenon fluorescent tube parallel after reflection output of pulsed light of sending;
(2) pulsed light of parallel output through after optical filtering and converging, after perhaps directly converging, shines on the light absorption sample successively, and absorbent body luminous energy produces optoacoustic effect, sends ultrasound wave;
(3) photoacoustic signal is gathered in ultrasonic detector fixed point scanning, rotation sweep or rectilinear scanning, by the acquisition component transmission and be stored in the computing machine;
(4) signal is carried out filtering and integration after, rebuild light absorption by backprojection algorithm dorsad or linear projection's algorithm and distribute and be shown in display screen.
2, according to claim 1 based on the light activated acousto-optic imaging method of pulse xenon lamp, it is characterized in that: in the step (1), described pulsed xenon fluorescent tube is the high power pulse light pipe, and the optical wavelength scope that it sends is 250nm～2200nm.
3, according to claim 1 based on the light activated acousto-optic imaging method of pulse xenon lamp, it is characterized in that: in the step (1), described reflection is realized by the elliptic cylinder reflection cavity.
4, according to claim 3 based on the light activated acousto-optic imaging method of pulse xenon lamp, it is characterized in that: described elliptic cylinder reflection cavity is to be made by stainless steel material, inwall is silver-plated after polishing, the xenon lamp pipe is positioned on the focal line of elliptic cylinder, makes pulsed light parallel output behind intracavity reflecting.
5, according to claim 1 based on the light activated acousto-optic imaging method of pulse xenon lamp, it is characterized in that: in the step (2), described optical filtering is realized that by the optical filter switch the logical scope of the band of described optical filter is 250-2200nm, can freely switch between the different optical filters.
6, according to claim 1 based on the light activated acousto-optic imaging method of pulse xenon lamp, it is characterized in that: in the step (2), described converging by optical cylindrical lens realized.
7, a kind of each described device based on the light activated acousto-optic imaging method of pulse xenon lamp of claim 1～6 of realizing is characterized in that: comprise the pulse power, xenon lamp, light path adjustment assembly, optical filtering switch, sample scanning platform, ultrasound acquisition assembly and signal Processing image reconstruction assembly;
Wherein, the pulse power is connected with xenon lamp; Light path is adjusted assembly and is connected with the optical filtering switch; The ultrasound acquisition assembly is connected with signal Processing image reconstruction assembly;
Described light path is adjusted assembly and is comprised elliptic cylinder reflection cavity and cylindrical lens;
Described ultrasound acquisition assembly comprises ultrasonic probe, signal amplifier/oscillograph and the data acquisition card that connects successively;
Described signal Processing image reconstruction assembly comprises computing machine, I/O card, data transmission card, LABVIEW software and matlab software.
8, device according to claim 7 is characterized in that: described sample scanning platform is driven by the computer control step actuator, can oscilaltion and 360 degree rotations.
9, device according to claim 7 is characterized in that: described ultrasonic probe comprises single-element detector or multiunit detector and corresponding acquisition component thereof.
10, device according to claim 7 is characterized in that: the direction of illumination of pulsed light and the detection direction of ultrasonic probe are that the homonymy emission oppositely receives, the Vertical Launch side direction receives or the subtend emission receives.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104027132A (en) * | 2014-06-09 | 2014-09-10 | 苏州大学 | Device and method based on multispectral photoacoustic tomography |
| CN109416346A (en) * | 2016-06-21 | 2019-03-01 | 株式会社岛津制作所 | Acoustic Wave Propagation Image Creation device and method |
| CN109393300A (en) * | 2018-11-19 | 2019-03-01 | 中国科学院大连化学物理研究所 | A kind of xenon flash lamp sterilizing unit used under low temperature environment |
| CN110488565A (en) * | 2019-08-26 | 2019-11-22 | 句容福芯电子有限公司 | A kind of apparatus and system for realizing air imaging using optoacoustic effect |
| CN112362732A (en) * | 2020-10-21 | 2021-02-12 | 南京理工大学 | Free-form surface defect detection method and system based on laser ultrasonic elliptical imaging |
| CN113081043A (en) * | 2021-04-12 | 2021-07-09 | 北京航空航天大学 | Ultrasonic imaging detector |
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2008
- 2008-12-10 CN CNA2008102198312A patent/CN101424667A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104027132A (en) * | 2014-06-09 | 2014-09-10 | 苏州大学 | Device and method based on multispectral photoacoustic tomography |
| CN109416346A (en) * | 2016-06-21 | 2019-03-01 | 株式会社岛津制作所 | Acoustic Wave Propagation Image Creation device and method |
| CN109393300A (en) * | 2018-11-19 | 2019-03-01 | 中国科学院大连化学物理研究所 | A kind of xenon flash lamp sterilizing unit used under low temperature environment |
| CN110488565A (en) * | 2019-08-26 | 2019-11-22 | 句容福芯电子有限公司 | A kind of apparatus and system for realizing air imaging using optoacoustic effect |
| CN112362732A (en) * | 2020-10-21 | 2021-02-12 | 南京理工大学 | Free-form surface defect detection method and system based on laser ultrasonic elliptical imaging |
| CN113081043A (en) * | 2021-04-12 | 2021-07-09 | 北京航空航天大学 | Ultrasonic imaging detector |
| CN113081043B (en) * | 2021-04-12 | 2022-07-05 | 北京航空航天大学 | Ultrasonic imaging detector |
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Application publication date: 20090506 |