CN216764871U - Multichannel unicellular magnetic bead capture test device - Google Patents
Multichannel unicellular magnetic bead capture test device Download PDFInfo
- Publication number
- CN216764871U CN216764871U CN202220228670.9U CN202220228670U CN216764871U CN 216764871 U CN216764871 U CN 216764871U CN 202220228670 U CN202220228670 U CN 202220228670U CN 216764871 U CN216764871 U CN 216764871U
- Authority
- CN
- China
- Prior art keywords
- magnetic bead
- cell
- channel
- sample feeding
- magnetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Landscapes
- Sampling And Sample Adjustment (AREA)
Abstract
The utility model belongs to the technical field of test devices, in particular to a multi-channel single-cell magnetic bead capture test device, which comprises a test chamber and a magnetic frame, wherein the top of the test chamber is provided with a magnetic bead sample feeding channel which penetrates through the test chamber, one end of the magnetic bead sample feeding channel is provided with a magnetic bead sample feeding branch pipe, the side wall of the inner cavity of the magnetic bead sample feeding branch pipe is embedded and provided with a magnetic bead control valve, the top of the test chamber is connected with a cell sample feeding channel in a penetrating way, in the application document, a plurality of cells can be respectively conveyed into corresponding mixers through the cell sample feeding channel, the number of the cell sample feeding channels is at least two, and by a strong magnet arranged in a magnetic frame, can be convenient for carry out the magnetic bead to multiple unicellular magnetic bead and catch the cell that has combined the magnetic bead, convenient operation has saved staff time consuming, has improved efficiency of the test.
Description
Technical Field
The utility model relates to the technical field of test devices, in particular to a multi-channel single-cell magnetic bead capture test device.
Background
The magnetic bead separation technology has the characteristics of high enrichment specificity, short detection time and the like, and is rapid and efficient. As the condition of adsorbing and desorbing the target in the magnetic sorting technology can be realized only by a very simple physical method of externally adding a magnetic field and withdrawing the magnetic field. In the field of cell sorting, target cell surface antigens are generally recognized and marked by virtue of high specificity of antibodies coupled on magnetic particles, then cell suspensions mixed with magnetic beads pass through a magnetic field, cells combined with the magnetic beads can be adsorbed on the side wall of the magnetic field, and unbound cells are removed to obtain purified target cells, so that efficient sorting and enrichment are realized.
In the prior art, when various unicellular magnetic beads are captured, the existing device can only capture a unicellular magnetic bead, the operation is troublesome, a large amount of time of workers is wasted, and the test efficiency is reduced.
SUMMERY OF THE UTILITY MODEL
This section is for the purpose of summarizing some aspects of embodiments of the utility model and to briefly introduce some preferred embodiments. Some simplifications or omissions may be made in this section as well as in the abstract of the specification and the title of the application to avoid obscuring the purpose of this section, the abstract of the specification and the title of the application, and such simplifications or omissions are not intended to limit the scope of the utility model.
The present invention has been made in view of the above and/or other problems with the prior art testing devices.
Therefore, the utility model aims to provide a multi-channel single-cell magnetic bead capture test device, which can respectively convey various cells into corresponding mixers through cell sampling channels, wherein the number of the cell sampling channels is at least two, and the cell combined with magnetic beads can be captured through strong magnets arranged in a magnetic frame, so that the magnetic bead capture of various single cells is facilitated, the operation is convenient, the time consumed by workers is saved, and the test efficiency is improved.
To solve the above technical problem, according to an aspect of the present invention, the present invention provides the following technical solutions:
the utility model provides a test device is caught to multichannel unicellular magnetic bead, includes proof box and magnetic frame, the magnetic bead sampling channel has been seted up at the top of proof box, magnetic bead sampling channel runs through the proof box, the one end of magnetic bead sampling channel is provided with the magnetic bead sampling and divides the pipe, the magnetic bead control valve is installed in the lateral wall embedding of magnetic bead sampling branch pipe inner chamber, the top through connection of proof box has the cell sampling channel, the cell control valve is installed in the lateral wall embedding of cell sampling channel inner chamber, the one end that cell sampling channel and magnetic bead sampling branch pipe were connected with the blender, the bottom of blender is provided with out the appearance passageway, magnetic frame fixed mounting is in the bottom of proof box inner chamber, the kit is installed in the embedding of magnetic frame.
As a preferred scheme of the multi-channel single-cell magnetic bead capture test device, the device comprises: the bottom of the test box is fixedly provided with a vibrating plate and a spring rod, and the bottom of the spring rod is provided with a base.
As a preferred scheme of the multi-channel single-cell magnetic bead capture test device, the device comprises: the front side wall of the test box is rotatably connected with a box door.
As a preferred scheme of the multi-channel single-cell magnetic bead capture test device, the device comprises: the front side wall of the box door is provided with an observation window, and the observation window is a transparent glass window.
As a preferred scheme of the multi-channel single-cell magnetic bead capture test device, the device comprises: the top of the kit is connected with the sample outlet channel.
As a preferred scheme of the multi-channel single-cell magnetic bead capture test device, the device comprises: the number of the magnetic bead sample introduction branched tubes is two.
Compared with the prior art: in this application document, 1 can carry multiple cell respectively in the blender that corresponds through cell sampling passageway, cell sampling passageway is minimum two, through the powerful magnetite of configuration in the magnetic frame, can be to the cell capture that has combined the magnetic bead, be convenient for carry out the magnetic bead to multiple unicellular and catch, convenient operation has saved staff time consuming, and the efficiency of the experiment is improved, 2 send vibrations through the board that shakes, the abundant mixture of magnetic bead and cell of being convenient for, the magnetic bead of being convenient for catches the cell, the capture effect of magnetic bead has been improved.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the present invention will be described in detail with reference to the accompanying drawings and detailed embodiments, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without inventive exercise. Wherein:
FIG. 1 is a schematic structural diagram of a multi-channel single-cell magnetic bead capture test device according to the present invention;
FIG. 2 is an exploded view of a multi-channel single-cell magnetic bead capture test device according to the present invention;
FIG. 3 is a schematic diagram of a vibrating plate of a multi-channel single-cell magnetic bead capture test device according to the present invention;
FIG. 4 is a schematic diagram of a magnetic rack of a multi-channel single-cell magnetic bead capture test device according to the present invention.
In the figure: 100 test chambers, 110 magnetic bead sample feeding channels, 120 magnetic bead sample feeding branch tubes, 130 magnetic bead control valves, 140 cell sample feeding channels, 150 cell control valves, 160 mixers, 170 sample discharging channels, 200 magnetic force frames, 210 reagent boxes, 300 vibrating plates, 310 spring rods, 320 bases, 400 box doors and 500 observation windows.
Detailed Description
In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in detail below.
In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, but the present invention may be practiced in other ways than those specifically described herein, and it will be apparent to those of ordinary skill in the art that the present invention may be practiced without departing from the spirit and scope of the present invention, and therefore the present invention is not limited to the specific embodiments disclosed below.
Next, the present invention will be described in detail with reference to the drawings, wherein for convenience of illustration, the cross-sectional view of the device structure is not enlarged partially according to the general scale, and the drawings are only examples, which should not limit the scope of the present invention. In addition, the three-dimensional dimensions of length, width and depth should be included in the actual fabrication.
In order to make the objects, technical solutions and advantages of the present invention more apparent, embodiments of the present invention will be described in detail with reference to the accompanying drawings.
The utility model provides a multi-channel single-cell magnetic bead capturing test device, please refer to fig. 1-4, which comprises a test box 100 and a magnetic frame 200, wherein the top of the test box 100 is provided with a magnetic bead sample introduction channel 110, the magnetic bead sample introduction channel 110 penetrates through the test box 100, one end of the magnetic bead sample introduction channel 110 is provided with a magnetic bead sample introduction branch pipe 120, the side wall of the inner cavity of the magnetic bead sample introduction branch pipe 120 is embedded and provided with a magnetic bead control valve 130, the top of the test box 100 is connected with a cell sample introduction channel 140 in a penetrating manner, the side wall of the inner cavity of the cell sample introduction channel 140 is embedded and provided with a cell control valve 150, one end of the cell sample introduction channel 140 and one end of the magnetic bead sample introduction branch pipe 120 are connected with a mixer 160, the bottom of the mixer 160 is provided with a sample outlet channel 170, the magnetic frame 200 is fixedly installed at the bottom of the inner cavity of the test box 100, and the magnetic frame 200 is embedded and provided with a kit 210.
The front side wall of the test chamber 100 is rotatably connected with a chamber door 400, and the device is conveniently taken through the chamber door 400.
The front side wall of the box door 400 is provided with an observation window 500, the observation window 500 is a transparent glass window, and the observation process of the test is convenient to observe through the observation window 500.
The top of the reagent cartridge 210 is connected to the sample outlet channel 170, so that the mixed magnetic beads and cell fluid can be conveniently delivered into the reagent cartridge 210.
The number of the magnetic bead sample introduction branched tubes 120 is two, so that the test on various cells is facilitated, and the operation is convenient.
With reference to fig. 1 to 4, the multi-channel single-cell magnetic bead capture test device of the present embodiment has the following specific use process: carry the single cell through cell sampling passageway 140 in the blender 160, carry the magnetic bead through magnetic bead sampling passageway 110 and advance a kind and divide pipe 120 with the magnetic bead, carry the magnetic bead respectively through magnetic bead sampling and divide pipe 120 in the blender 160 that corresponds, according to the demand, use magnetic bead control valve 130 to open and close magnetic bead sampling and divide pipe 120, carry the kit 210 in through appearance passageway 170 after mixing, through the powerful magnetite of configuration in the magnetic frame 200, can be to the cell capture that has combined the magnetic bead, cell sampling passageway 140 is two at least, be convenient for carry out the magnetic bead to multiple unicellular and catch, convenient operation, the time consuming by staff has been saved, the efficiency of the experiment has been improved.
Fig. 1-4 are schematic structural diagrams illustrating a second embodiment of a multi-channel single-cell magnetic bead capture test device according to the present invention, please refer to fig. 1-4, and different from the above embodiments, a vibration plate 300 and a spring rod 310 are fixedly installed at the bottom of a test chamber 100, and a base 320 is installed at the bottom of the spring rod 310, and the vibration plate 300 vibrates to facilitate sufficient mixing of magnetic beads and cells, facilitate capturing of cells by magnetic beads, and improve a magnetic bead capture effect.
While the utility model has been described above with reference to an embodiment, various modifications may be made and equivalents may be substituted for elements thereof without departing from the scope of the utility model. In particular, the various features of the disclosed embodiments of the utility model may be used in any combination, provided that no structural conflict exists, and the combinations are not exhaustively described in this specification merely for the sake of brevity and resource conservation. Therefore, it is intended that the utility model not be limited to the particular embodiments disclosed, but that the utility model will include all embodiments falling within the scope of the appended claims.
Claims (6)
1. The utility model provides a test device is caught to multichannel unicellular magnetic bead which characterized in that: comprises a test box (100) and a magnetic frame (200), wherein the top of the test box (100) is provided with a magnetic bead sample feeding channel (110), the magnetic bead sample feeding channel (110) penetrates through the test box (100), one end of the magnetic bead sample feeding channel (110) is provided with a magnetic bead sample feeding branch pipe (120), the side wall of the inner cavity of the magnetic bead sample feeding branch pipe (120) is embedded with a magnetic bead control valve (130), the top of the test box (100) is connected with a cell sample feeding channel (140) in a penetrating way, a cell control valve (150) is embedded and installed on the side wall of the inner cavity of the cell sample feeding channel (140), one end of the cell sample introduction channel (140) and one end of the magnetic bead sample introduction branched pipe (120) are connected with a mixer (160), the bottom of blender (160) is provided with out appearance passageway (170), magnetic frame (200) fixed mounting is in the bottom of proof box (100) inner chamber, embedding is installed kit (210) in magnetic frame (200).
2. The multi-channel single-cell magnetic bead capture assay device of claim 1, wherein: the bottom of the test box (100) is fixedly provided with a vibrating plate (300) and a spring rod (310), and the bottom of the spring rod (310) is provided with a base (320).
3. The multi-channel single-cell magnetic bead capture assay device of claim 1, wherein: the front side wall of the test box (100) is rotatably connected with a box door (400).
4. The multi-channel single-cell magnetic bead capture assay device of claim 3, wherein: the front side wall of the box door (400) is provided with an observation window (500), and the observation window (500) is a transparent glass window.
5. The multi-channel single-cell magnetic bead capture assay device of claim 1, wherein: the top of the reagent box (210) is connected with a sample outlet channel (170).
6. The multi-channel single-cell magnetic bead capture assay device of claim 1, wherein: the number of the magnetic bead sample feeding branch pipes (120) is two.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220228670.9U CN216764871U (en) | 2022-01-27 | 2022-01-27 | Multichannel unicellular magnetic bead capture test device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220228670.9U CN216764871U (en) | 2022-01-27 | 2022-01-27 | Multichannel unicellular magnetic bead capture test device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN216764871U true CN216764871U (en) | 2022-06-17 |
Family
ID=81978961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202220228670.9U Active CN216764871U (en) | 2022-01-27 | 2022-01-27 | Multichannel unicellular magnetic bead capture test device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN216764871U (en) |
-
2022
- 2022-01-27 CN CN202220228670.9U patent/CN216764871U/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Mach et al. | Automated cellular sample preparation using a Centrifuge-on-a-Chip | |
| CN203923172U (en) | Integral type paramagnetic particle method cellular segregation, cultivation, check-out console | |
| US20150010939A1 (en) | Flow Cytometric Systems for Sterile Separation of Magnetically Labeled Sample Components | |
| CN103861735B (en) | Magnetic separation device | |
| CN102243234A (en) | Automatic bacterial sorting and labeling method based on immune method, and apparatus thereof | |
| CN216764871U (en) | Multichannel unicellular magnetic bead capture test device | |
| CN104655831A (en) | Magnetic bead cleaning and separating device for full-automatic chemical luminescence immunity analyzer | |
| CN208366994U (en) | A kind of talus accumulation fluid-structure analysis testing equipment | |
| CN202049159U (en) | Automatic bacterium sorting and labeling device based on immune method | |
| CN207130273U (en) | A kind of magnetic force micro-fluidic chip for capturing bacterium | |
| CN205528823U (en) | Magnetic frame | |
| CN201020402Y (en) | Detachable utility type magnetic separating rack | |
| CN203816777U (en) | Magnetic separation device | |
| WO2004073486A3 (en) | Diagnostic device and method | |
| CN205749526U (en) | A kind of ELISA detection kit | |
| CN2819220Y (en) | Magnetic separator of enzyme target board | |
| CN204039380U (en) | A kind ofly be easy to the high magnetic tripping device moving liquid | |
| CN112266841A (en) | Biological sample processing chip device and processing method | |
| CN208588558U (en) | A kind of geological and mineral experiment sample quarterlies device | |
| CN108760425B (en) | Graphene oxide-based pretreatment device and application thereof in food detection | |
| CN103323492B (en) | Rapid assembly micro-flow detection cell device with magnetic separation | |
| CN208373116U (en) | A kind of easy-to-dismount micro-fluidic chip | |
| CN206089660U (en) | Biological nanometer paramagnetic particle method draws viral RNA kit | |
| CN206609632U (en) | Sample synchronous acquisition device in a kind of laboratory flotation column | |
| CN206975042U (en) | A kind of analyzer magnetic cleaning separating mechanism of the unilateral arrangement of magnet |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant |