CN216677077U

CN216677077U - Blood separation assembly

Info

Publication number: CN216677077U
Application number: CN202122852682.7U
Authority: CN
Inventors: 黄红
Original assignee: Zhuzhou Guohao Enterprise Management Partnership LP
Current assignee: Zhuzhou Maowu Medical Technology Co ltd
Priority date: 2021-11-21
Filing date: 2021-11-21
Publication date: 2022-06-07
Anticipated expiration: 2031-11-21

Abstract

The embodiment of the application provides a blood separation assembly, including centrifuge tube, first sleeve and second sleeve, the both ends of centrifuge tube respectively have an opening, and the one end of first sleeve and second sleeve is inlayed respectively and is established in two openings at centrifuge tube both ends, and the axial motion of centrifuge tube can be followed to first sleeve and second sleeve. The centrifugal cylinder is provided with a first neck and a second neck, the first neck and the second neck are respectively provided with a first flow through hole and a second flow through hole, and the first neck and the second neck divide the centrifugal cylinder into a centrifugal cavity, a first accommodating cavity and a second accommodating cavity. A first fixing plate and a first convex column are arranged in the first cover body, and a second fixing plate and a second convex column are arranged in the second cover body. The blood separation subassembly of this application embodiment can completely cut off red blood cell, anemia platelet plasma and rich platelet plasma in blood in the space of difference, makes operating personnel can conveniently extract rich platelet plasma, guarantees not to extract other compositions in the blood to the acquisition degree of difficulty of rich platelet plasma has been reduced.

Description

Blood separation assembly

Technical Field

The application relates to the technical field of medical equipment, in particular to a blood separation assembly.

Background

Blood is a red opaque liquid flowing in blood vessels and heart of human body, and belongs to connective tissue of human body, and its main components are blood plasma and blood cells. Plasma is the extracellular matrix of blood, and its main role is to carry blood cells, substances required for sustaining human vital activities and waste products generated in vivo. Blood cells are cells present in plasma, and mainly include three kinds of red blood cells, white blood cells, and platelets. Among them, platelets are rich in various Growth factors (Growth factors) that promote cell proliferation and differentiation, and can contribute to regeneration and repair of human tissues, so that platelets are widely used in the fields of clinical medicine and the like.

In the related art, in order to meet the demand of platelets in the fields of clinical medicine and the like, platelets are often obtained by centrifuging blood. The specific operation is that the collected blood is injected into a test tube, then the test tube containing the blood is placed into a centrifugal separation device for centrifugal separation, so that the blood is centrifugally separated into a red blood cell layer, a Platelet Rich Plasma (PRP) layer and a Platelet Poor Plasma (PPP) layer from bottom to top, and then the blood goes deep into the Platelet rich Plasma layer through a needle tube to extract the Platelet rich Plasma.

However, since the platelet-rich plasma layer is located between the red blood cell layer and the platelet-poor plasma layer, when the operator draws the platelet-rich plasma, it is difficult to accurately draw the needle deep into the platelet-rich plasma layer, so that the difficulty in obtaining the platelet-rich plasma is relatively high.

SUMMERY OF THE UTILITY MODEL

The embodiment of the application provides a blood separation subassembly can make operating personnel conveniently extract rich platelet plasma, has reduced the acquisition degree of difficulty of rich platelet plasma.

The blood separation assembly provided by the embodiment of the application comprises a centrifugal cylinder, a first sleeve and a second sleeve;

two ends of the centrifugal cylinder are respectively provided with an opening, one end of each of the first sleeve and the second sleeve is respectively embedded in the two openings at the two ends of the centrifugal cylinder, the other ends of the first sleeve and the second sleeve are closed to seal the two openings at the two ends of the centrifugal cylinder, and the first sleeve and the second sleeve can move along the axial direction of the centrifugal cylinder;

a first neck part and a second neck part are respectively arranged at two openings of the centrifugal cylinder close to two ends of the centrifugal cylinder, and a first flow through hole and a second flow through hole are respectively formed on the inner side walls of the first neck part and the second neck part;

an inner wall surface of the centrifugal cylinder, which is positioned between the first neck part and the second neck part, encloses to form a centrifugal cavity; a first accommodating cavity is formed by the first sleeve and the inner wall surface of the centrifugal cylinder between the first neck and the first sleeve in an enclosing manner; a second accommodating cavity is formed by the second sleeve and the inner wall surface of the centrifugal cylinder between the second neck and the second sleeve in an enclosing manner;

a first fixing plate and a first convex column are arranged in the first sleeve, and the outer side wall of the first fixing plate is connected with the inner side wall of the first sleeve; one end of the first convex column is connected with the first fixing plate, and the other end of the first convex column is opposite to the first flow through hole;

the second sleeve is internally provided with a second fixing plate and a second convex column, the outer side wall of the second fixing plate is connected with the inner side wall of the second sleeve, one end of the second convex column is connected with the second fixing plate, and the other end of the second convex column is opposite to the second flow through hole.

In a possible implementation, the blood separation assembly provided by the embodiment of the present application, the first sleeve includes a cylinder and a sealing partition, and both ends of the cylinder are provided with openings; one end of the cylinder body is embedded in the centrifugal cylinder, and the sealing partition plate is embedded in an opening of the cylinder body, which is far away from one end of the centrifugal cylinder.

In one possible embodiment, the blood separation assembly provided in the examples of the present application, the sealing membrane is a membrane made of an elastic material

In a possible implementation manner, in the blood separation assembly provided in this embodiment of the present application, a sidewall of the centrifugal cylinder has an infusion hole communicated with the centrifugal cavity, and a sealing plug is disposed in the infusion hole.

In a possible implementation manner, the blood separation assembly provided in the embodiment of the present application, the first fixing plate has a plurality of first liquid passing holes; the second fixing plate is provided with a plurality of second liquid passing holes.

In a possible implementation manner, in the blood separation assembly provided in this embodiment of the present application, internal threads are provided on an inner wall surface of the centrifuge tube near the two openings, external threads are provided on outer wall surfaces of the first sleeve and the second sleeve, and the external threads of the first sleeve and the second sleeve are screwed with the internal threads at two ends of the centrifuge tube.

Drawings

In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly introduced below, and it is obvious that the drawings in the following description are some embodiments of the present application, and for those skilled in the art, other drawings can be obtained according to these drawings without inventive exercise.

FIG. 1 is a schematic diagram of a blood separation assembly according to an embodiment of the present application;

description of reference numerals:

10-a centrifuge tube; 10 a-centrifugal chamber;

11-a first neck portion; 111-a first flow through hole;

12-infusion hole; 13-a second neck;

131-a second flow through hole; 20-a first sleeve;

20 a-a first receiving chamber; 21-barrel body;

22-a sealing separator; 23-a first stud;

24-a first fixing plate; 241-a first liquid passing hole;

30-a second sleeve; 30 a-a second receiving chamber;

31-a second stud; 32-a second fixing plate;

321-second liquid passing hole.

Detailed Description

In the related art, blood is centrifuged and then separated into a red blood cell layer, a Platelet Rich Plasma (PRP) layer, and a Platelet Poor Plasma (PPP) layer according to specific gravities of respective components in the blood. Wherein, the specific gravity of the red blood cells is the maximum, and the red blood cells sink to the bottommost part of the test tube to form a red blood cell layer; the specific gravity of the platelet-rich plasma is the second, and the platelet-rich plasma layer is formed on the red blood cell layer; the platelet poor plasma, which has the lowest specific gravity, will lie above the platelet rich plasma layer, forming a platelet poor plasma layer. Thus, the platelet rich plasma layer is located between the red blood cell layer and the platelet poor plasma layer. When extracting platelet-rich plasma, an operator needs to make the needle of the syringe needle tube penetrate through the platelet-poor plasma layer to reach the platelet-rich plasma layer for extraction. However, since the platelet-rich plasma layer is relatively thin, it is difficult to accurately insert the needle into the platelet-rich plasma layer for extraction, so that the platelet-rich plasma is difficult to obtain.

In view of the above, embodiments of the present application provide a blood separation assembly including a centrifuge bowl, a first sleeve, and a second sleeve. Can isolate red blood cell, anemia platelet plasma and rich platelet plasma in the blood in the space of difference, make operating personnel can conveniently extract rich platelet plasma, guarantee can not extract other compositions in the blood to the acquisition degree of difficulty of rich platelet plasma has been reduced.

Embodiments of the present application will be described in detail below with reference to the accompanying drawings.

Example one

Referring to fig. 1, an embodiment of the present application provides a blood separation assembly including a centrifuge cartridge 10, a first cartridge 20, and a second cartridge 30, wherein:

the centrifugal cylinder 10 is a hollow cylinder body 21, two ends of the centrifugal cylinder 10 are respectively provided with an opening, inner wall surfaces of the centrifugal cylinder 10 close to the two openings are provided with internal threads, outer wall surfaces of the first sleeve 20 and the second sleeve 30 are respectively provided with external threads, one ends of the first sleeve 20 and the second sleeve 30 are respectively embedded in the two openings at the two ends of the centrifugal cylinder 10, the external threads of the first sleeve 20 and the second sleeve 30 are in threaded connection with the internal threads at the two ends of the centrifugal cylinder 10, and the other ends of the first sleeve 20 and the second sleeve 30 are sealed to seal the two openings at the two ends of the centrifugal cylinder 10. When the first sleeve 20 and the second sleeve 30 are rotated, the first sleeve 20 and the second sleeve 30 may move in the axial direction of the centrifuge tube 10.

The two openings of the centrifuge bowl 10 near the two ends of the centrifuge bowl 10 are respectively provided with a first neck portion 11 and a second neck portion 13, and the inner side walls of the first neck portion 11 and the second neck portion 13 are respectively formed with a first flow through hole 111 and a second flow through hole 131.

The inner wall surface of the centrifuge bowl 10 between the first neck 11 and the second neck 13 encloses a centrifugal chamber 10a, and the centrifugal chamber 10a is an operation space for centrifugal separation of blood. The first sleeve 20 and the inner wall surface of the centrifuge tube 10 between the first neck 11 and the first sleeve 20 enclose a first accommodating cavity 20a, and the first accommodating cavity 20a is used for accommodating a specific certain component in the centrifuged blood, such as platelet-rich plasma. The second sleeve 30 and the inner wall surface of the centrifuge tube 10 between the second neck 13 and the second sleeve 30 enclose a second accommodating cavity 30a, and the second accommodating cavity 30a is used for accommodating a specific certain component in the centrifuged blood, such as red blood cells.

The first circulation hole 111 is used to introduce the component in the centrifugal chamber 10a into the first accommodation chamber 20a, and the second circulation hole 131 is used to introduce the component in the centrifugal chamber 10a into the second accommodation chamber 30 a.

Be equipped with first fixed plate 24 and first projection 23 in the first sleeve 20, the inside wall of first sleeve 20 is connected to the lateral wall of first fixed plate 24, and first fixed plate 24 is used for fixed first projection 23. One end of the first protruding pillar 23 is connected to the first fixing plate 24, and the other end of the first protruding pillar 23 faces the first flow hole 111. In this way, by rotating the first sleeve 20, the first sleeve 20 will rotate along the external thread of the centrifuge tube 10, so as to adjust the axial position of the first cover on the centrifuge tube 10, and adjust the distance between the first protruding pillar 23 and the first through-flow hole 111, thereby implementing the opening and closing of the first through-flow hole 111 through the first protruding pillar 23.

A second fixing plate 32 and a second protruding column 31 are arranged in the second sleeve 30, the outer side wall of the second fixing plate is connected with the inner side wall of the second sleeve 30, and the second fixing plate 32 is used for fixing the second protruding column 31. One end of the second convex column 31 is connected to the second fixing plate 32, and the other end of the second convex column 31 faces the second through hole 131. By rotating the second sleeve 30, the second sleeve 30 will rotate along the external thread of the centrifuge tube 10, so as to adjust the axial position of the second cover on the centrifuge tube 10, and adjust the distance between the second protruding column 31 and the second flow through hole 131, thereby realizing the opening and closing of the second flow through hole 131 through the second protruding column 31.

In a specific operation, the centrifugation of blood includes two separation operations, namely primary centrifugation and secondary centrifugation.

When the primary centrifugal separation is performed, the first sleeve 20 and the second sleeve 30 are respectively rotated, so that the first flow hole 111 and the second flow hole 131 are respectively blocked by the first convex column 23 and the second convex column 31, and the first accommodating cavity 20a and the second accommodating cavity 30a are both in a blocking state with the centrifugal cavity 10 a. Then injecting blood to be centrifugally separated into the centrifugal cavity 10a, and placing the first sleeve 20 of the blood separation device into a centrifugal separator upwards for centrifugal separation, so that red blood cells with the maximum specific gravity in the blood are settled at the bottom of the centrifugal cavity 10a to form a red blood cell layer; the plasma layer is formed by allowing plasma containing platelets in blood to be present on the red blood cell layer. Then, the second sleeve 30 is rotated until a gap is formed between the second convex pillar 31 and the second through hole 131, so that the second through hole 131 is opened, and the erythrocyte layer deposited at the bottom of the centrifugal cavity 10a flows into the second accommodating cavity 30a through the second through hole 131. Until the red blood cell layer is completely discharged from the centrifugal chamber 10a to the second accommodating chamber 30a, the second sleeve 30 is rotated to the second convex pillar 31 to block the second flow hole 131, so that the second flow hole 131 is closed to prevent the blood cell layer from flowing into the second accommodating chamber 30 a. After the primary centrifugation, only the plasma layer containing platelets remains in the chamber 10 a.

In order to obtain platelet-rich plasma having a high platelet concentration, after the primary centrifugation is completed, the blood separation device is placed in the centrifuge with the second sleeve 30 facing upward, and the blood is centrifuged to separate the plasma layer into a platelet-rich plasma layer at the bottom of the centrifugal chamber 10a and a platelet-poor plasma layer on the platelet-rich plasma layer. Then, the first sleeve 20 is rotated until a gap is formed between the first protruding pillar 23 and the first flow hole 111, so that the first flow hole 111 is opened, and the platelet-rich plasma layer deposited at the bottom of the centrifugal chamber 10a flows into the first accommodating chamber 20a through the first flow hole 111. Until the platelet rich plasma layer is completely discharged from the centrifugal cavity 10a to the first accommodating cavity 20a, the first sleeve 20 is rotated until the second convex column 31 blocks the first flow through hole 111, so that the flow through hole is closed, and the platelet rich plasma layer is prevented from flowing into the first accommodating cavity 20 a. After the second centrifugal separation, the platelet poor plasma layer is retained in the centrifugal cavity 10a, and the platelet rich plasma layer is retained in the first accommodating cavity 20 a. At this time, the platelet rich plasma in the first containing cavity 20a can be conveniently extracted, and other components in the blood are not extracted, so that the difficulty in obtaining the platelet rich plasma is reduced.

The blood separation utensil of this application embodiment can isolate red blood cell, anemia platelet plasma and rich platelet plasma in the blood in the space of difference, makes operating personnel can conveniently extract rich platelet plasma, guarantees not to extract other compositions in the blood to the acquisition degree of difficulty of rich platelet plasma has been reduced.

In addition, the first sleeve 20 and the second sleeve 30 can be rotated to isolate red blood cells, platelet poor plasma and platelet rich plasma in different spaces, and the operation mode is simple and easy to learn. Meanwhile, only one injection process and one extraction process are carried out in the operation process, so that the isolation between the blood and the external environment is ensured to a great extent, and the blood can be prevented from being polluted by external components.

In order to facilitate the operation, the centrifuge tube 10, the first sleeve 20 and the second sleeve 30 of the blood separation device are made of transparent materials, so that an operator can conveniently observe the distribution and flow of blood components in each layer of the blood separation device. On the basis of this, corresponding graduation marks can be arranged on the centrifugal cylinder 10, the first sleeve 20 and the second sleeve 30 to further facilitate the operation.

In the embodiment of the present application, the first fixing plate 24 has a plurality of 241, and the second fixing plate 32 has a plurality of second liquid passing holes 321. 241 and 321 are used for allowing the components in the first and

second receiving chambers

20a and 30a to pass through the first and

second fixing plates

24 and 32.

In the embodiment of the present application, the sidewall of the centrifugal cylinder 10 has an infusion hole 12 communicating with the centrifugal cavity 10a, and a sealing plug (not shown) is disposed in the infusion hole 12. The transfusion hole 12 is used for inputting blood to be centrifugally separated into the centrifugal cavity 10a, and the sealing plug can seal the transfusion hole 12 to isolate the centrifugal cavity 10a from the external environment.

In the embodiment of the present application, the first sleeve 20 includes a cylinder 21 and a sealing partition 22, and both ends of the cylinder 21 have openings. One end of the cylinder 21 is embedded in the centrifuge cylinder 10, and the sealing partition 22 is embedded in the opening of the cylinder 21 far away from the centrifuge cylinder 10. Thus, the cylinder 21 and the sealing partition 22 are detachable, the cylinder 21 can be made of hard material, and the sealing partition 22 can be made of elastic material, so that a syringe can be used to draw the contents of the first receiving chamber 20a through the sealing partition 22.

In the description of the embodiments of the application, it is to be understood that the terms "mounted," "connected," and "connected" are to be construed broadly and may include, for example, a fixed connection, an indirect connection via intermediate media, a connection between two elements, or an interaction between two elements, unless expressly stated or limited otherwise. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations. The terms "upper", "lower", "front", "rear", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience in describing and simplifying the description, but do not indicate or imply that the referred devices or elements must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention. In the description of the present invention, "a plurality" means two or more unless specifically stated otherwise.

The terms "first," "second," "third," "fourth," and the like in the description and in the claims of the present application and in the above-described drawings are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order. It is to be understood that the data so used may be interchanged under appropriate circumstances such that the embodiments of the application described herein may be implemented, for example, in sequences other than those illustrated or described herein. Furthermore, the terms "comprises," "comprising," and "having," and any variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the utility model has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A blood separation assembly, comprising a centrifuge bowl, a first sleeve and a second sleeve;

two openings of the centrifugal cylinder, which are close to two ends of the centrifugal cylinder, are respectively provided with a first neck part and a second neck part, and the inner side walls of the first neck part and the second neck part are respectively provided with a first flow through hole and a second flow through hole;

2. A blood separation assembly according to claim 1 wherein: the first sleeve comprises a cylinder body and a sealing partition plate, and two ends of the cylinder body are provided with openings; one end of the cylinder body is embedded in the centrifugal cylinder, and the sealing partition plate is embedded in an opening of the cylinder body, which is far away from one end of the centrifugal cylinder.

3. A blood separation assembly according to claim 2 wherein: the sealing partition plate is made of elastic materials.

4. A blood separation assembly according to any of claims 1-3 wherein: the side wall of the centrifugal cylinder is provided with an infusion hole communicated with the centrifugal cavity, and a sealing plug is arranged in the infusion hole.

5. A blood separation assembly according to any of claims 1-3 wherein: the first fixing plate is provided with a plurality of first liquid passing holes; the second fixing plate is provided with a plurality of second liquid passing holes.

6. A blood separation assembly according to any of claims 1-3 wherein: internal threads are arranged on the inner wall surfaces of the centrifugal cylinder close to the two openings, external threads are arranged on the outer wall surfaces of the first sleeve and the second sleeve, and the external threads of the first sleeve and the second sleeve are in threaded connection with the internal threads at the two ends of the centrifugal cylinder.