CN216458924U - Micro-fluidic chip's processing mechanism - Google Patents

Abstract

The utility model discloses a processing mechanism of a micro-fluidic chip, which comprises a rack, a conveying unit and a puncturing unit, wherein the conveying unit is arranged on the rack; the conveying unit comprises a conveying bracket, a chip fixing device and a conveying driving assembly; the conveying bracket is arranged on the rack; the chip fixing device is arranged on the conveying bracket through the conveying driving assembly; the conveying driving assembly is used for driving the chip holding device to transversely move on the conveying bracket; the puncturing unit is arranged on the rack and is positioned above the transverse moving track of the chip fixing device. The utility model can simplify the structure of the device, reduce the occupied space and process the microfluidic chip more efficiently.

Description

Micro-fluidic chip's processing mechanism

Technical Field

The utility model relates to the technical field of microfluidics, in particular to a processing mechanism of a microfluidic chip.

Background

The micro-fluidic chip is a chip integrating a plurality of experimental steps, and is generally provided with micro-size flow channels and chambers which are arranged in a certain rule, different reagents are released according to a certain sequence and flow into a designated chamber through different flow channels to complete designated biochemical reaction, so that the purposes of sample preparation, detection and the like are realized. However, the development of the current microfluidic chip is still in the early stage, and the operation of each experimental step is relatively dependent on manual work, so that the process is complex, the efficiency is low, and the popularization and application of the microfluidic technology in the fields of biology, chemistry, medicine and the like are limited to a certain extent.

In order to solve the above problems, apparatuses capable of automatically implementing each experimental step of the microfluidic chip have been purposely developed in the industry. For example, the microfluidic chip manipulation device, the microfluidic system and the microfluidic chip disclosed in the publication No. CN111135892B, the microfluidic chip manipulation device can automatically manipulate the valve body of the microfluidic chip, and is beneficial to popularization and application of the microfluidic technology. The puncturing device of the microfluidic chip control equipment drives the gear to rotate through the puncturing driving motor, and the gear drives the first pressing plate and the second pressing plate to move up and down in a lifting mode when rotating, so that the first pressing plate and the second pressing plate respectively drive the first puncturing part and the second puncturing part to move relative to the storage tube, and the first puncturing part and the second puncturing part respectively puncture a first sealing film and a second sealing film of the storage tube; in the device, the microfluidic chip is arranged in the chip holding device and moves downwards to the position under the puncturing device under the driving of the lifting mechanism, and the puncturing device performs a pressing action during puncturing, so that in an actual structure, an additional driving device is needed to drive the puncturing device to move horizontally, yielding is performed for the downward movement of the chip holding device, and therefore the relative movement steps of all parts in the operation process of the device are more, the overall structure is complex and the occupied volume is large.

SUMMERY OF THE UTILITY MODEL

The utility model aims to provide a processing mechanism of a microfluidic chip, which simplifies the structure of equipment, reduces the occupied space and has more efficient processing on the microfluidic chip.

In order to achieve the above purpose, the solution of the utility model is:

a processing mechanism of a microfluidic chip comprises a rack, a conveying unit and a puncturing unit; the conveying unit comprises a conveying bracket, a chip fixing device and a conveying driving assembly; the conveying bracket is arranged on the rack; the chip holding device is arranged on the conveying bracket through the conveying driving assembly; the conveying driving assembly is used for driving the chip holding device to transversely move on the conveying bracket; the puncturing unit is arranged on the rack and is positioned above the transverse moving track of the chip fixing device.

The conveying driving assembly comprises a screw rod, a first motor and a movable block; the screw rod is transversely arranged; the first motor is arranged on the conveying bracket and is in transmission connection with the screw rod; the movable block is movably matched on the screw rod; the chip holding device is mounted on the movable block.

The puncturing unit comprises a puncturing bracket, a linkage part, a first pressure plate, a second pressure plate and a puncturing driving assembly; the linkage piece, the first pressing plate and the second pressing plate are in sliding fit with the puncture bracket, the linkage piece can move transversely, and the first pressing plate and the second pressing plate can move vertically; the front end of the linkage piece is provided with a convex column, and the first pressing plate and the second pressing plate are respectively provided with a first through hole and a second through hole which are used for the convex column to be movably matched; the convex column penetrates through the first through hole and the second through hole simultaneously and moves in the first through hole and the second through hole along with the transverse movement of the linkage piece so as to drive the first pressing plate and the second pressing plate to move vertically; the first pressing plate and the second pressing plate vertically move and are provided with two stages when being pressed downwards, the first pressing plate and the second pressing plate are pressed downwards simultaneously in the pressing stage, and the first pressing plate continues to be pressed downwards and the second pressing plate is not moved in the pressing stage II; the puncture driving assembly is arranged on the puncture bracket and used for driving the linkage member to move transversely.

The first through hole and the second through hole are identical in starting and ending positions, the first through hole comprises a first inclined hole and a first transverse hole communicated with the upper end of the first inclined hole, the second through hole comprises a second inclined hole and a second transverse hole communicated with the upper end of the second inclined hole, the slope of the first inclined hole is smaller than or equal to that of the second inclined hole, and the length of the second transverse hole is larger than that of the first transverse hole.

The puncture support is provided with a sliding connection part, the sliding connection part is provided with a first rail, a second rail and a third rail, the first rail, the second rail and the third rail are matched with the linkage part, the first pressing plate and the second pressing plate in a sliding connection mode, the first rail is arranged along the transverse direction, and the second rail and the third rail are arranged along the vertical direction.

And the linkage piece, the first pressing plate and the second pressing plate are respectively provided with a first sliding block, a second sliding block and a third sliding block which are matched with the first rail, the second rail and the third rail.

The second pressing plate is provided with a sliding groove for the first pressing plate to be in movable fit, the bottom of the sliding groove is provided with a notch for the second sliding block to be in movable fit, and the first pressing plate is matched with the sliding groove and then the second sliding block is matched with the sliding connection part through the notch.

The puncture driving assembly comprises a second motor and a gear arranged on a rotating shaft of the second motor, a rack meshed with the gear is arranged on the linkage piece, and the rack is arranged along the transverse direction.

The lancing unit further includes a motor bracket for mounting the second motor.

The lancing unit further comprises a position detection device arranged on the lancing support, the position detection device being configured to detect the position of the linkage.

After the technical scheme is adopted, the puncturing unit and the chip fixing device are arranged up and down, the chip fixing device is driven by the conveying driving assembly to move transversely, and the chip fixing device moves transversely to the position below the puncturing unit when puncturing is carried out, the puncturing unit does not need to move, only needs to carry out puncturing operation, and has fewer processing steps of the whole structure and higher efficiency; under the condition that the puncture unit does not need to move, an additional driving device is not needed, the structure is simplified, and particularly, the occupation on the height space is smaller; in addition, the movable block is driven by the lead screw matched with the first motor to drive the chip holding device to move transversely, so that the chip holding device is higher in moving precision and more stable.

Drawings

FIG. 1 is a first perspective view of an embodiment of the present invention;

FIG. 2 is a second perspective view of the present invention;

FIG. 3 is a perspective view of FIG. 2 with the lancing unit hidden;

FIG. 4 is a first perspective view of a puncturing unit in a normal state according to an embodiment of the present invention;

FIG. 5 is a second perspective view of a puncturing unit in a normal state according to an embodiment of the utility model;

FIG. 6 is a first exploded view of a lancing unit according to an embodiment of the present invention;

FIG. 7 is a second exploded view of the lancing unit according to the present invention;

FIG. 8 is a sectional view of a lancing unit in its normal state according to one embodiment of the present invention;

FIG. 9 is a first perspective view of a first stage of lancing unit depression according to one embodiment of the present invention;

FIG. 10 is a second perspective view of a first lancing unit depression stage in accordance with the present invention;

FIG. 11 is a cross-sectional view of a first stage of lancing unit depression according to one embodiment of the present invention;

FIG. 12 is a first perspective view of a second stage of depression of the lancing unit in accordance with the present embodiment;

FIG. 13 is a second perspective view of a second stage of depression of the lancing unit in accordance with the present embodiment;

FIG. 14 is a cross-sectional view of lancing unit during stage two of depression according to one embodiment of the present invention;

the reference numbers illustrate:

1-a gantry; 2-a conveying unit; 21- - -a delivery stent;

22-a chip holding device; 23- -a lead screw; 24- -a first electric machine;

25- - -a movable block; 3- -a puncturing unit; 31- -piercing the stent;

311- -slip joint; 3111-a first track; 3112-a second track;

3113-third track; 32- -a linkage; 321-convex column;

322- -rack; 323-movable plate; 33- -a first platen;

331- -first via; 3311-first inclined hole; 3312-first transverse bore;

34- -a second platen; 341- -second via; 3411-a second angled hole;

3412-a second cross bore; 342-a chute; 343-a notch;

35- -a first slider; 36- -a second slider; 37- -third slider;

38-a limiting plate; 39-a second electric machine; 3A- - -gear;

3B- - -a motor bracket; 3C-position detection device.

Detailed Description

In order to further explain the technical solution of the present invention, the present invention is explained in detail by the following specific examples.

Referring to fig. 1 to 2, the present invention is a processing mechanism for a microfluidic chip, including a frame 1, a conveying unit 2, and a puncturing unit 3;

the conveying unit 2 comprises a conveying bracket 21, a chip holding device 22 and a conveying driving component; the conveying bracket 21 is arranged on the frame 1; the chip holding device 22 is mounted on the conveying bracket 21 through a conveying driving assembly; the conveying driving component is used for driving the chip holding device 22 to transversely move on the conveying bracket 21;

the pricking unit 3 is mounted on the frame 1 above the traverse trajectory of the chip holding device 22.

Specific embodiments of the present invention are shown below.

Referring to fig. 3, the above-mentioned conveying driving assembly includes a screw 23, a first motor 24, and a movable block 25; the screw rod 23 is transversely arranged; the first motor 24 is arranged on the conveying bracket 21 and is in transmission connection with the screw rod 23; the movable block 25 is movably matched on the screw rod 23; the chip holding device 22 is mounted on the movable block 25; when the first motor 24 is operated, the screw rod 23 is driven to rotate to drive the movable block 25 to move transversely, so as to drive the chip holding device 22 to move transversely on the conveying bracket 21. In this embodiment, the chip holder 22 is locked on the movable block 25 by bolts.

Referring to fig. 4 to 8, the lancing unit 3 includes a lancing bracket 31, a linkage 32, a first pressure plate 33, a second pressure plate 34 and a lancing drive assembly; the linkage piece 32, the first pressing plate 33 and the second pressing plate 34 are in sliding fit with the puncture support 31, the linkage piece 32 can move transversely, and the first pressing plate 33 and the second pressing plate 34 can move vertically; the front end of the linkage 32 is provided with a convex column 321, and the first pressing plate 33 and the second pressing plate 34 are respectively provided with a first through hole 331 and a second through hole 341 for the convex column 321 to be movably matched; the convex column 321 penetrates through the first through hole 331 and the second through hole 341 simultaneously, and moves in the first through hole 331 and the second through hole 341 along with the transverse movement of the linkage 32 so as to drive the first pressing plate 33 and the second pressing plate 34 to move vertically; the first pressing plate 33 and the second pressing plate 34 vertically move and are provided with two stages when being pressed downwards, the first pressing plate 33 and the second pressing plate 34 are simultaneously pressed downwards in the first pressing stage, and the first pressing plate 33 continues to be pressed downwards and the second pressing plate 34 is not moved in the second pressing stage; a lancing drive assembly is mounted on lancing carriage 31 for driving linkage 32 for lateral movement.

Furthermore, the positions of the first through hole 331 and the second through hole 341 are the same, and the first through hole 331 includes a first inclined hole 3311 and a first cross hole 3312 communicating with the upper end of the first inclined hole 3311, and the second through hole 341 includes a second inclined hole 3411 and a second cross hole 3412 communicating with the upper end of the second inclined hole 3411, the slope of the first inclined hole 3311 is smaller than or equal to that of the second inclined hole 3411, and correspondingly, the length of the second cross hole 3412 is greater than that of the first cross hole 3312, so that when the convex pillar 321 moves in the first through hole 331 and the second through hole 341, the stage in which the convex pillar 321 moves from the second inclined hole 3411 to the second cross hole 3412 is the first pressing stage, and the stage in which the convex pillar 321 moves from one end of the second cross hole 3412 to the other end thereof is the second pressing stage. In the first pressing stage, the convex pillar 321 moves transversely with the linkage 32, and presses the first pressing plate 33 and the second pressing plate 34 downwards at the same time by pressing the side walls of the first inclined hole 3311 and the second inclined hole 3411; then, in the second pressing stage, since the convex pillar 321 is already located in the second cross hole 3412 in the second through hole 341, when the convex pillar 321 continues to move laterally along with the linkage 32, the second pressing plate 34 will not be pressed down any more, and the first pressing plate 33 continues to be pressed down before the convex pillar 321 enters the first cross hole 3312, so as to perform the puncturing operation. In the case that the slope of the first inclined hole 3311 is smaller than that of the second inclined hole 3411, the thickness of the convex pillar 321 and the matching position of the first through hole 331 and the second through hole 341 are the same; in the case that the slope of the first inclined hole 3311 is equal to that of the second inclined hole 3411, the width of the first inclined hole 3311 may be set to be smaller than that of the second inclined hole 3411, the thickness of the position where the protruding column 321 is engaged with the first through hole 331 and the second through hole 341 is adapted to the width of the inclined hole, and the length of the first inclined hole 3311 is greater than that of the second inclined hole 3411.

Furthermore, the above-mentioned support 31 is provided with a sliding part 311, the sliding part 311 is provided with a first rail 3111, a second rail 3112 and a third rail 3113 for the linkage 32, the first pressing plate 33 and the second pressing plate 34 to slide and engage, wherein the first rail 3111 is arranged along the horizontal direction, and the second rail 3112 and the third rail 3113 are arranged along the vertical direction. In this embodiment, the first rail 3111, the second rail 3112 and the third rail 3113 are respectively arranged on two sides of the sliding portion 311, so as to avoid interference between the link 32 and the first and second pressing plates 33 and 34 when moving respectively; the linkage piece 32, the first pressing plate 33 and the second pressing plate 34 are respectively provided with a first sliding block 35, a second sliding block 36 and a third sliding block 37 which are matched with the first rail 3111, the second rail 3112 and the third rail 3113, the matching of the sliding blocks and the rails can ensure the direction stability of the linkage piece 32, the first pressing plate 33 and the second pressing plate 34 during movement, the first sliding block 35, the second sliding block 36 and the third sliding block 37, the linkage piece 32, the first pressing plate 33 and the second pressing plate 34 can be designed in a split mode, and the first sliding block 35, the second sliding block 36 and the third sliding block 37 and the linkage piece 32, the first pressing plate 33 and the second pressing plate 34 are locked on corresponding parts through bolts; a sliding groove 342 for the first pressing plate 33 to be movably matched is formed in the second pressing plate 34, a notch 343 for the second sliding block 36 to be movably matched is formed in the bottom of the sliding groove 342, and after the first pressing plate 33 is matched with the sliding groove 342, the second sliding block 36 is matched with the sliding connection part 311 through the notch 343; the puncturing unit 3 further comprises a limiting plate 38 disposed on the surface of the second pressing plate 34, and the limiting plate 38 and the second pressing plate 34 are clamped on both sides of the first pressing plate 33 to prevent the first pressing plate 33 from moving up and down and falling off to deviate from the working position.

Further, the piercing driving assembly includes a second motor 39 and a gear 3A disposed on a rotating shaft of the second motor 39, a rack 322 engaged with the gear 3A is disposed on the linkage member 32, the rack 322 is disposed along a transverse direction, and when the gear 3A is driven by the second motor 39 to rotate, the gear 3A drives the rack 322 to move transversely, that is, the linkage member 32 is driven to move transversely. The gear 3A is driven by the second motor 39 to drive the rack 322 to move, the circumferential rotation of the second motor 39 can be converted into the transverse movement of the linkage piece 32, the second motor 39 is vertically arranged to keep the same height with the linkage piece 32, the requirement of the overall structure on the height space can be reduced, and the volume of the final equipment is smaller. In this embodiment, the pricking unit 3 further comprises a motor bracket 3B for mounting the second motor 39, and the motor bracket 3B is fixed on the pricking bracket 31 through a bolt for fixing the second motor 39; the second motor 39 is a dc gear motor.

Further, the pricking unit 3 further comprises a position detecting device 3C disposed on the pricking bracket 31, wherein the position detecting device 3C is configured to detect a position of the linkage member 32, so as to automatically start and stop the driving device after the linkage member 32 moves to the predetermined position.

Further, the position detecting device 3C is a photoelectric sensor, the linkage 32 is provided with a movable plate 323 arranged opposite to the photoelectric sensor, and the movable plate 323 enters or leaves a triggering position of the photoelectric sensor along with the transverse movement of the linkage 32; the two position detection devices 3C are respectively and correspondingly arranged at the position of the linkage member 32 when the first pressing plate 33 rises to the top and the position of the linkage member 32 when the first pressing plate 33 falls to the bottom, namely, the two position detection devices 3C are used for detecting whether the linkage member 32 moves to the beginning and end positions in the working process, and the two ends of the linkage member 32 are respectively and correspondingly provided with a movable sheet 323.

Referring to fig. 9 to 11, when the puncturing unit 3 is in the second stage of pressing down, the second motor 39 drives the gear 3A to rotate, the gear 3A drives the linking member 32 to move rightward through the rack 322, the protruding pillar 321 on the linking member 32 moves at the positions of the first inclined hole 3311 of the first through hole 331 and the second inclined hole 3411 of the second through hole 341, and since the first inclined hole 3311 and the second inclined hole 3411 are both inclined upward, the protruding pillar 321 applies pressure to the lower side walls of the first inclined hole 3311 and the second inclined hole 3411, so that the first pressure plate 33 and the second pressure plate 34 move downward to realize the pressing down action until the protruding pillar 321 moves to the boundary between the second inclined hole 3411 and the second transverse hole 3412, at which time the second pressure plate 34 should finish the action of pressing the sealing film and no longer moves downward, and the present invention enters the second stage of pressing down.

Referring to fig. 12 to 14, when the puncturing unit 3 is in the pressing-down stage, the second motor 39 continues to drive the gear 3A to rotate, the gear 3A drives the linking member 32 to continue moving rightward through the rack 322, the convex pillar 321 on the linking member 32 moves at the positions of the first inclined hole 3311 of the first through hole 331 and the second transverse hole 3412 of the second through hole 341, and since the convex pillar 321 is still in the first inclined hole 3311, the convex pillar 321 continues to move the first pressing plate 33 downward until the convex pillar 321 moves to the boundary between the first inclined hole 3311 and the first transverse hole 3312, and at this time, the first pressing plate 33 should complete the puncturing operation and no longer move downward. At the same time, the photoelectric sensor at the right end of the piercing support 31 detects the movable plate 323 at the right end of the linkage 32 and sends a signal to the control system of the apparatus to shut down the second motor 39.

Through the scheme, the puncturing unit 3 and the chip fixing device 22 are arranged up and down, the chip fixing device 22 moves transversely under the driving of the conveying driving component, and moves transversely below the puncturing unit 3 when puncturing, the puncturing unit 3 does not need to move, only needs to perform puncturing operation, and has fewer processing steps of the whole structure and higher efficiency; under the condition that the puncture unit 3 does not need to move, an additional driving device does not need to be arranged, the structure is simplified, and the occupation on the height space is smaller; in addition, the movable block 25 is driven by the lead screw 23 in cooperation with the first motor 24 to drive the chip holding device 22 to move transversely, so that the chip holding device 22 moves more accurately and stably.

The above embodiments and drawings are not intended to limit the form and style of the present invention, and any suitable changes or modifications thereof by those skilled in the art should be considered as not departing from the scope of the present invention.

Claims (10)

1. A processing mechanism of a micro-fluidic chip is characterized in that:

comprises a frame, a conveying unit and a puncturing unit;

the conveying unit comprises a conveying bracket, a chip fixing device and a conveying driving assembly; the conveying bracket is arranged on the rack; the chip holding device is arranged on the conveying bracket through the conveying driving assembly; the conveying driving assembly is used for driving the chip holding device to transversely move on the conveying bracket;

the puncturing unit is arranged on the rack and is positioned above the transverse moving track of the chip fixing device.

2. The processing mechanism for microfluidic chips according to claim 1, wherein:

the conveying driving assembly comprises a screw rod, a first motor and a movable block;

the screw rod is transversely arranged;

the first motor is arranged on the conveying bracket and is in transmission connection with the screw rod;

the movable block is movably matched on the screw rod;

the chip holding device is mounted on the movable block.

3. The handling mechanism for microfluidic chips according to claim 1, wherein:

the puncturing unit comprises a puncturing bracket, a linkage part, a first pressure plate, a second pressure plate and a puncturing driving assembly;

the linkage part, the first pressing plate and the second pressing plate are in sliding fit with the puncture support, the linkage part can move transversely, and the first pressing plate and the second pressing plate can move vertically;

the front end of the linkage piece is provided with a convex column, and the first pressing plate and the second pressing plate are respectively provided with a first through hole and a second through hole which are used for the convex column to be movably matched;

the convex column penetrates through the first through hole and the second through hole simultaneously and moves in the first through hole and the second through hole along with the transverse movement of the linkage piece so as to drive the first pressing plate and the second pressing plate to move vertically;

the first pressing plate and the second pressing plate vertically move and are provided with two stages when being pressed downwards, the first pressing plate and the second pressing plate are pressed downwards simultaneously in the pressing stage, and the first pressing plate continues to be pressed downwards and the second pressing plate is not moved in the pressing stage II;

the puncture driving assembly is arranged on the puncture bracket and used for driving the linkage member to move transversely.

4. The processing mechanism for microfluidic chips according to claim 3, wherein:

the first through hole and the second through hole are identical in starting and ending positions, the first through hole comprises a first inclined hole and a first transverse hole communicated with the upper end of the first inclined hole, the second through hole comprises a second inclined hole and a second transverse hole communicated with the upper end of the second inclined hole, the slope of the first inclined hole is smaller than or equal to that of the second inclined hole, and the length of the second transverse hole is larger than that of the first transverse hole.

5. The processing mechanism for microfluidic chips according to claim 3, wherein:

the puncture support is provided with a sliding connection part, the sliding connection part is provided with a first rail, a second rail and a third rail, the first rail, the second rail and the third rail are matched with the linkage part, the first pressing plate and the second pressing plate in a sliding connection mode, the first rail is arranged along the transverse direction, and the second rail and the third rail are arranged along the vertical direction.

6. The handling mechanism for microfluidic chips according to claim 5, wherein:

and the linkage piece, the first pressing plate and the second pressing plate are respectively provided with a first sliding block, a second sliding block and a third sliding block which are matched with the first rail, the second rail and the third rail.

7. The processing mechanism for microfluidic chips according to claim 6, wherein:

the second pressing plate is provided with a sliding groove for the first pressing plate to be in movable fit, the bottom of the sliding groove is provided with a notch for the second sliding block to be in movable fit, and the first pressing plate is matched with the sliding groove and then the second sliding block is matched with the sliding connection part through the notch.

8. The processing mechanism for microfluidic chips according to claim 3, wherein:

the puncture driving assembly comprises a second motor and a gear arranged on a rotating shaft of the second motor, a rack meshed with the gear is arranged on the linkage piece, and the rack is arranged along the transverse direction.

9. The processing mechanism for microfluidic chips according to claim 8, wherein:

the lancing unit further includes a motor bracket for mounting the second motor.

10. The processing mechanism for microfluidic chips according to claim 3, wherein:

the lancing unit further comprises a position detection device arranged on the lancing support, the position detection device being configured to detect the position of the linkage.

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