CN110646631A - Calibration liquid, sample liquid conveying and heating device and POCT detection equipment - Google Patents

Calibration liquid, sample liquid conveying and heating device and POCT detection equipment Download PDF

Info

Publication number
CN110646631A
CN110646631A CN201911030325.3A CN201911030325A CN110646631A CN 110646631 A CN110646631 A CN 110646631A CN 201911030325 A CN201911030325 A CN 201911030325A CN 110646631 A CN110646631 A CN 110646631A
Authority
CN
China
Prior art keywords
calibration
heating
sample liquid
sample
driving
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201911030325.3A
Other languages
Chinese (zh)
Inventor
胡伟
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanjing Jing Jie Biological Technology Co Ltd
Original Assignee
Nanjing Jing Jie Biological Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanjing Jing Jie Biological Technology Co Ltd filed Critical Nanjing Jing Jie Biological Technology Co Ltd
Priority to CN201911030325.3A priority Critical patent/CN110646631A/en
Publication of CN110646631A publication Critical patent/CN110646631A/en
Pending legal-status Critical Current

Links

Images

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009Characterised by arrangements for controlling the aspiration or dispense of liquids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346Heating or cooling arrangements
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027General features of the devices
    • G01N2035/1048General features of the devices using the transfer device for another function
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584Control arrangements for automatic analysers
    • G01N35/00594Quality control, including calibration or testing of components of the analyser
    • G01N35/00693Calibration

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

The invention discloses a calibration liquid, sample liquid conveying and heating device and POCT detection equipment, belonging to the technical field of POCT detection, comprising a supporting mechanism, wherein a detection card is arranged on the supporting mechanism, and a calibration liquid bag and an air bag are respectively arranged at the upper side and the lower side in the detection card; the calibration liquid feeding mechanism is arranged on the supporting mechanism and can crush the calibration liquid bag to enable the calibration liquid to flow to the electrode plate of the detection card; the heating mechanism is arranged on the supporting mechanism and positioned below the detection card and is configured to heat the electrode plate; the sample liquid feeding mechanism is arranged on the supporting mechanism and positioned below the detection card, and can extrude the air bag to blow the sample liquid in the sample injection area of the detection card to the electrode plate; and the driving mechanism is arranged on the supporting mechanism and is configured to drive the sample liquid feeding mechanism and the heating mechanism to ascend or descend along the vertical direction. Compared with the prior art, the automatic calibration device is compact in structure and convenient to install, can realize stable conveying of calibration liquid and sample liquid, and improves accuracy of detection results.

Description

Calibration liquid, sample liquid conveying and heating device and POCT detection equipment
Technical Field
The invention relates to the technical field of POCT detection, in particular to a calibration liquid, a sample liquid conveying and heating device and POCT detection equipment.
Background
POCT (point-of-care testing), which refers to a new method for rapidly obtaining test results, is a clinical test performed near a patient, usually not necessarily performed by a clinical laboratory technician, but performed immediately at a sampling site, and thus a complicated processing procedure for a sample in a laboratory test is omitted.
Need realize the heating to the detection card, the transport of calibration liquid and the transport of sample liquid among the POCT check out test set, the one-time tight or rotary mechanism that currently generally adopts drives the extruded form of axle type part and realizes carrying calibration liquid and sample liquid and the heating to detecting the card, realizes that the structure of three function is complicated relatively, and three structure all sets up alone moreover for the POCT check out test set is bulky, and occupation space is great.
Disclosure of Invention
The invention aims to provide a calibration liquid, a sample liquid conveying and heating device and POCT detection equipment, and aims to solve the problems that in the prior art, the POCT detection equipment is large in size and large in occupied space due to the fact that three structures for conveying the calibration liquid, conveying the sample liquid and heating the sample liquid are independently arranged.
As the conception, the technical scheme adopted by the invention is as follows:
a calibration fluid, sample fluid delivery and heating apparatus comprising:
the device comprises a supporting mechanism, a detection card and a calibration liquid bag, wherein the detection card is arranged on the supporting mechanism, and the calibration liquid bag and the air bag are respectively arranged on the upper side and the lower side in the detection card;
the calibration liquid feeding mechanism is arranged on the supporting mechanism and is configured to crush the calibration liquid bag so as to enable the calibration liquid to flow to the electrode plate of the detection card;
the heating mechanism is arranged on the supporting mechanism and positioned below the detection card and is configured to heat the electrode plate;
the sample liquid feeding mechanism is arranged on the supporting mechanism and is positioned below the detection card, and is configured to be capable of extruding the air bag so as to blow the sample liquid in the sample injection area of the detection card to the electrode plate;
and a driving mechanism provided on the support mechanism and configured to drive the sample liquid feeding mechanism and the heating mechanism to ascend or descend in a vertical direction.
Furthermore, the sample liquid feeding mechanism is located below the heating mechanism, a first elastic piece is arranged between the sample liquid feeding mechanism and the heating mechanism, a second elastic piece is arranged between the heating mechanism and the supporting mechanism, the first elastic piece and the second elastic piece extend in the vertical direction, and the elastic coefficient of the first elastic piece is smaller than that of the second elastic piece.
Further, the sample liquid feeding mechanism comprises a driving plate and an extrusion block convexly arranged on the driving plate; the heating mechanism comprises a bearing plate and a heating element arranged on the bearing plate, and a through hole for the extrusion block to pass through is formed in the position, opposite to the extrusion block, of the bearing plate.
Furthermore, a guide post extending along the vertical direction is arranged on the supporting mechanism, and the guide post penetrates through the sample liquid feeding mechanism and the heating mechanism.
Further, the driving mechanism comprises a first driving member and a driving block, the driving block is located below the sample liquid feeding mechanism and abuts against the sample liquid feeding mechanism, and the first driving member is configured to drive the driving block to move along a first direction so as to drive the sample liquid feeding mechanism to ascend or descend.
Further, along first direction and orientation the direction of first driving piece, the interval sets up three step faces that highly increases gradually on the drive block in proper order, adjacent two connect through the inclined plane between the step face, sample liquid feed mechanism can the butt in step face or the inclined plane.
Further, the calibration liquid feeding mechanism comprises a second driving piece and a pressure head, the pressure head and the second driving piece are both located above the detection card, and the second driving piece is configured to drive the pressure head to move in the vertical direction.
Further, the calibration liquid feeding mechanism further comprises a support, the support is arranged on the supporting mechanism, and the second driving piece is arranged on the support.
Furthermore, a through hole is formed in the support, a sliding rod extending in the vertical direction is arranged on the pressure head, and the sliding rod is arranged in the through hole in a penetrating mode and can slide relative to the through hole.
In order to achieve the above object, the present invention further provides a POCT detection apparatus, which includes the calibration solution, the sample solution delivery and the heating device.
The invention has the beneficial effects that:
according to the calibration liquid, the sample liquid conveying and heating device and the POCT detection equipment, the POCT detection equipment is provided with the calibration liquid, the sample liquid conveying and heating device, the calibration liquid feeding mechanism, the heating mechanism and the sample liquid feeding mechanism are arranged on the supporting mechanism, and the driving mechanism drives the sample liquid feeding mechanism and the heating mechanism to ascend or descend. In addition, on the basis of compact structure, the three processes of conveying the calibration liquid, conveying the sample liquid and heating are separated, so that mutual interference of the three processes is avoided, and the sequence of the three processes can be adjusted according to actual detection requirements.
Drawings
FIG. 1 is a schematic structural diagram of a calibration solution and a sample solution conveying and heating device provided by the invention;
FIG. 2 is a disassembled schematic view of a calibration solution and a sample solution conveying and heating device provided by the invention;
FIG. 3 is a schematic structural view of a support structure provided by the present invention;
FIG. 4 is a schematic structural diagram of a test card provided by the present invention;
FIG. 5 is a schematic structural diagram of a calibration solution feeding mechanism provided by the present invention;
FIG. 6 is a schematic structural view of a heating mechanism and a sample liquid feeding mechanism according to the present invention;
fig. 7 is a schematic structural diagram of a driving mechanism provided in the present invention.
In the figure:
1. a support mechanism; 11. a support frame; 111. mounting grooves; 112. a notch; 12. a guide post; 13. a guide bar; 14. a first elastic member; 15. a second elastic member;
2. detecting the card; 21. an electrode plate region; 211. an electrode plate; 22. a sample introduction area; 23. the calibration solution enters the zone;
3. a calibration liquid feeding mechanism; 31. a support; 311. perforating holes; 32. a second driving member; 33. a pressure head; 34. a slide bar;
4. a heating mechanism; 41. a carrier plate; 411. a through hole; 42. an installation table;
5. a sample liquid feeding mechanism; 51. a drive plate; 511. a slider; 52. extruding the block;
6. a drive mechanism; 61. a first driving member; 62. a drive block; 621. a first step surface; 622. a second step surface; 623. a third step surface; 624. a bevel; 625. and (4) a guide hole.
Detailed Description
In order to make the technical problems solved, the technical solutions adopted and the technical effects achieved by the present invention clearer, the technical solutions of the present invention are further described below by way of specific embodiments with reference to the accompanying drawings. It is to be understood that the specific embodiments described herein are merely illustrative of the invention and are not limiting of the invention. It should be further noted that, for the convenience of description, only some but not all of the elements associated with the present invention are shown in the drawings.
In the description of the present invention, unless expressly stated or limited otherwise, the terms "connected," "connected," and "fixed" are to be construed broadly, e.g., as meaning permanently connected, removably connected, or integral to one another; can be mechanically or electrically connected; either directly or indirectly through intervening media, either internally or in any other relationship. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
In the present invention, unless otherwise expressly stated or limited, "above" or "below" a first feature means that the first and second features are in direct contact, or that the first and second features are not in direct contact but are in contact with each other via another feature therebetween. Also, the first feature being "on," "above" and "over" the second feature includes the first feature being directly on and obliquely above the second feature, or merely indicating that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature includes the first feature being directly under and obliquely below the second feature, or simply meaning that the first feature is at a lesser elevation than the second feature.
In the description of the present embodiment, the terms "upper", "lower", "right", etc. are used in an orientation or positional relationship based on that shown in the drawings only for convenience of description and simplicity of operation, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first" and "second" are used only for descriptive purposes and are not intended to have a special meaning.
As shown in fig. 1 to 7, the present embodiment provides a calibration liquid, sample liquid transporting and heating apparatus including a support mechanism 1, a calibration liquid feed mechanism 3, a heating mechanism 4, a sample liquid feed mechanism 5, and a drive mechanism 6. Wherein, be provided with detection card 2 on the supporting mechanism 1, the upper and lower both sides in the detection card 2 are provided with calibration liquid package (not shown in the figure) and gasbag (not shown in the figure) respectively, and it can be understood that detects card 2 level and places on supporting mechanism 1, and the inside upside of detecting card 2 is provided with calibration liquid package, and the inside downside of detecting card 2 is provided with the gasbag. The calibration liquid feeding mechanism 3 is arranged on the supporting mechanism 1 and can crush the calibration liquid bag so that the calibration liquid in the calibration liquid bag flows to the electrode plate 211 of the detection card 2. The heating mechanism 4 is provided on the support mechanism 1 and located below the detection card 2, and can heat the electrode plate 211. The sample liquid feeding mechanism 5 is disposed on the supporting mechanism 1 and below the detection card 2, and can extrude the air bag, and blow the sample liquid in the sample introduction region 22 of the detection card 2 to the electrode plate 211 of the detection card 2 by using the gas in the air bag. The driving mechanism 6 can drive the sample liquid feeding mechanism 5 and the heating mechanism 4 to ascend or descend along the vertical direction, and it can be understood that when the driving mechanism 6 drives the sample liquid feeding mechanism 5 to ascend, the sample liquid feeding mechanism 5 can press the air bag, so that the sample liquid in the sample introduction area 22 of the detection card 2 is blown to the electrode plate 211 of the detection card 2 by the gas in the air bag. When the heating mechanism 4 is driven by the driving mechanism 6 to move up and come into contact with the detection card 2, the electrode plate 211 on the detection card 2 can be heated.
Specifically, as shown in fig. 3, the supporting mechanism 1 includes a supporting frame 11, the supporting frame 11 is a cubic frame structure, and the top of the supporting frame 11 has two first arms oppositely spaced from each other, a mounting groove 111 is provided between the two first arms, and the mounting groove 111 is used for mounting the detection card 2. In order to facilitate the sample liquid feeding mechanism 5 below the detection card 2 to extrude the air bag on the detection card 2, a notch 112 is formed on the bottom plate of the mounting groove 111 at a position corresponding to the air bag.
In addition, the bottom of support frame 11 has the second arm that two relative intervals set up, and every second arm all is located a first arm below, and the second arm is parallel with first arm, all has guide post 12 along the vertical direction extension between every first arm and the second arm that corresponds, and the both ends of guide post 12 are connected respectively in corresponding first arm and second arm. In the present embodiment, two guide posts 12 are disposed between each first arm and the corresponding second arm, and the two guide posts 12 are disposed in parallel and spaced apart. Of course, in other embodiments, the number of the guide posts 12 can be set according to actual needs, such as one, three or more than three. Two third arms which are parallel to each other are connected between the two second arms, and the third arms are perpendicular to the second arms. A guide rod 13 extending along a first direction is arranged between the two second arms, the first direction is the same as the extending direction of the second arms, as shown in fig. 3, the first direction is cd direction in the figure, and the vertical direction is ab direction in the figure. In the present embodiment, two guide rods 13 are provided, but in other embodiments, the number of the guide rods 13 may be set according to actual needs, such as one, three or more than three.
Specifically, as shown in fig. 4, an electrode plate area 21, a sample injection area 22 and a calibration solution inlet area 23 are arranged inside the detection card 2, an electrode plate 211 is arranged in the electrode plate area 21, a calibration solution bag is arranged in the calibration solution inlet area 23, the sample injection area 22 and the calibration solution inlet area 23 are respectively connected to the electrode plate area 21 through grooves, and the air bag is arranged below the calibration solution inlet area 23. After the calibration liquid package is crushed, the calibration liquid in the calibration liquid package flows to the electrode plate area 21 along the groove between the calibration liquid inlet area 23 and the electrode plate area 21. It can be understood that in order to avoid the influence of the external environment on the measurement result, the electrode plate area 21 is designed to be a relatively closed space, so that the sample liquid injected into the sample injection area 22 needs to be pushed by an external force to flow to the electrode plate area 21, and therefore, the bottom of the detection card 2 is provided with an air bag, the air bag is pressed by the sample liquid feeding mechanism 5, and the sample liquid in the sample injection area 22 is blown to the electrode plate area 21 by the gas in the air bag. The detection card 2 is a common structure in the prior art, and the rest of the structure is not described herein.
Specifically, as shown in fig. 5, the calibration liquid feeding mechanism 3 includes a bracket 31, a second driving member 32 and a pressing head 33, the bracket 31 is a zigzag mechanism, and the bracket 31 is mounted on two first arms of the supporting frame 11. Second driving piece 32 is installed on support 31, and pressure head 33 is connected in the output of second driving piece 32, and pressure head 33 is located inside support 31, and second driving piece 32 and pressure head 33 all are located and detect 2 tops, and pressure head 33 can be at vertical direction upward reciprocating motion under the drive of second driving piece 32. Specifically, the pressure head 33 is a disk-shaped mechanism capable of increasing the contact area with the calibration liquid pack, thereby allowing the calibration liquid to flow into the electrode plate region 21 as much as possible. In addition, in this embodiment, the second driving member 32 is a linear stepping motor, and the feeding speed of the linear stepping motor is controlled to eliminate air bubbles in the calibration solution, thereby improving the accuracy of the subsequent detection result. Of course, the structure of the second driving member 32 in the present embodiment is not limited to this, and the second driving member 32 may also be a step cylinder or the like.
In addition, in order to improve the moving stability of the pressing head 33, in this embodiment, the pressing head 33 is provided with a sliding rod 34 extending along the vertical direction, a through hole 311 is opened at a position of the bracket 31 corresponding to the sliding rod 34, and the sliding rod 34 is inserted into the through hole 311 and can slide relative to the through hole 311. In the present embodiment, two sliding rods 34 are provided, and two sliding rods 34 are oppositely provided at two sides of the pressing head 33, however, in other embodiments, the number of the sliding rods 34 may be set according to actual needs, such as one, three, or more than three.
As shown in fig. 2 and 5, in order to further simplify the structure of the calibration liquid, sample liquid feeding and heating apparatus, in the present embodiment, both the heating mechanism 4 and the sample liquid feeding mechanism 5 are driven by the driving mechanism 6. Specifically, the heating mechanism 4 includes a carrier plate 41 and a mounting table 42 disposed on the carrier plate 41, the mounting table 42 corresponds to the electrode plate 211 in the detection card 2, and a heating member (not shown in the figure) is mounted on the mounting table 42, and when the heating mechanism 4 is driven by the driving mechanism 6 to ascend, so that the heating member abuts against the detection card 2, the heating member can heat the electrode plate 211.
The sample liquid feeding mechanism 5 comprises a driving plate 51 and a pressing block 52 protruding from the driving plate 51, the driving plate 51 is parallel to the bearing plate 41, and the driving plate 51 is connected to the output end of the driving mechanism 6. The corresponding position of the bearing plate 41 and the extrusion block 52 is provided with a through hole 411 for the extrusion block 52 to pass through, the through hole 411 is communicated with the notch 112 on the bottom plate of the mounting groove 111, and further the extrusion block 52 can pass through the through hole 411 and the notch 112 to extrude the air bag on the detection card 2.
The guide posts 12 are inserted into the driving plate 51 and the carrier plate 41, and the four guide posts 12 are respectively located at four corners of the driving plate 51, it can be understood that the driving plate 51 and the carrier plate 41 can slide along the guide posts 12 under the driving of the driving mechanism 6. In order to realize that the driving plate 51 and the bearing plate 41 can be driven by the driving mechanism 6, a first elastic member 14 is arranged between the driving plate 51 and the bearing plate 41, a second elastic member 15 is arranged between the bearing plate 41 and the first arm of the supporting frame 11, the first elastic member 14 and the second elastic member 15 extend along the vertical direction, and the elastic coefficient of the first elastic member 14 is smaller than that of the second elastic member 15. In this embodiment, the first elastic element 14 and the second elastic element 15 are both springs, and the first elastic element 14 and the second elastic element 15 are both sleeved on the guide post 12. It can be understood that, in order to enable the driving plate 51 and the carrier plate 41 to stably move, each guide post 12 is sleeved with the first elastic member 14 and the second elastic member 15.
By setting the elastic coefficient of the first elastic member 14 to be smaller than that of the second elastic member 15, when the driving mechanism 6 drives the driving plate 51 to ascend, the second elastic member 15 can be contracted first, at this time, the driving plate 51 and the bearing plate 41 ascend together until the heating member on the bearing plate 41 abuts against the detection card 2, at this time, the second elastic member 15 reaches the maximum compression amount, and the heating member can heat the electrode plate 211. Then, the driving plate 51 continues to ascend, and the first elastic member 14 starts to contract because the second elastic member 15 has reached the maximum compression amount, at which time the driving plate 51 ascends alone, and the pressing blocks 52 contact and press the air bag through the through holes 411 and the notches 112 in sequence.
As shown in fig. 6 and 7, the driving mechanism 6 includes a first driving member 61 and a driving block 62, the driving block 62 is located below the driving plate 51 and abuts against the driving plate 51, and the first driving member 61 can drive the driving block 62 to move along a first direction, so as to drive the driving plate 51 to ascend or descend. Specifically, along the first direction and the direction toward the first driving member 61, three step surfaces with gradually increasing height are sequentially arranged on the driving block 62 at intervals, and two adjacent step surfaces are connected by an inclined surface 624. The driving plate 51 is provided with a sliding piece 511, the sliding piece 511 can abut against a step surface or an inclined surface 624, and when the first driving piece 61 drives the driving block 62 to move along the first direction, the sliding piece 511 can slide along the inclined surface 624 or the step surface and gradually ascend or descend.
Specifically, for convenience of description, three step surfaces with gradually increasing heights are sequentially defined as a first step surface 621, a second step surface 622, and a third step surface 623, and when the first driver 61 drives the driving block 62 to move away from the first driver 61, the sliding member 511 rises from the first step surface 621 to the second step surface 622, and at this time, the heating member abuts against the detection card 2 to heat the electrode plate 211, that is, the height difference between the first step surface 621 and the second step surface 622 is equal to the maximum compression amount of the second elastic member 15. When the first driving element 61 continues to drive the driving block 62 to move away from the first driving element 61, the sliding element 511 gradually rises from the second step surface 622 to the third step surface 623, and in the process, the squeezing block 52 passes through the through hole 411 and the notch 112 to contact with the air bag and squeeze the air bag, so that the sample liquid in the sample injection region 22 is blown to the electrode plate region 21.
In order to reduce the friction between the sliding member 511 and the step surface and the inclined surface 624, it is preferable that the sliding member 511 is a roller in this embodiment, but in other embodiments, the sliding member 511 may be a slider having an arc-shaped surface to reduce the contact area between the sliding member 511 and the step surface or the inclined surface 624 as much as possible. In addition, in order to improve the stability of the driving block 62 during movement, in the present embodiment, the driving block 62 is provided with guide holes 625 on both sides of the second direction, two guide holes 625 are respectively provided in one-to-one correspondence with the two guide rods 13, and each guide rod 13 is inserted into the corresponding guide hole 625. The second direction is perpendicular to the first direction and perpendicular to the vertical direction, in particular, the second direction is as shown in fig. 7 as ef direction.
The operation of the calibration liquid, sample liquid delivering and heating apparatus will be described in detail below.
1. The test card 2 is installed in the installation groove 111, and the side of the test card 2 having the calibration liquid pack faces upward and the side having the air bag faces downward.
2. The first driving member 61 drives the driving block 62 to move away from the first driving member 61, the sliding member 511 gradually rises from the first step surface 621 to the second step surface 622 along the inclined surface 624, the heating member abuts against the detection card 2 and heats the electrode plate 211, and in the process, the driving plate 51 and the loading plate 41 rise synchronously.
3. The second driving member 32 drives the ram 33 to move downwards and extrude the calibration liquid bag, and the calibration liquid flows to the electrode plate area 21 along the groove between the calibration liquid inlet area 23 and the electrode plate area 21 after the calibration liquid bag is crushed, so that the calibration liquid is conveyed.
4. The first driving member 61 continues to drive the driving block 62 to move towards a square far away from the first driving member 61, the sliding member 511 gradually rises along the inclined surface 624 from the second step surface 622, at this time, the driving plate 51 rises alone, the pressing block 52 passes through the through hole 411 and the notch 112 and then contacts with and presses the air bag, the sample liquid in the sample injection region 22 is blown to the electrode plate region 21 by the gas in the air bag, and when the sliding member 511 rises to the third step surface 623, the transportation of the sample liquid is completed.
After the above actions are completed, the first driving member 61 and the second driving member 32 respectively drive the driving block 62 and the pressing head 33 to return to their original positions, and in the process, the driving plate 51 and the bearing plate 41 gradually return to their original positions.
In conclusion, the calibration liquid that this embodiment provided, sample liquid is carried and heating device, through with calibration liquid feed mechanism 3, heating mechanism 4 and sample liquid feed mechanism 5 all set up on supporting mechanism 1, actuating mechanism 6 drive sample liquid feed mechanism 5 and heating mechanism 4 rise or descend, compare in prior art, compact structure, be convenient for install and occupation space is less, and detection card 2 is inside upper and lower both sides are provided with calibration liquid package and gasbag respectively, carry the calibration liquid through the mode of calibration liquid feed mechanism 3 extrusion calibration liquid package, carry sample liquid through sample liquid feed mechanism 5 extrusion gasbag, can realize the stable transport of calibration liquid and sample liquid, the accuracy of testing result has been improved. In addition, on the basis of compact structure, the three processes of conveying the calibration liquid, conveying the sample liquid and heating are separated, mutual interference of the three processes is avoided, the sequence of the three processes can be adjusted according to actual detection requirements, and the use flexibility and the universality of the device are improved.
The embodiment also provides POCT detection equipment which is provided with the calibration liquid and sample liquid conveying and heating device, and has the advantages of compact structure, small volume and small occupied space.
The foregoing embodiments are merely illustrative of the principles and features of this invention, which is not limited to the above-described embodiments, but rather is susceptible to various changes and modifications without departing from the spirit and scope of the invention, which changes and modifications are within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims (10)

1. A calibration liquid, sample liquid conveying and heating device, characterized by comprising:
the device comprises a supporting mechanism (1), wherein a detection card (2) is arranged on the supporting mechanism (1), and a calibration liquid bag and an air bag are respectively arranged at the upper side and the lower side in the detection card (2);
the calibration liquid feeding mechanism (3) is arranged on the supporting mechanism (1) and is configured to crush the calibration liquid bag so as to enable the calibration liquid to flow to the electrode plate (211) of the detection card (2);
a heating mechanism (4) disposed on the support mechanism (1) and below the detection card (2), and configured to heat the electrode plate (211);
a sample liquid feeding mechanism (5) which is arranged on the supporting mechanism (1) and is positioned below the detection card (2), and is configured to be capable of pressing the air bag so as to blow the sample liquid in the sample inlet area (22) of the detection card (2) to the electrode plate (211);
and a driving mechanism (6) which is arranged on the supporting mechanism (1) and is configured to drive the sample liquid feeding mechanism (5) and the heating mechanism (4) to ascend or descend along the vertical direction.
2. The calibrator, sample fluid transportation and heating apparatus according to claim 1, wherein the sample fluid feeding mechanism (5) is located below the heating mechanism (4), a first elastic member (14) is disposed between the sample fluid feeding mechanism (5) and the heating mechanism (4), a second elastic member (15) is disposed between the heating mechanism (4) and the support mechanism (1), the first elastic member (14) and the second elastic member (15) both extend in a vertical direction, and an elastic coefficient of the first elastic member (14) is smaller than an elastic coefficient of the second elastic member (15).
3. The calibration liquid, sample liquid transporting and heating apparatus according to claim 2, wherein said sample liquid feeding mechanism (5) comprises a driving plate (51) and a pressing block (52) protruded on said driving plate (51); the heating mechanism (4) comprises a bearing plate (41) and a heating element arranged on the bearing plate (41), and a through hole (411) for the extrusion block (52) to pass through is formed in the position, opposite to the extrusion block (52), of the bearing plate (41).
4. The calibration liquid, sample liquid transporting and heating apparatus according to claim 2, wherein the support mechanism (1) is provided with a guide post (12) extending in a vertical direction, and the guide post (12) is inserted into the sample liquid feeding mechanism (5) and the heating mechanism (4).
5. The calibration liquid, sample liquid transporting and heating apparatus according to claim 2, wherein the driving mechanism (6) comprises a first driving member (61) and a driving block (62), the driving block (62) is located below the sample liquid feeding mechanism (5) and abuts against the sample liquid feeding mechanism (5), and the first driving member (61) is configured to drive the driving block (62) to move along a first direction to drive the sample liquid feeding mechanism (5) to ascend or descend.
6. The apparatus for transporting and heating calibration and sample liquids as claimed in claim 5, wherein along the first direction and the direction toward the first driving member (61), three step surfaces with gradually increasing height are sequentially arranged on the driving block (62) at intervals, two adjacent step surfaces are connected by an inclined surface (624), and the sample liquid feeding mechanism (5) can abut against the step surfaces or the inclined surface (624).
7. The calibration liquid, sample liquid conveying and heating apparatus according to claim 1, wherein the calibration liquid feeding mechanism (3) comprises a second driving member (32) and a ram (33), the ram (33) and the second driving member (32) are both located above the detection card (2), and the second driving member (32) is configured to drive the ram (33) to move in a vertical direction.
8. The calibration liquid, sample liquid transporting and heating apparatus according to claim 7, wherein said calibration liquid feeding mechanism (3) further comprises a bracket (31), said bracket (31) being disposed on said supporting mechanism (1), said second driving member (32) being disposed on said bracket (31).
9. The device for conveying and heating calibration liquid and sample liquid as claimed in claim 8, wherein the bracket (31) is provided with a through hole (311), the ram (33) is provided with a slide rod (34) extending along a vertical direction, and the slide rod (34) is inserted into the through hole (311) and can slide relative to the through hole (311).
10. POCT detection equipment, characterized by comprising the calibration fluid, the sample fluid delivery and heating device according to any one of claims 1-9.
CN201911030325.3A 2019-10-28 2019-10-28 Calibration liquid, sample liquid conveying and heating device and POCT detection equipment Pending CN110646631A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201911030325.3A CN110646631A (en) 2019-10-28 2019-10-28 Calibration liquid, sample liquid conveying and heating device and POCT detection equipment

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201911030325.3A CN110646631A (en) 2019-10-28 2019-10-28 Calibration liquid, sample liquid conveying and heating device and POCT detection equipment

Publications (1)

Publication Number Publication Date
CN110646631A true CN110646631A (en) 2020-01-03

Family

ID=68994930

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201911030325.3A Pending CN110646631A (en) 2019-10-28 2019-10-28 Calibration liquid, sample liquid conveying and heating device and POCT detection equipment

Country Status (1)

Country Link
CN (1) CN110646631A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111187703A (en) * 2020-02-21 2020-05-22 厦门大学 Chip clamping device and nucleic acid detection system
CN112722774A (en) * 2020-12-25 2021-04-30 珠海丽珠试剂股份有限公司 Reaction vessel conveying device and reaction vessel supplementing equipment using same
CN114113048A (en) * 2021-11-23 2022-03-01 南京晶捷生物科技有限公司 Optical detection equipment

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111187703A (en) * 2020-02-21 2020-05-22 厦门大学 Chip clamping device and nucleic acid detection system
CN112722774A (en) * 2020-12-25 2021-04-30 珠海丽珠试剂股份有限公司 Reaction vessel conveying device and reaction vessel supplementing equipment using same
CN114113048A (en) * 2021-11-23 2022-03-01 南京晶捷生物科技有限公司 Optical detection equipment
CN114113048B (en) * 2021-11-23 2023-10-27 南京晶捷生物科技有限公司 Optical detection equipment

Similar Documents

Publication Publication Date Title
CN110646631A (en) Calibration liquid, sample liquid conveying and heating device and POCT detection equipment
CN210894388U (en) Calibration liquid, sample liquid conveying and heating device and POCT detection equipment
CN107843583B (en) Microfluidic chemiluminescence analyzer and application method thereof
CN111634486A (en) Blood collection tube, separation gel injection machine and method for blood collection tube
WO2020181825A1 (en) Nucleic acid extraction apparatus
CN209802940U (en) Angle-adjustable combined regulator for flow cytometer
CN113145195A (en) Pipetting channel and pipetting method
CN112023701A (en) Heating type sample impurity-removing protein filtering device
CN218370142U (en) Product transfer device
CN110756241A (en) Liquid transfer device for food detection
CN107607068B (en) Battery height detection device
CN215796533U (en) Unloading module and encapsulating equipment in duplex position
CN212207223U (en) Novel additional preheating device structure of headspace sample injector
CN113770690A (en) Feeding and press-mounting device for composite flexible positioning pin
CN111634455A (en) Quantitative glue injection device and method of blood collection tube separation glue injection machine
CN113624398B (en) Test fixture for pressure sensor
CN111634487A (en) Heparin tube loading attachment of heparin tube separation gel injection machine
CN218539694U (en) Full-automatic micro-fluidic chip nucleic acid analyzer
CN111634489A (en) Tube rack conveying device and method of blood collection tube separation gel injection machine
CN220479459U (en) Airtight marking equipment of PCR board
CN111634663A (en) Heparin tube collection device of heparin tube separation gel injection machine
CN215404279U (en) Nucleic acid processing device
CN217479466U (en) Multifunctional driving device for biochip all-in-one machine
CN210449063U (en) Liquid preparation device for gene detection
CN112391275B (en) Micro-droplet chip crimping device

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination