CN216013121U - Device for collecting images of circulating tumor cells - Google Patents
Device for collecting images of circulating tumor cells Download PDFInfo
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- CN216013121U CN216013121U CN202122306399.4U CN202122306399U CN216013121U CN 216013121 U CN216013121 U CN 216013121U CN 202122306399 U CN202122306399 U CN 202122306399U CN 216013121 U CN216013121 U CN 216013121U
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- motor
- supporting groove
- sampling needle
- circulating tumor
- tumor cells
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Abstract
The utility model belongs to the technical field of medical appliances, in particular to a device for collecting images of circulating tumor cells, the device for collecting the images of the circulating tumor cells is provided with a supporting groove and a driving mechanism for driving the supporting groove to move left and right in a shell, a sample clamp is arranged on the supporting groove, a first motor is fixedly arranged at one end of the supporting groove, an electron microscope is arranged on the front side of the supporting groove, a laser emitter is arranged on the rear side of the supporting groove, after the sampling needle is used for sampling circulating epithelial cells, the sampling needle is arranged on the sample clamp, then the sample clamp is arranged on the supporting groove, under the drive of the first motor and the second motor, the cell on the sampling needle can be scanned section by section and all around, the detection time is reduced, the detection efficiency is improved, in the scanning process, the sampling needle can be controlled to rotate by a certain angle every time, and the detection precision is improved.
Description
Technical Field
The utility model belongs to the technical field of medical instrument, concretely relates to device of collection circulation tumor cell image.
Background
Circulating tumor cells are abbreviated as CTC, and tumor cells entering human peripheral blood are generally called circulating tumor cells. The detection of the circulating tumor cells can be effectively applied to in vitro early diagnosis and the rapid evaluation of the curative effect of chemotherapeutic drugs, and the individualized treatment comprises clinical drug screening, drug resistance detection, tumor recurrence monitoring, development of new tumor drugs and the like. For the conventional detection means of tumor, such as imaging, the doctor does not consider the tumor to be abnormal under the condition of less than one centimeter, but the doctor can see through domestic and foreign researches, and the tumor is not one centimeter, and many tumors have tumor cells entering the blood circulation under the condition of 2-4 mm, so that the significance of the method for early diagnosis cannot be underestimated.
The detection of the circulating tumor cells is generally to collect the tumor cells in a human body through a sampling needle, compared with other cell capture products, the sampling needle is used more like a traditional puncture needle, can be directly butted with departments and doctors of hospitals like other medical consumables and medicines, a functional area is directly inserted into an elbow venous blood vessel through the sampling needle, CTC (central control unit) enrichment is carried out in the blood vessel, the length of the functional area is two centimeters, a trace amount of special antibodies are coated on the functional area, the functional area stays in the blood vessel for half an hour in the collection process, and the specificity capture of the circulating tumor cells can be realized through the combination of the antibodies and antigens on the surface of the tumor cells.
In the detection process of the existing circulating tumor cell detector, the enrichment mode of CTC is blood sampling, other cells are contained in the CTC, the detection precision is not high, the result is influenced to a certain extent, manual labeling is needed in the detection, the detection time is long, the sampling time is 4 hours, and the efficiency is low.
SUMMERY OF THE UTILITY MODEL
The utility model aims at providing an gather device of circulation tumor cell image solves the technical problem that circulation tumor cell detector detects the precision not high, detection time is long, inefficiency among the prior art.
In order to solve the technical problem, the utility model discloses a following technical scheme:
the device for collecting the images of the circulating tumor cells comprises a shell, wherein a circuit board, a supporting groove and a driving mechanism for driving the supporting groove to move left and right are arranged in the shell;
the sample clamp is used for placing a sample clamp on the supporting groove, a cabin door is arranged on the shell, when the cabin door is opened, the sample clamp can be placed on the supporting groove, the sample clamp is used for placing a circulating tumor cell sampling needle, a first motor is fixedly arranged at one end of the supporting groove, an output shaft of the first motor is provided with a connecting seat, one end of the sample clamp is correspondingly provided with a connecting head, the connecting head is detachably arranged on the connecting seat, and the connecting head is in driving connection with a sampling needle clamping seat;
an electron microscope is arranged on the front side of the supporting groove, a laser emitter is arranged on the rear side of the supporting groove, and a laser lampshade is arranged between the laser emitter and the supporting groove;
when the sampling needle clamping seat is provided with a sampling needle, the first motor can drive the sampling needle to rotate, the laser emitted by the laser emitter can irradiate on the sampling needle, and the lens of the electron microscope can observe the part irradiated by the laser on the sampling needle;
the shell is provided with a display interface and a power interface, the first motor, the electron microscope and the laser emitter are electrically connected to the circuit board, and the electron microscope is in signal connection with the display interface.
Preferably, the driving mechanism comprises a guide rail installed in the housing, a sliding block matched with the guide rail is arranged at the bottom of the carrying groove, and a second motor is arranged in the housing and is connected to the sliding block in a driving mode.
Preferably, the first motor and the second motor are both stepping motors or servo motors.
Preferably, the sample clamp comprises a bottom plate, a plurality of supports are arranged on the bottom plate at intervals, and needle grooves for placing sampling needles are formed in the supports.
Preferably, a power module and a main controller are arranged on the circuit board, and the main controller is electrically connected to the laser emitter and the electron microscope through a first electric control switch and a second electric control switch respectively; the circuit board is also provided with a first motor driver and a second motor driver, and the main controller is electrically connected to the first motor driver and the second motor driver through a third electric control switch and a fourth electric control switch respectively; the first and second motor drivers are electrically connected to the first and second motors, respectively.
Compared with the prior art, the beneficial effects of the utility model are that: this device of gathering circulation tumor cell image is equipped with the support in the casing and carries the recess, and be used for the drive to hold in the palm and carry the actuating mechanism that removes about the recess, it presss from both sides to be used for placing the sample on the recess to hold in the palm to carry recess one end fixed and be equipped with first motor, be equipped with electron microscope at the front side that holds in the palm and carry the recess, the rear side is equipped with laser emitter, after sampling circulation epithelial cell with the sampling needle, install the sampling needle on the sample presss from both sides, then place the sample clamp on holding in the palm carries the recess, under the drive of first motor and second motor, can carry out the segmentation one by one to the cell on the sampling needle, the complete cycle scanning, reduce and detect for a long time, and improve detection efficiency, and in the scanning process, can control the sampling needle only rotate certain angle at every turn, improve and detect the precision.
Drawings
The accompanying drawings are included to provide a further understanding of the invention, and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention, and together with the description serve to explain the invention and not to limit the invention. In the drawings:
fig. 1 is a schematic view of a three-dimensional structure of an embodiment of the device for collecting images of circulating tumor cells of the present invention.
Fig. 2 is a schematic diagram of the internal structure of the housing in an embodiment of the device for collecting images of circulating tumor cells of the present invention.
Fig. 3 is a schematic view of a three-dimensional structure of a sample holder in an embodiment of the device for collecting images of circulating tumor cells of the present invention.
Fig. 4 is a rear view of an embodiment of the device for collecting images of circulating tumor cells according to the present invention.
Fig. 5 is a circuit block diagram of an embodiment of the device for collecting images of circulating tumor cells according to the present invention.
In the drawings, each reference numeral means: the device comprises a shell 1, a cabin door 11, a switch 111, a bottom plate 12, a heat dissipation hole 13, a display interface 14, a power supply interface 15, a debugging interface 16, a circuit board 2, a carrying groove 3, a sliding block 31, a first motor 32, a guide rail 4, a second motor 41, a screw rod 42, a sample clamp 5, a bottom plate 51, a vertical plate 52, a connector 53, a sampling needle clamping seat 54, a front end needle groove 541, a fastening screw 542, a support 55, a needle groove 551, a sampling needle 6, an electron microscope 7, a laser emitter 8 and a laser lampshade 81.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
An apparatus for acquiring images of circulating tumor cells is disclosed in FIGS. 1 to 5.
As shown in fig. 1, the device for acquiring images of circulating tumor cells comprises a housing 1, wherein a hatch 11 is arranged on the housing 1; as shown in fig. 2, a circuit board 2, a supporting groove 3 and a driving mechanism for driving the supporting groove 3 to move left and right are arranged on a bottom plate 12 of a housing 1, the driving mechanism includes a guide rail 4 installed on the bottom plate 12 of the housing 1, a sliding block 31 matched with the guide rail 4 is arranged at the bottom of the supporting groove 3, a second motor 41 is arranged on the bottom plate 12 of the housing 1, the second motor 41 is in driving connection with a screw rod 42, a nut matched with the screw rod 42 is arranged on the sliding block 31, and when the second motor 41 is started, the supporting groove 3 can be driven to move left and right.
Be used for placing sample holder 5 on the support year recess 3, like figure 1, be equipped with switch 111 on hatch door 11, open as hatch door 11 on casing 1, can place sample holder 5 on support year recess 3, hatch door 11 is L shape, and the aperture is great, and it is more convenient to put into sample holder 5.
The connector 53 is drivingly connected with a sampling needle clamping seat 54, a bearing is arranged on the vertical plate 52, and the sampling needle clamping seat 54 is installed on the bearing, so that the first motor 32 can drive the sampling needle clamping seat 54 to rotate.
The sampling needle clamping seat 54 is provided with a front end needle groove 541, the side surface is provided with a fastening screw 542, the bottom plate 51 is provided with two support seats 55 at intervals, the support seats 55 are provided with needle grooves 551 for placing the sampling needles 6, the sampling needles 6 are slender needles, the end parts of the sampling needles 6 are placed in the front end needle grooves 541 and are tightly pressed through the fastening screws 542, and the main body parts of the sampling needles 6 can be supported in the needle grooves 551.
As shown in fig. 2, an electron microscope 7 is disposed on the front side of the supporting groove 3, a laser emitter 8 is disposed on the rear side, a laser lampshade 81 is disposed between the laser emitter 8 and the supporting groove 3, ground glass is disposed in the lampshade 81, red, blue, green and white laser emitted by the laser emitter 8 irradiates cells on the sampling needle 6, and after passing through the laser lampshade 81, a light source formed by combining part of red, blue and green also irradiates the cells on the sampling needle 6, so as to excite fluorescent substances in the cells to emit longer fluorescence, and fluorescent signals are captured by an objective lens of the electron microscope 7 to present the stained cells as a scanned image.
As shown in fig. 4, heat dissipation holes 13 are formed in the back of the housing 1, and a heat dissipation fan is further disposed inside the housing 1; a display interface 14, a power interface 15 and a debugging interface 16 are further arranged on the back surface of the shell 1, the power interface 15, the first motor 32, the electron microscope 7 and the laser emitter 8 are electrically connected to the circuit board 2, the electron microscope 7 is in signal connection with the display interface 14, and the display interface 14 is used for connecting a display screen.
Referring to fig. 5, a power module and a main controller are disposed on the circuit board 2, the main controller is a single chip microcomputer, the main controller is electrically connected to the laser emitter and the electron microscope through a first electric control switch and a second electric control switch, respectively, and a first motor driver and a second motor driver are further disposed on the circuit board 2, the main controller is electrically connected to the first motor driver and the second motor driver through a third electric control switch and a fourth electric control switch, respectively, the first motor driver and the second motor driver are electrically connected to the first motor 32 and the second motor 41, respectively, the first motor 32 and the second motor 41 are step motors, the first electric control switch, the second electric control switch, the third electric control switch and the fourth electric control switch can adopt relays or silicon controllers, the first motor driver and the second motor driver are drivers matched with the step motors, and can control the rotation angles of the motors, Speed; the power supply module is used for providing stable direct current working voltage for the main controller and providing corresponding working voltage for the laser transmitter, the electron microscope, the first motor driver and the second motor driver.
When the sampling needle clamping seat 5 is provided with the sampling needle 6, the first motor 32 can drive the sampling needle 6 to rotate, the laser emitted by the laser emitter 8 can irradiate on the sampling needle 6, the laser irradiated part on the sampling needle 6 can be observed by the lens of the electron microscope 7, and the display connected to the electron microscope 7 can display the image observed by the electron microscope.
The working mode of the device for acquiring the circulating tumor cell image is as follows:
(1) loading, namely placing the tail end of the sampling needle 6 into the front end needle groove 541 of the sample clamp 5, tightly pushing through a fastening screw 542, and installing the sample clamp 5 loaded with the sampling needle for the circulating epithelial cells on the carrying groove 3;
(2) the sampling needle 6 is positioned at a working position, the electron microscope 7 is connected with a display, and the electron microscope 7 can start scanning after focusing;
(3) red, blue, green and white laser emitted by a laser emitter 8 is used for irradiating cells on the sampling needle 6, a light source synthesized by red, blue and green is used for irradiating the cells on the sampling needle 6, fluorescent substances in the cells are excited to emit longer fluorescence, and a fluorescence signal is captured by an objective lens of an electron microscope 7 to present the stained cells as a scanning image on a display;
(4) only one third position of the sampling needle 6 is shot in each scanning, the first motor 32 rotates at an angle of 60 degrees, the supporting groove 3 does not move in the process of rotating the first motor 32, when the sampling needle 6 rotates 6 times, the second motor 41 starts to work, the supporting groove 3 continues to move to the next position, and the steps are repeated. The sample image shot by the electron microscope is stored in a computer hard disk matched with a display; after the scanning is completed, the hatch 11 can be opened to take out the sample holder 5.
Each time the sample is changed, the area of the sample holder 5 in contact with the sample needle 6 is wiped with a 75% alcohol cotton swab, and after the alcohol has evaporated, the steps 1 to 4 are repeated for the next sample scan.
The detection principle is as follows: by using an immunofluorescence method, tumor cells are generally derived from epithelial tissues, keratin or other tumor markers can be expressed in the cells, and circulating tumor cells derived from solid tumors can be identified by virtue of immunofluorescence staining, so that the aim of detecting the circulating tumor cells is fulfilled.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (5)
1. An apparatus for acquiring images of circulating tumor cells, comprising: the circuit board supporting device comprises a shell, wherein a circuit board, a supporting groove and a driving mechanism for driving the supporting groove to move left and right are arranged in the shell;
the sample clamp is arranged on the supporting groove and is used for placing a sample clamp, a cabin door is arranged on the shell, when the cabin door is opened, the sample clamp can be placed on the supporting groove, and the sample clamp is used for placing a circulating tumor cell sampling needle; a first motor is fixedly arranged at one end of the supporting groove, a connecting seat is arranged on an output shaft of the first motor, a connecting head is correspondingly arranged at one end of the sample clamp, the connecting head is detachably arranged on the connecting seat, and the connecting head is in driving connection with a sampling needle clamping seat;
an electron microscope is arranged on the front side of the supporting groove, a laser emitter is arranged on the rear side of the supporting groove, and a laser lampshade is arranged between the laser emitter and the supporting groove; when the sampling needle clamping seat is provided with a sampling needle, the first motor can drive the sampling needle to rotate, the laser emitted by the laser emitter can irradiate on the sampling needle, and the lens of the electron microscope can observe the part irradiated by the laser on the sampling needle;
the shell is provided with a display interface and a power interface, the first motor, the electron microscope and the laser emitter are electrically connected to the circuit board, and the electron microscope is in signal connection with the display interface.
2. The apparatus for acquiring images of circulating tumor cells of claim 1, wherein: the driving mechanism comprises a guide rail arranged in the shell, a sliding block matched with the guide rail is arranged at the bottom of the supporting and carrying groove, a second motor is arranged in the shell, and the second motor is connected to the sliding block in a driving mode.
3. The apparatus for acquiring images of circulating tumor cells of claim 2, wherein: the first motor and the second motor are both stepping motors or servo motors.
4. The apparatus for acquiring images of circulating tumor cells of claim 1, wherein: the sample clamp comprises a bottom plate, a plurality of supports are arranged on the bottom plate at intervals, and needle grooves used for placing sampling needles are formed in the supports.
5. The apparatus for acquiring images of circulating tumor cells of claim 2, wherein: the circuit board is provided with a power supply module and a main controller, and the main controller is electrically connected to the laser transmitter and the electron microscope through a first electric control switch and a second electric control switch respectively; the circuit board is also provided with a first motor driver and a second motor driver, and the main controller is electrically connected to the first motor driver and the second motor driver through a third electric control switch and a fourth electric control switch respectively; the first and second motor drivers are electrically connected to the first and second motors, respectively.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202122306399.4U CN216013121U (en) | 2021-09-23 | 2021-09-23 | Device for collecting images of circulating tumor cells |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202122306399.4U CN216013121U (en) | 2021-09-23 | 2021-09-23 | Device for collecting images of circulating tumor cells |
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| Publication Number | Publication Date |
|---|---|
| CN216013121U true CN216013121U (en) | 2022-03-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202122306399.4U Expired - Fee Related CN216013121U (en) | 2021-09-23 | 2021-09-23 | Device for collecting images of circulating tumor cells |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117388229A (en) * | 2023-12-13 | 2024-01-12 | 德路通（石家庄）生物科技有限公司 | Cell image acquisition system |
-
2021
- 2021-09-23 CN CN202122306399.4U patent/CN216013121U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117388229A (en) * | 2023-12-13 | 2024-01-12 | 德路通（石家庄）生物科技有限公司 | Cell image acquisition system |
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Granted publication date: 20220311 |