CN208582402U - A kind of tumour optical detection and photo-thermal therapy system - Google Patents
A kind of tumour optical detection and photo-thermal therapy system Download PDFInfo
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- CN208582402U CN208582402U CN201721706041.8U CN201721706041U CN208582402U CN 208582402 U CN208582402 U CN 208582402U CN 201721706041 U CN201721706041 U CN 201721706041U CN 208582402 U CN208582402 U CN 208582402U
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Abstract
The utility model discloses a kind of tumour optical detection and photo-thermal therapy system, which is made of diagnosis and treatment bed, elevator, diagnosis and treatment plate, laser output control unit, elevating control unit, signal processing unit, station, central processing unit and display terminal.The system can realize the body scan to patient by diagnosis and treatment plate, and coordinate calibration can be carried out to the tumour cell that label has, collected fluorescence signal is analyzed simultaneously, and the scanning and treatment that tumour cell is realized in heating are carried out to corresponding tumour cell.The system has many advantages, such as that accurate positioning, treatment injury are small.
Description
Technical field
The utility model relates to a kind of tumour optical detections and photo-thermal therapy system.
Background technique
The common method of measurement tumour cell has blood test, biopsy, ultrasonic imaging, CT, nuclear-magnetism total at present
Vibration, tumor markers etc., wherein the accuracy of blood test is not very high；Biopsy is painful and is difficult to early period find
Lesion cell；Ultrasound image obtains useful information from some ambient noises, and the ultrasound pattern speckle noise generated exists
Amount excessively causes error big；The resolution ratio of CT is higher than some Traditional x-rays and other several imaging techniques, but because CT at
As principle, it is very difficult to tell tiny some changes of soft tissue；Another means, nuclear magnetic resonance image can increase soft tissue it
Between contrast, therefore the accuracy of medical diagnosis on disease improves, but artifact therein exists and brings chaff interferent to diagnosis again；It is swollen
The chip data of tumor markers has the speciality of higher-dimension small sample, and medicine scholar will analyze its data and also increase difficulty.Cause
This, often applies the synthesis of a variety of detection means in clinical diagnosis, and to make a definite diagnosis normal cell, whether canceration is that tumour is thin
Born of the same parents, this causes very big financial burden to patient, and cannot check early stage lesions position, and time-consuming for checking process, also damages
Consume a large amount of energy of people.
One of the research hotspot that biomolecule identification is current life scientific domain is carried out using fluorescent marker.Compared to
Traditional fluorescence labeling material such as organic dyestuff and quantum dot, lanthanide doped upper conversion nano crystalline substance with no photobleaching, without from
It fluoresces, the intrinsic advantage such as tissue penetration is deep, bio-toxicity is low, therefore has in terms of biological study and clinical application bigger
Application potential.The upper conversion nano crystalline substance of functionalization can study a series of lifes occurred in tumour from molecule, cellular level
Manage Pathologic changes.Using this technology, the growth and transfer of tumour in living body biological body, infectious diseases development can be observed
Process, the biological processes such as expression of specific gene.In addition, it is high to the detection sensitivity of tumor microwave transfer stove, it is not related to
Radioactive substance and method, it is very safe.
The conventional method of operation, radiotherapy, chemotherapy as treatment of cancer, adjoint side effect often bring to patient huge
Body and mind torments.In contrast, the heat therapy based on pure physical means, side effect is almost nil, is known as by international the world of medicine
" green remedy ".Currently, including radio frequency, microwave, laser, focusing a variety of technique for hyperthermia such as ultrasound, whole-body hyperthermia and isolated organ perfusion
It has been developed, but the targeting poor location of these technique for hyperthermia frequently results in adjacent healthy while heating tumor tissues
The thermal damage of tissue keeps its clinical application range limited.
In recent years, the photo-thermal therapy of mediated by nanoparticles is concerned.In this approach, receiving in tumor tissues is injected
Rice corpuscles absorbs external near-infrared radiation first and is converted into thermal energy, then drives the cancerous issue heating of surrounding, and finally leads
Cause tumour cell ablation.Since treatment has specific aim, safety is higher, more remarkable treatment effect.Biomaterial scholar at present
A variety of Nano-heaters including nanogold, copper sulfide, carbon nanotube are developed.But regrettably, these nanometers
All there are some problems in heater.For example, the nanogold of small size tends to reunite in biosystem, lead to higher biology poison
Property；Carbon nanotube has very strong Fluorescence quenching effect to marker material.
Recently, the multifunctional nano heater based on lanthanide doped up-conversion luminescence is got more attention, but is lacked at present
The equipment that matched can be used.
Utility model content
The utility model proposes a kind of tumour optical detection and photo-thermal therapy system in view of the above problems, can be used in into
The optical detection of row tumour and photo-thermal therapy eliminate tumour cell.
The technological means that the utility model uses is as follows:
A kind of tumour optical detection and photo-thermal therapy system, comprising: diagnosis and treatment bed, for carrying to be detected and treatment trouble
Person；Elevator, elevating movement can be carried out by being fixed on diagnosis and treatment bed side；Diagnosis and treatment plate, the diagnosis and treatment plate are fixed on the lifting
On machine and it is synchronous with the elevator move up and down, the diagnosis and treatment plate be built-in with laser output unit, mechanical scanner and
Multiple photoelectric detection units of the lower surface of the diagnosis and treatment plate are uniformly mounted on, the photoelectric detection unit center has laser defeated
The laser of exit port, the laser output unit output can be from each laser output mouth successively by the mechanical scanner
Output；Laser output control unit is used to control the output power of the laser output unit on the diagnosis and treatment plate；Lifting
Control unit is used to control the up and down motion of the elevator；Signal processing unit is used to receive the photodetection list
Electric signal that member detects simultaneously carries out current/voltage transformation and amplification to export to the electric signal；Station, for described
The assigning of the different instruction of tumour optical detection and photo-thermal therapy system, parameter setting and data store；Central processing unit, can
The signal of the output of different instruction and/or the signal processing unit based on the station is to control the elevating control
The output of unit and/or laser output control unit；And display terminal, for showing the information of diagnosing and treating process；
Further, the rectangular array manner of the multiple photoelectric detection unit is placed in the lower surface of the diagnosis and treatment plate；
Further, it is at least one of 808nm, 980nm and 1532nm that the laser output unit, which includes launch wavelength,
Laser；
Further, optical collimation lens are fixed on the laser output mouth；
Further, the central processing unit further includes being opened and closed for controlling each photoelectric detection unit
Photodetection control unit；
Further, further include warning device, be placed in patient's body tumour cell when the photoelectric detection unit detects
In specific fluorescent signal after generate alarm；
Further, the warning device is at least any one in buzzer and indicator light；
Further, the central processing unit further includes tumour lock cell, and the tumour lock cell is in the photoelectricity
Probe unit controls the mechanical scanner stop motion when detecting the specific fluorescent in patient's body tumour cell.
Compared with the prior art, tumour optical detection described in the utility model has beneficial below with photo-thermal therapy system
Effect: 1, the system is scanned and is added using the specific Nano-heaters that laser is fixed on tumor cell surface to specificity
Detection and the oncotherapy dual function of tumour may be implemented in heat, and providing to detection and the treatment of tumour can a kind of new reference
With powerful；2, multiple photoelectric detection units are distributed at matrix form, can be in order to scan, while being also easy to be visited according to photoelectricity
The position for surveying unit determines the position of tumour cell；3, laser output unit uses a variety of laser emission wavelengths, can be used for examining
Survey different types of Nano-heaters, universal performance enhancing；4, laser output mouth has collimation lens, ensure that swashing for output
Beam orthogonal improves scanning and treatment precision；5, there is warning device, facilitate medical worker understanding patient whether to have swollen
Tumor.
Detailed description of the invention
Fig. 1 is the tumour optical detection of the utility model and the structural schematic diagram of photo-thermal therapy system；
Fig. 2 is the distribution schematic diagram of diagnosis and treatment plate lower surface photoelectric detection unit；
Fig. 3 is the enlarged diagram of dotted portion in Fig. 2；
Fig. 4 is the structural schematic diagram of mechanical scanner.
In figure: 1, diagnosis and treatment bed, 2, elevator, 3, diagnosis and treatment plate, 4, laser output control unit, 5, elevating control unit, 6,
Signal processing unit, 7, station, 8, central processing unit, 9, display terminal, 31, laser output unit, 32, mechanical scanning dress
It sets, 33, photoelectric detection unit, 34, laser output mouth, 321, permanent-magnet brushless DC electric machine, 322, polyhedron rotating mirror,
323, galvanometer, 324, stepper motor.
Specific embodiment
As shown in Figure 1, a kind of tumour optical detection provided by the utility model and photo-thermal therapy system, comprising: for holding
The diagnosis and treatment bed 1 of to be detected and treatment patient is carried, 1 side of diagnosis and treatment bed is fixed with elevator 2, and elevator 2 can be in vertical direction
Upper up and down motion, is fixed with diagnosis and treatment plate 3 on elevator 2, and diagnosis and treatment plate 3 can with the up and down motion of elevator 2 and together fortune up and down
It is dynamic.Diagnosis and treatment plate 3 is strip structure, has laser output unit 31 in diagnosis and treatment plate 3, in the present embodiment, laser output unit 31
Using the laser that can export specific wavelength, the lower surface of diagnosis and treatment plate 3 is equipped with multiple photoelectric detection units 33, it is preferable that
The mode of the rectangular array of multiple photoelectric detection units 33 is arranged in the lower surface of diagnosis and treatment plate 3, in the present embodiment, such as Fig. 2 and
Shown in Fig. 3, diagnosis and treatment plate lower surface is uniformly distributed 100x100 side length for the square area of 1cm, built in each square area
There is a photoelectric detection unit 33,33 center of photoelectric detection unit has laser output mouth 34, also has machine in diagnosis and treatment plate 3
Tool scanning means 32, the laser beam that mechanical scanner 32 can issue laser output unit 31 is successively from each photodetection
It is projected in the laser output mouth 34 at 33 center of unit for carrying out laser scanning to patient and/or adding to tumour cell
Heat cure.Use matrix arrangement photoelectric detection unit 33 can be with each readily available corresponding photoelectric detection unit
Location information, to can accurately determine the position of tumour cell when different photoelectric detection units detects tumour cell
It sets.
As shown in figure 4, mechanical scanner 32 includes polyhedron rotating mirror 322, for driving polyhedron rotation anti-
Penetrate the permanent-magnet brushless DC electric machine 321, galvanometer 323 and the stepper motor 324 for driving galvanometer 323 to rotate of mirror 322.Permanent magnetism
The rotary shaft of body brushless motor 321 and stepper motor 324 is mutually perpendicular to and respectively drives polyhedron rotating mirror 322 and galvanometer
323 with realize laser beam row scanning and field scan, specifically, polyhedron rotating mirror 322 often turn over one side, laser light
For beam with regard to inswept a line, galvanometer 323 is every of reciprocating vibration primary, and for laser beam with regard to inswept one, the Collaboration of row-field scanning will
The laser beam exported from laser output unit 31 is successively exported from the laser output mouth 34 at multiple 33 centers of photoelectric detection unit
Entire scan (mechanical scanner and sweeping in existing laser television are realized to the patient being placed on diagnosis and treatment bed 1 to realize
Imaging apparatus structure is identical).
It is irradiated to and is lain in the patient on diagnosis and treatment bed 1 by the laser beam that laser output mouth 34 exports, and be reflected into
The laser beam of reflection is converted into current signal and defeated by the photoelectric detection unit 33 being placed on diagnosis and treatment plate 3, photoelectric detection unit 33
Enter to signal processing unit 6, during current signal is converted into voltage signal and amplifies and then input to by signal processing unit 6
Central processor 8, central processing unit 8 can carry out the signal of input handling and set reference signal in central processing unit 8
It is compared, the system is then controlled according to comparison result and carries out different operations.Concrete operations content includes at least in following
Hold: 1, when the reference signal of no signal inputs or inputs signal and setting is misfitted, central processing unit controls mechanical scanning
Device works on, i.e., laser is moved to next laser output mouth to be continued to scan on (namely Current Scan
Position does not have tumour cell, continues the scanning at next position)；2, when the signal of input and the reference signal of setting coincide,
Then central processing unit control mechanical scanner stops operating, and controls the output of laser to carry out heating destruction to current location
Tumour cell.
The tumour optical detection and photo-thermal therapy system further include laser output control unit 4, laser output control unit 4
Instruction is sent by central processing unit 8 to be controlled, and then the output of laser output unit 31 is controlled by laser output control unit 4
Laser intensity.For example, when central processing unit 8 has detected tumour cell by photoelectric detection unit 33, central processing unit 8
Signal based on feedback calculates nanometer light heater temperature, and is compared with the temperature threshold set in central processing unit 8, so
It is sent and is instructed to laser output control unit 4 according to comparison result afterwards, and then dynamically control 31 output work of laser output unit
Rate is used to heat to treat tumour cell.Concrete operations content includes at least the following contents: 1, when calculating temperature is lower than
When set temperature threshold value, central processing unit sends instruction improving laser output power；2, when calculating temperature is higher than set temperature threshold
When value, central processing unit, which sends instruction, reduces laser output power.
The tumour optical detection and photo-thermal therapy system further include elevating control unit 5, and elevating control unit 5 can be in
Under central processor 8 controls, controls the elevating movement of elevator 2 and then adjusting diagnosis and treatment plate 3 is convenient for diagnosis and treatment plate at a distance from patient
Patient is scanned and is treated.
The tumour optical detection and photo-thermal therapy system further include station 7, and station 7 can be used for the difference of the system
Instruction assign, parameter setting and data storage etc. functions.
The tumour optical detection and photo-thermal therapy system further include display terminal 9, which can be in the system of progress
The display of relevant information is carried out when work, the information of display may include following content: structural model figure, each photoelectricity of human body
The working condition of probe unit, power information, the photoelectric detection unit of laser output are detected and are received positioned at the specific of tumor surface
The information such as the position of the real time temperature of nanometer light heater, tumour when rice light heater.
Further, the laser output unit 31 being placed in diagnosis and treatment plate 3 may include the laser of a variety of output wavelengths, this
It is tri- kinds of lasers of 808nm, 980nm and 1532nm that laser output unit, which includes launch wavelength, in embodiment.Using multi-wavelength
Laser can enhance the universal performance of the system in order to which different types of Nano-heaters are scanned and are identified.
Laser output unit be not limited to the present embodiment in three kinds of wavelength laser, can be replaced and be added according to actual needs
Add.
Further, optical collimation lens can also be fixed on laser output mouth 34, optical collimation lens can be with
The laser for being reflected into laser output mouth 34 by mechanical scanner 32 is collimated, scanning accuracy is improved.
It further, further include being opened and closed for controlling each photoelectric detection unit 33 in central processing unit 8
Photodetection control unit.When the system has the photodetection control for controlling each photoelectric detection unit and being opened and closed
When unit processed, central processing unit 8 can control mechanical scanner 32 and photoelectric detection unit 33 works asynchronously, that is, center
Processor 8 controls mechanical scanner 32 and the laser beam that laser output unit 31 exports is incident on an Electro-Optical Sensor Set 33
Laser output mouth 34 when, corresponding photoelectric detection unit 33 works, and central processing unit 8 passes through photoelectric detection unit
The photodetection control unit of opening and closing control remaining photoelectric detection unit closing so that every time only and incident laser
Corresponding photoelectric detection unit work not only can exclude to interfere with each other between different photoelectric detection units in scanning process
Scanning and detection accuracy are improved, while reducing power consumption, and convenient for determining that the position scanned every time is easy to determine the position of tumour.
Further, the tumour optical detection and photo-thermal therapy system can also include warning device, when photodetection list
Member generates alarm after detecting the specific specific fluorescent signal for being fixed on patient's body tumor cell surface.Specifically, work as light
Electric probe unit detects (signal processing unit after the specific specific fluorescent signal for being fixed on patient's body tumor cell surface
When the signal and setting reference signal for being input to central processing unit coincide), central processing unit can control warning device and generate report
Police is to prompt medical worker.Warning device can be the common alarm structure such as buzzer or indicator light.
Further, central processing unit further includes tumour lock cell, and tumour lock cell is detected in photoelectric detection unit
To patient's body tumor cell surface specific fluorescent when control the mechanical scanner stop motion.Specifically, in order to just
Heating can be carried out to the tumour cell detected at once after scanning to tumour cell in the system reaches therapeutic effect,
After the signal that central processing unit sends signal processor is analyzed relatively, if the signal and setting reference signal that receive
It coincide, mechanical scanner stop motion is immediately controlled in the tumour lock cell in central processing unit at this time, and laser beam is stopped
At the position with tumour, then tumour cell is heated by dynamic regulation laser power again.
The preferable specific embodiment of the above, only the utility model, but the protection scope of the utility model is not
It is confined to this, anyone skilled in the art is within the technical scope disclosed by the utility model, practical according to this
Novel technical solution and its inventive concept is subject to equivalent substitution or change, should all cover the protection scope of the utility model it
It is interior.
Claims (8)
1. a kind of tumour optical detection and photo-thermal therapy system, characterized by comprising:
Diagnosis and treatment bed (1), for carrying to be detected and treatment patient；
Elevator (2), elevating movement can be carried out by being fixed on diagnosis and treatment bed side；
Diagnosis and treatment plate (3), the diagnosis and treatment plate (3) is fixed on the elevator (2) and fortune up and down synchronous with the elevator (2)
Dynamic, the diagnosis and treatment plate (3) is built-in with laser output unit (31), mechanical scanner (32) and is uniformly mounted on the diagnosis and treatment
Multiple photoelectric detection units (33) of plate lower surface, photoelectric detection unit (33) center have laser output mouth (34),
The laser beam of laser output unit (31) output can be from each laser output mouth by the mechanical scanner (32)
(34) it is sequentially output；
Laser output control unit (4) is used to control the output of the laser output unit (31) on the diagnosis and treatment plate (3)
Power；
Elevating control unit (5), is used to control the up and down motion of the elevator (2)；
Signal processing unit (6) is used to receive the electric signal that the photoelectric detection unit (33) detects and to the telecommunications
Number carry out current/voltage transformation and amplification to export；
Station (7), the assigning of different instruction for the tumour optical detection and photo-thermal therapy system, parameter setting and
Data storage；
Central processing unit (8), can be based on the output of the different instruction and/or the signal processing unit of the station (7)
Output of the signal to control the elevating control unit and/or laser output control unit；And
Display terminal (9), for showing the information of diagnosing and treating process.
2. tumour optical detection according to claim 1 and photo-thermal therapy system, it is characterised in that: the multiple photoelectricity is visited
Survey the lower surface that unit (33) rectangular array manner is placed in the diagnosis and treatment plate (3).
3. tumour optical detection according to claim 1 or 2 and photo-thermal therapy system, it is characterised in that: the laser is defeated
It is at least one of 808nm, 980nm and 1532nm laser that unit (31), which includes launch wavelength, out.
4. tumour optical detection according to claim 3 and photo-thermal therapy system, it is characterised in that: the laser output
Optical collimation lens are fixed on mouth (34).
5. tumour optical detection according to claim 1 and photo-thermal therapy system, it is characterised in that: the central processing unit
It (8) further include the photodetection control unit opened and closed for controlling each photoelectric detection unit (33).
6. tumour optical detection according to claim 1 and photo-thermal therapy system, it is characterised in that: further include alarm dress
It sets, alarm is generated after the photoelectric detection unit detects the specific fluorescent signal being placed in patient's body tumour cell.
7. tumour optical detection according to claim 6 and photo-thermal therapy system, it is characterised in that: the warning device is extremely
It is less any one in buzzer and indicator light.
8. tumour optical detection according to claim 1 and photo-thermal therapy system, it is characterised in that: the central processing unit
It further include tumour lock cell, the tumour lock cell detects in patient's body tumour cell in the photoelectric detection unit
Specific fluorescent when control the mechanical scanner stop motion.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201721706041.8U CN208582402U (en) | 2017-12-08 | 2017-12-08 | A kind of tumour optical detection and photo-thermal therapy system |
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| CN201721706041.8U CN208582402U (en) | 2017-12-08 | 2017-12-08 | A kind of tumour optical detection and photo-thermal therapy system |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112438804A (en) * | 2019-08-28 | 2021-03-05 | 美国发现集团有限公司 | Control system and control method of nano robot |
| CN112438803A (en) * | 2019-08-28 | 2021-03-05 | 美国发现集团有限公司 | Control system and control method of micro-nano robot |
| CN113950354A (en) * | 2019-04-08 | 2022-01-18 | 会聚R.N.R有限公司 | System and method for optimizing radiation therapy |
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2017
- 2017-12-08 CN CN201721706041.8U patent/CN208582402U/en active Active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113950354A (en) * | 2019-04-08 | 2022-01-18 | 会聚R.N.R有限公司 | System and method for optimizing radiation therapy |
| CN113950354B (en) * | 2019-04-08 | 2024-05-28 | 会聚R.N.R有限公司 | System for optimizing radiation therapy |
| CN112438804A (en) * | 2019-08-28 | 2021-03-05 | 美国发现集团有限公司 | Control system and control method of nano robot |
| CN112438803A (en) * | 2019-08-28 | 2021-03-05 | 美国发现集团有限公司 | Control system and control method of micro-nano robot |
| CN112438803B (en) * | 2019-08-28 | 2024-06-14 | 湖南早晨纳米机器人有限公司 | Control system and control method of micro-nano robot |
| CN112438804B (en) * | 2019-08-28 | 2024-06-14 | 湖南早晨纳米机器人有限公司 | Control system and control method of nano robot |
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