CN215986002U

CN215986002U - A appearance that disintegrates for drug test

Info

Publication number: CN215986002U
Application number: CN202121496260.4U
Authority: CN
Inventors: 张兴飞
Original assignee: Renhe Xidelung Pharmaceutical Co ltd
Current assignee: Renhe Xidelung Pharmaceutical Co ltd
Priority date: 2021-07-02
Filing date: 2021-07-02
Publication date: 2022-03-08
Anticipated expiration: 2031-07-02

Abstract

The utility model relates to a disintegration tester for drug testing, which comprises a base, a host machine arranged on the base and a hanging basket component arranged on the host machine, wherein the host machine is provided with a hot bath box for heating the hanging basket component, a heating device for controlling the internal temperature of the hot bath box and a driving device for driving the hanging basket component to move up and down; a cavity for placing a heating medium is arranged in the hot bath box, two beakers for placing a disintegrating medium are arranged in the hot bath box, the bottoms of the beakers are positioned in the hot bath box, and the tops of the beakers penetrate through a through hole in the upper surface of the hot bath box; the hanging basket assembly comprises an upper cover plate, a lower cover plate and a plurality of disintegration pipes positioned between the upper cover plate and the lower cover plate, a hanging rod is vertically arranged in the center of the upper surface of the upper cover plate, and the upper end of the hanging rod is fixedly connected with a connecting plate; the driving assembly comprises a fixing plate detachably connected with the connecting plate. The utility model has the advantages of convenient disassembly, convenient lifting, stable structure and the like.

Description

A appearance that disintegrates for drug test

Technical Field

The utility model relates to a disintegration tester, in particular to a disintegration tester for drug tests, and belongs to the technical field of drug test equipment.

Background

Disintegration refers to the physical dissolution process of a pharmaceutical formulation prior to absorption. The disintegration time is the time for pills, tablets and capsules to be disintegrated into granules under certain conditions, is considered as a main factor influencing the bioavailability of oral medicaments, and according to the examination method of disintegration time limit of Chinese pharmacopoeia 95, the disintegration means that a solid preparation is completely disintegrated and dissolved or broken into granules in the examination time limit, and the granules except insoluble coating materials or broken capsule shells pass through a screen. The determination of disintegration time limit adopts a lifting disintegration apparatus, the common tablet can be completely disintegrated within 15min, the hard capsule in the capsule can be completely disintegrated within 30min, and the soft capsule can be completely disintegrated within 1 h. The degree of disintegration refers to the limit of time required for some pharmaceutical dosage forms (tablets, pills, etc.) to completely disintegrate and pass through a screen, as measured under certain conditions using a test device prescribed by pharmacopoeia. The disintegrating medium is usually water, artificial intestinal juice, or artificial gastric juice. The measurement temperature was 37. + -. 0.5 ℃. Is one of the indexes for measuring the quality of the medicine.

The absorption speed of the drug in vivo is often determined by the speed of dissolution, the drug in a solid preparation must be disintegrated and dissolved before being absorbed and then converted into a solution, if the drug is not easily released from the preparation or the dissolution speed of the drug is extremely slow, the absorption speed or degree of the drug in the preparation can be problematic, on the other hand, some drugs with strong pharmacological action and small safety index can cause obvious adverse reactions if the dissolution speed of the drug which is rapidly absorbed is too fast, the time for maintaining the drug effect is shortened, and in this case, the dissolution speed of the drug in the preparation is controlled. Along with the continuous development of machinery modernization, the appearance that disintegrates on the market is jagged, is not enough and defect to a certain extent, and its hanging flower basket subassembly of current appearance that disintegrates is difficult to dismantle, is unfavorable for the washing of hanging flower basket, and the resistance that meets water at the in-process that hanging flower basket subassembly goes up and down is great for the load of host computer increases, and the appearance steadiness that disintegrates that has now in addition is relatively poor, has certain potential safety hazard.

SUMMERY OF THE UTILITY MODEL

The utility model mainly aims at the problems in the prior art and provides a disintegration tester for drug tests.

The purpose of the utility model is mainly realized by the following scheme:

the disintegration tester for the drug test comprises a base, a host arranged on the base and a hanging basket component arranged on the host, wherein the host is provided with a hot bath box for heating the hanging basket component, a heating device for controlling the internal temperature of the hot bath box and a driving device for driving the hanging basket component to move up and down; a cavity for placing a heating medium is arranged in the hot bath box, two beakers for placing a disintegrating medium are arranged in the hot bath box, the bottoms of the beakers are positioned in the hot bath box, and the tops of the beakers penetrate through a through hole in the upper surface of the hot bath box; the hanging basket assembly comprises an upper cover plate, a lower cover plate and a plurality of disintegration pipes positioned between the upper cover plate and the lower cover plate, a hanging rod is vertically arranged in the center of the upper surface of the upper cover plate, and a connecting plate is fixedly connected to the upper end of the hanging rod; the driving assembly comprises a fixing plate detachably connected with the connecting plate.

Preferably, a plurality of positioning holes are annularly distributed on the upper cover plate and the lower cover plate, and a screen is arranged in the positioning holes of the lower cover plate.

Preferably, each disintegrating pipe corresponds to one positioning hole, and the upper cover plate and the lower cover plate fix the disintegrating pipes between the two corresponding positioning holes through bolt rods.

Preferably, the lower cover plate is further provided with a plurality of through holes.

Preferably, the driving device further comprises a driving motor, a rotary table, a limiting connecting rod, a guide rod and a supporting assembly, an empty box is arranged in the rear side of the host, the driving motor is arranged in the empty box, an output shaft of the driving motor is connected with the coaxial rotary table, the end face edge position of the rotary table is connected with one end of the limiting connecting rod in a rotating mode, the limiting connecting rod is perpendicular to the connecting rod, the other end of the limiting connecting rod is connected to the middle of the connecting rod in a rotating mode, the two ends of the connecting rod are fixed with the guide rod in a vertical mode, and the upper end of the guide rod penetrates through one end of the host and the fixed plate to be fixedly connected with the other end of the fixed plate.

Preferably, the support assembly comprises two support rods symmetrically arranged at the top of the main machine, support plates are fixed on the two support rods, and the upper ends of the guide rods penetrate through the main machine and the support plates and then are fixedly connected with one end of the fixing plate.

Preferably, a guide pipe coaxial with the guide rod and sleeved outside the guide rod is fixedly arranged on the top of the main machine, and the upper end of the guide pipe is in contact with the bottom of the support plate.

Preferably, a rectangular sliding groove is formed in the connecting plate, a rectangular sliding block is arranged at one end, close to the connecting plate, of the fixing plate, the rectangular sliding block slides up and down in the rectangular sliding groove, a threaded hole is formed in the outer side of the rectangular sliding block, a fastening bolt is connected to the threaded hole in a threaded mode, and the connecting plate is detachably connected with the fixing plate through the fastening bolt.

Preferably, two support tables for placing the beakers are fixedly arranged at the bottom in the hot bath box.

Preferably, the side of base is equipped with the mounting panel, threaded connection has adjusting bolt on the mounting panel, and the bottom of base is provided with fixed suction cup.

Therefore, the utility model has the following advantages:

(1) according to the utility model, the driving motor is started through the arranged driving assembly, the connecting rod is driven under the action of the limiting connecting rod, so that the guide rod moves up and down, the lifting motion can be realized by the unidirectional rotation of the driving motor, the structure is stable, the requirement on the motor is low, and the cost is reduced;

(2) according to the utility model, through the arrangement of the connecting plate and the fixing plate, the hanging basket component can be detached only by loosening the fastening bolt, so that the cleaning of the hanging basket is facilitated;

(3) according to the utility model, the whole device can be stably fixed on the operation platform through the fixed sucker through the arranged base, and the fixed sucker is conveniently separated from the operation platform through the arrangement of the adjusting bolt, so that the operation is convenient.

Drawings

FIG. 1 is a schematic diagram of an embodiment of the present invention;

FIG. 2 is a schematic view showing the internal structure of the hot bath box according to the present invention;

FIG. 3 is a schematic view of the construction of the basket assembly of the present invention;

FIG. 4 is a schematic view of the structure of the lower cover plate of the present invention;

FIG. 5 is a schematic view of the structure of the driving device of the present invention;

FIG. 6 is a schematic view of the connection of the connecting plate and the fixing plate according to the present invention;

fig. 7 is a schematic structural view of the base in the present invention.

Illustration of the drawings: 1-base, 2-main frame, 3-hot bath box, 4-heating device, 5-cavity, 6-beaker, 7-upper cover plate, 8-lower cover plate, 9-disintegration tube, 10-suspension rod, 11-connecting plate, 12-fixing plate, 13-positioning hole, 14-screen, 15-hanging basket component, 16-bolt rod, 17-through hole, 18-driving motor, 19-rotary table, 20-limit connecting rod, 21-connecting rod, 22-guide rod, 23-empty box, 24-supporting rod, 25-supporting plate, 26-guide tube, 27-rectangular chute, 28-rectangular slide block, 29-threaded hole, 30-fastening bolt, 31-supporting table, 32-mounting plate, 33-adjusting bolt, 34-fixed suction cup.

Detailed Description

The technical solution of the present invention is further specifically described below by way of specific examples in conjunction with the accompanying drawings. It is to be understood that the practice of the utility model is not limited to the following examples, and that any variations and/or modifications may be made thereto without departing from the scope of the utility model.

In the present invention, all parts and percentages are by weight, unless otherwise specified, and the equipment and materials used are commercially available or commonly used in the art. The methods in the following examples are conventional in the art unless otherwise specified. The components or devices in the following examples are, unless otherwise specified, standard parts or parts known to those skilled in the art, the structure and principle of which are known to those skilled in the art through technical manuals or through routine experimentation.

Example 1:

as shown in figure 1, the utility model provides a technical scheme, which is a disintegration tester for drug testing and comprises a base 1, a main machine 2 arranged on the base 1 and a hanging basket assembly 15 arranged on the main machine 2, wherein the main machine 2 is provided with a hot bath box 3 for heating the hanging basket assembly 15, a heating device 4 for controlling the internal temperature of the hot bath box 3 and a driving device for driving the hanging basket assembly 15 to move up and down.

As shown in fig. 2, a cavity 5 for placing a heating medium is arranged in the hot bath box 3, two beakers 6 for placing disintegrating media are arranged in the hot bath box 3, two support tables 31 for placing the beakers 6 are fixedly arranged at the bottom in the hot bath box 3, the bottom of each beaker 6 is located on the support table 31 in the hot bath box 3, the top of each beaker 6 penetrates through a through hole in the upper surface of the hot bath box 3, and the support tables 31 are arranged to ensure that the whole beaker 6 is heated and ensure the accuracy of medicine monitoring.

As shown in fig. 3, the basket assembly 15 comprises an upper cover plate 7, a lower cover plate 8 and six disintegration tubes 9 positioned between the upper cover plate 7 and the lower cover plate 8, a hanger rod 10 is vertically arranged in the center of the upper surface of the upper cover plate 7, and a connecting plate 11 is fixedly connected to the upper end of the hanger rod 10.

The driving assembly includes a fixed plate 12 detachably coupled to the connection plate 11.

The heating device 4 includes but is not limited to an electric heating wire or an electric heating tube, the heating temperature of the heating device 4 is kept at about 37 ℃, but the user can still set the heating temperature of the heating device 4 in a customized manner; the hot bath box 3 is made of transparent materials including but not limited to glass and the like, so that the disintegration condition of the medicine can be observed conveniently; the connecting plate 11 and the fixing plate 12 are detachably connected, so that the hanging basket assembly 15 is convenient to detach and clean.

Example 2:

as shown in fig. 3 and 4, the present invention provides another technical solution, which is a disintegration tester for drug testing, and is different from the embodiment in that six positioning holes 13 are annularly arranged on an upper cover plate 7 and a lower cover plate 8, a screen 14 is embedded in the positioning holes 13 of the lower cover plate 8, each disintegration tube 9 corresponds to the positioning holes 13 one by one, the disintegration tubes 9 are open at the upper and lower ends, the disintegration tubes 9 are fixed between the two positioning holes 13 corresponding to each other at the upper and lower ends between the upper cover plate 7 and the lower cover plate 8 through bolt rods 16, and steps are arranged on the upper portions of the positioning holes 13 of the upper cover plate 7 and the lower portions of the positioning holes 13 of the lower cover plate 8, so as to facilitate the disintegration tubes 9 to be clamped in the positioning holes 13.

In addition, the lower cover plate 8 is also provided with a through hole 17, and the design of the through hole 17 can reduce the resistance of water in the process on the hanging basket assembly 15, reduce the load of the main machine 2 and reduce the cost.

Example 3:

as shown in fig. 5, the present invention provides another technical solution, a disintegration tester for drug testing, which is different from the embodiment in that the driving device further includes a driving motor 18, a turntable 19, a limit connecting rod 20, a connecting rod 21, a guide rod 22 and a supporting component, a hollow box 23 is arranged in the rear side of the main machine 2, the driving motor 18 is installed in the hollow box 23 through bolts, an output shaft of the driving motor 18 is connected with the coaxial turntable 19, an end face edge position of the turntable 19 is rotatably connected with one end of the limit connecting rod 20, the limit connecting rod 20 is perpendicular to the connecting rod 21, the other end of the limit connecting rod 20 is rotatably connected to the middle of the connecting rod 21, the vertically arranged guide rod 22 is fixed at both ends of the connecting rod 21, the upper end of the guide rod 22 penetrates through the main machine 2 and is fixedly connected with one end of the fixing plate 12, the driving motor 18 is started, the connecting rod 21 is driven under the action of the limit connecting rod 20, and further the guide rod 22 moves up and down, the lifting movement can be realized by the unidirectional rotation of the driving motor 18, the structure is stable, the requirement on the motor is low, and the cost is reduced.

The supporting assembly comprises two supporting rods 24 symmetrically arranged at the top of the host machine 2, supporting plates 25 are fixed on the two supporting rods 24, the upper ends of the guide rods 22 penetrate through the host machine 2 and the supporting plates 25 and then are fixedly connected with one ends of the fixing plates 12, guide pipes 26 coaxial with the guide rods 22 and sleeved outside the guide rods 22 are fixedly arranged at the top of the host machine 2, the upper ends of the guide pipes 26 are in contact with the bottoms of the supporting plates 25, and the guide pipes 26 are used for enabling the guide rods 22 to reciprocate up and down more stably.

As shown in fig. 6, be equipped with rectangle spout 27 on the connecting plate 11, the one end that the fixed plate 12 is close to the connecting plate 11 is equipped with rectangle slider 28, rectangle slider 28 slides from top to bottom in rectangle spout 27, the outside of rectangle slider 28 is equipped with screw hole 29, threaded connection has fastening bolt 30 on the screw hole 29, connecting plate 11 can dismantle the connection through fastening bolt 30 with fixed plate 12, after the use is accomplished, can manually promote hanging flower basket subassembly 15 upwards, make taking out of beaker 6 can not receive hanging flower basket subassembly 15's hindrance, then unscrew the fastening bolt and just can dismantle the hanging flower basket subassembly, make things convenient for the washing of hanging flower basket.

Example 4:

as shown in fig. 7, the present invention provides another technical solution, a disintegration apparatus for drug testing, which is different from the embodiment in that mounting plates 32 are fixed on both left and right side surfaces of a base 1, the mounting plates 32 are arranged on both front and rear sides of each side, an adjusting bolt 33 is connected to the mounting plates 32 through a thread, a fixed suction cup 34 is arranged at the bottom of the base 1, the base 1 with a host machine 2 is fixed on an operation table through the fixed suction cup 34, and the fixed suction cup 34 can be separated from the operation table by rotating the adjusting bolt 33 after use, so that the present invention has the advantages of convenient operation and strong practicability.

It should be understood that this example is only for illustrating the present invention and is not intended to limit the scope of the present invention. Further, it should be understood that various changes or modifications of the present invention may be made by those skilled in the art after reading the teaching of the present invention, and such equivalents may fall within the scope of the present invention as defined in the appended claims.

Claims

1. A appearance that disintegrates for drug test, include base (1), install host computer (2) and hanging flower basket subassembly (15) of setting on host computer (2) on base (1), its characterized in that: the main machine (2) is provided with a hot bath box (3) for heating the hanging basket component (15), a heating device (4) for controlling the internal temperature of the hot bath box (3) and a driving device for driving the hanging basket component (15) to move up and down; a cavity (5) for placing a heating medium is arranged in the hot bath box (3), two beakers (6) for placing a disintegration medium are arranged in the hot bath box (3), the bottoms of the beakers (6) are positioned in the hot bath box (3), and the tops of the beakers (6) penetrate through holes in the upper surface of the hot bath box (3); the hanging basket assembly (15) comprises an upper cover plate (7), a lower cover plate (8) and a plurality of disintegration pipes (9) positioned between the upper cover plate (7) and the lower cover plate (8), a hanging rod (10) is vertically arranged in the center of the upper surface of the upper cover plate (7), and the upper end of the hanging rod (10) is fixedly connected with a connecting plate (11); the driving device comprises a fixing plate (12) detachably connected with the connecting plate (11).

2. The disintegration tester for pharmaceutical testing of claim 1, wherein: a plurality of positioning holes (13) are annularly distributed on the upper cover plate (7) and the lower cover plate (8), and a screen (14) is arranged in the positioning holes (13) of the lower cover plate (8).

3. The disintegration tester for pharmaceutical testing of claim 2, wherein: each disintegration tube (9) corresponds to one positioning hole (13), and the disintegration tube (9) is fixed between the two positioning holes (13) corresponding up and down between the upper cover plate (7) and the lower cover plate (8) through a bolt rod (16).

4. The disintegration tester for pharmaceutical testing of claim 3, wherein: the lower cover plate (8) is also provided with a plurality of through holes (17).

5. The disintegration tester for pharmaceutical testing of claim 1, wherein: drive arrangement still includes driving motor (18), carousel (19), spacing connecting rod (20), connecting rod (21), guide bar (22) and supporting component, establish in the rear side of host computer (2) empty case (23), driving motor (18) are installed in empty case (23), and the output shaft of driving motor (18) has coaxial carousel (19), the terminal surface border position of carousel (19) rotates with the one end of spacing connecting rod (20) and is connected, spacing connecting rod (20) set up with connecting rod (21) are perpendicular, and the other end of spacing connecting rod (20) rotates and connects in the centre of connecting rod (21), the both ends of connecting rod (21) all are fixed with guide bar (22) of vertical setting, the one end fixed connection of host computer (2) and fixed plate (12) is passed to the upper end of guide bar (22).

6. The disintegration tester for pharmaceutical testing of claim 5, wherein: the supporting component comprises two supporting rods (24) symmetrically arranged at the top of the main machine (2), a supporting plate (25) is fixed on each supporting rod (24), and the upper end of the guide rod (22) penetrates through the main machine (2) and the supporting plate (25) and then is fixedly connected with one end of the fixing plate (12).

7. The disintegration tester for pharmaceutical testing of claim 6, wherein: the top of the main machine (2) is fixedly provided with a guide pipe (26) which is coaxial with the guide rod (22) and is sleeved outside the guide rod (22), and the upper end of the guide pipe (26) is contacted with the bottom of the support plate (25).

8. The disintegration tester for pharmaceutical testing of claim 7, wherein: be equipped with rectangle spout (27) on connecting plate (11), the one end that fixed plate (12) are close to connecting plate (11) is equipped with rectangle slider (28), rectangle slider (28) are in slide from top to bottom in rectangle spout (27), and the outside of rectangle slider (28) is equipped with screw hole (29), threaded connection has fastening bolt (30) on screw hole (29), connecting plate (11) pass through with fixed plate (12) fastening bolt (30) carry out the connection of dismantling.

9. The disintegration tester for pharmaceutical testing of claim 1, wherein: two supporting platforms (31) for placing the beakers (6) are fixedly arranged at the bottom in the hot bath box (3).

10. The disintegration tester for pharmaceutical testing of claim 1, wherein: the side of base (1) is equipped with mounting panel (32), threaded connection has adjusting bolt (33) on mounting panel (32), and the bottom of base (1) is provided with fixed suction cup (34).