CN215415903U - Nail in-vivo paramagnetic resonance measuring probe device for radiation dose measurement - Google Patents
Nail in-vivo paramagnetic resonance measuring probe device for radiation dose measurement Download PDFInfo
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- CN215415903U CN215415903U CN202120771370.0U CN202120771370U CN215415903U CN 215415903 U CN215415903 U CN 215415903U CN 202120771370 U CN202120771370 U CN 202120771370U CN 215415903 U CN215415903 U CN 215415903U
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- 239000000523 sample Substances 0.000 title claims abstract description 31
- 230000005855 radiation Effects 0.000 title claims abstract description 28
- 238000005259 measurement Methods 0.000 title claims abstract description 25
- 230000005298 paramagnetic effect Effects 0.000 title claims abstract description 13
- 238000001727 in vivo Methods 0.000 title abstract description 14
- 230000008878 coupling Effects 0.000 claims abstract description 44
- 238000010168 coupling process Methods 0.000 claims abstract description 44
- 238000005859 coupling reaction Methods 0.000 claims abstract description 44
- 238000001514 detection method Methods 0.000 claims abstract description 37
- 239000002184 metal Substances 0.000 claims description 9
- 229910052751 metal Inorganic materials 0.000 claims description 9
- 238000004980 dosimetry Methods 0.000 claims description 8
- 230000005672 electromagnetic field Effects 0.000 claims description 3
- 210000000282 nail Anatomy 0.000 abstract description 27
- 238000004435 EPR spectroscopy Methods 0.000 abstract description 22
- 210000004905 finger nail Anatomy 0.000 abstract description 11
- 238000011156 evaluation Methods 0.000 abstract description 7
- 238000000338 in vitro Methods 0.000 abstract description 7
- 238000000034 method Methods 0.000 description 10
- 150000003254 radicals Chemical class 0.000 description 5
- 230000005865 ionizing radiation Effects 0.000 description 4
- 230000035945 sensitivity Effects 0.000 description 4
- 210000000988 bone and bone Anatomy 0.000 description 3
- 238000012623 in vivo measurement Methods 0.000 description 3
- 238000013461 design Methods 0.000 description 2
- 210000004209 hair Anatomy 0.000 description 2
- 230000005291 magnetic effect Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 210000000515 tooth Anatomy 0.000 description 2
- 229910001369 Brass Inorganic materials 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000010951 brass Substances 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001362 electron spin resonance spectrum Methods 0.000 description 1
- 238000012854 evaluation process Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
- G01T1/00—Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
- G01T1/02—Dosimeters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- High Energy & Nuclear Physics (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Heart & Thoracic Surgery (AREA)
- Radiology & Medical Imaging (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Magnetic Resonance Imaging Apparatus (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Abstract
The utility model relates to a nail in-vivo paramagnetic resonance measuring probe device for measuring radiation dose, which comprises a resonant cavity, a tuner, a coupling structure and a tuning bolt, wherein the resonant cavity is provided with a first end and a second end; the surface of the resonant cavity is provided with a narrow slit sample detection port, the resonant cavity is connected with a tuner, and the tuner is connected to a microwave bridge through a waveguide. The tuner is internally provided with a microwave coupling structure, and the coupling structure adjusts the coupling coefficient of the microwave coupling structure through a tuning bolt. The utility model can directly carry out electron paramagnetic resonance detection on the fingernails in vivo so as to evaluate the radiation dose of the personnel, solves the problem of mechanical induced signal interference in the prior in vitro fingernail measurement, and improves the accuracy of dose evaluation.
Description
Technical Field
The utility model relates to the technical field of ionizing radiation dose and electron paramagnetic resonance, in particular to a nail in-vivo paramagnetic resonance measuring probe device for measuring radiation dose.
Background
In the emergency rescue of nuclear accident medicine, the radiation dose evaluation of irradiated personnel is an important basis for classified diagnosis, emergency treatment and emergency decision of field wounded personnel and reasonable utilization of limited treatment resources.
Ionizing radiation induces free radical generation in a variety of tissues, where free radicals from tissues such as teeth, bones, nails, hair, etc. are present for a long time, and have value for dose reconstruction. Compared with teeth and bones, nails are easier to measure, the dosimetry characteristics of the nail are better than those of hair, and the nail is also advantageous when the nail is used for local irradiation of hands caused by relatively common radiographic inspection and thickness gauges. The main component of nails is alpha keratin, in which ionizing radiation induces the production of free radicals, the amount of which is linear with the radiation dose and has an additive effect. Free radicals are a group with unpaired electrons and can be specifically detected by Electron Paramagnetic Resonance (EPR) method, so that ionizing radiation dose evaluation can be achieved by nail EPR measurement. The method has the advantages of high measurement speed, field implementation, good radiation specificity and the like, and the measurement speed is several minutes.
Currently, the commonly used method for evaluating nail EPR dosage is to cut nails and then measure in vitro (in vitro), and an EPR spectrum obtained by the method contains a Background Signal (BKG), a Radiation Induced Signal (RIS) and a Mechanical Induced Signal (MIS) caused by nail cutting. MIS is similar to RIS in characteristics, has covered RIS to a certain extent to the RIS that adopts and MIS separation method all have certain restriction at present, have led to the problem such as the dose evaluation error is great, dose value lower limit is higher, this is the main bottleneck that influences current nail EPR dose evaluation method practicality. If the in-vivo measurement of the fingernails can be realized, namely the fingernails are not cut into pieces but are directly measured, the generation of MIS signals can be avoided, and the problem of interference of MIS to RIS is fundamentally solved.
SUMMERY OF THE UTILITY MODEL
In view of the problems in the prior art, the present invention is directed to a nail-on-body electron paramagnetic resonance measurement apparatus for radiation dose measurement, which is a nail-on-body measurement apparatus for radiation dose measurement, and more particularly, to a microwave resonant cavity with a narrow-slit detection port and an associated apparatus thereof. The resonant cavity is provided with a narrow-slit type sample detection port on the surface of the cavity, and can detect the inserted fingernails. The resonant cavity is connected to the waveguide by a tuner. The adapter adjusts the coupling coefficient through the small hole and the tuning bolt in front of the small hole. The whole structure of the resonant cavity is processed by brass with good conductivity, and the surface resistance is further reduced by a surface silver plating process. The utility model can directly carry out electron paramagnetic resonance detection on the fingernails in vivo so as to evaluate the radiation dose of the personnel, solves the problem of mechanical induced signal interference in the prior in vitro fingernail measurement, and improves the accuracy of dose evaluation.
The technical scheme of the utility model is as follows:
a nail paramagnetic resonance measuring probe device for measuring radiation dose comprises a resonant cavity, a tuner, a coupling structure and a tuning bolt; the resonant cavity is a hollow cavity body so as to restrain microwaves in the resonant cavity; the surface of the resonant cavity is provided with a sample detection port, the resonant cavity is connected with a tuner, and the tuner is connected to a microwave bridge through a waveguide; the tuner is internally provided with a microwave coupling structure, the microwave coupling structure is provided with a coupling hole, and the coupling coefficient of the microwave coupling structure is adjusted through the coupling hole and a tuning bolt arranged at the coupling hole.
Preferably, the sample detection port is a narrow slit detection port.
Preferably, the height of the narrow slit detection port is 0.8mm-2 mm; the slit detection opening extends in the entire width direction of the first side of the resonant cavity.
Preferably, the microwave electromagnetic field in the resonant cavity is TE101 mode.
Preferably, a narrow slit detection port is arranged at the front part of the resonant cavity; an opening is arranged at the rear part of the resonant cavity, and the rear part of the resonant cavity is connected to the tuner.
Preferably, a metal sheet is disposed between the opening and the dispenser, and the resonant cavity is connected to the dispenser through the metal sheet.
Preferably, a coupling hole is opened on the metal thin plate; the size of the coupling hole is adjusted through the relative position of the tuning bolt and the coupling hole, and then the coupling coefficient is adjusted.
Compared with the prior art, the utility model has the advantages that:
the novel microwave resonant cavity is the most key factor for realizing nail in-vivo EPR measurement. Conventional EPR spectrometers are limited to microwave cavity structures and cannot be used for in vivo nail measurements. The microwave resonant cavity is the probe of the EPR spectrometer, the mode of realizing is measured at the EPR of body to its theory of operation has been decided, and its sensitivity also is the most key factor of deciding EPR measurement sensitivity, is the most core part of EPR spectrometer. The commonly used microwave resonant cavity generally adopts a closed metal cavity structure, a detection sensitive zone is positioned at the geometric center of the resonant cavity, and a fingernail can only be cut into pieces and then put into a sample tube and inserted into the center of the resonant cavity for in-vitro measurement.
According to the nail in-vivo electron paramagnetic resonance measuring device for measuring radiation dose, the nail is used as a measuring sample, so that the problem that the detection effect is influenced due to the severe attenuation of microwaves when a tooth water-containing sample is adopted is solved; meanwhile, the fingernails are exposed on the body surface, compared with samples such as teeth and bones, the method is simple and easy to operate, and the method has the advantages of detecting the dose of local irradiation of the hands. The method adopts an in-vivo measurement method, and avoids the problem of mechanical induced signal interference caused by the need of nail shearing in the in-vitro measurement method. The device provided by the utility model overcomes the problem that the conventional radiation dose evaluation process based on a genetic method takes long time, for example, tens of hours generally, and can carry out rapid dose detection, and the detection result only needs 3 to 5 minutes.
Drawings
The advantages of the above and/or additional aspects of the present invention will become apparent and readily appreciated from the following description of the embodiments taken in conjunction with the accompanying drawings of which:
FIG. 1 is a schematic structural diagram of a nail in-vivo electron paramagnetic resonance measuring device for radiation dose measurement according to the present invention.
Detailed Description
In order that the above objects, features and advantages of the present invention can be more clearly understood, a more particular description of the utility model will be rendered by reference to the appended drawings. It should be noted that the embodiments and features of the embodiments of the present application may be combined with each other without conflict.
The utility model relates to a nail in-vivo paramagnetic resonance measuring probe device for measuring radiation dose, which comprises a resonant cavity, a tuner, a coupling structure and a tuning bolt; the surface of the resonant cavity is provided with a narrow slit sample detection port, the resonant cavity is connected with a tuner, and the tuner is connected to a microwave bridge through a waveguide. The tuner is internally provided with a microwave coupling structure, and the coupling structure adjusts the coupling coefficient of the microwave coupling structure through a tuning bolt. The utility model can directly carry out electron paramagnetic resonance detection on the fingernails in vivo so as to evaluate the radiation dose of the personnel, solves the problem of mechanical induced signal interference in the prior in vitro fingernail measurement, and improves the accuracy of dose evaluation.
Specifically, as shown in fig. 1, the nail-on-body electron paramagnetic resonance measuring device for radiation dosimetry according to the embodiment of the utility model comprises a resonant cavity 1, a tuner 2, a coupling structure and a tuning bolt 3. The microwave cavity comprises a resonant cavity body, and is characterized in that a detection port 4 is arranged on the resonant cavity body, the detection port is a narrow slit detection port, the resonant cavity body is connected with a tuner, a coupling structure is arranged in the tuner, the coupling coefficient of the coupling structure is adjusted through a small hole and a tuning bolt in front of the small hole, and the tuner is connected to a microwave bridge through a waveguide. The small hole is here a coupling hole.
Preferably, the microwave electromagnetic field 5 in the resonant cavity is the TE101 mode.
Preferably, the resonant cavity is a hollow cavity.
Preferably, the resonant cavity is configured to confine microwaves therein. A narrow gap detection opening is formed in the front of the resonant cavity, and a nail extends into the resonant cavity from the narrow gap detection opening.
An opening is provided at a rear portion of the resonant cavity, which is connected to the tuner, e.g. to a first side of the tuner.
Specifically, the resonant cavity has a first side portion, a second side portion, a third side portion, a fourth side portion, a fifth side portion and a rear portion, the first side portion of the resonant cavity is a front portion of the resonant cavity, the second side portion of the resonant cavity is a left side portion of the resonant cavity, the third side portion of the resonant cavity is a right side portion of the resonant cavity, the fourth side portion of the resonant cavity is an upper portion of the resonant cavity, the fifth side portion of the resonant cavity is a lower portion of the resonant cavity, and the slit detection port is disposed at the first side portion of the resonant cavity.
Preferably, the height of the narrow slit detection port is 0.8mm-2mm, so as to better perform radiation detection; if the height of the narrow slit detection opening is not enough, the measured sample can be influenced to enter the resonant cavity, and if the height of the narrow slit detection opening is too large, the detection sensitivity can be reduced. The slit opening extends in the entire width direction of the first side of the resonant cavity.
Furthermore, a metal sheet is arranged in the tuner and provided with a coupling hole, the tuning bolt is fixed to the tuner and is a metal cap, an operating part is arranged at the upper part of the tuning bolt, and the lower part of the tuning bolt is positioned in front of the coupling hole to adjust the coupling coefficient through the relative position of the tuning bolt and the coupling hole.
Preferably, the waveguide is connected to a second side of the coordinator, the second side of the coordinator being disposed opposite the first side of the coordinator. Preferably, the waveguide is connected to the coordinator by a fastener.
And a standard sample hole is arranged on the second side part or the third side part of the resonant cavity, and a reference standard sample 6 is arranged in the standard sample hole.
Aiming at the requirements of nail in-vivo EPR measurement, the utility model designs a new resonant cavity structure, a narrow-slit sample detection port is arranged on the surface of the resonant cavity, a detection sensitive region is moved to the sample detection port region from the center of the cavity through a new microwave field type design, and the physical conditions such as matched modulation magnetic field, scanning magnetic field and other EPR necessary physical conditions are supplemented, so that the nail in-vivo EPR measurement is realized. Compared with teeth, the nail in-vivo measurement is simpler and easier, but the concentration of the radiation-induced free radicals in the nail is lower, and the volume of an effective sample is smaller, so that the requirement on the sensitivity of an EPR resonant cavity is higher.
It will be understood that the above embodiments are merely exemplary embodiments taken to illustrate the principles of the present invention, which is not limited thereto. Those of ordinary skill in the art will understand that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.
In the description of the present invention, it should be noted that the terms "upper", "lower", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, which are merely for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and operate, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first" and "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; the communication may be direct, indirect via an intermediate medium, or internal to both elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art. In addition, in the description of the present invention, "at least three" means two or more unless otherwise specified.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the utility model, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (7)
1. A nail paramagnetic resonance measuring probe device for measuring radiation dose is characterized by comprising a resonant cavity, a tuner, a coupling structure and a tuning bolt; the resonant cavity is a hollow cavity body so as to restrain microwaves in the resonant cavity; the surface of the resonant cavity is provided with a sample detection port, the resonant cavity is connected with a tuner, and the tuner is connected to a microwave bridge through a waveguide; the tuner is internally provided with a microwave coupling structure, the microwave coupling structure is provided with a coupling hole, and the coupling coefficient of the microwave coupling structure is adjusted through the coupling hole and a tuning bolt arranged at the coupling hole.
2. The on-fingernail paramagnetic resonance measurement probe apparatus for radiation dosimetry of claim 1, wherein the sample detection port is a slit detection port.
3. The on-fingernail paramagnetic resonance measurement probe apparatus for radiation dosimetry of claim 2, wherein the slot detection port has a height of 0.8mm to 2 mm; the slit detection opening extends in the entire width direction of the first side of the resonant cavity.
4. The nail paramagnetic resonance measurement probe device for radiation dosimetry according to claim 3, wherein the microwave electromagnetic field in the resonant cavity is the TE101 mode.
5. The on-fingernail paramagnetic resonance measurement probe apparatus for radiation dosimetry of claim 4, wherein a slot detection port is provided at the front of the resonant cavity; an opening is arranged at the rear part of the resonant cavity, and the rear part of the resonant cavity is connected to the tuner.
6. A nail paramagnetic resonance measurement probe device for radiation dosimetry according to claim 5, wherein a metal sheet is provided between the opening and the dispenser, the resonant cavity being connected to the dispenser through the metal sheet.
7. The on-fingernail paramagnetic resonance measurement probe apparatus for radiation dosimetry of claim 6 wherein a coupling aperture is opened in the metal sheet; the size of the coupling hole is adjusted through the relative position of the tuning bolt and the coupling hole, and then the coupling coefficient is adjusted.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| CN202120363805 | 2021-02-08 | ||
| CN2021203638058 | 2021-02-08 |
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| CN215415903U true CN215415903U (en) | 2022-01-04 |
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| CN202110405192.4A Active CN113093260B (en) | 2021-02-08 | 2021-04-15 | In-vivo measurement method and device for radiation dose measurement |
| CN202120771370.0U Active CN215415903U (en) | 2021-02-08 | 2021-04-15 | Nail in-vivo paramagnetic resonance measuring probe device for radiation dose measurement |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2892005B2 (en) * | 1988-02-24 | 1999-05-17 | 科学技術振興事業団 | Electron spin resonance device |
| AU2005249510A1 (en) * | 2004-06-01 | 2005-12-15 | Graham S. Timmins | Detecting melanoma by electron paramagnetic resonance |
| ATE470822T1 (en) * | 2007-01-19 | 2010-06-15 | Martin Professional As | DRIVE FOR LIGHT GENERATING MEANS |
| WO2009073686A1 (en) * | 2007-12-03 | 2009-06-11 | Trans Dermal Patents Company, Llc | Agent delivery system and uses of the same |
| US20110130647A1 (en) * | 2008-07-31 | 2011-06-02 | The Trustees of Dartmouth College noneprofit corporation | System And Method Using Coupler-Resonators For Electron Paramagnetic Resonance Spectroscopy |
| US9255901B2 (en) * | 2008-08-31 | 2016-02-09 | The Trustees Of Dartmouth College | System and method for post-exposure dosimetry using electron paramagnetic resonance spectroscopy |
| US8674694B2 (en) * | 2009-08-28 | 2014-03-18 | James S. Hyde | Coil system and method for post-exposure dosimetry using electron paramagnetic resonance spectroscopy |
| EP3047306A4 (en) * | 2013-09-16 | 2017-08-30 | Robert M. Gougelet | Radiation exposure self test (rest) - optimized personal dosimetry and kiosk for reliably indicating exposure to radiation |
| FR3026850B1 (en) * | 2014-10-07 | 2016-11-11 | Inst De Radioprotection Et De Surete Nucleaire | METHOD FOR DOSIMETRY OF IONIZING RADIATION BY DIRECT RPE MEASUREMENT ON GLASS OF A SCREEN OF AN ELECTRONIC APPARATUS |
| CN105676265A (en) * | 2014-11-18 | 2016-06-15 | 中国辐射防护研究院 | Sample preparation method of nail electron paramagnetic resonance technical detection for radiation dose estimation |
| US10371780B2 (en) * | 2015-06-19 | 2019-08-06 | The Trustees Of Dartmouth College | System and method for post-exposure dosimetry using electron paramagnetic resonance spectroscopy of teeth |
| KR102355880B1 (en) * | 2017-03-03 | 2022-01-25 | 글로벌 레조넌스 테크놀로지스, 엘엘씨 | Non-resonant electron spin resonant probe and associated hardware for detection of radiation exposure |
| CN111349559B (en) * | 2020-03-13 | 2022-10-14 | 中国人民解放军军事科学院军事医学研究院 | Small broadband microwave biological effect irradiation device |
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| CN113093260B (en) | 2024-05-24 |
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