CN102657559B - For the electron paramagnetic resonance resonator in bulk measurement people's tooth - Google Patents
For the electron paramagnetic resonance resonator in bulk measurement people's tooth Download PDFInfo
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- CN102657559B CN102657559B CN201210124520.4A CN201210124520A CN102657559B CN 102657559 B CN102657559 B CN 102657559B CN 201210124520 A CN201210124520 A CN 201210124520A CN 102657559 B CN102657559 B CN 102657559B
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- electron paramagnetic
- tooth
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- 238000004435 EPR spectroscopy Methods 0.000 title claims abstract description 22
- 238000005259 measurement Methods 0.000 title claims description 7
- 238000001514 detection method Methods 0.000 claims abstract description 30
- 230000005291 magnetic effect Effects 0.000 claims abstract description 15
- 230000008878 coupling Effects 0.000 claims abstract description 12
- 238000010168 coupling process Methods 0.000 claims abstract description 12
- 238000005859 coupling reaction Methods 0.000 claims abstract description 12
- 229910052751 metal Inorganic materials 0.000 claims abstract description 4
- 239000002184 metal Substances 0.000 claims abstract description 4
- 230000005855 radiation Effects 0.000 abstract description 3
- 238000001727 in vivo Methods 0.000 abstract description 2
- 210000000214 mouth Anatomy 0.000 description 19
- 238000000034 method Methods 0.000 description 10
- 230000005298 paramagnetic effect Effects 0.000 description 6
- 239000000463 material Substances 0.000 description 4
- 238000001362 electron spin resonance spectrum Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 150000003254 radicals Chemical class 0.000 description 3
- 210000003298 dental enamel Anatomy 0.000 description 2
- 230000002285 radioactive effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 206010043183 Teething Diseases 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- -1 diphenylpicrylhydrazine free radical Chemical class 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000005251 gamma ray Effects 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000005408 paramagnetism Effects 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 230000036346 tooth eruption Effects 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
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- Control Of Motors That Do Not Use Commutators (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Abstract
Present invention relates to the electron paramagnetic resonance resonator that one kind can measure people's tooth in body (in vivo).The external shape of the resonator is cylinder, Rectangular samples detection mouth is offered in cavity side, sample detection opening's edge circular cylindrical cavity is tangential to be run through, and its long side is vertical with the direction of microwave magnetic field component in resonator and parallel with electric grain direction in cavity wall；Place a pair of coils that modulation magnetic field is provided in the both sides of sample detection mouth；Tuning bolt outside using coupling aperture realizes that the coupling of resonator and microwave system is adjusted；Resonator and the good metal of deployment unit overall structure electric conductivity make.Present invention is mainly used for being measured in body electron paramagnetic resonance people's tooth, the quick estimation of dose of radiation is realized, electron paramagnetic resonance detection can also be implemented outside chamber to overall structure or the larger sample for being inconvenient to insert in resonator of volume should not be destroyed.
Description
Technical field
Present invention relates to a kind of electron paramagnetic resonance detection means, and specifically, being related to one kind can be in body (in
Vivo the electron paramagnetic resonance resonator of people's tooth) is measured.Its volume of this resonator by particular design and profile are suitable
Tooth is directly detected in inserting inside human mouth, it is affiliated so as to obtain the electron paramagnetic resonance spectrum (EPR) of enamel specimen
Technical field is New Biophysical Techniques and new method.
Background technology
Electron paramagnetic resonance (abbreviation EPR) is that Zeeman level jump occurs for detecting the spin magnetic moment of non-coupling electronics in material
The technology moved.The paramagnetisms such as the free radical contained in material, transition metal, lattice defect can be analyzed using this technology
The content and property at center.Therefore the Technique of Electron Paramagnetic Resonance is widely used in physics, chemistry, geology, archaeology, material supply section
Many fields such as and biomedicine.
Free Radical Signal in measurement human teeth can obtain important biological information.Such as when personnel are ionized
After radiation, the content of free radical in the Technique of Electron Paramagnetic Resonance detection tooth can be utilized, it is possible thereby to for estimating human body
Radioactive dose.
Traditional electron paramagnetic resonance analyzing detecting method is, it is necessary to which sample to be placed in the center of sample cavity.Due to micro-
The particular/special requirement of wave frequency rate and microwave field pattern so that the volume and profile of resonator are restricted, so as to the sample in resonator
The profile and volume of product have corresponding limitation.In fact, when conditional electronic paramagnetic resonance spectrometer measures, usually sample is carried out
Inserted after pulverization process in a diameter of 1~5 millimeter of sample cell, sample cell is then inserted into resonator, carried out electron paramagnetic and be total to
Shake research.Therefore traditional electron paramagnetic resonance analysis can only detect teeth in vitro, and need from oral cavity to take out tooth simultaneously
Sample is made after crushing to measure.The problem of this method is due to experiment condition and sampling, exists in actual applications
Larger limitation.
For this invention aiming above mentioned problem, electron paramagnetic resonance measurement can be carried out outside resonator by establishing one kind
Method, so as to realize to tooth in bulk measurement.This method is mainly used to rapidly estimate personnel's radioactive dose,
Sample that is larger to other volumes and not allowing to destroy can be used for and carry out local paramagnetic resonance detection.
The content of the invention
This invention provides a kind of resonator that can carry out electron paramagnetic resonance measurement to people's tooth in body, specific side
Case is as follows：The profile of resonator cavity 1 is cylinder, and radius is less than 15 millimeters, and length is less than 30 millimeters, 1~2 millimeter of cavity wall thickness,
Size and profile are suitable to insert in human mouth.Rectangular samples detection mouth 2 is offered in the side of cavity 1, sample detection mouth is located at
Circular cylindrical cavity axial centre or close center.Sample detection opening's edge wall thickness direction is longitudinally through to inside cavity space,
Run through along circular cylindrical cavity is tangential.The sample detection mouth long edge size is the 1/2~1/3 of cavity internal diameter, and short side dimension is cavity
The 1/5~1/15 of interior length.The long side of this sample detection mouth it is vertical with the direction of microwave magnetic field component in resonator and and cavity wall
Upper electric grain direction is parallel.A pair of the coils 3 for providing modulation magnetic field are placed in the both sides of sample detection mouth, and the coil is examined in sample
Survey the modulation magnetic field that mouth position produces some strength needed for electron paramagnetic resonance.The base 10 of cavity passes through screw using screw
9 are connected with deployment unit 5.Deployment unit uses the coupling iris 4 with coupling aperture 8 to couple with resonator, and its thickness is less than 0.2
Millimeter.Coupling constant is adjusted by the tuning bolt 7 being arranged on outside coupling aperture, metal small cap is carried at the top of tuning bolt
6.The opposite side of deployment unit is connected with waveguide, and is connected to spectrometer microwave bridge unit by waveguide.Resonator and deployment unit
Overall structure makes of metal with good conductivity, and electroplate or gold improve electric conductivity.
This resonator can produce microwave resonance after the microwave of loading specific frequency in inside cavity.Set by special
Meter mode of resonance and sample detection hole site can be such that sample detection hole position is concentrated in microwave magnetic field component in resonator with size
Position, while avoid in resonator microwave electric field component compared with concentrated position so that resonance quality factor are without greater loss.It is humorous
The microwave magnetic field component for intracavitary of shaking can leak from sample detection mouth position.The modulation coil of sample detection mouth both sides is passed through
High frequency modulated magnetic field needed for paramagnetic resonance can be provided after driving current at sample detection mouth.
When carrying out actually detected, resonator can enter testee oral cavity, and tooth is bitten sample detection mouth by testee.
Now the modulation magnetic field outside the microwave resonant cavity in resonator can act on tooth, resonator at sample detection mouth simultaneously
Outer apply again can be realized as being measured in body electron paramagnetic resonance for tooth with corresponding scanning magnetic field.
The resonant cavity of the present invention is relatively simple for structure, is easy to process and makes；Small volume, profile is round and smooth, is advantageous to put
Inside entrance cavity.Modulation magnetic field device is placed on the outside of sample detection mouth, at utmost reduced special to intra resonant cavity electromagnetism
The influence of property.
Present invention is mainly used for being measured in body electron paramagnetic resonance people's tooth, to realize that the quick of dose of radiation is estimated
Calculate, can also be to being inconvenient to destroy overall structure or the larger sample for being inconvenient to insert intra resonant cavity of volume outside resonator in fact
Electron paramagnetic resonance detection is applied, such as：The rare sample of fixed alternative the fossil sample or geological research of archaeology.
Brief description of the drawings
Fig. 1 is that electron paramagnetic resonance resonator of the present invention implements structural representation.
Embodiment
Resonator internal diameter is 22 millimeters, and resonator inner height is 28.2 millimeters, and cavity thickness are 1.5 millimeters, cavity body structure
Material is copper, electroplate.Long edge size is 10 millimeters at the longitudinally through mouth of sample detection mouth rectangle, and short side is 3 millimeters, sample
Product detection mouth and the tangential insertion of cavity wall.Modulation coil is fixed at the both sides 5cm of sample detection mouth center, applies the modulation of 100K hertz
Electric current.The cavity is connected by deployment unit and waveguide with the microwave system of Bruker-A300 type electron paramagnetic resonance spectrometers
Connect, microwave resonance frequency is 9.55G hertz, and microwave field pattern is TE111 types in resonator.Practical application effect is as follows：Utilize this
Described resonator detection diphenylpicrylhydrazine free radical (DPPH) spotted samples of invention, can obtain good electron paramagnetic and be total to
Shake spectral line.Using the human teeth of Resonance detector gamma-ray irradiation of the present invention, the electricity of teething body enamel can be detected
Sub- Paramagnetic Resonance Singnal.
Claims (1)
1. a kind of electron paramagnetic resonance resonator being used in bulk measurement people's tooth, resonator cavity (1) profile is cylinder, partly
Footpath is less than 15 millimeters, and length is less than 30 millimeters, 1~2 millimeter of cavity wall thickness；The base (10) of cavity passes through screw (9) using screw
It is connected with deployment unit (5), deployment unit uses the coupling iris (4) with coupling aperture (8) to couple with resonator, coupling iris
Thickness is less than 0.2 millimeter；Coupling constant is adjusted by the tuning bolt (7) being arranged on outside coupling aperture, tuning bolt top
Portion carries metal small cap (6), it is characterized in that：Rectangular samples detection mouth (2), sample detection mouth are offered in cavity (1) side
It is longitudinally through to inside cavity space, edge along cavity wall thickness direction positioned at circular cylindrical cavity axial centre or close to center
Circular cylindrical cavity is tangential to be run through, and long edge size is the 1/2~1/3 of cavity internal diameter, and short side dimension is 1/5~1/ of length in cavity
15, long side is vertical with the direction of microwave magnetic field component in resonator and parallel with electric grain direction in cavity wall；Sample detection mouth
Both sides place provide modulation magnetic field a pair of coils (3), the coil detection mouth position produce electron paramagnetic resonance needed for
The modulation magnetic field of some strength.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210124520.4A CN102657559B (en) | 2012-04-26 | 2012-04-26 | For the electron paramagnetic resonance resonator in bulk measurement people's tooth |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210124520.4A CN102657559B (en) | 2012-04-26 | 2012-04-26 | For the electron paramagnetic resonance resonator in bulk measurement people's tooth |
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| Publication Number | Publication Date |
|---|---|
| CN102657559A CN102657559A (en) | 2012-09-12 |
| CN102657559B true CN102657559B (en) | 2017-12-22 |
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| CN201210124520.4A Active CN102657559B (en) | 2012-04-26 | 2012-04-26 | For the electron paramagnetic resonance resonator in bulk measurement people's tooth |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103033526B (en) * | 2013-01-05 | 2017-09-12 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | A kind of cylindrical electron paramagnetic resonance probe of external sample measurement |
| CN103018269B (en) * | 2013-01-05 | 2017-09-12 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | A kind of rectangle electron paramagnetic resonance probe of chamber external pelivimetry sample |
| CN104698023B (en) * | 2015-02-25 | 2017-05-03 | 中国科学技术大学 | Remote tuning device for electron paramagnetic resonance probe |
| EP3339872B1 (en) * | 2016-12-21 | 2019-02-13 | Bruker BioSpin GmbH | Epr resonator with extended transparency and homogeneity in rf range |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1199134A (en) * | 1997-08-01 | 1999-04-13 | Yuusuke Nonomura | Small local magnetic field inserting type mri |
| CN2401894Y (en) * | 1999-12-03 | 2000-10-18 | 中国人民解放军军事医学科学院放射医学研究所 | Paramagnetic resonance resonant-cavity |
| CN2530266Y (en) * | 2001-11-20 | 2003-01-08 | 中国科学院电工研究所 | Special magnetic field device for paramagnetic resonance in vivo measuring human tooth |
| CN1417572A (en) * | 2001-11-06 | 2003-05-14 | 中国人民解放军军事医学科学院放射医学研究所 | Electronic paramagnetic resonance measurement scheme of personal radiation dose |
| JP2004041412A (en) * | 2002-07-11 | 2004-02-12 | Communication Research Laboratory | Image stabilizing method in mri and head coil in mri |
| TWM324205U (en) * | 2007-03-02 | 2007-12-21 | Lian-Pin Hwang | Single-sided portable NMR apparatus |
| WO2010142760A2 (en) * | 2009-06-10 | 2010-12-16 | Sirona Dental Systems Gmbh | Sensor and magnetic field unit for use in a magnetic resonance tomography system or in a magnetic resonance spectroscopy system |
-
2012
- 2012-04-26 CN CN201210124520.4A patent/CN102657559B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1199134A (en) * | 1997-08-01 | 1999-04-13 | Yuusuke Nonomura | Small local magnetic field inserting type mri |
| CN2401894Y (en) * | 1999-12-03 | 2000-10-18 | 中国人民解放军军事医学科学院放射医学研究所 | Paramagnetic resonance resonant-cavity |
| CN1417572A (en) * | 2001-11-06 | 2003-05-14 | 中国人民解放军军事医学科学院放射医学研究所 | Electronic paramagnetic resonance measurement scheme of personal radiation dose |
| CN2530266Y (en) * | 2001-11-20 | 2003-01-08 | 中国科学院电工研究所 | Special magnetic field device for paramagnetic resonance in vivo measuring human tooth |
| JP2004041412A (en) * | 2002-07-11 | 2004-02-12 | Communication Research Laboratory | Image stabilizing method in mri and head coil in mri |
| TWM324205U (en) * | 2007-03-02 | 2007-12-21 | Lian-Pin Hwang | Single-sided portable NMR apparatus |
| WO2010142760A2 (en) * | 2009-06-10 | 2010-12-16 | Sirona Dental Systems Gmbh | Sensor and magnetic field unit for use in a magnetic resonance tomography system or in a magnetic resonance spectroscopy system |
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| CN102657559A (en) | 2012-09-12 |
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