CN214781744U - Multi-row PCR tube cover closing device and opening and closing assembly - Google Patents

Abstract

The utility model relates to a many ally oneself with and arrange lid ware and subassembly that opens and shuts of PCR pipe more, close and cover the ware and include the body, be provided with hollow portion of gripping on this body, the outward flange is provided with and is used for pressing into the tube cap the orificial nip portion of many ally oneself with row PCR pipes. The opening and closing assembly comprises a cover opener and the cover closing device, wherein the cover opener is used for opening the tube covers of the multiple-row PCR tubes, and the cover opener is detachably connected to the body. Through the technical scheme, the cover closing device provided by the disclosure can achieve the sealing effect required by the tube cover and the tube body of the PCR tube only by small clamping force, is convenient and quick to operate, and can solve the risk problem of liquid leakage or aerosol caused by manual cover closing failure; simultaneously, through the cap opener in the subassembly that opens and shuts, can be convenient quick open a plurality of tube caps of many gang row PCR pipe simultaneously, improve the efficiency of uncapping, can solve the PCR pipe pollution problem that artifical gloves of uncapping were easily scratched and are brought.

Description

Multi-row PCR tube cover closing device and opening and closing assembly

Technical Field

The disclosure relates to the technical field of PCR, in particular to a cover closing device and an opening and closing assembly of a multi-gang PCR tube.

Background

In the course of analytical molecular biology research and medical clinical diagnosis, a Polymerase Chain Reaction (PCR) technique is indispensable, and a PCR is a method for rapidly amplifying a specific gene or DNA sequence in vitro, and is also called an in vitro amplification method of a gene.

In the PCR reaction experiment, a PCR tube is needed to carry out thermal cycle reaction, sample preparation and storage on the liquid reagent. And when the PCR tube is applied, a sealed environment needs to be ensured, so the PCR tube usually includes a cover body to realize the sealed environment. However, the conventional cover body of the PCR tube is broken by an experiment operator with a fingernail, and each tube cover needs to be manually pressed when the cover closing operation of the PCR tube is performed, which is time-consuming and labor-consuming.

At present PCR experiment operation in-process, because most scientific research personnel open single PCR tube cap and all open with the finger of wearing gloves directly, because single PCR body is bulky less, not only hardly open but also cover along great to the oppression of finger, break gloves very easily, finger direct contact tube cap also can pollute the tube cap inboard, and it is inefficient to open the lid in big batch operation, influences the experiment progress. When the cover of the PCR tube is closed, each tube cover needs to be manually pressed, the cover is easy to be closed and not tight, and the problems of liquid leakage, experimental environment pollution and the like can occur during PCR amplification reaction.

Therefore, in the prior art, the following problems mainly exist in the opening and closing operation of the PCR tube:

1. the pollution problem caused by the fact that laboratory operators are easy to scratch when wearing gloves;

2. the risk problem of liquid leakage or aerosol caused by untight closing of the cover during experimental operation;

3. the complex operation of opening and closing the PCR tube cap during the experiment operation.

SUMMERY OF THE UTILITY MODEL

The first purpose of this disclosure is to provide a many close lid wares of arranging PCR pipe more, should close lid ware simple structure, the simple operation can solve because artifical close lid not tight and the weeping or the aerosol risk problem that leads to.

The second purpose of this disclosure is to provide a subassembly that opens and shuts of row PCR pipe more, this subassembly that opens and shuts can be used for opening and the tube cap of closed row PCR pipe more, simple structure, and the simple operation can solve PCR pipe and easily pollute and close not tight scheduling problem of lid.

In order to achieve the above object, the present disclosure provides a lid closer for multiple rows of PCR tubes, which comprises a body, wherein a hollow holding portion is disposed on the body, and a pressing portion for pressing a tube lid into the tube openings of the multiple rows of PCR tubes is disposed on the outer edge of the body.

Optionally, the pressing portion includes a plurality of pressing structures disposed on different outer sidewalls of the body, and the pressing structure on each sidewall has a different structure to press the different tube caps.

Optionally, the pressing part includes a flat cover pressing structure having circular grooves arranged side by side to correspond to the plurality of PCR tubes one to one.

Optionally, the pressing portion includes a convex cover pressing structure having pressing protrusions arranged side by side to correspond to the plurality of PCR tubes one to one, and the pressing protrusions include two arc-shaped protrusions concentrically arranged and symmetrically arranged opposite to each other.

Optionally, the convex cover pressing structure further includes a positioning block, and the positioning blocks are arranged at one end of the plurality of pressing protrusions side by side.

Optionally, the body is of a square structure, and the pressing portion is disposed on at least one outer side wall of the square structure.

In order to achieve the second object, the present disclosure provides an opening and closing assembly for multiple PCR tubes, where the opening and closing assembly includes an opening lid device for opening a tube lid of the multiple PCR tubes and the above-mentioned closing lid device, and the opening lid device is detachably connected to the body.

Optionally, the body is provided with an installation groove, the installation groove is arranged around the holding portion, the cover opener is arranged in the installation groove and detachably connected with the cover closer, and a holding opening communicated with the holding portion is formed in the cover opener.

Optionally, the cap opener includes the board of gripping, with the pinion rack of the tip fixed connection of the board of gripping, the tooth pitch on the pinion rack with the pipe diameter phase-match of PCR pipe, the tooth on the pinion rack is the wedge setting, the board of gripping with the pinion rack sets up perpendicularly and the integral type is connected.

Optionally, the lid opener and the body are magnetically connected, a first magnet mounting groove is formed in the mounting groove, a second magnet mounting groove opposite to the first magnet mounting groove is formed in the lid opener, a first magnet is embedded in one of the first magnet mounting groove and the second magnet mounting groove, and a second magnet or magnetic metal is embedded in the other one of the first magnet mounting groove and the second magnet mounting groove.

Through the technical scheme, namely, the pressing part is arranged on the body of the cap closing device, when the cap is closed, the holding part on the body is held by a hand, and then the tube cap is pressed into the tube openings of the multiple rows of PCR tubes by the pressing part, so that the sealing effect required by the tube cap and the tube body of the PCR tubes can be achieved only by small clamping force, the operation is convenient and rapid, and the risk problem of liquid leakage or aerosol caused by untight manual cap closing can be solved; simultaneously, through the subassembly that opens and shuts that this disclosure provided, can have simultaneously uncap and close and cover the function, a plurality of tube caps that many gang rows PCR pipe were opened to uncap ware wherein when can be convenient quick, improve the efficiency of uncapping, can solve the PCR pipe pollution problem that artifical uncapping gloves easily lacerated and brought.

Additional features and advantages of the disclosure will be set forth in the detailed description which follows.

Drawings

The accompanying drawings, which are included to provide a further understanding of the disclosure and are incorporated in and constitute a part of this specification, illustrate embodiments of the disclosure and together with the description serve to explain the disclosure without limiting the disclosure. In the drawings:

FIG. 1 is a perspective view of a lid closer for a multi-gang PCR tube as set forth in an exemplary embodiment of the present disclosure;

FIG. 2 is a front view of a lid closer of a multi-gang PCR tube as set forth in an exemplary embodiment of the present disclosure;

FIG. 3 is a bottom view of a lid closer of a multi-gang PCR tube as set forth in an exemplary embodiment of the present disclosure;

FIG. 4 is a top view of a lid closer of a multi-gang PCR tube set forth in an exemplary embodiment of the present disclosure;

FIG. 5 is a perspective view of an opening and closing assembly of a multi-gang PCR tube as set forth in an exemplary embodiment of the disclosure;

fig. 6 is a perspective view of a cap opener of an opening and closing assembly of a multi-gang PCR tube, as set forth in an exemplary embodiment of the present disclosure;

fig. 7 is a front view of a cap opener of an opening and closing assembly of a multi-gang PCR tube proposed in an exemplary embodiment of the present disclosure;

fig. 8 is a bottom view of a cap opener of an opening and closing assembly of a multi-gang PCR tube as set forth in an exemplary embodiment of the present disclosure;

fig. 9 is a right side view of a cap opener of an opening and closing assembly of a multi-gang PCR tube set forth in an exemplary embodiment of the present disclosure;

fig. 10 is a rear view of a cap opener of an opening and closing assembly of a multi-gang PCR tube as set forth in exemplary embodiments of the present disclosure.

Description of the reference numerals

100-body; 110-flat cover pressing structure; 111-circular grooves; 120-convex cover pressing structure; 121-pressing the protrusion; 122-arc-shaped protrusion; 123-positioning blocks; 130-a mounting groove; 131-a first groove; 132-a second groove; 133-a first magnet mounting slot; 200-a cap opener; 210-a grip plate; 211-a grip opening; 212-a second magnet mounting slot; 220-toothed plate.

Detailed Description

The following detailed description of specific embodiments of the present disclosure is provided in connection with the accompanying drawings. It should be understood that the detailed description and specific examples, while indicating the present disclosure, are given by way of illustration and explanation only, not limitation.

In the present disclosure, the use of directional terms such as "inner and outer" refers to the inner and outer of the associated component profile, unless stated to the contrary. "first, second, etc. means that there is no ordering or importance in order to distinguish one element from another.

The present disclosure will now be further described with reference to the drawings and specific examples.

According to a first aspect of the present disclosure, a lid closer for a multi-gang PCR tube is provided. Referring to fig. 1 to 4, the cap closer includes a body 100, the body 100 is provided with a hollow holding portion, and the outer edge is provided with a pressing portion for pressing the cap into the nozzles of the multiple rows of PCR tubes.

Through above-mentioned technical scheme, through the closed lid ware that this disclosure provided promptly, when closing the lid operation, hold the portion of gripping, then press down the tube cap with the nip portion in order pressing it into the mouth of pipe of many gang rows PCR pipe, only need less block dynamics just can reach the tube cap of PCR pipe and the required sealed effect of body, convenient operation is swift, can solve because the manual work closes the weeping or the aerosol risk problem that the lid is not tight and lead to.

The multiplex PCR tubes may be 8-row PCR tubes, or 12-row PCR tubes, or multiplex PCR tubes formed by connecting other numbers of PCR tubes side by side, which is not limited in this disclosure.

In some embodiments, it is contemplated that the multi-row PCR tube has a different type of cap, such as a flat cap with a flat upper surface, or a convex cap with a convex upper surface. Thus, in a specific embodiment, the press-fit portion may include a plurality of press-fit structures disposed on different outer sidewalls of the body 100, and the structure of the press-fit structure on each sidewall is different to press different tube covers.

According to some embodiments of the present disclosure, in the case that the tube caps of the multiple rows of PCR tubes are flat caps, referring to fig. 2 to 3, the press-fit portion may include a flat cap press-fit structure 110, the flat cap press-fit structure 110 having circular grooves 111 arranged side by side to correspond to the multiple PCR tubes one to one; when closing the lid operation, aim at corresponding tube cap upper surface with circular recess 111, then hold the portion of gripping and press, only need less block dynamics just can reach the required sealed effect of the mouth of pipe of tube cap and PCR pipe.

Specifically, in order to achieve a better sealing effect, in some embodiments, the circular groove 111 is aligned between the outer edge of the tube cap and the position of the tube cap relative to the nozzle of the PCR tube during the cap closing operation, and then the cap is pressed to obtain a good sealing effect. Wherein, the diameter of the circular groove 111 is smaller than the diameter of the outer edge of the tube cover and is larger than or equal to the diameter of the tube opening of the PCR tube.

In some embodiments, the body 100 may be formed by fastening an upper housing and a lower housing, and the corresponding circular groove 111 may also be a circular through hole, which may reduce the manufacturing cost of the body 100. Of course, it is also possible that the body 100 may be made of a solid structure. The present disclosure is not specifically limited herein.

According to still other embodiments of the present disclosure, in the case that the tube caps of the multiple rows of PCR tubes are convex caps, referring to fig. 1, 2 and 4, the press-fit part may include a convex cap press-fit structure 120, the convex cap press-fit structure 120 having press protrusions 121 arranged side by side to correspond to the multiple PCR tubes one to one, the press protrusions 121 including two concentrically arranged arc-shaped protrusions 122, the two arc-shaped protrusions 122 being symmetrically arranged opposite to each other. When closing the lid operation, cover two protruding 122 buckles of arc on protruding, then hold the portion of gripping and press, only need less block dynamics just can reach the required sealed effect of body of tube cap and PCR pipe.

Specifically, in order to achieve a better sealing effect, in some embodiments, the distance between the most distal ends of the inner sidewalls of the two arc-shaped protrusions 122 is smaller than the diameter of the outer edge of the tube cover, and is greater than or equal to the diameter of the nozzle of the PCR tube.

In the embodiment of the present disclosure, in order to facilitate the two arc-shaped protrusions 122 to be more quickly and accurately fastened to the convex cover, as described with reference to fig. 1, 2 and 4, the convex cover pressing structure 120 may further include a positioning block 123, and the positioning block 123 is disposed at one end of the plurality of pressing protrusions side by side. When closing the lid operation, at first support locating piece 123 on the lateral wall of the one end of the many rows of PCR pipes along its side by side direction, then just can be with two arc-shaped protrusion 122 faster, accurate lock on the convex cover, make and close lid operation convenient and fast more. The distance between the positioning block 123 and the pressing protrusion 121 adjacent to the positioning block corresponds to the distance between one end of the multiple PCR tubes along the side-by-side direction and the PCR tube adjacent to the multiple PCR tubes, so that the positioning block 123 has a positioning function.

In some embodiments, the body 100 is a square structure, and the press fit portion is disposed on at least one outer sidewall of the square structure. For example, the flat cover press-fit structure 110 and the convex cover press-fit structure 120 may be disposed on both adjacent sidewalls, or may be disposed on opposite sidewalls as shown in fig. 1 to 4. The present disclosure is not specifically limited herein.

In this embodiment, the flat cover press-fit structure 110 and/or the convex cover press-fit structure 120 may also have an arc-shaped profile that is convex outward. When the cap is closed, the circular groove 111 at one end of the flat cap pressing structure 110 or the pressing protrusion 121 at one end of the convex cap pressing structure 120 is aligned with the PCR tubes at one end of the multiple rows of PCR tubes, and then the flat cap pressing structure 110 or the convex cap pressing structure 120 is rotated and pressed along the arc-shaped contour thereof, so that the tube caps on the multiple rows of PCR tubes are pressed one by one, thereby achieving a better sealing effect.

According to a second aspect of the present disclosure, there is provided an opening and closing assembly for multi-gang PCR tubes, as shown in fig. 1 to 10, comprising a lid opener 200 for opening lids of the multi-gang PCR tubes and the above lid closer, the lid opener 200 being detachably coupled to the body 100.

Through above-mentioned technical scheme, the subassembly that opens and shuts that this disclosure provided promptly can dismantle the connection with the ware that closes the lid, can have simultaneously and uncap and close the lid function, also can solve simultaneously because the artifical gloves that uncap are easily scratched the PCR pipe pollution problem that brings.

In some embodiments, in order to facilitate better performing the opening and closing operations, referring to fig. 1, 5 and 6, the body 100 is provided with an installation groove 130, the installation groove 130 is disposed around the grip portion, the lid opener 200 is disposed in the installation groove 130 and detachably connected to the lid opener, and the lid opener 200 is formed with a grip 211 communicating with the grip portion. In the closing operation, the lid opener 200 may be removed from the mounting groove 130 and then the holding portion may be held by hand to perform the closing operation, or the lid may be closed by inserting a hand into the holding opening 211 and holding the main body 100 without removing the lid opener 200.

In some embodiments, in order to enable the cap opener 200 to simultaneously open the plurality of tube caps of the PCR tubes in multiple rows, referring to fig. 5 to 10, the cap opener 200 may include a holding plate 210, a toothed plate 220 fixedly connected to an end of the holding plate 210, a pitch of teeth on the toothed plate 220 matches a tube diameter of the PCR tubes, teeth on the toothed plate 220 are arranged in a wedge shape, the holding plate 210 is arranged vertically and integrally connected to the toothed plate (220), when a cap opening operation is performed, the grip plate 210 is held by hand or the hand is inserted into the grip opening 211 to grip the grip plate 210, then, the teeth on the toothed plate 220 are correspondingly inserted into the gaps between two adjacent PCR tubes, the holding plate 210 is pulled to enable the part of the toothed plate 220 inserted between the multiple rows of PCR tubes to tilt upwards, the cover opening mode is convenient and quick, and the problem that PCR tubes are polluted due to the fact that gloves are easily scratched when the cover is opened manually can be solved.

Referring to fig. 9, the teeth of the toothed plate 220 are arranged in a wedge shape, so that the teeth of the toothed plate 220 can be conveniently and rapidly inserted into the gaps between the multiple rows of PCR tubes.

In some embodiments, the number of teeth on the toothed plate 220 may be set according to the number of PCR tubes in a multiple-row PCR tube, or may be set to a fixed number according to the size of the mounting groove. The present disclosure is not specifically limited herein.

In some embodiments, in order to facilitate the installation of the door opener 200 in the mounting groove 130, as shown in fig. 1 to 2, a first groove 131 for receiving the tooth plate 220 may be provided in the mounting groove 130. When the cover opener 200 is installed on the cover closer, the tooth plate 220 is placed in the first groove 131, so that the cover opener can have good accommodating and hiding functions.

In some embodiments, in order to facilitate the removal of the cap opener 200 from the mounting groove 130, as shown in fig. 1, 2 and 5, a second groove 132 may be provided in the mounting groove 130 opposite to the position of the grip 211. When the cap opener 200 is removed from the cap opener, a hand may be partially inserted into the grip opening 211, and the second groove 132 allows fingers to be bent inside the second groove 132 to grasp the grip plate 210, thereby easily removing the cap opener 200.

In some embodiments, in order to facilitate the easy removal of the lid opener from the lid closer or the easy installation of the lid opener on the lid closer, referring to fig. 1, 5 and 10, the lid opener 200 and the body 100 may be magnetically connected, a first magnet installation groove 133 is provided in the installation groove 130, a second magnet installation groove 212 opposite to the first magnet installation groove 133 is provided on the lid opener 200, and one of the first magnet installation groove 133 and the second magnet installation groove 212 is embedded with a first magnet and the other is embedded with a second magnet or a magnetic metal. The cap opener 200 can be adsorbed in the mounting groove 130 of the cap opener by the magnetic force action of the first magnet and the second magnet or the magnetic metal. In other embodiments, the cap opener 200 and the cap closer may be connected by a snap connection or other detachable connection.

The preferred embodiments of the present disclosure are described in detail with reference to the accompanying drawings, however, the present disclosure is not limited to the specific details of the above embodiments, and various simple modifications may be made to the technical solution of the present disclosure within the technical idea of the present disclosure, and these simple modifications all belong to the protection scope of the present disclosure.

It should be noted that the various features described in the above embodiments may be combined in any suitable manner without departing from the scope of the invention. In order to avoid unnecessary repetition, various possible combinations will not be separately described in this disclosure.

In addition, any combination of various embodiments of the present disclosure may be made, and the same should be considered as the disclosure of the present disclosure, as long as it does not depart from the spirit of the present disclosure.

Claims (10)

1. The cover closing device for the multi-row PCR tubes is characterized by comprising a body (100), wherein a hollow holding part is arranged on the body (100), and a pressing part used for pressing tube covers into tube openings of the multi-row PCR tubes is arranged on the outer edge of the body (100).

2. The closure of claim 1, wherein the press fit comprises a plurality of press fit structures disposed on different exterior sidewalls of the body (100), the press fit structures on each sidewall being different in configuration to press different ones of the tube caps.

3. The lid closer of claim 1, wherein the press-fit portion comprises a flat lid press-fit structure (110), the flat lid press-fit structure (110) having circular grooves (111) arranged side by side to correspond one-to-one to the plurality of PCR tubes.

4. The lid closer according to claim 1, wherein the press-fit portion comprises a convex lid press-fit structure (120), the convex lid press-fit structure (120) having press protrusions (121) arranged side by side to correspond to the plurality of PCR tubes one by one, the press protrusions (121) comprising two concentrically arranged arc-shaped protrusions (122), the two arc-shaped protrusions (122) being symmetrically arranged opposite to each other.

5. The lid closer according to claim 4, wherein the male lid press-fit structure (120) further comprises a positioning block (123), the positioning block (123) being disposed side by side at one end of the plurality of pressing protrusions (121).

6. The lid closure as claimed in any of claims 1 to 5, wherein the body (100) is of square configuration and the press fit is provided on at least one outer side wall of the square configuration.

7. An opening and closing assembly of a multi-gang PCR tube, characterized in that the opening and closing assembly comprises a cap opener (200) for opening a tube cap of the multi-gang PCR tube and the cap closer of any one of claims 1 to 6, wherein the cap opener (200) is detachably connected to the body (100).

8. The opening and closing assembly according to claim 7, wherein a mounting groove (130) is formed on the body (100), the mounting groove (130) is arranged around the holding portion, the lid opener (200) is arranged in the mounting groove (130) and is detachably connected with the lid opener, and a holding opening (211) communicated with the holding portion is formed on the lid opener (200).

9. The opening and closing assembly according to claim 7 or 8, wherein the cap opener (200) comprises a holding plate (210) and a toothed plate (220) fixedly connected with the end of the holding plate (210), the pitch of teeth on the toothed plate (220) is matched with the pipe diameter of the PCR pipe, the teeth on the toothed plate (220) are arranged in a wedge shape, and the holding plate (210) and the toothed plate (220) are vertically arranged and integrally connected.

10. The opening and closing assembly according to claim 8, wherein the cap opener (200) is magnetically coupled to the body (100), a first magnet installation groove (133) is provided in the installation groove (130), a second magnet installation groove (212) opposite to the first magnet installation groove (133) is provided on the cap opener (200), one of the first magnet installation groove (133) and the second magnet installation groove (212) is embedded with a first magnet, and the other is embedded with a second magnet or a magnetic metal.

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