CN214654915U - Detection device for detecting circular RNA gene in blood plasma - Google Patents
Detection device for detecting circular RNA gene in blood plasma Download PDFInfo
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- CN214654915U CN214654915U CN202120221027.9U CN202120221027U CN214654915U CN 214654915 U CN214654915 U CN 214654915U CN 202120221027 U CN202120221027 U CN 202120221027U CN 214654915 U CN214654915 U CN 214654915U
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- fixedly connected
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- 238000001514 detection method Methods 0.000 title claims abstract description 35
- 108091028075 Circular RNA Proteins 0.000 title claims description 15
- 210000002381 plasma Anatomy 0.000 title abstract description 11
- 102000042567 non-coding RNA Human genes 0.000 title abstract description 7
- 239000007788 liquid Substances 0.000 claims abstract description 53
- 238000012360 testing method Methods 0.000 claims abstract description 15
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 13
- 230000005540 biological transmission Effects 0.000 claims description 22
- 239000002699 waste material Substances 0.000 abstract description 3
- 125000004122 cyclic group Chemical group 0.000 abstract description 2
- 108091027963 non-coding RNA Proteins 0.000 abstract description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 4
- 244000309464 bull Species 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000008859 change Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 108060002716 Exonuclease Proteins 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 102000013165 exonuclease Human genes 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
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Abstract
The utility model discloses a detection apparatus for cyclic annular RNA gene in detection blood plasma relates to gene detection technical field, comprising a base plate, the top fixedly connected with support frame of bottom plate, the top fixedly connected with motor of support frame, the first pivot of left output end fixedly connected with of motor, the left end fixedly connected with rotary disk of first pivot, the first guide pillar of right side fixedly connected with of rotary disk, the outside sliding connection of first guide pillar has the guide frame, the bottom fixedly connected with pull rod of guide frame. The utility model discloses in, first guide pillar makes guide frame, pull rod, piston plate remove, and the piston plate moves up and down can let in quantitative gas to the liquid case, can carry the test tube with quantitative liquid at every turn, makes the liquid feeding volume stable, prevents to appear the error, through the cooperation of first contact point, second contact point, solenoid valve etc. prevents to detect liquid and spills, drips on detecting the dish, causes pollution and waste.
Description
Technical Field
The utility model relates to a gene detection technical field especially relates to a detection device for cyclic RNA gene in detection blood plasma.
Background
Unlike traditional linear RNA (including 5 'end and 3' end), the RNA molecule is in a closed ring structure, is not influenced by RNA exonuclease, is more stable in expression, is not easy to degrade through the interaction of RNA related to diseases, and plays an important role in regulating and controlling the diseases.
However, before the detection of the common gene detection device, a certain amount of liquid to be detected is mostly added into the detection disc manually by people, the operation process is complex, operation errors are easy to occur, and the detection result is influenced, so that the detection device for detecting the circular RNA gene in the blood plasma is provided.
SUMMERY OF THE UTILITY MODEL
The utility model aims at solving the defects existing in the prior art and providing a detection device for detecting circular RNA genes in blood plasma.
In order to achieve the above purpose, the utility model adopts the following technical scheme:
a detection device for detecting circular RNA genes in plasma comprises a bottom plate, wherein the top of the bottom plate is fixedly connected with a support frame, the top of the support frame is fixedly connected with a motor, the left output end of the motor is fixedly connected with a first rotating shaft, the left end of the first rotating shaft is fixedly connected with a rotating disk, the right side of the rotating disk is fixedly connected with a first guide pillar, the outer side of the first guide pillar is slidably connected with a guide frame, the bottom of the guide frame is fixedly connected with a pull rod, the bottom of the pull rod is fixedly connected with a piston plate, the left side of the support frame is fixedly connected with an outer frame, the bottom of the outer frame is fixedly connected with a transmission air pipe, the bottom of the transmission air pipe is fixedly connected with a liquid tank, the top and the right side of the liquid tank are fixedly connected with a liquid outlet pipe, the right output end of the motor is fixedly connected with a second rotating shaft, the outer side of the second rotating shaft is fixedly connected with a first gear, the right side fixedly connected with bull stick of support frame, the outside fixedly connected with second gear of bull stick, the top of bottom plate is rotated and is connected with the bracing piece, the outside fixedly connected with fixed disk of bracing piece, the spacing dish of outside fixedly connected with of bracing piece, the top fixedly connected with second guide pillar of fixed disk, the top fixedly connected with transfer line of bottom plate, the top fixedly connected with of transfer line detects the dish, the outside fixedly connected with guide disc of transfer line, the right side inner wall fixedly connected with detector of support frame, the outside fixedly connected with evenly distributed's of detecting the dish guide arm.
Preferably, a controller is externally connected to the outer side of the support frame, the controller is in a DATA-7311 type, one ends, far away from the detection plate, of the guide rods are fixedly connected with first contact points, the right side of the liquid tank is fixedly connected with second contact points, an electromagnetic valve is fixedly connected to the outer side of the liquid outlet pipe, and the controller is electrically connected with the electromagnetic valve, the first contact points and the second contact points.
Preferably, the top of the liquid tank is fixedly connected with a liquid feeding pipe, the top wall of the liquid feeding pipe is in threaded connection with an end cover, the inner side of the guide disc is provided with guide grooves which are matched with the second guide pillars and are uniformly distributed, and the outer side of the guide disc is provided with limiting grooves which are matched with the limiting disc and are uniformly distributed.
Preferably, the left side of the outer frame is fixedly connected with an air inlet pipe, the outer side of the air inlet pipe is fixedly connected with a first one-way valve, and the outer side of the transmission air pipe is fixedly connected with a second one-way valve.
Preferably, the top of the detection plate is provided with evenly distributed test tube slots, the number of the guide rods is equal to that of the test tube slots, the number of the guide rods is four, and the outer side of the piston plate is in sliding connection with the inner side of the outer frame.
Preferably, the first gear is in transmission connection with the second gear through a chain, a first bevel gear is fixedly connected to the left side of the rotating rod, a second bevel gear is fixedly connected to the outer side of the supporting rod, and the first bevel gear is meshed with the second bevel gear.
Compared with the prior art, the above technical scheme of the utility model following profitable technological effect has:
1. the utility model discloses in, through the second pivot, detect the dish, the second guide pillar, the cooperation of guide pulley etc, the rotation that the second pivot rotated and drives first gear makes the second gear through the chain further, the bull stick, first bevel gear rotates, first bevel gear drives second bevel gear, the bracing piece, the fixed disk, spacing dish, the rotation of second guide pillar drive guide pulley, second guide pillar and guide pulley intermittent type nature's contact, conveniently detect the joining of liquid, and change in proper order the test tube automatically and carry out the liquid feeding, reduce staff's operation, guarantee the accuracy in the testing process.
2. The utility model discloses in, through the piston board, the rotary disk, the liquid tank, the cooperation of drain pipe etc, first pivot rotation drives the rotation of rotary disk, the rotation of first guide pillar, first guide pillar makes the guide frame, the pull rod, the piston board removes, the piston board moves up and down can let in quantitative gas to the liquid tank, can carry the test tube with quantitative liquid at every turn in, make the liquid feeding volume stable, prevent the error, through the cooperation of first contact point, the second contact point, solenoid valve etc., prevent that detection liquid from spilling, drip on detecting the dish, cause pollution and waste.
Drawings
FIG. 1 is a schematic structural diagram of a device for detecting circular RNA genes in plasma according to the present invention.
FIG. 2 is a schematic view of the top view of the fixing plate of the device for detecting circular RNA genes in plasma according to the present invention.
FIG. 3 is a left side view of the rotary plate of the device for detecting circular RNA gene in plasma according to the present invention.
Reference numerals: 1. a base plate; 2. a support frame; 3. a motor; 4. a first rotating shaft; 5. rotating the disc; 6. a first guide post; 7. a guide frame; 8. a pull rod; 9. a piston plate; 10. an outer frame; 11. A transmission air pipe; 12. a liquid tank; 13. a liquid outlet pipe; 14. a second rotating shaft; 15. a first gear; 16. a rotating rod; 17. a second gear; 18. a support bar; 19. fixing the disc; 20. a limiting disc; 21. a second guide post; 22. a transmission rod; 23. a guide disc; 24. detecting a disc; 25. a detector; 26. a guide rod.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be described in detail with reference to the accompanying drawings. It should be understood that the description is intended to be illustrative only and is not intended to limit the scope of the present invention. Moreover, in the following description, descriptions of well-known structures and techniques are omitted so as to not unnecessarily obscure the concepts of the present invention.
As shown in FIGS. 1-3, the utility model provides a detection device for detecting circular RNA gene in blood plasma, which comprises a bottom plate 1, a support frame 2 is fixedly connected to the top of the bottom plate 1, a motor 3 is fixedly connected to the top of the support frame 2, a first rotating shaft 4 is fixedly connected to the left output end of the motor 3, a rotating disc 5 is fixedly connected to the left end of the first rotating shaft 4, a first guide pillar 6 is fixedly connected to the right side of the rotating disc 5, a guide frame 7 is slidably connected to the outer side of the first guide pillar 6, a pull rod 8 is fixedly connected to the bottom of the guide frame 7, a piston plate 9 is fixedly connected to the bottom of the pull rod 8, an outer frame 10 is fixedly connected to the left side of the support frame 2, a transmission air pipe 11 is fixedly connected to the bottom of the outer frame 10, a liquid tank 12 is fixedly connected to the bottom of the transmission air pipe 11, a liquid outlet pipe 13 is fixedly connected to the top right side of the liquid tank 12, a second rotating shaft 14 is fixedly connected to the right output end of the motor 3, a first gear 15 is fixedly connected to the outer side of the second rotating shaft 14, a rotating rod 16 is fixedly connected to the right side of the support frame 2, a second gear 17 is fixedly connected to the outer side of the rotating rod 16, a supporting rod 18 is rotatably connected to the top of the bottom plate 1, a fixed disc 19 is fixedly connected to the outer side of the supporting rod 18, a limiting disc 20 is fixedly connected to the outer side of the supporting rod 18, a second guide post 21 is fixedly connected to the top of the fixed disc 19, a transmission rod 22 is fixedly connected to the top of the bottom plate 1, a detection disc 24 is fixedly connected to the top of the transmission rod 22, a guide disc 23 is fixedly connected to the outer side of the transmission rod 22, a detector 25 is fixedly connected to the inner wall of the right side of the support frame 2, and guide rods 26 which are uniformly distributed are fixedly connected to the outer side of the detection disc 24;
the outer side of the supporting frame 2 is externally connected with a controller, the model of the controller is DATA-7311, one ends of the guide rods 26 far away from the detection disc 24 are fixedly connected with first contact points, the right side of the liquid box 12 is fixedly connected with second contact points, the outer side of the liquid outlet pipe 13 is fixedly connected with an electromagnetic valve, the controller is electrically connected with the electromagnetic valve, the first contact points and the second contact points, the top of the liquid box 12 is fixedly connected with a liquid feeding pipe, the top wall of the liquid feeding pipe is in threaded connection with an end cover, the inner side of the guide disc 23 is provided with guide grooves which are matched with the second guide pillars 21 and are uniformly distributed, the outer side of the guide disc 23 is provided with limit grooves which are matched with the limit disc 20 and are uniformly distributed, the left side of the outer frame 10 is fixedly connected with an air inlet pipe, the outer side of the air inlet pipe is fixedly connected with a first one-way valve, the outer side of the transmission air pipe 11 is fixedly connected with a second one-way valve, the top of the detection disc 24 is provided with uniformly distributed test pipe grooves, the number of the guide rods 26 is the same as that of the test tube grooves, the number of the guide rods 26 is four, the outer side of the piston plate 9 is in sliding connection with the inner side of the outer frame 10, the first gear 15 is in transmission connection with the second gear 17 through a chain, the left side of the rotating rod 16 is fixedly connected with a first bevel gear, the outer side of the supporting rod 18 is fixedly connected with a second bevel gear, and the first bevel gear is meshed with the second bevel gear.
In the utility model, the liquid to be detected is added into the liquid tank 12 through the liquid inlet pipe, at the moment, the motor 3 is started, the output end of the motor 3 drives the first rotating shaft 4 and the second rotating shaft 14 to rotate, the first rotating shaft 4 rotates to drive the rotating disc 5 to rotate, the rotating disc 5 drives the first guide post 6 to rotate, the first guide post 6 drives the guide frame 7 to move up and down, the guide frame 7 drives the pull rod 8 and the piston plate 9 to move, when the pull rod 8 moves up, gas is sucked from the air inlet pipe, when the pull rod 8 and the piston plate 9 descend, gas is conveyed into the liquid tank 12 from the transmission air pipe 11, at the moment, the detection liquid in the liquid tank 12 is conveyed into the liquid outlet pipe 13 through air pressure, the liquid outlet pipe 13 enters into the test tube placed at the top of the detection disc 24, when the second rotating shaft 14 rotates, the rotation of the first gear 15 is driven, the first gear 15 drives the rotation of the second gear 17 through a chain, the second gear 17 drives the rotation of the rotating rod 16, the rotating rod 16 drives the first bevel gear and further rotates the second bevel gear, the second bevel gear drives the supporting rod 18 to rotate, the supporting rod 18 drives the fixed disk 19, the limiting disk 20 and the second guide post 21 to rotate, the second guide post 21 drives the guide disk 23 to rotate, when the second guide post 21 is contacted with and separated from the guide disk 23, the guide disk 23 is rotated by 45 degrees, further the detection disk 24 is rotated by 45 degrees, then the rotation is stopped, the detection disk 24 intermittently rotates, when the piston plate 9 moves upwards, the detection disk 24 rotates by 45 degrees under the transmission action, test tubes which are not added with detection liquid are transferred to the bottom of the liquid outlet pipe 13, when the guide rod 26 drives the first contact point to be contacted with the second contact point, the controller controls the electromagnetic valve to be opened, the second guide post 21 is separated from the guide disk 23, the detection disk 24 stops rotating, and the piston plate 9 begins to descend, will detect liquid and extrude from liquid case 12, through the transport of drain pipe 13, fall and place the test tube on detecting dish 24, when detecting dish 24 and continue to rotate, piston plate 9 begins to rise once more, and first contact point breaks away from with the second contact point, and the solenoid valve is closed, prevents to detect liquid and spills, drips on detecting dish 24, causes pollution and waste, can be in proper order will detect liquid and add the test tube at detecting dish 24 top, when the test tube that contains to detect liquid rotates the bottom of detector 25, detect.
In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and to simplify the description, but do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore should not be construed as limiting the present invention.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless specifically limited otherwise.
The above, only be the concrete implementation of the preferred embodiment of the present invention, but the protection scope of the present invention is not limited thereto, and any person skilled in the art is in the technical scope of the present invention, according to the technical solution of the present invention and the utility model, the concept of which is equivalent to replace or change, should be covered within the protection scope of the present invention.
Claims (6)
1. The detection device for detecting the circular RNA genes in the plasma comprises a bottom plate (1) and is characterized in that a support frame (2) is fixedly connected to the top of the bottom plate (1), a motor (3) is fixedly connected to the top of the support frame (2), a first rotating shaft (4) is fixedly connected to the left output end of the motor (3), a rotating disc (5) is fixedly connected to the left end of the first rotating shaft (4), a first guide pillar (6) is fixedly connected to the right side of the rotating disc (5), a guide frame (7) is slidably connected to the outer side of the first guide pillar (6), a pull rod (8) is fixedly connected to the bottom of the guide frame (7), a piston plate (9) is fixedly connected to the bottom of the pull rod (8), an outer frame (10) is fixedly connected to the left side of the support frame (2), and a transmission air pipe (11) is fixedly connected to the bottom of the outer frame (10), the bottom of the transmission air pipe (11) is fixedly connected with a liquid tank (12), the right side of the top of the liquid tank (12) is fixedly connected with a liquid outlet pipe (13), the right output end of the motor (3) is fixedly connected with a second rotating shaft (14), the outer side of the second rotating shaft (14) is fixedly connected with a first gear (15), the right side of the support frame (2) is fixedly connected with a rotating rod (16), the outer side of the rotating rod (16) is fixedly connected with a second gear (17), the top of the bottom plate (1) is rotatably connected with a support rod (18), the outer side of the support rod (18) is fixedly connected with a fixed disk (19), the outer side of the support rod (18) is fixedly connected with a limiting disk (20), the top of the fixed disk (19) is fixedly connected with a second guide pillar (21), the top of the bottom plate (1) is fixedly connected with a transmission rod (22), and the top of the transmission rod (22) is fixedly connected with a detection disk (24), the outer side of the transmission rod (22) is fixedly connected with a guide disc (23), the inner wall of the right side of the support frame (2) is fixedly connected with a detector (25), and the outer side of the detection disc (24) is fixedly connected with guide rods (26) which are uniformly distributed.
2. The device for detecting the circular RNA genes in the plasma as claimed in claim 1, wherein a controller is externally connected to the outer side of the support frame (2), the controller is of a type of DATA-7311, one end of each of the plurality of guide rods (26) far away from the detection disc (24) is fixedly connected with a first contact point, the right side of the liquid tank (12) is fixedly connected with a second contact point, the outer side of the liquid outlet pipe (13) is fixedly connected with an electromagnetic valve, and the controller is electrically connected with the electromagnetic valve, the first contact point and the second contact point.
3. The device for detecting the circular RNA genes in the plasma according to claim 1, wherein a liquid feeding pipe is fixedly connected to the top of the liquid tank (12), an end cover is connected to the top wall of the liquid feeding pipe in a threaded manner, guide grooves which are matched with the second guide pillars (21) and are uniformly distributed are formed in the inner side of the guide disc (23), and limit grooves which are matched with the limit disc (20) and are uniformly distributed are formed in the outer side of the guide disc (23).
4. The device for detecting the circular RNA genes in the plasma according to claim 1, wherein an air inlet pipe is fixedly connected to the left side of the outer frame (10), a first one-way valve is fixedly connected to the outer side of the air inlet pipe, and a second one-way valve is fixedly connected to the outer side of the transmission air pipe (11).
5. The device for detecting the circular RNA genes in the plasma according to claim 1, wherein the top of the detection plate (24) is provided with evenly distributed test tube slots, the number of the guide rods (26) is the same as that of the test tube slots, the number of the guide rods (26) is four, and the outer side of the piston plate (9) is slidably connected with the inner side of the outer frame (10).
6. The device for detecting the circular RNA genes in the plasma according to claim 1, wherein the first gear (15) is in transmission connection with the second gear (17) through a chain, the left side of the rotating rod (16) is fixedly connected with a first bevel gear, the outer side of the supporting rod (18) is fixedly connected with a second bevel gear, and the first bevel gear is meshed with the second bevel gear.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120221027.9U CN214654915U (en) | 2021-01-27 | 2021-01-27 | Detection device for detecting circular RNA gene in blood plasma |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120221027.9U CN214654915U (en) | 2021-01-27 | 2021-01-27 | Detection device for detecting circular RNA gene in blood plasma |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN214654915U true CN214654915U (en) | 2021-11-09 |
Family
ID=78519558
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202120221027.9U Expired - Fee Related CN214654915U (en) | 2021-01-27 | 2021-01-27 | Detection device for detecting circular RNA gene in blood plasma |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN214654915U (en) |
-
2021
- 2021-01-27 CN CN202120221027.9U patent/CN214654915U/en not_active Expired - Fee Related
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| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20211109 |