CN214334974U

CN214334974U - Whole blood detection reagent card shell

Info

Publication number: CN214334974U
Application number: CN202122043025.8U
Authority: CN
Inventors: 何长锋; 王学士; 谢煜萍; 姚丛丛
Original assignee: Shandong Zifeng Biotechnology Co ltd
Current assignee: Shandong Zifeng Biotechnology Co ltd
Priority date: 2021-08-27
Filing date: 2021-08-27
Publication date: 2021-10-01
Anticipated expiration: 2031-08-27

Abstract

The utility model relates to a detect whole blood reagent card shell belongs to reagent card shell technical field, the upper cover sets up first pit, second protruding strip, the bottom of first pit sets up rectangle application of sample hole, the dorsal part of application of sample hole corresponds the position of the blood filtration membrane of reagent card, the second pit corresponds the position of nitrocellulose membrane, second protruding strip is located the dorsal part of upper cover, the direction setting of second protruding strip perpendicular to guiding gutter, the second protruding strip corresponds the position between bonding pad and the nitrocellulose membrane; the back side of the upper cover is provided with a flow guide groove along the direction of the sample adding hole, and the flow guide groove covers the position of the sample adding hole and can guide a sample to the position of the nitrocellulose membrane of the reagent card; the lower shell is matched with the upper cover to form a box body structure. The contact area of the sample and the blood filtering membrane is increased, the flow of the sample is guided, and the red blood cell damage of the whole blood sample is avoided or reduced. The number of the red blood cells left on the blood filter membrane is increased, and the accuracy of the detection result is improved.

Description

Whole blood detection reagent card shell

Technical Field

The utility model belongs to the technical field of the reagent card shell, concretely relates to detect whole blood reagent card shell.

Background

The information in this background section is only for enhancement of understanding of the general background of the invention and is not necessarily to be construed as an admission or any form of suggestion that this information forms the prior art that is already known to a person of ordinary skill in the art.

The reagent card shell is a plastic card used in the immunochromatography reagent process, a test piece consisting of an NC membrane, absorbent paper, a combination pad, a buffer pad and a blood filtration membrane is loaded in the card, as shown in figure 1, and the reagent card shell forms a reagent detection card by bearing the components. As shown in FIG. 2, a circular sample adding hole is formed in a card shell of the prior art, and a sample is added through the circular sample adding hole during use, but the inventor finds that the sample and a blood filtering membrane have the problem of insufficient contact area, so that insufficient blood filtering can be caused, and red blood cells in the sample can be damaged when the whole blood sample is detected by the prior art.

And the reagent card shell adopts the integrated configuration of epitheca and inferior valve, but when carrying out the instrument operation, the condition that exists by the carousel separation, whether can not be fine confirmation press in place when carrying out the epitheca and inferior valve and assembling simultaneously.

SUMMERY OF THE UTILITY MODEL

To the problem that exists among the above-mentioned prior art, the utility model aims at providing a detect whole blood reagent card shell.

In order to solve the technical problem, the technical scheme of the utility model is that:

a reagent cartridge for detecting whole blood, comprising:

the upper cover is provided with a first pit, a second pit and a second protruding strip, the bottom of the first pit is provided with a rectangular sample adding hole, the back side of the sample adding hole corresponds to the position of a blood filtering membrane of the reagent card, the second pit corresponds to the position of a nitrocellulose membrane, the second protruding strip is positioned on the back side of the upper cover and is arranged in the direction perpendicular to the flow guide groove, and the second protruding strip corresponds to the position between the combination pad and the nitrocellulose membrane;

the back side of the upper cover is provided with a diversion trench along the direction of the sample adding hole, and the diversion trench covers the position of the sample adding hole;

the lower shell is matched with the upper cover to form a box body structure.

The upper cover structure of the card shell is designed, and the rectangular sample adding hole can improve the contact area of the sample and the blood filtering membrane. Set up the guiding gutter through the dorsal part at the upper cover, play the effect of water conservancy diversion, avoid the destruction of erythrocyte. In actual use, the reagent card is placed under the upper cover.

The added sample such as blood enters the position of a blood filtering membrane through a sample adding hole, then passes through a buffer pad and a combination pad and reaches the position of an NC membrane (nitrocellulose membrane). The utility model discloses the application of sample hole that sets up, it has set up open guiding gutter structure, and it can improve area of contact, plays moreover from the effect of straining water conservancy diversion between blood membrane and the NC membrane, makes to flow more smoothly, has improved the space between upper cover and the reagent card moreover, has reduced the destruction of erythrocyte.

The utility model discloses one or more technical scheme has following beneficial effect:

whole blood reagent card shell is favorable to the application of sample process through the improvement to the shape and the structure of application of sample hole, improves the area of contact of sample and blood filtering membrane, plays the effect of water conservancy diversion to the flow of sample simultaneously, avoids or reduces the phenomenon that causes the erythrocyte destruction of whole blood sample. The number of the red blood cells left on the blood filter membrane is increased, and the accuracy of the detection result is improved.

Through the structural design of upper cover and inferior valve, make the structure of card shell more stable, split when can preventing mechanical motion. And the clearance between the upper cover and the lower shell is controlled, and lateral chromatography flow is facilitated during chromatography.

Drawings

The accompanying drawings, which form a part hereof, are included to provide a further understanding of the invention, and are incorporated in and constitute a part of this specification, illustrate exemplary embodiments of the disclosure and together with the description serve to explain the invention and not to limit the invention unduly.

FIG. 1 is a block diagram of a test strip;

FIG. 2 is a diagram of a prior art reagent cartridge;

FIG. 3 is a general structure diagram of a whole blood detection reagent cartridge;

FIG. 4 is a front view of the upper cover;

FIG. 5 is a rear view of the upper cover;

FIG. 6 is a front view of the lower case;

FIG. 7 is a rear view of the lower case;

wherein, 1, upper cover, 2, inferior valve, 3, application of sample hole, 4, guiding gutter, 5, first protruding strip, 6, first concave type card strip, 7, the concave type card strip of second, 8, recess, 9, the second pit, 10, filter membrane, 11, blotter, 12, combination pad, 13, NC membrane, 14, absorbent paper, 15, PVC bottom plate, 16, cylinder type arch, 17, the protruding strip of second, 18, first pit, 19, concave arris.

Detailed Description

It should be noted that the following detailed description is intended to provide further explanation of the invention. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs.

It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments according to the present disclosure. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof, unless the context clearly indicates otherwise.

A reagent cartridge for detecting whole blood, comprising:

the back side of the upper cover is provided with a flow guide groove along the direction of the sample adding hole, and the flow guide groove covers the position of the sample adding hole and can guide a sample to the position of the nitrocellulose membrane of the reagent card;

the lower shell is matched with the upper cover to form a box body structure.

As a further technical scheme, the short side of the rectangular sampling hole is of an arc-shaped structure.

As a further technical scheme, the upper cover is provided with two parallel first protruding strips, the first protruding strips are arranged along the direction of the diversion trench, and the distance between the two first protruding strips is larger than the width of the diversion trench.

As a further technical scheme, one end of the upper cover, which is far away from the first concave pit, is provided with a cylindrical bulge. Further, the number of the cylindrical protrusions is set to 1 to 4.

As a further technical scheme, the inner side of the lower shell is provided with a first concave clamping strip and a second concave clamping strip which are raised, the first concave clamping strip is matched with the first convex strip in a clamping way, and the open end of the first concave clamping strip is propped against one end of the first pit.

As a further technical scheme, the second concave clamping strip is matched and clamped with the first convex strip, and the open end of the second concave clamping strip is propped against one end of the second concave pit.

As a further technical scheme, the open ends of the first concave clamping strip and the second concave clamping strip are oppositely arranged.

As a further technical scheme, the edge of the top of the lower shell is provided with a concave edge, and the edge of the upper cover is provided with a clamping table matched with the concave edge.

As a further technical scheme, two opposite grooves are formed in the side portion of the clamping shell.

As shown in fig. 1, a conventional reagent card is configured such that a hemofiltration membrane 10, a buffer pad 11, a bonding pad 12, a (nitrocellulose membrane) NC membrane 13, and a water absorbent paper 14 are arranged in this order from the left end to the right end, a PVC base plate 15 is provided at the bottom, and the hemofiltration membrane 10, the buffer pad 11, the bonding pad 12, the NC membrane 13, and the water absorbent paper 14 are provided above the PVC base plate. The blood filtering membrane 10, the buffer pad 11 and the combining pad 12 are sequentially and partially overlapped, the NC membrane 13 and the absorbent paper 14 are partially overlapped, and the combining pad 12 and the absorbent paper 14 are matched to press the NC membrane.

The existing reagent card using method is to place the reagent card into a reagent card shell, so that the pollution of the reagent card is avoided, and the external strain force can be resisted. The fluorescence immunoassay appearance is used for the incubation and the detection of detect reagent, reagent card back of packing into the card shell, add blood sample through adding the sample hole 3, then put into fluorescence immunoassay appearance with the card shell, in fluorescence immunoassay appearance, can take place the rotation, make the card shell rotate to the position that detect reagent corresponds, then manual add detect reagent to the position of the second pit 9 of card shell, detect in proper order like this, reagent card after adding detect reagent rotates to the position that detects, carry out fluorescence detection and obtain the result, then the card shell is discharged.

So can take place to rotate at this in-process card shell and need whole card shell stable in structure, the blood sample moves the position of second pit from application of sample hole 3, so the utility model discloses in design open guiding gutter 4's structure to make its abundant water conservancy diversion to the position of the NC membrane that the second pit corresponds, reduce and destroy.

As shown in fig. 4 and 5, the utility model relates to a detect whole blood reagent card shell includes: the reagent card comprises an upper cover 1 and a lower cover, wherein the upper cover 1 is provided with a first pit 18, a second pit 9 and a second raised strip 17, the bottom of the first pit 18 is provided with a rectangular sample adding hole 3, the back side of the sample adding hole 3 corresponds to the position of a blood filtering membrane of the reagent card, the second pit 9 corresponds to the position of a nitrocellulose membrane, the second raised strip 17 is positioned on the back side of the upper cover, the second raised strip 17 is arranged in a direction perpendicular to a flow guide groove 4, and the second raised strip 17 corresponds to the position between a combination pad and an NC membrane; a flow guide groove 4 is arranged on the back side of the upper cover 1 along the direction of the sample adding hole 3, and the flow guide groove 4 covers the position of the sample adding hole 3 and can guide a sample to the position of a nitrocellulose membrane of the reagent card; the lower casing 2 is matched with the upper cover 1 to form a box body structure.

The reagent card shell that detects and use generally drips the sample into application of sample hole 3, then with the inside blood filtration membrane contact of card shell, current circular application of sample hole, the sample can cause the blood filtration inadequately with the area of contact of blood filtration membrane. The utility model discloses in designed rectangle application of sample hole, with the area of contact grow of straining the blood membrane.

And rectangle application of sample hole 3 and guiding gutter 4 that the dorsal part set up cooperate, the guiding gutter is the same with rectangular direction, the application of sample hole is located the middle part region of guiding gutter, leave the space between guiding gutter and the blood filtering membrane, the sample adds the back, can expand on the blood filtering membrane under the water conservancy diversion effect of guiding gutter, be favorable to improving the area of contact of sample and blood filtering membrane, play the effect from water conservancy diversion between blood filtering membrane and the NC membrane, it is more smooth and easy to make the sample flow to the NC membrane from blood filtering membrane, and improved the space between upper cover and the reagent card, the destruction of erythrocyte has been reduced. The detection effect is more accurate after the sample flows to the NC membrane.

The upper cover is provided with second protruding strips 17, the second protruding strips 17 are perpendicular to the direction of the diversion trench 4, and the second protruding strips 17 correspond to the positions between the bonding pads and the NC membrane. Corresponding to the position between the conjugate pad and the NC membrane shown in fig. 1, since the sample liquid flows into the NC membrane through the conjugate pad, the second raised strips 17 serve to block the liquid from directly flowing past, allowing the liquid to pass through the conjugate pad and then enter the NC membrane, facilitating the inspection of the sample.

Furthermore, the short side of the rectangular sample adding hole 3 is of an arc-shaped structure. The short edge of the sampling hole is of an arc-shaped structure, so that the effect of buffering samples is achieved, and the flow guide is facilitated.

Further, the upper cover is provided with two parallel first protruding strips 5, the first protruding strips 5 are arranged along the direction of the diversion trench 4, and the distance between the two first protruding strips is larger than the width of the diversion trench 4. The two first protruding strips 5 have a matching effect with the concave clamping strips and have a limiting effect.

As shown in fig. 5, further, a cylindrical protrusion 16 is provided at an end of the upper cover 1 away from the first recess. Further, the number of the cylindrical projections 16 is set to 1 to 4. As shown in fig. 5 and fig. 1, a cylindrical protrusion is disposed at an end away from the first concave, corresponding to the position of the absorbent paper in fig. 1, for pressing the absorbent paper, so as to position the reagent card.

Further, still include inferior valve 2, form the box body structure with upper cover 1 cooperation. The upper cover 1 and the lower shell 2 are combined to form a containing structure, and a test piece is placed in the containing structure, so that the detection and the transfer are convenient.

Further, the inner side of the lower shell 2 is provided with a first concave clamping strip 6 which is convex, the first concave clamping strip 6 is matched with the first convex strip 5 to be clamped, and the open end of the first concave clamping strip 6 is propped against one end of the first concave pit. As shown in fig. 5 and 6, the first concave-shaped clamping strip is clamped with a position on one side of the sample adding hole of the first concave pit, is clamped with the first convex strip, and abuts against the edge of the first concave pit. The utility model discloses in, the first protruding strip of upper cover and the first concave type card strip of inferior valve cooperate, explain the lock degree of upper cover and inferior valve better, can not only better clip the reagent card, play the effect of stabilizing the reagent card, the structure of whole card shell is more stable moreover, is difficult to break away from, need place fluorescence immunoassay appearance at the whole card shell of in-process that detects, at instrument moving in-process, is difficult to part.

As shown in fig. 6 and 7, a second concave clamping strip 7 is disposed on the inner side of the lower shell, the second concave clamping strip 7 is engaged with the first convex strip 5, and the open end of the second concave clamping strip 7 abuts against one end of the second concave pit. As shown in fig. 5 and 6, the second concave-shaped locking strip 7 is engaged with one side of the second concave recess, engaged with the first convex strip, and abutted against the edge of the second concave recess.

Furthermore, the open ends of the first concave clamping strip 6 and the second concave clamping strip 7 are oppositely arranged. Through relative setting, will follow both sides and carry first pit and second pit respectively, first concave type card strip 6 and the concave type card strip 7 of second are located the inferior valve, with inferior valve fixed connection, so improved the fixed action of upper cover and inferior valve. The phenomenon of separation caused when the instrument operates is avoided.

And the first concave card strip 6 and the second concave card strip 7 are structures protruding relative to the lower shell 2, so that the gaps between the upper cover and the lower shell can be controlled, and the lateral chromatography flow in the chromatography detection of the reagent card is facilitated.

Furthermore, the top edge of the lower shell 2 is provided with a concave edge 19, and the edge of the upper cover is provided with a clamping table matched with the concave edge 19. As shown in fig. 3 and 4, the edge of the lower case is provided with the concave ridge 19, the concave ridge has different heights, the edge of the upper cover is provided with the clamping table, the clamping table is convex relative to the edge structure, so that the clamping of the upper cover and the lower case can be facilitated, the pressing in place can be confirmed during the assembling, and the stability is improved.

Further, two opposite grooves 8 are provided at the side of the card housing. The lateral part of card shell sets up the recess, can conveniently detect the time taking convenience.

The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. The utility model provides a detect whole blood reagent card shell which characterized in that: the method comprises the following steps:

the lower shell is matched with the upper cover to form a box body structure.

2. The reagent cartridge for testing whole blood according to claim 1, wherein: the one end that first pit was kept away from to the upper cover sets up the cylinder type arch, and the upper cover sets up the first protruding strip of two parallels, and first protruding strip sets up along the direction of guiding gutter, and the interval between two first protruding strips is greater than the width of guiding gutter.

3. The reagent cartridge for testing whole blood according to claim 2, wherein: the inner side of the lower shell is provided with a first concave clamping strip and a second concave clamping strip which are raised, the first concave clamping strip is matched with the first convex strip in a clamping way, and the open end of the first concave clamping strip is propped against one end of the first pit.

4. The reagent cartridge for testing whole blood according to claim 3, wherein: the second concave clamping strip is matched and clamped with the first convex strip, and the open end of the second concave clamping strip is propped against one end of the second concave pit.

5. The reagent cartridge for testing whole blood according to claim 3, wherein: the open ends of the first concave clamping strip and the second concave clamping strip are arranged oppositely.

6. The reagent cartridge for testing whole blood according to claim 1, wherein: the top edge of inferior valve sets up the concave ridge, and the edge of upper cover sets up the card platform with concave ridge matched with.